DE60234944D1 - Isolierte dna-moleküle, die für einen humanisierten calcitonin gene-related peptide receptor kodiered assayverfahren - Google Patents

Isolierte dna-moleküle, die für einen humanisierten calcitonin gene-related peptide receptor kodiered assayverfahren

Info

Publication number: DE60234944D1
Authority: DE; Germany
Prior art keywords: receptor; humanized; cgrp; ramp1; related peptide
Prior art date: 2001-09-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60234944T

Other languages

English (en)

Inventor

Stefanie A Kane

Christopher A Salvatore

John J Mallee

Kenneth S Koblan

Kevin R Oliver

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-27

Filing date

2002-09-26

Publication date

2010-02-11

2002-09-26 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2010-02-11 Application granted granted Critical

2010-02-11 Publication of DE60234944D1 publication Critical patent/DE60234944D1/de

2022-09-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

102000014468 Calcitonin Gene-Related Peptide Receptors Human genes 0.000 title abstract 3
108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
238000003556 assay Methods 0.000 title 1
102000007184 Receptor Activity-Modifying Protein 1 Human genes 0.000 abstract 4
108010033494 Receptor Activity-Modifying Protein 1 Proteins 0.000 abstract 4
108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 abstract 3
102000004414 Calcitonin Gene-Related Peptide Human genes 0.000 abstract 3
102000056906 Calcitonin Receptor-Like Human genes 0.000 abstract 2
101710118454 Calcitonin gene-related peptide type 1 receptor Proteins 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 2
230000000144 pharmacologic effect Effects 0.000 abstract 2
102000005962 receptors Human genes 0.000 abstract 2
108020003175 receptors Proteins 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
DNKYDHSONDSTNJ-XJVRLEFXSA-N chembl1910953 Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CN=CN1 DNKYDHSONDSTNJ-XJVRLEFXSA-N 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
230000009261 transgenic effect Effects 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Veterinary Medicine (AREA)
Cell Biology (AREA)
Immunology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DE60234944T 2001-09-27 2002-09-26 Isolierte dna-moleküle, die für einen humanisierten calcitonin gene-related peptide receptor kodiered assayverfahren Expired - Lifetime DE60234944D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32529501P	2001-09-27	2001-09-27
PCT/US2002/030501 WO2003027252A2 (en)	2001-09-27	2002-09-26	Isolated dna molecules encoding humanized calcitonin gene-related peptide receptor, related non-human transgenic animals and assay methods

Publications (1)

Publication Number	Publication Date
DE60234944D1 true DE60234944D1 (de)	2010-02-11

Family

ID=23267273

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60234944T Expired - Lifetime DE60234944D1 (de)	2001-09-27	2002-09-26	Isolierte dna-moleküle, die für einen humanisierten calcitonin gene-related peptide receptor kodiered assayverfahren

Country Status (7)

Country	Link
US (1)	US7193070B2 (de)
EP (1)	EP1438325B1 (de)
JP (1)	JP4603261B2 (de)
AT (1)	ATE453661T1 (de)
CA (1)	CA2461917C (de)
DE (1)	DE60234944D1 (de)
WO (1)	WO2003027252A2 (de)

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ES2561828T3 (es)	2002-01-25	2016-03-01	Novo Nordisk A/S	Anticuerpos monoclonales contra bucles extracelulares de C5aR
US7220862B2 (en)	2002-06-05	2007-05-22	Bristol-Myers Squibb Company	Calcitonin gene related peptide receptor antagonists
US7842808B2 (en)	2002-06-05	2010-11-30	Bristol-Myers Squibb Company	Anti-migraine spirocycles
US20040063735A1 (en)	2002-06-05	2004-04-01	Chaturvedula Prasad V.	Calcitonin gene related peptide receptor antagonists
WO2004097421A2 (en) *	2003-04-29	2004-11-11	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with calcitonin receptor-like receptor (calcrl)
CA2549330A1 (en)	2003-12-05	2005-07-21	Bristol-Myers Squibb Company	Calcitonin gene related peptide receptor antagonists
AR046787A1 (es)	2003-12-05	2005-12-21	Bristol Myers Squibb Co	Agentes antimigrana heterociclicos
AU2004304665B2 (en) *	2003-12-24	2009-03-12	Novo Nordisk A/S	Transgenic non-human mammal comprising a polynucleotide encoding human or humanized C5aR
TW200533398A (en)	2004-03-29	2005-10-16	Bristol Myers Squibb Co	Novel therapeutic agents for the treatment of migraine
US7384931B2 (en)	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en)	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en)	2004-12-03	2008-11-11	Bristol-Myers Squibb Company	Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
FR2882628B1 (fr) *	2005-03-04	2011-03-18	Centre Nat Rech Scient	Souris transgeniques et leurs applications comme modele experimental
US7834007B2 (en)	2005-08-25	2010-11-16	Bristol-Myers Squibb Company	CGRP antagonists
DK1957106T4 (da)	2005-11-14	2019-10-28	Teva Pharmaceuticals Int Gmbh	Antagonist-antistoffer, der er rettet mod calcitonin-gen-relateret peptid og fremgangsmåder til anvendelse af disse
JP2009201355A (ja) *	2006-06-02	2009-09-10	Osaka Univ	高血圧モデル非ヒト動物
BRPI0715703A2 (pt)	2006-08-22	2013-09-17	G2 Inflammation Pty Ltd	anticorpos anti-c5ar com propriedades melhoradas
JP2010536326A (ja) *	2007-04-26	2010-12-02	アキリオンファーマシューティカルズ，インコーポレーテッド	Ｈｃｖのキメラｎｓ４ａタンパク質を発現する細胞およびアッセイ法におけるその使用
CN104193824A (zh)	2008-02-20	2014-12-10	G2炎症私人有限公司	人源化抗-C5aR抗体
JP5537441B2 (ja)	2008-03-04	2014-07-02	ファイザー・リミテッド	慢性疼痛を治療する方法
JO3382B1 (ar) *	2008-12-23	2019-03-13	Amgen Inc	أجسام مضادة ترتبط مع مستقبل cgrp بشري
CN107441487B (zh)	2009-08-28	2021-09-14	泰华制药国际有限公司	通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法
AU2012266487B2 (en)	2011-06-06	2016-12-08	Novo Nordisk A/S	Therapeutic antibodies
JP6267986B2 (ja) *	2014-02-13	2018-01-24	株式会社特殊免疫研究所	ヒトの特定分子と結合する分子標的物質のｉｎｖｉｖｏ評価法
US10556945B2 (en)	2014-03-21	2020-02-11	Teva Pharmaceuticals International Gmbh	Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
WO2015143409A1 (en)	2014-03-21	2015-09-24	Labrys Biologics, Inc.	Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
JP6956631B2 (ja)	2014-09-15	2021-11-02	アムジェンインコーポレイテッド	二重特異性抗ｃｇｒｐ受容体／ｐａｃ１受容体抗原結合タンパク質及びその使用
JOP20200116A1 (ar)	2015-04-24	2017-06-16	Amgen Inc	طرق لعلاج أو الوقاية من الصداع النصفي
AU2017331593B2 (en)	2016-09-23	2022-04-28	Teva Pharmaceuticals International Gmbh	Treating refractory migraine
EA202092335A1 (ru)	2018-04-02	2021-01-22	Эмджен Инк.	Композиции на основе эренумаба и пути их применения

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2002
- 2002-09-26 CA CA2461917A patent/CA2461917C/en not_active Expired - Fee Related
- 2002-09-26 JP JP2003530824A patent/JP4603261B2/ja not_active Expired - Fee Related
- 2002-09-26 AT AT02763731T patent/ATE453661T1/de not_active IP Right Cessation
- 2002-09-26 US US10/490,594 patent/US7193070B2/en not_active Expired - Fee Related
- 2002-09-26 EP EP02763731A patent/EP1438325B1/de not_active Expired - Lifetime
- 2002-09-26 WO PCT/US2002/030501 patent/WO2003027252A2/en active Application Filing
- 2002-09-26 DE DE60234944T patent/DE60234944D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2003027252A3 (en)	2003-06-19
US7193070B2 (en)	2007-03-20
CA2461917A1 (en)	2003-04-03
US20040197859A1 (en)	2004-10-07
JP4603261B2 (ja)	2010-12-22
EP1438325A4 (de)	2005-02-23
JP2005503809A (ja)	2005-02-10
EP1438325A2 (de)	2004-07-21
EP1438325B1 (de)	2009-12-30
CA2461917C (en)	2012-01-17
ATE453661T1 (de)	2010-01-15
WO2003027252A2 (en)	2003-04-03

Legal Events

Date	Code	Title	Description
2011-01-20	8364	No opposition during term of opposition

Publication	Publication Date	Title
DE60234944D1 (de)	2010-02-11	Isolierte dna-moleküle, die für einen humanisierten calcitonin gene-related peptide receptor kodiered assayverfahren
DE602005026072D1 (de)	2011-03-03	Ligand für den formylpeptidrezeptorähnlichen-2 (FPRL2) G Protein gekoppelten Rezeptor
BR9912437A (pt)	2001-09-25	ácidos nucléicos codificando um receptor ligado à proteìna g envolvido na transdução sensória
RU2006138490A (ru)	2008-05-20	Одноцепочечное триспецифическое антитело рекомбинант анти-сеа/cd3/cd28, полученный путем генетической инженерии
DE69838334D1 (de)	2007-10-11	Kdr, ein menschlicher tyrosin kinase rezeptor
NO20020861D0 (no)	2002-02-22	PD-1, en reseptor for B7-4, og anvendelser derav
ATE189607T1 (de)	2000-02-15	Dna codierend für einen menschlichen neuropeptid y/peptid yy/pankreaspolypeptid-rezeptor (y4) und seine verwendung
WO2002070652A3 (en)	2005-11-24	Novel molecules of the card-related protein family and uses thereof
ATE431406T1 (de)	2009-05-15	Neuer typ-1-cytokinrezeptor glm-r
DK1756273T3 (da)	2010-02-01	Signalpeptid til frembringelse af et polypeptid
WO2002070657A3 (en)	2003-07-03	93870, a human g-protein coupled receptor and uses therefor
FI3687287T3 (fi)	2023-10-12	Humanisoitua c1q-kompleksia ilmentävät jyrsijät
WO2003033661A8 (en)	2003-12-24	Methods of using 279, a human g protein-coupled receptor
WO2002068591A3 (en)	2004-12-09	G-protein coupled receptor nucleic acids, polypeptides, antibodies and uses thereof
DK1863834T3 (da)	2010-11-01	Polypeptider og nukleinsyrer, der koder disse
WO2002038767A3 (en)	2003-09-04	G protein-coupled receptor protein and nucleic acid molecules and uses therefor
DE69930873D1 (de)	2006-05-24	Dna-moleküle kodierende spleissvarianten des humanen melanocortin-1-rezeptorproteins
DE69940268D1 (de)	2009-02-26	Chlamydia antigen, dns fragmente welche für solche kodieren und deren verwendung
WO2003020913A3 (en)	2006-12-07	Anopheles gambiae odorant receptors and genes
MXPA03011843A (es)	2004-03-26	Un nuevo receptor copulado a proteina g, gave3.
US20080305547A1 (en)	2008-12-11	Method for enhanced functional expression of cell receptors
WO2003029413A3 (en)	2003-10-16	A novel g protein-coupled receptor, gave 10
WO2003030616A3 (en)	2003-08-07	21132, a human g-protein coupled receptor family member and uses therefor
WO2002070690A3 (en)	2003-01-16	Abca5 transporter and uses thereof
WO2003100004A3 (en)	2004-03-18	A novel g protein-coupled receptor, gave2