DE68925161T2 - Alkylavermectin-Derivate - Google Patents

Alkylavermectin-Derivate

Info

Publication number
DE68925161T2
DE68925161T2 DE68925161T DE68925161T DE68925161T2 DE 68925161 T2 DE68925161 T2 DE 68925161T2 DE 68925161 T DE68925161 T DE 68925161T DE 68925161 T DE68925161 T DE 68925161T DE 68925161 T2 DE68925161 T2 DE 68925161T2
Authority
DE
Germany
Prior art keywords
alkylavermectin
derivatives
alkylavermectin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68925161T
Other languages
English (en)
Other versions
DE68925161D1 (de
Inventor
Philip Eskola
Thomas L Shin
Helmmut Mrozik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE68925161D1 publication Critical patent/DE68925161D1/de
Application granted granted Critical
Publication of DE68925161T2 publication Critical patent/DE68925161T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE68925161T 1988-07-22 1989-07-19 Alkylavermectin-Derivate Expired - Fee Related DE68925161T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/222,868 US4906619A (en) 1988-07-22 1988-07-22 Alkyl avermectin derivatives

Publications (2)

Publication Number Publication Date
DE68925161D1 DE68925161D1 (de) 1996-02-01
DE68925161T2 true DE68925161T2 (de) 1996-08-01

Family

ID=22834068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68925161T Expired - Fee Related DE68925161T2 (de) 1988-07-22 1989-07-19 Alkylavermectin-Derivate

Country Status (7)

Country Link
US (1) US4906619A (de)
EP (1) EP0351923B1 (de)
JP (1) JPH0278683A (de)
AU (1) AU606292B2 (de)
DE (1) DE68925161T2 (de)
NZ (1) NZ229918A (de)
ZA (1) ZA895566B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1318629C (en) * 1988-05-10 1993-06-01 Edward P. Tiley Macrolide compounds
US4873224A (en) * 1988-05-23 1989-10-10 Merck & Co., Inc. Avermectin derivatives
US5120646A (en) * 1988-10-18 1992-06-09 Chen Shieh Shung T Process for the preparation of anthelmintive bioconversion products
US5030622A (en) * 1989-06-02 1991-07-09 Merck & Co., Inc. Avermectin derivatives
US5177063A (en) * 1991-03-11 1993-01-05 Merck & Co., Inc. Avermectin compounds with a 6,5-spiroketal ring system
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
US5171742A (en) * 1991-10-15 1992-12-15 Merck & Co., Inc. Avermectin compounds with a 6,5-spiroketal ring system ad a 23-acyl substituent
US5162363A (en) * 1992-03-18 1992-11-10 Merck & Co., Inc. 23-nor-23-thia avermectin analogs are active anthelmintic agents
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US5241083A (en) * 1992-07-01 1993-08-31 Merck & Co., Inc. Process for converting the 13-α-hydroxy group of avermectin aglycones
US5411946A (en) * 1993-02-24 1995-05-02 Merck & Co., Inc. Avermectin derivatives
BR0009861A (pt) * 1999-02-09 2002-01-15 Kitasato Inst Derivados de avermectina
WO2002012248A1 (fr) * 2000-08-09 2002-02-14 The Kitasato Institute Derives d'avermectine
CA2418968C (en) * 2000-08-09 2009-11-24 The Kitasato Institute Avermectin derivatives
WO2004058786A1 (en) * 2002-12-31 2004-07-15 Council Of Scientific And Industrial Research Process for the synthesis of 2-deoxy-d-glucose
GB0302547D0 (en) * 2003-02-04 2003-03-12 Syngenta Participations Ag Avermectins and avermectin monosaccharide substituted in the 4'- and 4" position having pesticidal properties
GB0313937D0 (en) * 2003-06-16 2003-07-23 Syngenta Participations Ag Avermectin B1 monosaccharide derivatives having an aminosulfonyloxy substituentin the 4'-position
GB0320176D0 (en) * 2003-08-28 2003-10-01 Syngenta Participations Ag Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
ES2537424T3 (es) 2008-12-04 2015-06-08 Merial Limited Derivados de dímeros de avermectina y de milbemicina
EP2512467A1 (de) 2009-12-17 2012-10-24 Merial Limited Zusammensetzung mit makrocyclischen lactonverbindungen undspirodioxepinoindolen
PT2785719T (pt) 2011-12-02 2018-02-08 Merial Inc Formulações injetáveis de moxidectina de ação prolongada e novas formas cristalinas de moxidectina
CN103214532B (zh) * 2013-02-28 2018-07-06 河北威远生物化工有限公司 阿维菌素B2a/2b胺基衍生物、衍生物盐和阿维菌素B2a/2b胺基衍生物盐的制备方法及用途
CN112707939B (zh) * 2020-12-25 2022-06-24 河北威远生物化工有限公司 一种4″-(s)-甲氨基阿维菌素B2a苯甲酸盐的纯化方法
CN113735924A (zh) * 2021-09-01 2021-12-03 河北威远生物化工有限公司 一种23-酮阿维菌素B2a/B2b衍生物的制备方法
CN115611959A (zh) * 2022-10-14 2023-01-17 河北威远生物化工有限公司 一种阿维菌素B2a衍生物及其制备方法与应用
CN116491516A (zh) * 2023-03-02 2023-07-28 河北威远生物化工有限公司 甲氨基阿维菌素B2a及其盐类化合物在制备促进植物生长的药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4427663A (en) * 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4789684A (en) * 1985-05-02 1988-12-06 Merck & Co., Inc. Anthelmintic fermentation products of microorganisms
US4713571A (en) * 1986-01-23 1987-12-15 Canon Kabushiki Kaisha Driving circuit of a vibration wave motor
GB8606105D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
US4833168A (en) * 1986-10-03 1989-05-23 Merck & Co., Inc. Avermectin reformatsky adducts
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock

Also Published As

Publication number Publication date
DE68925161D1 (de) 1996-02-01
EP0351923A3 (de) 1991-03-13
US4906619A (en) 1990-03-06
ZA895566B (en) 1990-04-25
NZ229918A (en) 1992-03-26
AU606292B2 (en) 1991-01-31
EP0351923B1 (de) 1995-12-20
EP0351923A2 (de) 1990-01-24
AU3885189A (en) 1990-01-25
JPH0278683A (ja) 1990-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee