WO2002038767A3 - G protein-coupled receptor protein and nucleic acid molecules and uses therefor - Google Patents

G protein-coupled receptor protein and nucleic acid molecules and uses therefor Download PDF

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Publication number
WO2002038767A3
WO2002038767A3 PCT/US2001/049696 US0149696W WO0238767A3 WO 2002038767 A3 WO2002038767 A3 WO 2002038767A3 US 0149696 W US0149696 W US 0149696W WO 0238767 A3 WO0238767 A3 WO 0238767A3
Authority
WO
WIPO (PCT)
Prior art keywords
c5rl
nucleic acid
acid molecules
protein
proteins
Prior art date
Application number
PCT/US2001/049696
Other languages
French (fr)
Other versions
WO2002038767A2 (en
Inventor
Kamalakar Gulukota
Harleen Kaur
Brian G Bates
Janet E Paulsen
Original Assignee
Inst Genetics Llc
Kamalakar Gulukota
Harleen Kaur
Brian G Bates
Janet E Paulsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Genetics Llc, Kamalakar Gulukota, Harleen Kaur, Brian G Bates, Janet E Paulsen filed Critical Inst Genetics Llc
Priority to AU2002231194A priority Critical patent/AU2002231194A1/en
Publication of WO2002038767A2 publication Critical patent/WO2002038767A2/en
Publication of WO2002038767A3 publication Critical patent/WO2002038767A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Novel C5RL polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length C5RL proteins, the invention further provides isolated C5RL fusion proteins, antigenic peptides and anti-C5RL antibodies. The invention also provides C5RL nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a C5RL gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
PCT/US2001/049696 2000-11-07 2001-11-07 G protein-coupled receptor protein and nucleic acid molecules and uses therefor WO2002038767A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002231194A AU2002231194A1 (en) 2000-11-07 2001-11-07 G protein-coupled receptor protein and nucleic acid molecules and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24655300P 2000-11-07 2000-11-07
US60/246,553 2000-11-07

Publications (2)

Publication Number Publication Date
WO2002038767A2 WO2002038767A2 (en) 2002-05-16
WO2002038767A3 true WO2002038767A3 (en) 2003-09-04

Family

ID=22931171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/049696 WO2002038767A2 (en) 2000-11-07 2001-11-07 G protein-coupled receptor protein and nucleic acid molecules and uses therefor

Country Status (2)

Country Link
AU (1) AU2002231194A1 (en)
WO (1) WO2002038767A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4559081B2 (en) 2002-01-25 2010-10-06 ジーツー セラピーズ リミテッド Anti-C5aR antibody and use thereof
WO2005050199A1 (en) * 2003-10-31 2005-06-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein- coupled receptor 77 (gpr77)
WO2005101013A2 (en) * 2004-04-15 2005-10-27 Reglia Ab Materials and methods for screening modulators of neural regneration
EP2051997B1 (en) 2006-08-22 2015-03-18 G2 Inflammation Pty Ltd Anti-c5ar antibodies with improved properties
EP2826791A3 (en) 2008-02-20 2015-07-29 Novo Nordisk A/S Humanized anti-C5aR antibodies
WO2012168199A1 (en) 2011-06-06 2012-12-13 Novo Nordisk A/S Therapeutic antibodies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1111049A1 (en) * 1998-09-03 2001-06-27 Asahi Kasei Kabushiki Kaisha Novel receptor protein and method for diagnosing inflammatory diseases by using the same
WO2001049847A2 (en) * 1999-12-30 2001-07-12 Millennium Pharmaceuticals, Inc. 26904, 38911, and 39404, seven-transmembrane proteins/g-protein coupled receptors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1111049A1 (en) * 1998-09-03 2001-06-27 Asahi Kasei Kabushiki Kaisha Novel receptor protein and method for diagnosing inflammatory diseases by using the same
WO2001049847A2 (en) * 1999-12-30 2001-07-12 Millennium Pharmaceuticals, Inc. 26904, 38911, and 39404, seven-transmembrane proteins/g-protein coupled receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOULAY F ET AL: "EXPRESSION CLONING OF A RECEPTOR FOR C5A ANAPHYLATOXIN ON DIFFERENTIATED HL-60 CELLS", BIOCHEMISTRY, vol. 30, no. 12, 1991, pages 2993 - 2999, XP000828087, ISSN: 0006-2960 *
OHNO MITSUHARU ET AL: "A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.", MOLECULAR IMMUNOLOGY, vol. 37, no. 8, June 2000 (2000-06-01), pages 407 - 412, XP002224051, ISSN: 0161-5890 *

Also Published As

Publication number Publication date
AU2002231194A1 (en) 2002-05-21
WO2002038767A2 (en) 2002-05-16

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