DE69739856D1 - Agonisten für den rezeptor des hepatozyten-wachstumsfaktors und deren anwendungen - Google Patents

Agonisten für den rezeptor des hepatozyten-wachstumsfaktors und deren anwendungen

Info

Publication number
DE69739856D1
DE69739856D1 DE69739856T DE69739856T DE69739856D1 DE 69739856 D1 DE69739856 D1 DE 69739856D1 DE 69739856 T DE69739856 T DE 69739856T DE 69739856 T DE69739856 T DE 69739856T DE 69739856 D1 DE69739856 D1 DE 69739856D1
Authority
DE
Germany
Prior art keywords
agonists
growth factor
hepatocyte growth
receptor agonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739856T
Other languages
English (en)
Inventor
Kenneth J Hillan
Ralph H Schwall
Kelly H Tabor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69739856D1 publication Critical patent/DE69739856D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE69739856T 1996-07-03 1997-06-20 Agonisten für den rezeptor des hepatozyten-wachstumsfaktors und deren anwendungen Expired - Lifetime DE69739856D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2121596P 1996-07-03 1996-07-03
PCT/US1997/010688 WO1998000543A1 (en) 1996-07-03 1997-06-20 Hepatocyte growth factor receptor agonists and uses thereof

Publications (1)

Publication Number Publication Date
DE69739856D1 true DE69739856D1 (de) 2010-06-02

Family

ID=21803007

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69739856T Expired - Lifetime DE69739856D1 (de) 1996-07-03 1997-06-20 Agonisten für den rezeptor des hepatozyten-wachstumsfaktors und deren anwendungen

Country Status (11)

Country Link
US (1) US6099841A (de)
EP (1) EP0922102B1 (de)
JP (1) JP2000515735A (de)
AT (1) ATE465257T1 (de)
AU (1) AU729029B2 (de)
CA (1) CA2258153C (de)
DE (1) DE69739856D1 (de)
DK (1) DK0922102T3 (de)
IL (1) IL127558A0 (de)
WO (1) WO1998000543A1 (de)
ZA (1) ZA975851B (de)

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US9701754B1 (en) 2002-10-23 2017-07-11 City Of Hope Covalent disulfide-linked diabodies and uses thereof
MXPA05008521A (es) * 2003-02-13 2005-10-20 Pharmacia Corp Anticuerpos a c-met para el tratamiento de canceres.
US7407660B2 (en) * 2003-04-16 2008-08-05 Genentech, Inc. Methods and compositions for selective modulation of vascularization
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ITMI20031127A1 (it) * 2003-06-05 2004-12-06 Uni Degli Studi Del Piemont E Orientale Am Anticorpi anti-hgf-r e loro uso
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US20060003931A1 (en) * 2004-05-06 2006-01-05 Genentech, Inc. Crystal structure of the hepatocyte growth factor and methods of use
ATE475099T1 (de) * 2004-10-20 2010-08-15 Peas Inst Ab Beurteilung der biologischen aktivität von hgf (hepatocyte growth factor)
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EP1852124A4 (de) * 2005-01-24 2009-08-12 Kringle Pharma Inc Fibrose-hemmer für ein implantiertes organ
EP1867339A4 (de) * 2005-03-02 2010-05-26 Mitsubishi Tanabe Pharma Corp Antivirales mittel
ES2539790T3 (es) * 2005-03-25 2015-07-06 Genentech, Inc. Métodos y composiciones para modular c-met hiperestabilizado
US20060263808A1 (en) * 2005-03-25 2006-11-23 Genentech, Inc. C-met mutations in lung cancer
EP1863519B1 (de) 2005-03-31 2013-09-25 The General Hospital Corporation Modulation von hgf/hgfr-aktivität zur behandlung von lymphödem
JP2008545753A (ja) * 2005-06-02 2008-12-18 ギャラクシー バイオテック， エルエルシー 抗体で脳腫瘍を処置する方法
JP2009531324A (ja) 2006-03-20 2009-09-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 癌標的化のための操作された抗前立腺幹細胞抗原（ｐｓｃａ）抗体
US8133867B2 (en) 2006-03-20 2012-03-13 Seikagaku Corporation Method for treating rheumatoid arthritis with an antibody that binds to a hepatocyte growth factor receptor
AR059922A1 (es) * 2006-04-01 2008-05-07 Galaxy Biotech Llc Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
ATE528286T1 (de) 2006-12-20 2011-10-15 Bayer Healthcare Llc 4-ä4-ä(ä3-tert-butyl-1-ä3-(hydroxymethyl)phenyl - 1h-pyrazol-5-ylücarbamoyl)-aminoü-3- chlorophenoxyü-n-methylpyridin-2-carboxamid als inhibitor der vegfr kinase zur behandlung von krebs
JP6126773B2 (ja) 2007-09-04 2017-05-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原（ｐｓｃａ）抗体
US20110092452A1 (en) * 2008-03-05 2011-04-21 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating pancreatic cancer
CA2752510C (en) 2009-02-17 2024-01-23 Neil Bander Methods and kits for diagnosis of cancer and prediction of therapeutic value
JP2013511969A (ja) 2009-11-25 2013-04-11 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 確定的内胚葉細胞の肝分化のための方法
US8772459B2 (en) 2009-12-02 2014-07-08 Imaginab, Inc. J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use
WO2012003338A1 (en) 2010-07-01 2012-01-05 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
HUE044419T2 (hu) 2010-07-09 2019-10-28 Bioverativ Therapeutics Inc Feldogozható egyetlen láncú molekulák és ezek alkalmazásával készült peptidek
US9688773B2 (en) 2010-11-03 2017-06-27 Argen-X N.V. C-Met antibody combinations
US9738707B2 (en) 2011-07-15 2017-08-22 Biogen Ma Inc. Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto
EP2773660A2 (de) 2011-11-03 2014-09-10 Argen-X B.V. Chimäre mensch-kamel-antigene und ihre verwendung
BR112014016887A2 (pt) 2012-01-10 2018-08-14 Biogen Idec Inc potencialização do transporte de moléculas terapêu-ticas através da barreira hematoencefálica
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
CA2899089C (en) 2013-03-15 2021-10-26 Biogen Ma Inc. Factor ix polypeptide formulations
WO2015056713A1 (ja) * 2013-10-15 2015-04-23 国立大学法人東京大学 ｃ－Ｍｅｔタンパク質アゴニスト
MA39776A (fr) 2014-03-24 2017-02-01 Hoffmann La Roche Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
BR112017005202A2 (pt) 2014-09-16 2017-12-12 Symphogen As anticorpos anti-met e composições
RU2017127609A (ru) 2015-02-04 2019-03-04 Ф. Хоффманн-Ля Рош Аг Антисмысловые олигомеры тау-белка и их применение
CN115181778A (zh) 2015-02-04 2022-10-14 百时美施贵宝公司 选择治疗性分子的方法
MX2018001566A (es) 2015-08-07 2019-04-25 Imaginab Inc Construcciones de union a antigeno para moleculas diana.
GB201611123D0 (en) * 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
IT201800000535A1 (it) 2018-01-03 2019-07-03 Procedimenti per la cura del cancro.
SG11202108525VA (en) 2019-02-21 2021-09-29 Regeneron Pharma Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind met
CA3143640A1 (en) * 2019-07-26 2021-02-04 Fei Yi Methods and compositions for producing hepatocytes
EP4031574A1 (de) 2019-09-16 2022-07-27 Regeneron Pharmaceuticals, Inc. Radioaktiv markierte met-bindungsproteine für immuno-pet-bildgebung
US20240084041A1 (en) 2022-09-01 2024-03-14 Regeneron Pharmaceuticals, Inc. Methods of treating non-small cell lung cancer using mesenchymal epithelial transition factor (met)-targeted agents

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Also Published As

Publication number Publication date
US6099841A (en) 2000-08-08
JP2000515735A (ja) 2000-11-28
AU729029B2 (en) 2001-01-25
CA2258153C (en) 2004-08-17
EP0922102B1 (de) 2010-04-21
DK0922102T3 (da) 2010-08-16
ATE465257T1 (de) 2010-05-15
IL127558A0 (en) 1999-10-28
AU3494997A (en) 1998-01-21
WO1998000543A1 (en) 1998-01-08
EP0922102A1 (de) 1999-06-16
CA2258153A1 (en) 1998-01-08
ZA975851B (en) 1999-01-04

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