SG11202108525VA - Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind met - Google Patents
Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind metInfo
- Publication number
- SG11202108525VA SG11202108525VA SG11202108525VA SG11202108525VA SG11202108525VA SG 11202108525V A SG11202108525V A SG 11202108525VA SG 11202108525V A SG11202108525V A SG 11202108525VA SG 11202108525V A SG11202108525V A SG 11202108525VA SG 11202108525V A SG11202108525V A SG 11202108525VA
- Authority
- SG
- Singapore
- Prior art keywords
- met
- methods
- antigen binding
- binding molecules
- bispecific antigen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 201000008106 ocular cancer Diseases 0.000 title 1
Classifications
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07—ORGANIC CHEMISTRY
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962808839P | 2019-02-21 | 2019-02-21 | |
US201962823788P | 2019-03-26 | 2019-03-26 | |
PCT/US2020/019126 WO2020172475A1 (en) | 2019-02-21 | 2020-02-20 | Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind met |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202108525VA true SG11202108525VA (en) | 2021-09-29 |
Family
ID=70057228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202108525VA SG11202108525VA (en) | 2019-02-21 | 2020-02-20 | Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind met |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220040319A1 (en) |
EP (1) | EP3927435A1 (en) |
JP (1) | JP2022523360A (en) |
KR (1) | KR20210130755A (en) |
CN (1) | CN113727757A (en) |
AU (1) | AU2020224136A1 (en) |
CA (1) | CA3128519A1 (en) |
IL (1) | IL285308A (en) |
MX (1) | MX2021010114A (en) |
SG (1) | SG11202108525VA (en) |
WO (1) | WO2020172475A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3146933A1 (en) | 2019-09-16 | 2021-03-25 | Marcus KELLY | Radiolabeled met binding proteins for immuno-pet imaging |
WO2022204332A1 (en) * | 2021-03-24 | 2022-09-29 | Combangio, Inc. | Compositions comprising c-met agonist antibodies and methods for use in ocular treatment |
WO2023055207A1 (en) | 2021-10-01 | 2023-04-06 | 주식회사 엘지화학 | Thermoplastic resin composition |
WO2024002235A1 (en) * | 2022-06-29 | 2024-01-04 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-egfr/met antibodies and uses thereof |
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2020
- 2020-02-20 CA CA3128519A patent/CA3128519A1/en active Pending
- 2020-02-20 US US16/796,380 patent/US20220040319A1/en active Pending
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- 2020-02-20 WO PCT/US2020/019126 patent/WO2020172475A1/en unknown
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- 2020-02-20 JP JP2021549279A patent/JP2022523360A/en active Pending
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2021
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CA3128519A1 (en) | 2020-08-27 |
EP3927435A1 (en) | 2021-12-29 |
AU2020224136A1 (en) | 2021-09-02 |
KR20210130755A (en) | 2021-11-01 |
CN113727757A (en) | 2021-11-30 |
WO2020172475A1 (en) | 2020-08-27 |
JP2022523360A (en) | 2022-04-22 |
IL285308A (en) | 2021-09-30 |
MX2021010114A (en) | 2021-12-10 |
US20220040319A1 (en) | 2022-02-10 |
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