DE60329123D1 - Benzoädüazepinderivate für die behandlung von neurologischen krankheiten - Google Patents
Benzoädüazepinderivate für die behandlung von neurologischen krankheitenInfo
- Publication number
- DE60329123D1 DE60329123D1 DE60329123T DE60329123T DE60329123D1 DE 60329123 D1 DE60329123 D1 DE 60329123D1 DE 60329123 T DE60329123 T DE 60329123T DE 60329123 T DE60329123 T DE 60329123T DE 60329123 D1 DE60329123 D1 DE 60329123D1
- Authority
- DE
- Germany
- Prior art keywords
- benzoedetazepine
- derivatives
- treatment
- neurological diseases
- neurological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000000926 neurological effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0229820A GB0229820D0 (en) | 2002-12-20 | 2002-12-20 | Novel compounds |
GB0312607A GB0312607D0 (en) | 2003-06-02 | 2003-06-02 | Novel compounds |
PCT/EP2003/014556 WO2004056369A1 (en) | 2002-12-20 | 2003-12-18 | Benzo ‘ d!azepine derivatives for the treatment of neurological disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60329123D1 true DE60329123D1 (de) | 2009-10-15 |
Family
ID=32683982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60329123T Expired - Lifetime DE60329123D1 (de) | 2002-12-20 | 2003-12-18 | Benzoädüazepinderivate für die behandlung von neurologischen krankheiten |
Country Status (28)
Country | Link |
---|---|
US (4) | US7696193B2 (de) |
EP (3) | EP2186516B1 (de) |
JP (2) | JP4584831B2 (de) |
KR (2) | KR100897642B1 (de) |
AR (1) | AR042542A1 (de) |
AT (1) | ATE441417T1 (de) |
AU (1) | AU2003294909B2 (de) |
BR (1) | BR0317483A (de) |
CA (1) | CA2509413C (de) |
CY (1) | CY1109558T1 (de) |
DE (1) | DE60329123D1 (de) |
DK (1) | DK1572215T3 (de) |
EG (1) | EG25204A (de) |
ES (3) | ES2401216T3 (de) |
HK (1) | HK1085647A1 (de) |
IL (2) | IL169091A (de) |
IS (1) | IS2907B (de) |
MA (1) | MA27582A1 (de) |
MX (1) | MXPA05006567A (de) |
MY (1) | MY138478A (de) |
NO (2) | NO331068B1 (de) |
NZ (1) | NZ540148A (de) |
PL (2) | PL220722B1 (de) |
PT (1) | PT1572215E (de) |
RU (2) | RU2388752C2 (de) |
SI (1) | SI1572215T1 (de) |
TW (1) | TWI323256B (de) |
WO (1) | WO2004056369A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1572215T1 (sl) | 2002-12-20 | 2010-01-29 | Venue Glaxo Group Ltd Glaxo We | Benzo(d)azepinski derivati za zdravljenje nevroloĺ kih motenj |
AU2004283452A1 (en) * | 2003-10-23 | 2005-05-06 | F. Hoffmann-La Roche Ag | Benzazepine derivatives as MAO-B inhibitors |
GB0329214D0 (en) * | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
GB0405628D0 (en) * | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
GB0408083D0 (en) * | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
JP2008502644A (ja) * | 2004-06-18 | 2008-01-31 | グラクソ グループ リミテッド | ヒスタミンh3アンタゴニストとしての3−シクロアルキルベンズアゼピン |
GB0418267D0 (en) * | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
CA2594383A1 (en) * | 2005-01-07 | 2006-07-13 | Glaxo Group Limited | 6- (2 , 3 , 4 , 5-tetrahydro-lh-benzo [d] azepin-7-yloxy) -nicotamide derivatives as radiolabelled ligands |
GB0513886D0 (en) | 2005-07-06 | 2005-08-10 | Glaxo Group Ltd | Novel compounds |
EP1928437A2 (de) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenese mittels muscarinrezeptormodulation |
WO2007045989A1 (en) * | 2005-10-20 | 2007-04-26 | Pfizer Limited | Pyridyl derivatives useful as h3 ligands |
AU2006308167A1 (en) | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
RU2417226C2 (ru) * | 2005-11-18 | 2011-04-27 | Ф.Хоффманн-Ля Рош Аг | Производные азаиндол-2-карбоксамида |
JP5285603B2 (ja) * | 2006-05-30 | 2013-09-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンh3受容体のモジュレーターとしての置換ピリジルアミド化合物 |
US20070293475A1 (en) * | 2006-06-20 | 2007-12-20 | Alcon Manufacturing Ltd. | Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma |
US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
RU2449989C2 (ru) * | 2006-06-23 | 2012-05-10 | Эбботт Лэборетриз | Производные циклопропиламина в качестве модуляторов h3-гистаминового рецептора |
GB2441014A (en) * | 2006-09-14 | 2008-02-20 | Glaxo Group Ltd | Polymorphic form of 6-(3-cyclobuty1-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methyl-nicotinamide hydrochloride for use in therapy |
CL2008000597A1 (es) * | 2007-03-01 | 2008-09-05 | Glaxo Group Ltd | Forma de dosificacion que comprende 6-(3-ciclobutil-2,3,4,5-tetrahidro-1h-benzo[d]azepin-7-il oxi)-n-metil nicotinamida, un estabilizante y un excipiente; procedimiento de preparacion; y su uso para tratar enfermedades neurologicas. |
CL2008000596A1 (es) * | 2007-03-01 | 2008-09-05 | Glaxo Group Ltd | Forma de dosificacion que comprende 1-(6-[(3-ciclobutil-2,3,4,5-tetrahidro-1h-3-benzazepin-7-il)oxi]-3-piridinil)-2-pirrolidinona, un estabilizador, un excipiente; procedimiento de preparacion; y su uso para tratar enfermedades neurologicas. |
ES2642888T3 (es) | 2007-05-22 | 2017-11-20 | Wyeth Llc | Procedimientos mejorados de fabricación de hidrazidas |
AU2008294708B2 (en) * | 2007-09-06 | 2012-03-15 | Glaxo Group Limited | Piperazine derivative having affinity for the histamine H3 receptor |
US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
WO2010094643A1 (en) | 2009-02-17 | 2010-08-26 | Glaxo Group Limited | Quinoline derivatives and their uses for rhinitis and urticaria |
US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
WO2011051423A1 (en) | 2009-11-02 | 2011-05-05 | Glaxo Group Limited | Treatment or prophylaxis of dementia, neurodegenerative disorders, schizophrenia, adhd, somnolence or epilepsy |
WO2011083316A1 (en) * | 2010-01-08 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Benzazepine derivatives for the treatment of central nervous system disorders |
WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
RS54248B1 (en) * | 2011-02-23 | 2016-02-29 | Suven Life Sciences Limited | NEW UNITS AS LISTS OF HISTAMINE H3 RECEPTORS |
GB201104153D0 (en) | 2011-03-11 | 2011-04-27 | Glaxo Group Ltd | Novel compounds |
AU2012229172B2 (en) | 2011-03-14 | 2017-02-09 | Alkahest, Inc. | Benzodioxane inhibitors of leukotriene production |
US9139567B2 (en) | 2011-07-19 | 2015-09-22 | Boehringer Ingelheim International Gmbh | Arylpyrazole ethers as inhibitors of leukotriene A4 hydrolase |
KR20140113719A (ko) * | 2012-01-16 | 2014-09-24 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 치료 용도 |
CN104114538B (zh) * | 2012-01-16 | 2016-04-13 | 葛兰素史克知识产权发展有限公司 | 治疗用途 |
CN104487435A (zh) | 2012-03-06 | 2015-04-01 | 勃林格殷格翰国际有限公司 | 用于抑制白三烯生成的苯并二氧杂环己烷与其他活性剂的组合 |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
EP2647377A1 (de) | 2012-04-06 | 2013-10-09 | Sanofi | Verwendung eines H3-Rezeptorantagonisten zur Behandlung von Morbus Alzheimer |
US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
JP6353899B2 (ja) | 2013-07-15 | 2018-07-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
US9573957B2 (en) | 2013-07-15 | 2017-02-21 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
WO2016123629A1 (en) * | 2015-01-30 | 2016-08-04 | Vanderbilt University | Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
EP4251148A1 (de) | 2020-11-27 | 2023-10-04 | Richter Gedeon Nyrt. | Histamin-h3-rezeptorantagonisten/inversagonisten zur behandlung von autismusspektrumsstörungen |
CA3221177A1 (en) | 2021-11-01 | 2023-05-04 | Meghan Kerrisk Campbell | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
US4233217A (en) * | 1968-03-11 | 1980-11-11 | Pennwalt Corporation | Substituted 1,2,4,5-tetrahydro-3H, 3 benzazepines |
CA974989A (en) | 1968-03-11 | 1975-09-23 | Wallace And Tiernan Inc. | Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby |
DE2207430C3 (de) | 1972-02-14 | 1982-05-13 | Pennwalt Corp., 19102 Philadelphia, Pa. | 1,2,4,5-Tetrahydro-3H-3-benzazepin, ein Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Mittel |
US4210749A (en) * | 1974-11-12 | 1980-07-01 | Pennwalt Corporation | Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines |
US4206210A (en) * | 1977-01-19 | 1980-06-03 | Smithkline Corporation | Alkylthio-7,8-dihdroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity |
US4843081A (en) * | 1984-09-04 | 1989-06-27 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl substituted cycloalkyl compounds |
DE3717561A1 (de) | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US5175157A (en) * | 1985-11-27 | 1992-12-29 | Boehringer Ingelheim Gmbh | Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them |
JPS6394239A (ja) | 1986-10-08 | 1988-04-25 | Konica Corp | 色素画像の安定性を改良したハロゲン化銀写真感光材料 |
PH27337A (en) * | 1987-03-27 | 1993-06-08 | Schering Corp | Substituted benzazepines their preparation and pharmaceutical compositions containing them |
DK325188D0 (da) | 1988-06-15 | 1988-06-15 | Novo Industri As | Hidtil ukendte benzazepinderivater |
FR2642756B1 (fr) | 1989-02-07 | 1994-03-04 | Sanofi | Derives cycloaminoalkoxyphenyle, leur procede de preparation ainsi que les compositions pharmaceutiques ou veterinaires en contenant |
US4959374A (en) * | 1989-07-06 | 1990-09-25 | Beecham Group P.L.C. | Novel compounds |
ZA914536B (en) | 1990-06-15 | 1992-03-25 | Schering Corp | 8-lower alkyl-5-cycloalkyl or 5-cycloakenyl substituted benzazepines and pharmaceutical compositions containing them |
TW197435B (de) | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
PT100602A (pt) | 1991-06-21 | 1993-09-30 | Smithkline Beecham Plc | Uso de derivados de tetra-hidrobenzazepinas, derivados de tetra-hidrobenzazepinas,sua preparacao e composicoes farmaceuticas que os contem |
GB9116824D0 (en) | 1991-08-05 | 1991-09-18 | Smithkline Beecham Corp | Chemical compounds |
GB9119467D0 (en) | 1991-09-12 | 1991-10-23 | Smithkline Beecham Corp | Chemical compounds |
JPH05194406A (ja) | 1991-11-12 | 1993-08-03 | Yoshitomi Pharmaceut Ind Ltd | 新規アミド化合物 |
US5241065A (en) | 1992-02-25 | 1993-08-31 | Schering Corporation | 2,3,4,5-tetrahydro-1h-3-benzazepines having anti-psychotic activity |
JPH05239024A (ja) | 1992-02-28 | 1993-09-17 | Takeda Chem Ind Ltd | 縮合複素環カルボン酸誘導体、その製造法、中間体および剤 |
US5364791A (en) | 1992-05-14 | 1994-11-15 | Elisabetta Vegeto | Progesterone receptor having C. terminal hormone binding domain truncations |
AU685054C (en) | 1992-05-14 | 2003-02-27 | Baylor College Of Medicine | Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy |
SE9300657D0 (sv) | 1993-02-26 | 1993-02-26 | Astra Ab | New compounds |
DE4332168A1 (de) | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5387685A (en) | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
AU1090795A (en) | 1993-11-12 | 1995-05-29 | Cell Therapeutics, Inc. | Method for preventing tissue injury from hypoxia |
WO1995014028A2 (en) | 1993-11-18 | 1995-05-26 | Washington University | Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections |
DE4429079A1 (de) | 1994-08-17 | 1996-02-22 | Thomae Gmbh Dr K | Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DE19530996A1 (de) | 1995-08-23 | 1997-02-27 | Boehringer Mannheim Gmbh | Cyclische Guanidine, Verfahren zu ihrer Herstellung und Arzneimittel |
EP0920417A4 (de) | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | Il-8 rezeptor antagonisten |
US5932590A (en) | 1996-12-05 | 1999-08-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1998031356A1 (en) | 1997-01-17 | 1998-07-23 | Takeda Chemical Industries, Ltd. | Idebenone containing combination agent for treating alzheimer's disease |
GB9724372D0 (en) | 1997-11-18 | 1998-01-14 | Smithkline Beecham Plc | Novel compounds |
EP1043311A4 (de) | 1997-11-20 | 2001-01-24 | Teijin Ltd | Biphenylamidin-derivate |
AU745855B2 (en) | 1998-02-02 | 2002-04-11 | Lg Chemical Ltd. | Farnesyl transferase inhibitors having a piperidine structure and process for preparation thereof |
EP0937723A1 (de) | 1998-02-18 | 1999-08-25 | Roche Diagnostics GmbH | Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
CA2328396C (en) | 1998-04-20 | 2009-02-10 | Basf Aktiengesellschaft | New substituted amides, their production and their use |
CN1307565A (zh) | 1998-04-29 | 2001-08-08 | 史密丝克莱恩比彻姆有限公司 | 用作mrs抑制剂和杀菌剂的喹诺酮化合物 |
EP0982300A3 (de) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Alkylamine ohne Imidazolring als Histamin-H3-antagonisten und deren therapeutische Anwendung |
GB9816982D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
ES2255311T3 (es) | 1998-10-08 | 2006-06-16 | Smithkline Beecham Plc | Derivados de tetrahidrobenzazepina utiles como moduladores de los receptores d3 de dopamina (agentes anti-psicoticos). |
WO2000023437A1 (fr) | 1998-10-16 | 2000-04-27 | Takeda Chemical Industries, Ltd. | Composes azotes hererocycliques condenses; procede de fabrication et agents les renfermant |
JP4615727B2 (ja) | 1998-12-24 | 2011-01-19 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Aβタンパク質生成の阻害剤としてのスクシノイルアミノベンゾジアゼピン |
GB9914255D0 (en) | 1999-06-18 | 1999-08-18 | Lilly Forschung Gmbh | Pharmaceutical compounds |
CA2375628A1 (en) | 1999-07-09 | 2001-01-18 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
ES2209728T3 (es) * | 1999-08-06 | 2004-07-01 | F. Hoffmann-La Roche Ag | Tetrahidro-benzo(d)azepinas y su uso como antagonistas de receptores de glutamato metabotropico. |
AU1569501A (en) | 1999-11-09 | 2001-06-06 | Eli Lilly And Company | Beta-aminoacid compounds useful for inhibiting beta-amyloid peptide release and/or its synthesis |
KR20020067937A (ko) | 2000-01-26 | 2002-08-24 | 오노 야꾸힝 고교 가부시키가이샤 | 벤젠 축합 헤테로환 유도체 및 그 유도체를 유효성분으로서 함유하는 약제 |
JP2001226269A (ja) | 2000-02-18 | 2001-08-21 | Takeda Chem Ind Ltd | メラニン凝集ホルモン拮抗剤 |
DE60115132T2 (de) | 2000-04-21 | 2006-07-06 | Pfizer Products Inc., Groton | Thyroid-Rezeptorliganden |
BR0110638A (pt) | 2000-05-11 | 2003-03-25 | Bristol Myers Squibb Co | Análogos de tetraidroisoquinolina úteis como secretagogos de hormÈnio do crescimento |
JP2002371059A (ja) * | 2000-05-16 | 2002-12-26 | Takeda Chem Ind Ltd | メラニン凝集ホルモン拮抗剤 |
US7229986B2 (en) * | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
CA2414976A1 (en) | 2000-07-04 | 2002-01-10 | Takeda Chemical Industries, Ltd. | Gpr14 antagonistic agent |
US20040053826A1 (en) * | 2000-08-10 | 2004-03-18 | Yoshio Matsumoto | Uses of polypeptides |
CA2418464A1 (en) * | 2000-08-25 | 2003-02-05 | Takeda Chemical Industries, Ltd. | Prophylactic or therapeutic agent for central nervous system diseases |
CA2428844A1 (en) | 2000-11-14 | 2002-05-23 | Michael Stewart Hadley | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
UA77165C2 (en) | 2000-11-17 | 2006-11-15 | Lilly Co Eli | (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition |
FR2819512B1 (fr) | 2001-01-18 | 2003-02-21 | Servier Lab | Nouveaux composes cyclo[d] azepane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CN100384423C (zh) | 2001-02-02 | 2008-04-30 | 布里斯托尔-迈尔斯斯奎布公司 | 取代的氮杂吲哚氧代乙酰哌嗪衍生物的组合物和抗病毒活性 |
US6649606B1 (en) | 2001-11-09 | 2003-11-18 | Bristol-Myers Squibb Co. | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity |
US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
ATE308544T1 (de) | 2002-04-26 | 2005-11-15 | Pfizer Prod Inc | N-substituiete heteroaryloxy-aryl-spiro- pyrimidine-2,4,6-trion metalloproteinase inhibitoren |
AU2003223012A1 (en) | 2002-04-26 | 2003-11-10 | Pfizer Products Inc. | Pyrimidine-2, 4, 6-trione metallo-proteinase inhibitors |
US20060089347A1 (en) * | 2002-08-20 | 2006-04-27 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
DK1562595T3 (da) | 2002-09-19 | 2008-08-18 | Lilly Co Eli | Diarylethere som opioidreceptorantagonister |
GB0224083D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
SI1572215T1 (sl) * | 2002-12-20 | 2010-01-29 | Venue Glaxo Group Ltd Glaxo We | Benzo(d)azepinski derivati za zdravljenje nevroloĺ kih motenj |
CA2512000C (en) * | 2002-12-26 | 2011-08-09 | Eisai Co., Ltd. | Selective estrogen receptor modulator |
JP2006516989A (ja) | 2003-02-07 | 2006-07-13 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 抗菌剤として使用するための二環式環によりn−置換されたオキサゾリジノン誘導体 |
EP1663868A2 (de) | 2003-08-08 | 2006-06-07 | Glaxo Group Limited | Verfahren zur herstellung von radioaktiv markierten verbindungen |
AU2004283452A1 (en) | 2003-10-23 | 2005-05-06 | F. Hoffmann-La Roche Ag | Benzazepine derivatives as MAO-B inhibitors |
GB0329214D0 (en) * | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
JP4982184B2 (ja) | 2003-12-18 | 2012-07-25 | アボット ゲーエムベーハー ウント カンパニー カーゲー | テトラヒドロベンズアゼピンおよびドーパミンd3レセプターの調節におけるこれらの使用 |
GB0405628D0 (en) * | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
GB0408083D0 (en) * | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
JP2008502644A (ja) * | 2004-06-18 | 2008-01-31 | グラクソ グループ リミテッド | ヒスタミンh3アンタゴニストとしての3−シクロアルキルベンズアゼピン |
GB0418267D0 (en) * | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
-
2003
- 2003-12-18 SI SI200331706T patent/SI1572215T1/sl unknown
- 2003-12-18 RU RU2005122932/04A patent/RU2388752C2/ru not_active IP Right Cessation
- 2003-12-18 DE DE60329123T patent/DE60329123D1/de not_active Expired - Lifetime
- 2003-12-18 PL PL377315A patent/PL220722B1/pl unknown
- 2003-12-18 CA CA2509413A patent/CA2509413C/en not_active Expired - Fee Related
- 2003-12-18 NZ NZ540148A patent/NZ540148A/en not_active IP Right Cessation
- 2003-12-18 MX MXPA05006567A patent/MXPA05006567A/es active IP Right Grant
- 2003-12-18 AR ARP030104722A patent/AR042542A1/es not_active Application Discontinuation
- 2003-12-18 PL PL397229A patent/PL397229A1/pl unknown
- 2003-12-18 ES ES09168438T patent/ES2401216T3/es not_active Expired - Lifetime
- 2003-12-18 RU RU2009138602/04A patent/RU2423353C1/ru not_active IP Right Cessation
- 2003-12-18 ES ES03785885T patent/ES2333008T3/es not_active Expired - Lifetime
- 2003-12-18 EP EP09168436A patent/EP2186516B1/de not_active Expired - Lifetime
- 2003-12-18 EP EP09168438A patent/EP2133340B1/de not_active Expired - Lifetime
- 2003-12-18 EP EP03785885A patent/EP1572215B1/de not_active Expired - Lifetime
- 2003-12-18 MY MYPI20034867A patent/MY138478A/en unknown
- 2003-12-18 AU AU2003294909A patent/AU2003294909B2/en not_active Ceased
- 2003-12-18 US US10/539,385 patent/US7696193B2/en active Active
- 2003-12-18 WO PCT/EP2003/014556 patent/WO2004056369A1/en active IP Right Grant
- 2003-12-18 TW TW092135892A patent/TWI323256B/zh not_active IP Right Cessation
- 2003-12-18 BR BR0317483-2A patent/BR0317483A/pt not_active Application Discontinuation
- 2003-12-18 DK DK03785885T patent/DK1572215T3/da active
- 2003-12-18 PT PT03785885T patent/PT1572215E/pt unknown
- 2003-12-18 AT AT03785885T patent/ATE441417T1/de active
- 2003-12-18 ES ES09168436T patent/ES2401319T3/es not_active Expired - Lifetime
- 2003-12-18 KR KR1020077019049A patent/KR100897642B1/ko not_active IP Right Cessation
- 2003-12-18 KR KR1020057011441A patent/KR100765027B1/ko not_active IP Right Cessation
- 2003-12-18 JP JP2005502553A patent/JP4584831B2/ja not_active Expired - Fee Related
-
2005
- 2005-06-09 IL IL169091A patent/IL169091A/en active IP Right Grant
- 2005-06-14 EG EGNA2005000295 patent/EG25204A/xx active
- 2005-07-12 NO NO20053384A patent/NO331068B1/no not_active IP Right Cessation
- 2005-07-18 IS IS7941A patent/IS2907B/is unknown
- 2005-07-20 MA MA28405A patent/MA27582A1/fr unknown
-
2006
- 2006-03-13 HK HK06103210.2A patent/HK1085647A1/xx not_active IP Right Cessation
-
2007
- 2007-07-31 US US11/831,191 patent/US7704994B2/en not_active Expired - Lifetime
-
2008
- 2008-12-19 US US12/339,145 patent/US7799773B2/en not_active Expired - Lifetime
-
2009
- 2009-12-01 CY CY20091101260T patent/CY1109558T1/el unknown
- 2009-12-17 IL IL202827A patent/IL202827A/en active IP Right Grant
-
2010
- 2010-02-17 US US12/707,147 patent/US8207331B2/en not_active Expired - Lifetime
- 2010-07-09 JP JP2010157004A patent/JP5315299B2/ja not_active Expired - Fee Related
-
2011
- 2011-03-17 NO NO20110408A patent/NO332218B1/no not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE374196T1 (de) | Dihydrobenzodiazepin-2-on-derivative für die behandlung von neurologischen erkrankungen | |
ATE441417T1 (de) | Benzoädüazepinderivate für die behandlung von neurologischen krankheiten | |
ATE439844T1 (de) | Kombinationen für die behandlung entzündlicher erkrankungen | |
DE60218493D1 (de) | Substituierte 7-aza-ä2.2.1übicycloheptane für die behandlung von krankheiten | |
ATE286895T1 (de) | Sulfonyl-pyrrolidinderivate geeignet für die behandlung von neurologischen krankheiten | |
ATE440866T1 (de) | Nogo-a-neutralisierende immunglobuline zur behandlung neurologischer krankheiten | |
ATE551340T1 (de) | Azabicyclisch- substituierte annelierte heteroaryl-verbinungen für die behandlung von krankheiten | |
ATE424386T1 (de) | Pyridin-verbindungen für die behandlung von prostaglandin-vermittelten krankheiten | |
ATE345331T1 (de) | Verbindungen verwendbar für die behandlung von entzündungskrankheiten | |
ATE417037T1 (de) | Diarylharnstoffderivate, die sich zur behandlung von proteinkinaseabhängigen krankheiten eignen | |
ATE418554T1 (de) | 1-acyl-pyrrolidin-derivate für die behandlung von viralen infektionen | |
DE60239558D1 (de) | Kombinationen für die behandlung von immun-entzündlichen erkrankungen | |
DE60108754D1 (de) | Substituierte bizyklische derivate für die behandlung von unnormalem zellwachstum | |
DE60303238D1 (de) | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten | |
ATE396202T1 (de) | Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen | |
ATE390407T1 (de) | Phenethanolamin-derivate zur behandlung von atemwegserkrankungen | |
DE60124302D1 (de) | Thiazolderivate zur behandlung von ppar-lierte krankheiten | |
ATE402165T1 (de) | Piperazin derivate und ihre verwendung für die behandlung von neurologischen und psychiatrischen krankheiten. | |
DE60231107D1 (de) | Tetrahydro-pyrazinoä1,2-aüindole für die behandlung von krankheiten des zentralnervensystems | |
ATE443704T1 (de) | Pyridopyrimidinone zur behandlung von krebserkrankungen | |
ATE413399T1 (de) | Morpholinyl-harnstoff-derivative fuer die behandlung von krankheiten verbunden mit entzuendlichen prozessen | |
DE60236743D1 (de) | Zur behandlung androgenabhängiger krankheiten | |
ATE333872T1 (de) | Zusammensetzng auf diclofenac-basis für die topische behandlung von erkrankungen des oropharynx | |
ATE272619T1 (de) | Anilin-disulfid-derivate zur behandlung allergischer erkrankungen | |
ATE391507T1 (de) | S-methyl-dihydro-ziprasidone für die behandlung von schizophrenie |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |