DE68913802D1 - Thymosin und TNF-kodierende DNA. - Google Patents

Thymosin und TNF-kodierende DNA.

Info

Publication number
DE68913802D1
DE68913802D1 DE89400912T DE68913802T DE68913802D1 DE 68913802 D1 DE68913802 D1 DE 68913802D1 DE 89400912 T DE89400912 T DE 89400912T DE 68913802 T DE68913802 T DE 68913802T DE 68913802 D1 DE68913802 D1 DE 68913802D1
Authority
DE
Germany
Prior art keywords
val
ser
arg
pro
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89400912T
Other languages
English (en)
Other versions
DE68913802T2 (de
Inventor
Den Ichi Mizuno
Gen-Ichiro Soma
Yoshiaki Biotechnology R Tsuji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE68913802D1 publication Critical patent/DE68913802D1/de
Application granted granted Critical
Publication of DE68913802T2 publication Critical patent/DE68913802T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE68913802T 1988-04-03 1989-04-03 Thymosin und TNF-kodierende DNA. Expired - Fee Related DE68913802T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63081683A JP2828988B2 (ja) 1988-04-03 1988-04-03 新規ｄｎａとその生産方法、それを有する新規プラスミド、新規ポリペプチドとその生産方法、及び該ポリペプチドからなる新規抗腫瘍剤

Publications (2)

Publication Number Publication Date
DE68913802D1 true DE68913802D1 (de) 1994-04-21
DE68913802T2 DE68913802T2 (de) 1994-10-13

Family

ID=13753155

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68913802T Expired - Fee Related DE68913802T2 (de) 1988-04-03 1989-04-03 Thymosin und TNF-kodierende DNA.

Country Status (5)

Country Link
EP (1) EP0341100B1 (de)
JP (1) JP2828988B2 (de)
AT (1) ATE102997T1 (de)
CA (1) CA1340244C (de)
DE (1) DE68913802T2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02101019A (ja) * 1988-10-05 1990-04-12 Genichiro Soma 抗エイズ剤
DE69232586T2 (de) * 1991-07-05 2002-11-28 Peptech Ltd Giftigkeit von tnf und lps ausschaltende peptide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155549B1 (de) * 1984-03-06 1991-03-20 Dainippon Pharmaceutical Co., Ltd. DNS den menschlichen Tumornekrosisfaktor kodierend und das menschliche Tumornekronisfaktor-Polypeptid
ATE116367T1 (de) * 1986-02-04 1995-01-15 Den Ichi Mizuno Für antitumor-polypeptide kodierende dns, die polypeptide und diese polypeptide enthaltenden antitumor-wirkstoffe.

Also Published As

Publication number Publication date
ATE102997T1 (de) 1994-04-15
JPH01256390A (ja) 1989-10-12
EP0341100A3 (en) 1990-09-12
EP0341100A2 (de) 1989-11-08
EP0341100B1 (de) 1994-03-16
JP2828988B2 (ja) 1998-11-25
CA1340244C (en) 1998-12-15
DE68913802T2 (de) 1994-10-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee