DE69301771T2 - T-Butyl-R-(-)-4-cyano-3-hydroxybutyrat und Verfahren zu seiner Herstellung - Google Patents
T-Butyl-R-(-)-4-cyano-3-hydroxybutyrat und Verfahren zu seiner HerstellungInfo
- Publication number
- DE69301771T2 DE69301771T2 DE69301771T DE69301771T DE69301771T2 DE 69301771 T2 DE69301771 T2 DE 69301771T2 DE 69301771 T DE69301771 T DE 69301771T DE 69301771 T DE69301771 T DE 69301771T DE 69301771 T2 DE69301771 T2 DE 69301771T2
- Authority
- DE
- Germany
- Prior art keywords
- hydroxybutyrate
- cyano
- butyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16549692A JP3171931B2 (ja) | 1992-06-02 | 1992-06-02 | (R)−(−)−4−シアノ−3−ヒドロキシ酪酸t−ブチルエステル及びその製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69301771D1 DE69301771D1 (de) | 1996-04-18 |
DE69301771T2 true DE69301771T2 (de) | 1996-10-02 |
Family
ID=15813505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69301771T Revoked DE69301771T2 (de) | 1992-06-02 | 1993-05-20 | T-Butyl-R-(-)-4-cyano-3-hydroxybutyrat und Verfahren zu seiner Herstellung |
Country Status (4)
Country | Link |
---|---|
US (1) | US5430171A (de) |
EP (1) | EP0573184B1 (de) |
JP (1) | JP3171931B2 (de) |
DE (1) | DE69301771T2 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5908953A (en) * | 1996-12-18 | 1999-06-01 | Mitsubishi Chemical Corporation | Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester |
JPH11171850A (ja) * | 1997-12-12 | 1999-06-29 | Kanegafuchi Chem Ind Co Ltd | 酪酸エステル誘導体の製造方法 |
KR100313668B1 (ko) * | 1999-02-03 | 2001-11-26 | 박영구 | (r)-4-시아노-3-히드록시부티르산 에스테르의 제조방법 |
US6781009B2 (en) | 2000-10-31 | 2004-08-24 | Sumitomo Chemical Company, Limited | Method for producing 4-cyano-3-oxobutanoate and 4-ctano-3-hydroxybutanoate |
JP4765217B2 (ja) * | 2001-07-30 | 2011-09-07 | 住友化学株式会社 | (r)−4−シアノ−3−ヒドロキシブタン酸エステルの製造法 |
WO2003106415A2 (en) * | 2002-06-13 | 2003-12-24 | Diversa Corporation | Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid |
ATE501264T1 (de) * | 2002-08-09 | 2011-03-15 | Codexis Inc | Enzymatische verfahren zur herstellung 4- substituierter 3-hydroxybuttersäure-derivate |
US7541171B2 (en) * | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
US7588928B2 (en) * | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
BRPI0413501A (pt) | 2003-08-11 | 2006-10-10 | Codexis Inc | polipetìdeo, polinucleotìdeo isolado ou recombinante, vetor de expressão, célula hospedeira, e, método de preparar um polipetìdeo de hhdh |
JP2007502111A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体およびビシナルなシアノ,ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
US8187856B2 (en) * | 2008-12-18 | 2012-05-29 | Codexis, Inc. | Recombinant halohydrin dehalogenase polypeptides |
JP6126185B2 (ja) | 2015-10-22 | 2017-05-10 | 株式会社バンダイ | 人形体の関節構造 |
CA3077629A1 (en) | 2017-10-02 | 2019-04-11 | Tbf Environmental Technology Inc. | Solvent compounds for use as glycol ether replacements |
WO2019069209A1 (en) | 2017-10-02 | 2019-04-11 | Tbf Environmental Technology Inc. | SOLVENT COMPOUNDS FOR USE AS AGENTS OF COALESCENCE |
CN115267003B (zh) * | 2022-08-09 | 2023-08-08 | 宣城菁科生物科技有限公司 | 一种s(-)-4-氯-3-羟基丁酸乙酯异构体含量的检测方法 |
CN115286504B (zh) * | 2022-08-18 | 2024-01-26 | 上海博氏医药科技有限公司 | 一种合成(r)-2-(2-(叔丁氧基)-2-氧乙基)戊酸的方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3427322A (en) * | 1964-02-03 | 1969-02-11 | Marathon Oil Co | Preparation of cyanoethers |
US3386827A (en) * | 1964-08-17 | 1968-06-04 | Ibm | Thermo-developable light-sensitive diazo compositions and elements |
NZ194557A (en) * | 1979-08-17 | 1984-09-28 | Merck & Co Inc | Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions |
US4611068A (en) * | 1984-11-19 | 1986-09-09 | Merck Frosst Canada, Inc. | Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein |
US4855481A (en) * | 1984-11-19 | 1989-08-08 | Merck Frosst Canada, Inc. | Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein |
JPS61146191A (ja) * | 1984-12-20 | 1986-07-03 | Kanegafuchi Chem Ind Co Ltd | (S)−γ−ハロ−β−ヒドロキシ酪酸エステルの製造法 |
US4611067A (en) * | 1985-01-31 | 1986-09-09 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein |
JPH0678277B2 (ja) * | 1988-02-19 | 1994-10-05 | 高砂香料工業株式会社 | 光学活性アルコールおよびその誘導体の製造方法 |
US5003080A (en) * | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
CA1307796C (en) * | 1988-04-27 | 1992-09-22 | Kenji Inoue | Method for preparing optically active 3,4-dihydroxy butyric acid derivatives |
JPH0525113A (ja) * | 1991-07-23 | 1993-02-02 | Nikko Kyodo Co Ltd | 新規な4−シアノ酪酸誘導体及びその製造方法 |
US5155251A (en) * | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
-
1992
- 1992-06-02 JP JP16549692A patent/JP3171931B2/ja not_active Expired - Fee Related
-
1993
- 1993-05-20 EP EP93303947A patent/EP0573184B1/de not_active Revoked
- 1993-05-20 DE DE69301771T patent/DE69301771T2/de not_active Revoked
-
1994
- 1994-07-11 US US08/272,623 patent/US5430171A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP3171931B2 (ja) | 2001-06-04 |
EP0573184B1 (de) | 1996-03-13 |
EP0573184A1 (de) | 1993-12-08 |
US5430171A (en) | 1995-07-04 |
DE69301771D1 (de) | 1996-04-18 |
JPH05331128A (ja) | 1993-12-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8331 | Complete revocation |