DE3687763D1 - Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns-sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen. - Google Patents
Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns-sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen.Info
- Publication number
- DE3687763D1 DE3687763D1 DE8686200766T DE3687763T DE3687763D1 DE 3687763 D1 DE3687763 D1 DE 3687763D1 DE 8686200766 T DE8686200766 T DE 8686200766T DE 3687763 T DE3687763 T DE 3687763T DE 3687763 D1 DE3687763 D1 DE 3687763D1
- Authority
- DE
- Germany
- Prior art keywords
- oxidation
- muteine
- muteins
- resistant
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Dental Preparations (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69259685A | 1985-01-18 | 1985-01-18 | |
US81065685A | 1985-12-17 | 1985-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3687763D1 true DE3687763D1 (de) | 1993-03-25 |
DE3687763T2 DE3687763T2 (de) | 1993-06-09 |
Family
ID=36846757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686200766T Expired - Lifetime DE3687763T2 (de) | 1985-01-18 | 1986-01-17 | Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns-sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0200280B1 (de) |
JP (1) | JP2595206B2 (de) |
AT (1) | ATE85810T1 (de) |
AU (2) | AU5245186A (de) |
CA (1) | CA1340265C (de) |
DE (1) | DE3687763T2 (de) |
NZ (1) | NZ214854A (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5342614A (en) * | 1984-12-21 | 1994-08-30 | Otsuka Pharmaceutical Co., Ltd. | Method of treating arthritus or inflammation with IL-1β or derivatives thereof |
US6107465A (en) * | 1984-12-21 | 2000-08-22 | Otsuka Pharmaceutical Co., Ltd. | IL-1β and derivatives thereof and drugs |
CA1340265C (en) * | 1985-01-18 | 1998-12-15 | Kirston E. Koths | Oxidation resistant muteins |
AU595864B2 (en) * | 1986-03-14 | 1990-04-12 | Otsuka Pharmaceutical Co., Ltd. | Il-1 alpha derivatives and drugs |
US4835260A (en) * | 1987-03-20 | 1989-05-30 | Genetics Institute, Inc. | Erythropoietin composition |
JPH03500415A (ja) * | 1988-07-05 | 1991-01-31 | アムジエン・インコーポレーテツド | インターロイキン2類似体 |
JP4534030B2 (ja) * | 1999-06-29 | 2010-09-01 | 独立行政法人産業技術総合研究所 | 硫黄原子を含まない酵素蛋白質 |
PT1682180E (pt) | 2003-11-04 | 2010-02-10 | Novartis Vaccines & Diagnostic | Anticorpos monoclonais antagonistas anti-cd40 e métodos para a sua utilização |
CA2712432C (en) * | 2008-01-29 | 2018-09-25 | Ablynx N.V. | Methods to stabilize single variable domains |
KR102220006B1 (ko) | 2011-03-11 | 2021-02-24 | 아시스땅스 퍼블리끄-오삐또 드 빠리 | 자가면역 - 관련 또는 염증성 장애를 치료하기 위한 저용량 il2 의 용도 |
EP3013355B1 (de) | 2013-06-25 | 2019-08-07 | ICM - Institut du Cerveau et da la Moelle Epinière | Il-2 zur verwendung in der behandlung von alzheimer-krankheit und verwandten erkrankungen |
EP2918285A1 (de) | 2014-03-11 | 2015-09-16 | Université Pierre et Marie Curie (Paris 6) | Interleukin-2 zur Behandlung einer Lebensmittelallergie |
RU2573933C1 (ru) * | 2014-08-21 | 2016-01-27 | Дафот Энтерпрайсис Лимитед | Пептид для лечения сахарного диабета 2-го типа и его осложнений |
CA3001429C (en) * | 2015-10-22 | 2023-07-11 | Iltoo Pharma | Pharmaceutical compositions of il-2 |
JP7206190B2 (ja) | 2016-06-22 | 2023-01-17 | ダヴィド・クラッツマン | 遺伝的に修飾されたtリンパ球 |
BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
MX2019013517A (es) | 2017-05-24 | 2020-08-17 | Pandion Operations Inc | Inmunotolerancia dirigida. |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
EP3752178A1 (de) | 2018-02-16 | 2020-12-23 | Iltoo Pharma | Verwendung von interleukin 2 zur behandlung des sjögren-syndroms |
EP3806888B1 (de) | 2018-06-12 | 2024-01-31 | Obsidian Therapeutics, Inc. | Von pde5 abgeleitete regulatorische konstrukte und verfahren zur verwendung in der immuntherapie |
WO2020007937A1 (en) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
EP3880838A4 (de) | 2018-11-15 | 2022-11-02 | The Board of Trustees of the Leland Stanford Junior University | Zusammensetzungen und verfahren zur prognose und klassifizierung von präeklampsie |
TW202110885A (zh) | 2019-05-20 | 2021-03-16 | 美商潘迪恩治療公司 | 靶向MAdCAM之免疫耐受性 |
CN115190885A (zh) | 2019-12-12 | 2022-10-14 | 艾尔图制药公司 | 白细胞介素2嵌合构建体 |
EP4107187A4 (de) | 2020-02-21 | 2024-07-03 | Pandion Operations Inc | Gewebegezielte immuntoleranz mit einem cd39-effektor |
TW202146041A (zh) | 2020-03-06 | 2021-12-16 | 尼姆大學醫學中心 | 用於肌肉萎縮性脊髓側索硬化症之治療的低劑量人類介白素-2 |
IL311883A (en) | 2021-10-06 | 2024-06-01 | Assist Publique H?Pitaux De Paris | Interleukin 2 chimeric constructs with targeted specificity for inflammatory tissues |
WO2024056154A1 (en) | 2022-09-12 | 2024-03-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Interleukin-2 for use in treating autism spectrum disorder |
WO2024121173A1 (en) | 2022-12-05 | 2024-06-13 | Centre Hospitalier Universitaire De Nimes | Low dose human interleukin-2 for the treatment of amyotrophic lateral sclerosis in a subgroup of patients |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2544348C3 (de) * | 1975-10-03 | 1979-12-13 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | L-Leucin-13-Motilin, Verfahren zu dessen Herstellung und dasselbe enthaltendes Mittel |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
JPS605600B2 (ja) * | 1982-10-25 | 1985-02-12 | 工業技術院長 | 新規なポリペプチド |
DE3482387D1 (en) * | 1983-03-07 | 1990-07-05 | Hoffmann La Roche | Polypeptide. |
US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
NZ208612A (en) * | 1983-06-24 | 1991-09-25 | Genentech Inc | Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations |
WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
US4530787A (en) | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
DE3419995A1 (de) * | 1984-05-29 | 1985-12-05 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens |
JPS6124599A (ja) * | 1984-07-11 | 1986-02-03 | Kyowa Hakko Kogyo Co Ltd | 新規ヒトインタ−フエロン−rポリペプチド誘導体 |
CA1340265C (en) * | 1985-01-18 | 1998-12-15 | Kirston E. Koths | Oxidation resistant muteins |
-
1986
- 1986-01-16 CA CA000499697A patent/CA1340265C/en not_active Expired - Fee Related
- 1986-01-17 NZ NZ214854A patent/NZ214854A/xx unknown
- 1986-01-17 DE DE8686200766T patent/DE3687763T2/de not_active Expired - Lifetime
- 1986-01-17 EP EP86200766A patent/EP0200280B1/de not_active Expired - Lifetime
- 1986-01-17 AT AT86200766T patent/ATE85810T1/de not_active IP Right Cessation
- 1986-01-17 AU AU52451/86A patent/AU5245186A/en not_active Abandoned
- 1986-01-18 JP JP61007216A patent/JP2595206B2/ja not_active Expired - Lifetime
- 1986-11-05 AU AU64846/86A patent/AU585084B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0200280A3 (en) | 1988-08-24 |
CA1340265C (en) | 1998-12-15 |
DE3687763T2 (de) | 1993-06-09 |
JPS61224985A (ja) | 1986-10-06 |
JP2595206B2 (ja) | 1997-04-02 |
AU5245186A (en) | 1986-07-31 |
AU585084B2 (en) | 1989-06-08 |
AU6484686A (en) | 1987-02-05 |
NZ214854A (en) | 1989-07-27 |
EP0200280B1 (de) | 1993-02-17 |
ATE85810T1 (de) | 1993-03-15 |
EP0200280A2 (de) | 1986-11-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: CHIRON CORP. (N.D.GES.D. STAATES DELAWARE), EMERYV |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US |