DE60336014D1 - Pyrrolobenzodiazepine zur behandlung proliferativer erkrankungen - Google Patents

Pyrrolobenzodiazepine zur behandlung proliferativer erkrankungen

Info

Publication number
DE60336014D1
DE60336014D1 DE60336014T DE60336014T DE60336014D1 DE 60336014 D1 DE60336014 D1 DE 60336014D1 DE 60336014 T DE60336014 T DE 60336014T DE 60336014 T DE60336014 T DE 60336014T DE 60336014 D1 DE60336014 D1 DE 60336014D1
Authority
DE
Germany
Prior art keywords
group
pyrrolobenzodiazepine
treatment
proliferative diseases
sup
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60336014T
Other languages
English (en)
Inventor
David Edwin Thurston
Philip Wilson Howard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADC Products UK Ltd
Original Assignee
ADC Products UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADC Products UK Ltd filed Critical ADC Products UK Ltd
Application granted granted Critical
Publication of DE60336014D1 publication Critical patent/DE60336014D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60336014T 2002-11-14 2003-11-14 Pyrrolobenzodiazepine zur behandlung proliferativer erkrankungen Expired - Lifetime DE60336014D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0226593.2A GB0226593D0 (en) 2002-11-14 2002-11-14 Compounds
PCT/GB2003/004963 WO2004043963A1 (en) 2002-11-14 2003-11-14 Pyrrolobenzodiazepines

Publications (1)

Publication Number Publication Date
DE60336014D1 true DE60336014D1 (de) 2011-03-24

Family

ID=9947829

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60336014T Expired - Lifetime DE60336014D1 (de) 2002-11-14 2003-11-14 Pyrrolobenzodiazepine zur behandlung proliferativer erkrankungen

Country Status (15)

Country Link
US (1) US7407951B2 (de)
EP (1) EP1575955B1 (de)
JP (1) JP4750418B2 (de)
KR (1) KR101059183B1 (de)
CN (1) CN100396683C (de)
AT (1) ATE497963T1 (de)
AU (1) AU2003282251B2 (de)
BR (1) BR0316241A (de)
CA (1) CA2505489C (de)
DE (1) DE60336014D1 (de)
GB (1) GB0226593D0 (de)
MX (1) MXPA05005179A (de)
NZ (1) NZ540050A (de)
WO (1) WO2004043963A1 (de)
ZA (1) ZA200504432B (de)

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AU2003282251A1 (en) 2004-06-03
KR101059183B1 (ko) 2011-08-25
ZA200504432B (en) 2006-02-22
JP4750418B2 (ja) 2011-08-17
NZ540050A (en) 2007-02-23
WO2004043963A1 (en) 2004-05-27
CA2505489A1 (en) 2004-05-27
MXPA05005179A (es) 2005-11-17
ATE497963T1 (de) 2011-02-15
BR0316241A (pt) 2005-10-04
CN1735616A (zh) 2006-02-15
JP2006507313A (ja) 2006-03-02
CN100396683C (zh) 2008-06-25
GB0226593D0 (en) 2002-12-24
CA2505489C (en) 2011-11-15
AU2003282251B2 (en) 2010-03-18
EP1575955B1 (de) 2011-02-09
KR20050086643A (ko) 2005-08-30
EP1575955A1 (de) 2005-09-21
US20060128693A1 (en) 2006-06-15

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