DE69722434D1 - Buttersäure-ester mit antiproliferativer wirkung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Buttersäure-ester mit antiproliferativer wirkung und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
DE69722434D1
DE69722434D1 DE69722434T DE69722434T DE69722434D1 DE 69722434 D1 DE69722434 D1 DE 69722434D1 DE 69722434 T DE69722434 T DE 69722434T DE 69722434 T DE69722434 T DE 69722434T DE 69722434 D1 DE69722434 D1 DE 69722434D1
Authority
DE
Germany
Prior art keywords
pct
pharmaceutical compositions
compositions containing
acid ester
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69722434T
Other languages
English (en)
Other versions
DE69722434T2 (de
Inventor
Alberto Perbellini
Danila Coradini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigea SRL
Original Assignee
Sigea SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigea SRL filed Critical Sigea SRL
Application granted granted Critical
Publication of DE69722434D1 publication Critical patent/DE69722434D1/de
Publication of DE69722434T2 publication Critical patent/DE69722434T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0036—Galactans; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69722434T 1996-11-29 1997-11-26 Buttersäure-ester mit antiproliferativer wirkung und diese enthaltende pharmazeutische zusammensetzungen Expired - Lifetime DE69722434T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT96MI002505A IT1286510B1 (it) 1996-11-29 1996-11-29 Esteri butirrici ad attivita' antiproliferativa e composizioni farmaceutiche che li contengono
ITMI962505 1996-11-29
PCT/EP1997/006589 WO1998023648A1 (en) 1996-11-29 1997-11-26 New butyric esters with antiproliferative activity and the pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
DE69722434D1 true DE69722434D1 (de) 2003-07-03
DE69722434T2 DE69722434T2 (de) 2004-04-08

Family

ID=11375310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722434T Expired - Lifetime DE69722434T2 (de) 1996-11-29 1997-11-26 Buttersäure-ester mit antiproliferativer wirkung und diese enthaltende pharmazeutische zusammensetzungen

Country Status (9)

Country Link
US (1) US6140313A (de)
EP (1) EP0941253B1 (de)
JP (1) JP4256475B2 (de)
AT (1) ATE241648T1 (de)
AU (1) AU5751598A (de)
CA (1) CA2272720C (de)
DE (1) DE69722434T2 (de)
IT (1) IT1286510B1 (de)
WO (1) WO1998023648A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4790911B2 (ja) 1999-01-13 2011-10-12 アルケミア オンコロジー ピーティワイ リミテッド 薬物の効力を増強するための組成物および方法
IT1318403B1 (it) 2000-03-17 2003-08-25 Cooperativa Ct Ricerche Poly T Esteri polisaccaridici di n-derivati di acido glutammico.
AUPQ879500A0 (en) 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
JPWO2002066496A1 (ja) * 2001-02-20 2004-06-17 タカラバイオ株式会社 修飾剤
ITTS20010013A1 (it) * 2001-06-04 2002-12-04 Ct Ricerche Poly Tec H A R L S Nuovi derivati di ialuronano.
ITTS20010017A1 (it) 2001-07-17 2003-01-17 Ct Ricerche Polytech Soc Coop Esteri polisaccaridici di acido retinoico.
ITMI20022745A1 (it) * 2002-12-23 2004-06-24 Coimex Scrl United Companies Esteri misti dell'acido ialuronico ad attivita' citostatica e prodifferenziante e procedimento per la loro produzione.
ITMI20040605A1 (it) * 2004-03-29 2004-06-29 Coimex S C R L United Companie Esteri butirrici dell'acido ialuronico a basso grado di sostituzione procedimento per la loro preparazione ed uso
AU2006274509B2 (en) 2005-07-27 2012-01-19 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
EA013877B1 (ru) 2005-09-07 2010-08-30 Алкемиа Онколоджи Пти Лимитед Терапевтические композиции, содержащие гиалуроновую кислоту и терапевтические антитела, а также способы лечения
US20070065484A1 (en) * 2005-09-21 2007-03-22 Chudzik Stephen J In situ occlusion using natural biodegradable polysaccharides
US8241656B2 (en) * 2005-09-21 2012-08-14 Surmodics, Inc Articles including natural biodegradable polysaccharides and uses thereof
US7993678B2 (en) * 2005-09-26 2011-08-09 Novozymes Biopolymer A/S Hyaluronic acid derivatives
DE102005046237A1 (de) * 2005-09-28 2007-04-05 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Buttersäureester von Kohlenhydraten und Kohlenhydratpolyolen
US20080154241A1 (en) * 2006-12-07 2008-06-26 Burkstrand Michael J Latent stabilization of bioactive agents releasable from implantable medical articles
EP1942117A1 (de) * 2006-12-29 2008-07-09 Sigea S.R.L. Derivate aus Carboxypolysacchariden
ITMI20072237A1 (it) * 2007-11-27 2009-05-28 Sigea Srl Esteri misti butirrico-formico di polisaccaridi acidi, loro preparazione ed uso come dermocosmetici
EP2921504B1 (de) * 2012-11-14 2017-07-12 National Institute of Advanced Industrial Science and Technology Beta-1,3-glucan-derivat und verfahren zur herstellung des beta-1,3-glucan-derivats
CZ304654B6 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
PL3245233T3 (pl) * 2015-01-13 2019-06-28 Bmg Pharma S.P.A. Sposób wytwarzania w wodzie estrów soli sodowej kwasu hialuronowego z kwasem masłowym
IT201900021693A1 (it) 2019-11-20 2021-05-20 Bmg Pharma S P A Derivati butirrati o butirrati e formiati dell’acido ialuronico reticolati e loro procedimento di reticolazione
IT202000016984A1 (it) 2020-07-13 2022-01-13 Bmg Pharma S P A Composizioni igienizzanti e antiinfettive per le mucose orali

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU497159B2 (en) * 1974-02-21 1978-12-07 Commonwealth Scientific And Industrial Research Organization Removing limonin from citrus fruit juice
ES2071608T3 (es) * 1986-08-20 1995-07-01 Univ Miami Esteres de alcanoilo de heparina de bajo peso molecular.
FR2633929B2 (fr) * 1987-09-25 1995-05-24 Picardie Universite Derives non toxiques de l'acide n-butyrique, presentant des actions therapeutiques retardees
US4959466A (en) * 1988-01-25 1990-09-25 Arco Chemical Technology, Inc. Partially esterified polysaccharide (PEP) fat substitutes
EP0330106A1 (de) * 1988-02-25 1989-08-30 Akzo Nobel N.V. Modifizierte Cellulose für biocompatible Dialysemembranen II und Verfahren zu deren Herstellung
JP2667441B2 (ja) * 1988-05-18 1997-10-27 生化学工業株式会社 血管内皮細胞増殖抑制剤
FR2634485B1 (fr) * 1988-07-21 1992-02-28 Sanopi Glycosaminoglycanes selectivement o-acyles, leur preparation et compositions pharmaceutiques les contenant
ES2088003T3 (es) * 1990-04-16 1996-08-01 Eastman Chem Co Procedimiento para preparar esteres de celulosa por uso de acidos carboxilicos.
WO1994008617A1 (en) * 1992-10-16 1994-04-28 Brigham And Women's Hospital, Inc. O-derivatized alginic acid antigens
DE4414138A1 (de) * 1994-04-22 1995-10-26 Consortium Elektrochem Ind Acylierte gamma-Cyclodextrine
FR2723096B1 (fr) * 1994-07-28 1996-10-18 Univ Picardie Esters associant les acides phenylacetique,3-phenyl-propionique, 4-phenyl-butyrique et n-butyrique au d-mannose, au xylitol et a leurs derives. applications comme medicaments
WO1996013632A1 (en) * 1994-10-28 1996-05-09 Novo Nordisk A/S A process for chemical finishing of insoluble polymers
DE19529409A1 (de) * 1995-08-10 1997-02-13 Wolff Walsrode Ag Maleinsäureadditionsproduktgruppen enthaltende, thermoplastische und biologisch abbaubare Polysaccharidester/-etherester
DE19607847C1 (de) * 1996-03-01 1997-11-20 Suedzucker Ag Aliphatische Carbonsäureester von Inulin
US5916883A (en) * 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives

Also Published As

Publication number Publication date
EP0941253B1 (de) 2003-05-28
WO1998023648A1 (en) 1998-06-04
DE69722434T2 (de) 2004-04-08
JP4256475B2 (ja) 2009-04-22
ITMI962505A0 (it) 1996-11-29
CA2272720A1 (en) 1998-06-04
JP2001505940A (ja) 2001-05-08
IT1286510B1 (it) 1998-07-15
CA2272720C (en) 2008-01-08
AU5751598A (en) 1998-06-22
ITMI962505A1 (it) 1998-05-29
EP0941253A1 (de) 1999-09-15
US6140313A (en) 2000-10-31
ATE241648T1 (de) 2003-06-15

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Legal Events

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8364 No opposition during term of opposition