DE69330714D1 - Chinuclidine derivate als substanz p antagonisten - Google Patents
Chinuclidine derivate als substanz p antagonistenInfo
- Publication number
- DE69330714D1 DE69330714D1 DE69330714T DE69330714T DE69330714D1 DE 69330714 D1 DE69330714 D1 DE 69330714D1 DE 69330714 T DE69330714 T DE 69330714T DE 69330714 T DE69330714 T DE 69330714T DE 69330714 D1 DE69330714 D1 DE 69330714D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- substituted
- alkoxy
- hydrogen
- disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6533792 | 1992-03-23 | ||
PCT/US1993/001810 WO1993019064A1 (en) | 1992-03-23 | 1993-03-05 | Quinuclidine derivatives as substance p antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69330714D1 true DE69330714D1 (de) | 2001-10-11 |
DE69330714T2 DE69330714T2 (de) | 2002-02-07 |
Family
ID=13284021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69330714T Expired - Fee Related DE69330714T2 (de) | 1992-03-23 | 1993-03-05 | Chinuclidine derivate als substanz p antagonisten |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0632809B1 (de) |
JP (1) | JP2656702B2 (de) |
KR (1) | KR950700908A (de) |
AT (1) | ATE205207T1 (de) |
AU (1) | AU3782493A (de) |
CA (1) | CA2132541C (de) |
DE (1) | DE69330714T2 (de) |
DK (1) | DK0632809T3 (de) |
ES (1) | ES2160596T3 (de) |
FI (1) | FI944394A (de) |
GR (1) | GR3037025T3 (de) |
HU (1) | HU9402745D0 (de) |
IL (1) | IL105098A0 (de) |
MX (1) | MX9301634A (de) |
NO (1) | NO943526D0 (de) |
PT (1) | PT632809E (de) |
WO (1) | WO1993019064A1 (de) |
ZA (1) | ZA932016B (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2700472B1 (fr) | 1993-01-19 | 1995-02-17 | Rhone Poulenc Rorer Sa | Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2. |
IL109646A0 (en) * | 1993-05-19 | 1994-08-26 | Pfizer | Heteroatom substituted alkyl benzylamino-quinuclidines |
US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
DK0708771T3 (da) * | 1993-07-15 | 1999-06-21 | Pfizer | Benzyloxyquinuclidiner som substans P antagonister |
EP0719253B1 (de) * | 1993-09-17 | 2004-04-28 | Pfizer Inc. | 3-amino-5-carboxy-substituierte piperidine und 3-amino-4-carboxy-substituierte pyrrolidine als tachykinin-antagonisten |
US6083943A (en) * | 1993-09-17 | 2000-07-04 | Pfizer Inc | Substituted azaheterocyclecarboxylic acid |
EP0653208A3 (de) * | 1993-11-17 | 1995-10-11 | Pfizer | Substanz P Antagonisten zur Behandlung oder Verhütung des sonnenbrandes. |
EP0659409A3 (de) * | 1993-11-23 | 1995-08-09 | Pfizer | Substanz P Antagonisten zur Hemmung der Angiogenese. |
EP0655246A1 (de) * | 1993-11-30 | 1995-05-31 | Pfizer Inc. | Substanz P Antagonisten zur Behandlung von durch Helicobacter Pylori oder andere spirale Urease-positive Gram-negative Bakterien verursachten Krankheiten |
IL116249A (en) * | 1994-12-12 | 2003-07-06 | Pfizer | Nk-1 receptor antagonists for the treatment of neuronal damage and stroke |
TW458774B (en) | 1995-10-20 | 2001-10-11 | Pfizer | Antiemetic pharmaceutical compositions |
MX9706944A (es) * | 1996-09-12 | 1998-08-30 | Pfizer | Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p. |
CN1414953A (zh) | 1999-11-03 | 2003-04-30 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途 |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
US20040001895A1 (en) * | 2002-06-17 | 2004-01-01 | Pfizer Inc. | Combination treatment for depression and anxiety |
MX2007000428A (es) | 2004-07-15 | 2008-03-05 | Amr Technology Inc | Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina. |
ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
CA2615403C (en) | 2005-07-15 | 2015-06-16 | Amr Technology, Inc. | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
AU2006297443B2 (en) | 2005-09-29 | 2010-08-12 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
CA2664113C (en) | 2006-09-22 | 2013-05-28 | Merck & Co., Inc. | Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
EP2109608B1 (de) | 2007-01-10 | 2011-03-23 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Amidsubstituierte indazole als poly-(adp-ribose)-polymerase (parp)-hemmer |
US8106086B2 (en) | 2007-04-02 | 2012-01-31 | Msd K.K. | Indoledione derivative |
JP5501227B2 (ja) | 2007-06-27 | 2014-05-21 | メルク・シャープ・アンド・ドーム・コーポレーション | ヒストンデアセチラーゼ阻害剤としての4−カルボキシベンジルアミノ誘導体 |
AU2009222122A1 (en) | 2008-03-03 | 2009-09-11 | Tiger Pharmatech | Tyrosine kinase inhibitors |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
EP2413932A4 (de) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | Hemmer der akt-aktivität |
EP2429293B1 (de) | 2009-05-12 | 2014-10-29 | Bristol-Myers Squibb Company | KRISTALLINE FORMEN VON (S)-7-([1,2,4]TRIAZOL[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLORPHENYL)-1,2,3,4-TETRAHYDROISOCHINOLIN UND IHRE VERWENDUNG |
KR20120034644A (ko) | 2009-05-12 | 2012-04-12 | 알바니 몰레큘라 리써치, 인크. | 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도 |
ES2662072T3 (es) | 2009-05-12 | 2018-04-05 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma |
KR101485645B1 (ko) | 2009-10-14 | 2015-01-22 | 머크 샤프 앤드 돔 코포레이션 | p53 활성을 증가시키는 치환된 피페리딘 및 그의 용도 |
WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
CN107090456B (zh) | 2010-08-02 | 2022-01-18 | 瑟纳治疗公司 | 使用短干扰核酸的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1基因表达的抑制 |
HUE044815T2 (hu) | 2010-08-17 | 2019-11-28 | Sirna Therapeutics Inc | Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
US9351965B2 (en) | 2010-12-21 | 2016-05-31 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
CN103732592A (zh) | 2011-04-21 | 2014-04-16 | 默沙东公司 | ***-1受体抑制剂 |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
EP3919620A1 (de) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Zusammensetzungen mit kurzer interferierender nukleinsäure (sina) |
CA2882950A1 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
LT2925888T (lt) | 2012-11-28 | 2018-01-10 | Merck Sharp & Dohme Corp. | Vėžio gydymo kompozicijos ir būdai |
BR112015013611A2 (pt) | 2012-12-20 | 2017-11-14 | Merck Sharp & Dohme | composto, e, composição farmacêutica |
WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
US20210309688A1 (en) | 2018-08-07 | 2021-10-07 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
US20210277009A1 (en) | 2018-08-07 | 2021-09-09 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
ATE211743T1 (de) * | 1991-05-22 | 2002-01-15 | Pfizer | Substituierte 3-aminochinuclidine |
-
1992
- 1992-11-17 JP JP4307179A patent/JP2656702B2/ja not_active Expired - Fee Related
-
1993
- 1993-03-05 ES ES93907099T patent/ES2160596T3/es not_active Expired - Lifetime
- 1993-03-05 AT AT93907099T patent/ATE205207T1/de not_active IP Right Cessation
- 1993-03-05 AU AU37824/93A patent/AU3782493A/en not_active Abandoned
- 1993-03-05 HU HU9402745A patent/HU9402745D0/hu unknown
- 1993-03-05 PT PT93907099T patent/PT632809E/pt unknown
- 1993-03-05 EP EP93907099A patent/EP0632809B1/de not_active Expired - Lifetime
- 1993-03-05 WO PCT/US1993/001810 patent/WO1993019064A1/en active IP Right Grant
- 1993-03-05 DE DE69330714T patent/DE69330714T2/de not_active Expired - Fee Related
- 1993-03-05 CA CA002132541A patent/CA2132541C/en not_active Expired - Fee Related
- 1993-03-05 DK DK93907099T patent/DK0632809T3/da active
- 1993-03-18 IL IL105098A patent/IL105098A0/xx unknown
- 1993-03-22 ZA ZA932016A patent/ZA932016B/xx unknown
- 1993-03-23 MX MX9301634A patent/MX9301634A/es unknown
-
1994
- 1994-09-22 KR KR1019940703285A patent/KR950700908A/ko not_active Application Discontinuation
- 1994-09-22 FI FI944394A patent/FI944394A/fi not_active Application Discontinuation
- 1994-09-22 NO NO943526A patent/NO943526D0/no unknown
-
2001
- 2001-10-25 GR GR20010401896T patent/GR3037025T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO943526L (no) | 1994-09-22 |
GR3037025T3 (en) | 2002-01-31 |
NO943526D0 (no) | 1994-09-22 |
MX9301634A (es) | 1994-07-29 |
KR950700908A (ko) | 1995-02-20 |
CA2132541C (en) | 1997-11-25 |
IL105098A0 (en) | 1993-07-08 |
DK0632809T3 (da) | 2001-11-12 |
AU3782493A (en) | 1993-10-21 |
DE69330714T2 (de) | 2002-02-07 |
CA2132541A1 (en) | 1993-09-30 |
ES2160596T3 (es) | 2001-11-16 |
EP0632809B1 (de) | 2001-09-05 |
FI944394A0 (fi) | 1994-09-22 |
PT632809E (pt) | 2001-12-28 |
ATE205207T1 (de) | 2001-09-15 |
WO1993019064A1 (en) | 1993-09-30 |
HU9402745D0 (en) | 1994-12-28 |
JPH05320162A (ja) | 1993-12-03 |
FI944394A (fi) | 1994-09-22 |
ZA932016B (en) | 1994-09-22 |
EP0632809A1 (de) | 1995-01-11 |
JP2656702B2 (ja) | 1997-09-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |