DE68928868T2 - Cyclobutanderivat und Verfahren zu seiner Herstellung - Google Patents

Cyclobutanderivat und Verfahren zu seiner Herstellung

Info

Publication number
DE68928868T2
DE68928868T2 DE68928868T DE68928868T DE68928868T2 DE 68928868 T2 DE68928868 T2 DE 68928868T2 DE 68928868 T DE68928868 T DE 68928868T DE 68928868 T DE68928868 T DE 68928868T DE 68928868 T2 DE68928868 T2 DE 68928868T2
Authority
DE
Germany
Prior art keywords
preparation
cyclobutane derivative
cyclobutane
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68928868T
Other languages
English (en)
Other versions
DE68928868D1 (de
Inventor
Yuh-Ichiro Ichikawa
Aya Narita
Kaoru Matsuo
Keiko Aoyama
Fumiko Matsumura
Yukihiro Nishiyama
Kenichi Matsubara
Takemitsu Nagahata
Hiroo Hoshino
Jun-Ichi Seki
Koichi Narasaka
Yujiro Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Application granted granted Critical
Publication of DE68928868D1 publication Critical patent/DE68928868D1/de
Publication of DE68928868T2 publication Critical patent/DE68928868T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE68928868T 1988-09-09 1989-09-05 Cyclobutanderivat und Verfahren zu seiner Herstellung Expired - Fee Related DE68928868T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP22447688 1988-09-09
JP29513588 1988-11-22
JP4303689 1989-02-27
JP15822389 1989-06-22

Publications (2)

Publication Number Publication Date
DE68928868D1 DE68928868D1 (de) 1999-01-14
DE68928868T2 true DE68928868T2 (de) 1999-04-29

Family

ID=27461311

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68928868T Expired - Fee Related DE68928868T2 (de) 1988-09-09 1989-09-05 Cyclobutanderivat und Verfahren zu seiner Herstellung

Country Status (6)

Country Link
EP (1) EP0358154B1 (de)
KR (1) KR0128661B1 (de)
AU (1) AU622926B2 (de)
CZ (1) CZ277764B6 (de)
DE (1) DE68928868T2 (de)
ES (1) ES2124210T3 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214048A (en) * 1987-05-19 1993-05-25 Nippon Kayaku Kabushiki Kaisha Oxetanocins
US5597824A (en) * 1987-11-03 1997-01-28 Abbott Laboratories Analogs of oxetanyl purines and pyrimidines
US5130462A (en) * 1988-03-30 1992-07-14 E. R. Squibb & Sons, Inc. Cyclobutane derivatives
US5723609A (en) * 1988-03-30 1998-03-03 E. R. Squibb & Sons, Inc. Bis (hydroxymethyl) cyclobutyl purines
US5126345A (en) * 1988-03-30 1992-06-30 E. R. Squibb & Sons, Inc. Bis (hydroxymethyl) cyclobutyl triazolopyrimidines
US5185459A (en) * 1988-03-30 1993-02-09 E. R. Squibb & Sons Inc. Bis protected (hydroxymethyl)cyclobutanols
AU638629B2 (en) * 1988-09-09 1993-07-01 Nippon Kayaku Kabushiki Kaisha Cyclobutane derivatives
NL8921278A (nl) * 1988-11-22 1990-10-01 Nippon Kayaku Kk Nieuw cyclobutaanderivaat en werkwijze voor het bereiden ervan.
US5202459A (en) * 1989-11-07 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for producing cyclobutane derivative
DE3991368T1 (de) * 1989-11-22 1991-01-10 Nippon Kayaku Kk Neues cyclobutanderivat und verfahren zu seiner herstellung
US5256806A (en) * 1989-12-18 1993-10-26 E. R. Squibb & Sons, Inc. Intermediates for the preparation of optically active cyclobutane nucleoside
US5198583A (en) * 1989-12-18 1993-03-30 E. R. Squibb & Sons, Inc. Optically active cyclobutane nucleoside and intermediates, therefor
US5064961A (en) * 1989-12-18 1991-11-12 E. R. Squibb & Sons, Inc. Process for preparing an optically active cyclobutane nucleoside
US5250697A (en) * 1990-03-01 1993-10-05 Nippon Kayaku Kabushiki Kaisha Cyclobutane derivatives
US5235052A (en) * 1990-04-16 1993-08-10 Bristol-Myers Squibb Company Process for preparing substituted cyclobutane purines
US5344962A (en) * 1990-05-24 1994-09-06 E. R. Squibb & Sons, Inc. Intermediates in the synthesis of an optically active cyclobutane nucleoside
IE72143B1 (en) * 1990-05-24 1997-03-26 Squibb & Sons Inc Process for preparing an optically active cyclobutanone an intermediate in the synthesis of an optically active cyclobutane nucleoside
US5233076A (en) * 1990-05-24 1993-08-03 E. R. Squibb & Sons, Inc. Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside
CA2042931A1 (en) * 1990-05-24 1991-11-25 Robert Zahler Fluorinated bis (hydroxymethyl) cyclobutyl purines and pyrimidines
US5324730A (en) * 1990-05-24 1994-06-28 Nippon Kayaku Kabushiki Kaisha Phenoxyphosphoryloxymethyl cyclobutyl purines
US5374625A (en) * 1990-07-24 1994-12-20 Nippon Kayaku Kabushiki Kaisha Adenine and guanine derivatives for the treatment of hepatitis virus infections
US5166397A (en) * 1990-09-20 1992-11-24 Nippon Kayaku Kabushiki Kaisha Process for producing optically active cyclobutylamines
CA2052315A1 (en) * 1990-10-09 1992-04-10 Masashi Nagai Cyclobutane derivatives
USH1142H (en) 1990-11-05 1993-02-02 Optically active cyclobutyl pyrimidine
US5218142A (en) * 1991-10-02 1993-06-08 E. R. Squibb & Sons, Inc. Process for the preparation of an antiviral agent
US5237096A (en) * 1991-10-02 1993-08-17 E. R. Squibb & Sons, Inc. Process for the preparation of an antiviral agent
US5525726A (en) * 1991-10-02 1996-06-11 E. R. Squibb & Sons, Inc. Process for the preparation of an antiviral agent
US5237095A (en) * 1991-10-02 1993-08-17 E. R. Squibb & Sons, Inc. Process for the preparation of an antiviral agent
US5233086A (en) * 1991-10-02 1993-08-03 E. R. Squibb & Sons, Inc. Intermediates for the preparation of an antiviral agent
US5185463A (en) * 1991-10-02 1993-02-09 E. R. Squibb & Sons, Inc. Process for the preparation of an antiviral agent
EP0554025A3 (en) * 1992-01-27 1993-11-18 Squibb & Sons Inc Fluorinated cyclobutyl purines and pyrimidines
US5412134A (en) * 1992-05-26 1995-05-02 E. R. Squibb & Sons, Inc. Process for preparing diprotected 2,3-hydroxymethyl cyclobutanol
US5874578A (en) * 1992-07-13 1999-02-23 Bristol-Myers Squibb Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
IL117574A0 (en) * 1995-04-03 1996-07-23 Bristol Myers Squibb Co Processes for the preparation of cyclobutanone derivatives
WO1998052930A1 (fr) * 1997-05-20 1998-11-26 Nippon Kayaku Kabushiki Kaisha Nouveaux derives de cyclobutane et leur procede de production
CN100469769C (zh) 2003-03-24 2009-03-18 弗·哈夫曼-拉罗切有限公司 作为逆转录酶抑制剂的苄基-哒嗪酮
ATE490470T1 (de) 2003-10-24 2010-12-15 Immunaid Pty Ltd Therapieverfahren
AU2006303368B2 (en) 2005-10-19 2011-05-26 F. Hoffmann-La Roche Ag Non-Nucleoside Reverse Transcriptase Inhibitors
WO2008019968A1 (en) 2006-08-16 2008-02-21 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
ES2550152T3 (es) 2006-12-13 2015-11-04 F. Hoffmann-La Roche Ag Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa
EA016386B1 (ru) 2007-05-30 2012-04-30 Ф. Хоффманн-Ля Рош Аг Ненуклеозидные ингибиторы обратной транскриптазы
RU2495878C2 (ru) 2007-12-21 2013-10-20 Ф.Хоффманн-Ля Рош Аг Гетероциклические антивирусные соединения
EP2377865B1 (de) * 2008-11-27 2014-12-17 National University Corporation Kagawa University Cyclobutylpurinderivat, angiogeneseförderndes mittel, lumenisierungsförderndes mittel, neurocytenwachstumsförderndes mittel und arzneimittel
PT2435825E (pt) 2009-05-27 2015-11-02 Biotempus Ltd Métodos para o tratamento de doenças
WO2011077100A1 (en) 2009-12-24 2011-06-30 Cipla Limited Antiretroviral composition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177348A (en) * 1977-12-13 1979-12-04 United States Government Carbocyclic analogs of cytosine nucleosides
US4617304A (en) * 1984-04-10 1986-10-14 Merck & Co., Inc. Purine derivatives
EP0184473A1 (de) * 1984-10-26 1986-06-11 Merck & Co. Inc. Regiospezifische Synthese von 9-substituierten Purinazyklonukleosidverbindungen
US4782062A (en) * 1987-05-11 1988-11-01 Merck & Co., Inc. 9-(2-hydroxymethyl)cycloalkylmethyl) guanines
US4855466A (en) * 1987-12-28 1989-08-08 E. R. Squibb & Sons, Inc. Purinyl cyclobutanes
US5723609A (en) * 1988-03-30 1998-03-03 E. R. Squibb & Sons, Inc. Bis (hydroxymethyl) cyclobutyl purines
IL92096A0 (en) * 1988-10-25 1990-07-12 Abbott Lab Carboxylic nucleoside analogs
AU4378589A (en) * 1988-10-25 1990-05-03 Bristol-Myers Squibb Company Carbocyclic nucleoside analogs

Also Published As

Publication number Publication date
EP0358154A2 (de) 1990-03-14
EP0358154B1 (de) 1998-12-02
AU4081789A (en) 1990-03-15
ES2124210T3 (es) 1999-02-01
KR0128661B1 (ko) 1998-04-04
AU622926B2 (en) 1992-04-30
EP0358154A3 (de) 1990-09-05
CS517589A3 (en) 1992-11-18
DE68928868D1 (de) 1999-01-14
CZ277764B6 (en) 1993-04-14
KR900004735A (ko) 1990-04-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee