DE60334471D1 - Primer für nukleinsäureamplifikation in pcr-basierten klonalitätsstudien - Google Patents
Primer für nukleinsäureamplifikation in pcr-basierten klonalitätsstudienInfo
- Publication number
- DE60334471D1 DE60334471D1 DE60334471T DE60334471T DE60334471D1 DE 60334471 D1 DE60334471 D1 DE 60334471D1 DE 60334471 T DE60334471 T DE 60334471T DE 60334471 T DE60334471 T DE 60334471T DE 60334471 D1 DE60334471 D1 DE 60334471D1
- Authority
- DE
- Germany
- Prior art keywords
- rearrangement
- pcr
- tcrd
- nucleic acid
- acid amplification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41777902P | 2002-10-11 | 2002-10-11 | |
PCT/NL2003/000690 WO2004033728A2 (en) | 2002-10-11 | 2003-10-13 | Nucleic acid amplification primers for pcr-based clonality studies |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60334471D1 true DE60334471D1 (de) | 2010-11-18 |
Family
ID=32094087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60334471T Expired - Lifetime DE60334471D1 (de) | 2002-10-11 | 2003-10-13 | Primer für nukleinsäureamplifikation in pcr-basierten klonalitätsstudien |
Country Status (12)
Country | Link |
---|---|
US (3) | US8859748B2 (de) |
EP (3) | EP2418287B1 (de) |
JP (1) | JP4708029B2 (de) |
CN (1) | CN1965089A (de) |
AT (1) | ATE483822T1 (de) |
AU (1) | AU2003300565A1 (de) |
CA (1) | CA2501863A1 (de) |
DE (1) | DE60334471D1 (de) |
DK (2) | DK1549764T3 (de) |
ES (3) | ES2438782T3 (de) |
HK (2) | HK1167436A1 (de) |
WO (1) | WO2004033728A2 (de) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143496A (en) * | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
JP2002233382A (ja) * | 2001-02-09 | 2002-08-20 | Sapporo Breweries Ltd | ビール酵母の識別方法 |
BR0313024A (pt) * | 2002-07-30 | 2005-07-12 | Wyeth Corp | Formulações parenterais contendo um hidroxiéster de rapamicina |
AU2003902299A0 (en) * | 2003-05-13 | 2003-05-29 | Flinders Medical Centre | A method of analysing a marker nucleic acid molecule |
EP1692263A4 (de) * | 2003-10-29 | 2008-01-02 | Ribomed Biotechnologies Inc | Zusammensetzungen, verfahren und nachweistechnologien zur reiterativen oligonukleotidsynthese |
FR2863274B1 (fr) * | 2003-12-05 | 2012-11-16 | Commissariat Energie Atomique | Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications. |
WO2006046860A1 (en) * | 2004-10-25 | 2006-05-04 | Erasmus Universiteit Rotterdam | Determining the replicative history of lymphocytes |
ES2382746T3 (es) * | 2005-04-15 | 2012-06-13 | Epigenomics Ag | Método para determinar la metilación de ADN en muestras de sangre u orina |
EP3492602A1 (de) | 2005-06-15 | 2019-06-05 | Complete Genomics, Inc. | Einzelne molekülarrays für genetische und chemische analyse |
WO2007123392A1 (en) * | 2006-04-24 | 2007-11-01 | Erasmus Universiteit Rotterdam | Determining the replicative history of lymphocytes |
US20080050724A1 (en) * | 2006-08-24 | 2008-02-28 | Microfluidic Systems, Inc. | Method of detecting one or more limited copy targets |
WO2008026927A2 (en) * | 2006-08-30 | 2008-03-06 | Academisch Medisch Centrum | Process for displaying t- and b-cell receptor repertoires |
US20080153094A1 (en) * | 2006-10-13 | 2008-06-26 | Minor James M | Reduction of nonspecific binding in nucleic acid assays and nucleic acid synthesis reactions |
US20100216138A1 (en) | 2007-06-01 | 2010-08-26 | Alexander Alan Morley | Method for dna breakpoint analysis |
EP2062982A1 (de) * | 2007-11-26 | 2009-05-27 | ImmunID | Verfahren zur Untersuchung der kombinatorischen Diversität von V(D)J. |
US20160068905A1 (en) | 2007-11-26 | 2016-03-10 | Immunid | Method for Studying V(D)J Combinatory Diversity |
US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
WO2009137255A2 (en) * | 2008-04-16 | 2009-11-12 | Hudsonalpha Institute For Biotechnology | Method for evaluating and comparing immunorepertoires |
JP5733796B2 (ja) | 2008-05-13 | 2015-06-10 | ジェン−プロウブ インコーポレイテッド | 標的核酸配列の選択的ハイブリダイゼーションおよび捕捉における使用のため不活化可能型標的捕捉オリゴマー |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
GB2497007B (en) | 2008-11-07 | 2013-08-07 | Sequenta Inc | Methods of monitoring disease conditions by analysis of the full repertoire of the V-D junction or D-J junction sequences of an individual |
US9394567B2 (en) | 2008-11-07 | 2016-07-19 | Adaptive Biotechnologies Corporation | Detection and quantification of sample contamination in immune repertoire analysis |
US20100124741A1 (en) * | 2008-11-18 | 2010-05-20 | Quest Disgnostics Investments Incorporated | METHODS FOR DETECTING IgH/BCL-1 CHROMOSOMAL TRANSLOCATION |
US8367330B2 (en) * | 2008-12-22 | 2013-02-05 | Quest Diagnostics Investments Incorporated | Methods for detecting TCR-gamma gene rearrangement |
ES2568509T3 (es) | 2009-01-15 | 2016-04-29 | Adaptive Biotechnologies Corporation | Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales |
US9524369B2 (en) | 2009-06-15 | 2016-12-20 | Complete Genomics, Inc. | Processing and analysis of complex nucleic acid sequence data |
US20100330571A1 (en) | 2009-06-25 | 2010-12-30 | Robins Harlan S | Method of measuring adaptive immunity |
US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
EE201000013A (et) * | 2010-01-29 | 2011-10-17 | Selfdiagnostics O� | Meetod ja kiirtesti seade sihtmrk-molekuli proovimaterjalist detekteerimiseks |
JP2011223940A (ja) * | 2010-04-21 | 2011-11-10 | Asahi Breweries Ltd | 偽陰性を排除するpcr検査方法およびそれに使用するプライマー |
AU2011249041B2 (en) | 2010-05-06 | 2014-10-30 | Adaptive Biotechnologies Corp. | Monitoring health and disease status using clonotype profiles |
US11022573B2 (en) * | 2010-08-31 | 2021-06-01 | Canon U.S.A., Inc. | Positive controls |
WO2012031050A1 (en) * | 2010-08-31 | 2012-03-08 | Canon U.S. Life Sciences, Inc. | Thermal calibration |
JP2014503223A (ja) | 2011-01-14 | 2014-02-13 | シービー バイオテクノロジーズ インコーポレイテッド | 免疫多様性の評価方法およびその使用 |
WO2012158967A1 (en) * | 2011-05-17 | 2012-11-22 | Dxterity Diagnostics Incorporated | Methods and compositions for detecting target nucleic acids |
WO2013010074A1 (en) | 2011-07-13 | 2013-01-17 | Primeradx, Inc. | Multimodal methods for simultaneous detection and quantification of multiple nucleic acids in a sample |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
CA2853088C (en) | 2011-10-21 | 2018-03-13 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
WO2013067413A1 (en) | 2011-11-04 | 2013-05-10 | Gen-Probe Incorporated | Molecular assay reagents and methods |
EP3388535B1 (de) | 2011-12-09 | 2021-03-24 | Adaptive Biotechnologies Corporation | Diagnose von lymphoid-malignomen und nachweis von minimaler resterkrankung |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
GB201203720D0 (en) * | 2012-03-02 | 2012-04-18 | Babraham Inst | Method of identifying VDJ recombination products |
ES2662128T3 (es) | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
CN102605070A (zh) * | 2012-03-19 | 2012-07-25 | 中国人民解放军第二军医大学 | 淋巴细胞基因重排克隆性检测试剂盒及其检测方法 |
RU2631797C2 (ru) | 2012-05-08 | 2017-09-26 | Эдэптив Байотекнолоджиз Корпорейшн | Композиции и способы измерения и калибровки систематической ошибки амплификации в мультиплексных пцр-реакциях |
ES2749118T3 (es) | 2012-10-01 | 2020-03-19 | Adaptive Biotechnologies Corp | Evaluación de la inmunocompetencia por la diversidad de los receptores de inmunidad adaptativa y caracterización de la clonalidad |
WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
EP2959020B1 (de) | 2013-02-22 | 2019-09-18 | Adaptive Biotechnologies Corporation | Verfahren zur auswahl von seltene klonotypen |
GB2584364A (en) | 2013-03-15 | 2020-12-02 | Abvitro Llc | Single cell bar-coding for antibody discovery |
CA2914367A1 (en) * | 2013-06-07 | 2014-12-11 | Athena Diagnostics, Inc. | Molecular barcoding for multiplex sequencing |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
WO2015063121A1 (en) * | 2013-10-29 | 2015-05-07 | Region Syddanmark | Method for analyzing body fluid samples |
US20160326571A1 (en) * | 2013-10-31 | 2016-11-10 | Atherotech, Inc. | Methods for nucleic acid amplification |
CN106103711A (zh) | 2013-11-21 | 2016-11-09 | 组库创世纪株式会社 | T细胞受体和b细胞受体库分析***及其在治疗和诊断中的应用 |
AU2015227054A1 (en) | 2014-03-05 | 2016-09-22 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
WO2015154028A1 (en) * | 2014-04-04 | 2015-10-08 | Affymetrix, Inc. | Improved compositions and methods for molecular inversion probe assays |
US10202640B2 (en) | 2014-05-07 | 2019-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing |
EP3536786B1 (de) | 2014-09-15 | 2021-06-30 | AbVitro LLC | Nukleotidbibliotheksequenzierung mit hohem durchsatz |
WO2016069886A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corporation | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
EP3018214B1 (de) | 2014-11-05 | 2017-12-13 | Fundacion de Investigacion Hospital 12 de Octubre | Verfahren zur Quantifizierung des Niveaus minimaler Resterkrankung bei einer Person |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
EP3224384A4 (de) | 2014-11-25 | 2018-04-18 | Adaptive Biotechnologies Corp. | Charakterisierung von adaptiver immunreaktion auf impfungen oder infektionen unter verwendung von immunrepertoiresequenzierung |
ES2858306T3 (es) | 2015-02-24 | 2021-09-30 | Adaptive Biotechnologies Corp | Método para determinar el estado de HLA mediante secuenciación del repertorio inmunitario |
CA2979726A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
US11124823B2 (en) | 2015-06-01 | 2021-09-21 | Becton, Dickinson And Company | Methods for RNA quantification |
CN108474026A (zh) * | 2016-01-29 | 2018-08-31 | 豪夫迈·罗氏有限公司 | 用于核酸测序的新的衔接子和使用方法 |
US20170226593A1 (en) * | 2016-02-08 | 2017-08-10 | The Johns Hopkins University | Handheld nucleic acid-based assay for rapid identification |
US11459619B2 (en) | 2016-02-08 | 2022-10-04 | The Johns Hopkins University | Handheld nucleic acid-based assay for rapid identification |
US20190017112A1 (en) * | 2016-02-11 | 2019-01-17 | Htg Molecular Diagnostics, Inc. | Method of direct target sequencing using nuclease protection |
EP3432796A4 (de) * | 2016-03-23 | 2019-09-18 | The Methodist Hospital System | Beurteilung der tcr-klonalität vor einer transplantation zur vorhersage des überlebens nach einer lebertransplantation |
US20170275680A1 (en) * | 2016-03-24 | 2017-09-28 | Paul Chi Hang Li | Methods and Apparatus for Nanoparticle-assisted Nucleic Acid Amplification, Hybridization and Microarray Analysis |
WO2017174572A1 (en) * | 2016-04-04 | 2017-10-12 | F. Hoffmann-La Roche Ag | Nucleic acid sample preparation methods |
CN106191262A (zh) * | 2016-07-18 | 2016-12-07 | 南开大学 | 一种分析Igκ基因二次重排中间产物的方法及试剂盒 |
US20180037942A1 (en) * | 2016-08-03 | 2018-02-08 | Cellular Research, Inc. | Enzyme-independent molecular indexing |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
CN106701954A (zh) * | 2017-01-09 | 2017-05-24 | 浙江大学 | 一种用于检测肝癌的引物组及检测方法 |
US10822662B2 (en) | 2017-03-06 | 2020-11-03 | Karkinos Precision Oncology LLC | Diagnostic methods for identifying T-cell lymphoma and leukemia by high-throughput TCR-β sequencing |
CN108823306A (zh) * | 2017-05-03 | 2018-11-16 | 杭州赫玛生物科技有限公司 | 检测白血病细胞的***和方法 |
CA3078729A1 (en) * | 2017-10-10 | 2019-04-18 | Memorial Sloan Kettering Cancer Center | System and methods for primer extraction and clonality detection |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
CH714402A1 (fr) * | 2017-12-04 | 2019-06-14 | Fond Luc Montagnier | Procédé de détection de la présence d'un élément biochimique. |
US11946095B2 (en) | 2017-12-19 | 2024-04-02 | Becton, Dickinson And Company | Particles associated with oligonucleotides |
WO2019237146A1 (en) * | 2018-06-11 | 2019-12-19 | Monoquant Pty Ltd | Amplification method and primers for use therein |
CN110656161B (zh) * | 2018-06-28 | 2022-12-13 | 苏州云泰生物医药科技有限公司 | 用于检测人免疫球蛋白基因重排的毛细管电泳试剂盒及其使用方法 |
US20220073983A1 (en) * | 2018-07-18 | 2022-03-10 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
EP3908678A1 (de) | 2019-01-10 | 2021-11-17 | Iovance Biotherapeutics, Inc. | System und verfahren zur überwachung der klonalität und persistenz von adoptiven zelltherapien |
WO2020150356A1 (en) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
WO2023076832A1 (en) * | 2021-10-25 | 2023-05-04 | Singular Genomics Systems, Inc. | Manipulating and detecting biological samples |
CN113957128A (zh) * | 2021-12-21 | 2022-01-21 | 迈杰转化医学研究(苏州)有限公司 | 一种核酸完整性评估试剂盒及评估方法 |
CN117363722A (zh) * | 2023-12-07 | 2024-01-09 | 北京旌准医疗科技有限公司 | 一种用于检测igk和igl基因的引物组合及其应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5296351A (en) * | 1988-10-20 | 1994-03-22 | Alexander A. Morley | Method for diagnosis of monoclonality in leukaemia and lymphoma |
IT1244983B (it) * | 1991-04-29 | 1994-09-13 | Raggio Italgene Spa | Procedimento per rivelare sequenze di acidi nucleici e kit per la sua utilizzazione. |
US5472693A (en) * | 1993-02-16 | 1995-12-05 | The Dow Chemical Company | Family of anti-carcinoembryonic antigen chimeric antibodies |
FR2724182B1 (fr) * | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
US20020150891A1 (en) * | 1994-09-19 | 2002-10-17 | Leroy E. Hood | Diagnostic and therapeutic compositions and methods which utilize the t cell receptor beta gene region |
US6087096A (en) | 1995-11-13 | 2000-07-11 | Dau; Peter C. | Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions |
JP4302894B2 (ja) | 1998-10-09 | 2009-07-29 | メディカル リサーチ カウンシル | 多様性を生み出す方法 |
WO2000028086A1 (en) * | 1998-11-06 | 2000-05-18 | Ivs Technologies Llc | Methods and compositions for diagnostic assays |
NZ517121A (en) | 1999-09-13 | 2004-05-28 | Nugen Technologies Inc | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
DE60116500T2 (de) * | 2000-06-28 | 2006-09-21 | Ascendia Ab | Dna/rna-einbettungsmedium und verfahren zur verwendung |
-
2003
- 2003-10-13 EP EP10185191.3A patent/EP2418287B1/de not_active Expired - Lifetime
- 2003-10-13 EP EP03756746A patent/EP1549764B1/de not_active Expired - Lifetime
- 2003-10-13 EP EP10185204.4A patent/EP2460889B1/de not_active Expired - Lifetime
- 2003-10-13 ES ES10185191.3T patent/ES2438782T3/es not_active Expired - Lifetime
- 2003-10-13 JP JP2004542919A patent/JP4708029B2/ja not_active Expired - Lifetime
- 2003-10-13 AU AU2003300565A patent/AU2003300565A1/en not_active Abandoned
- 2003-10-13 WO PCT/NL2003/000690 patent/WO2004033728A2/en active Application Filing
- 2003-10-13 DK DK03756746.8T patent/DK1549764T3/da active
- 2003-10-13 ES ES10185204.4T patent/ES2442791T3/es not_active Expired - Lifetime
- 2003-10-13 CA CA002501863A patent/CA2501863A1/en not_active Abandoned
- 2003-10-13 CN CNA2003801059981A patent/CN1965089A/zh active Pending
- 2003-10-13 DK DK10185191.3T patent/DK2418287T3/da active
- 2003-10-13 DE DE60334471T patent/DE60334471D1/de not_active Expired - Lifetime
- 2003-10-13 ES ES03756746T patent/ES2354068T3/es not_active Expired - Lifetime
- 2003-10-13 US US10/531,106 patent/US8859748B2/en active Active - Reinstated
- 2003-10-13 AT AT03756746T patent/ATE483822T1/de active
-
2012
- 2012-08-15 HK HK12108019.6A patent/HK1167436A1/xx not_active IP Right Cessation
- 2012-12-06 HK HK12112606.7A patent/HK1171794A1/xx not_active IP Right Cessation
-
2014
- 2014-06-23 US US14/312,583 patent/US10280462B2/en active Active
-
2019
- 2019-05-06 US US16/404,583 patent/US20200172973A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2354068T3 (es) | 2011-03-09 |
EP2460889B1 (de) | 2013-11-20 |
ATE483822T1 (de) | 2010-10-15 |
CA2501863A1 (en) | 2004-04-22 |
EP2460889A3 (de) | 2012-07-04 |
EP1549764B1 (de) | 2010-10-06 |
WO2004033728A2 (en) | 2004-04-22 |
AU2003300565A1 (en) | 2004-05-04 |
HK1167436A1 (en) | 2012-11-30 |
JP4708029B2 (ja) | 2011-06-22 |
ES2442791T3 (es) | 2014-02-13 |
EP1549764A2 (de) | 2005-07-06 |
US8859748B2 (en) | 2014-10-14 |
DK2418287T3 (da) | 2013-12-16 |
EP2418287A3 (de) | 2012-07-04 |
EP2418287A2 (de) | 2012-02-15 |
JP2006501842A (ja) | 2006-01-19 |
EP2460889A2 (de) | 2012-06-06 |
CN1965089A (zh) | 2007-05-16 |
EP2418287B1 (de) | 2013-09-18 |
US20200172973A1 (en) | 2020-06-04 |
US10280462B2 (en) | 2019-05-07 |
US20060234234A1 (en) | 2006-10-19 |
ES2438782T3 (es) | 2014-01-20 |
HK1171794A1 (en) | 2013-04-05 |
US20150099646A1 (en) | 2015-04-09 |
DK1549764T3 (da) | 2011-01-24 |
WO2004033728A3 (en) | 2004-08-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE483822T1 (de) | Primer für nukleinsäureamplifikation in pcr- basierten klonalitätsstudien | |
ATE137269T1 (de) | Verbessertes verfahren zur amplifikation von nuklein säurezielsequenz, einsetzbar für die polymerase und ligasekettenreaktion | |
EP2272952B8 (de) | Thermostabiler oder thermoactiver DNA-polymerase mit abgeschwächter 3'-5' Exonukleaseaktivität | |
DE69523360D1 (de) | Isotherme Amplifikation von Nukleinsäuren durch Strangverdrängung | |
NZ244071A (en) | Oligonucleotide probe composition and kit for detecting hepatitis c | |
DE69834056D1 (de) | De novo oder "universaler" sequenzierungs-array | |
DK0550696T3 (da) | Oprenset termostabilt nukleinsyre-polymeraseenzym fra Thermosipho africanus | |
DE602004023659D1 (de) | Standardisiertes und optimiertes quantitatives reverse-transkriptase Echtzeit-Polymerasekettenreaktionsverfahren zum Nachweis von minimalen Resterkrankungen bei Leukämie | |
ES2151002T3 (es) | Deteccion del treponema pallidum y haemophilus ducreyi. | |
EP0477972A3 (en) | Nucleotide sequences useful as type-specific probes, pcr primers and lcr probes for the amplification and detection of human papilloma virus, and related kits and methods | |
DE60044867D1 (de) | Methode zur amplifizierung von hla klasse i allelen | |
ES2286212T3 (es) | Secuencias suprimidas especificamente del genoma de mycobacterium tuberculosis, y su uso en el diagnostico y como vacunas. | |
DE69425386D1 (de) | Nukleotidsonden | |
AU2003234932A1 (en) | Nucleic acid amplification primers for detecting cytokeratins and examination method with the use of the primers | |
Gasser et al. | Screening for nucleotide variations in ribosomal DNA arrays of Oesophagostomum bifurcum by polymerase chain reaction‐coupled single‐strand conformation polymorphism | |
ATE198219T1 (de) | Verfahren und mittel für die analyse von genetischem polymorphismus des angiotensin- umwandlungs-enzyms i | |
SE9002060D0 (sv) | A method of detecting an infection caused by a specific type of virus, primers, probes and a test kit | |
KR920019935A (ko) | 쭈쭈가무시균의 종 특이 dna염기서열 및 이를 이용한 쭈쭈가무시병의 진단방법 | |
RU93013954A (ru) | Способ обнаружения вируса иммунодефицита | |
RU97103934A (ru) | Способ выявления вируса классической чумы свиней с помощью специфических олигонуклеотидных праймеров и полимеразной цепной реакции |