DE60217090D1 - Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel - Google Patents
Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittelInfo
- Publication number
- DE60217090D1 DE60217090D1 DE60217090T DE60217090T DE60217090D1 DE 60217090 D1 DE60217090 D1 DE 60217090D1 DE 60217090 T DE60217090 T DE 60217090T DE 60217090 T DE60217090 T DE 60217090T DE 60217090 D1 DE60217090 D1 DE 60217090D1
- Authority
- DE
- Germany
- Prior art keywords
- diagnostic imaging
- amyloid plaque
- aggregation inhibitors
- imaging products
- plaque aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000037259 Amyloid Plaque Diseases 0.000 title abstract 5
- 238000004220 aggregation Methods 0.000 title abstract 2
- 230000002776 aggregation Effects 0.000 title abstract 2
- 238000002059 diagnostic imaging Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 238000003384 imaging method Methods 0.000 abstract 2
- 102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28528201P | 2001-04-23 | 2001-04-23 | |
US285282P | 2001-04-23 | ||
PCT/US2002/012626 WO2002085903A2 (en) | 2001-04-23 | 2002-04-23 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60217090D1 true DE60217090D1 (de) | 2007-02-08 |
DE60217090T2 DE60217090T2 (de) | 2007-07-12 |
Family
ID=23093574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60217090T Expired - Lifetime DE60217090T2 (de) | 2001-04-23 | 2002-04-23 | Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel |
Country Status (12)
Country | Link |
---|---|
US (5) | US6696039B2 (de) |
EP (1) | EP1381604B1 (de) |
JP (1) | JP4317955B2 (de) |
KR (1) | KR20040058111A (de) |
CN (1) | CN100422180C (de) |
AT (1) | ATE349446T1 (de) |
AU (1) | AU2002258915B2 (de) |
CA (1) | CA2444214A1 (de) |
DE (1) | DE60217090T2 (de) |
ES (1) | ES2274973T3 (de) |
TW (1) | TWI245764B (de) |
WO (1) | WO2002085903A2 (de) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7544511B2 (en) * | 1996-09-25 | 2009-06-09 | Neuralstem Biopharmaceuticals Ltd. | Stable neural stem cell line methods |
GB0018473D0 (en) * | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
ES2536449T3 (es) * | 2000-08-24 | 2015-05-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer |
CN100422180C (zh) | 2001-04-23 | 2008-10-01 | 宾夕法尼亚州大学理事会 | 淀粉样斑块聚集抑制剂和诊断成像剂 |
EP1474178A1 (de) * | 2002-02-13 | 2004-11-10 | Amersham plc | Benzodiazolderivate zur in vivo abbildung von amyloiden ablagerungen |
US20040185429A1 (en) * | 2002-12-09 | 2004-09-23 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
US8293488B2 (en) | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
AU2004206956A1 (en) * | 2003-01-22 | 2004-08-05 | The General Hospital Corporation | Amyloid-binding, metal-chelating agents |
CA2438032C (en) * | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
CN102532055B (zh) * | 2003-03-14 | 2016-05-11 | 匹兹堡大学联邦制高等教育 | 苯并噻唑衍生物化合物、组合物及用途 |
GB0307855D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
EP1631561B1 (de) | 2003-05-07 | 2010-08-18 | General Electric Company | Zusammensetzungen und verfahren zur in vivo abbildung von loeslichen beta-amyloid |
US8236282B2 (en) | 2003-08-22 | 2012-08-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Benzothiazole derivative compounds, compositions and uses |
US20050049487A1 (en) * | 2003-08-26 | 2005-03-03 | Johnson Bruce Fletcher | Compounds and kits for preparing imaging agents and methods of imaging |
US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
JP5311739B2 (ja) * | 2004-03-18 | 2013-10-09 | サントリーホールディングス株式会社 | 放射性ラベル基を有する3−[3−(ベンゾイルアミド)ベンジルオキシ]アスパラギン酸誘導体とその製造方法 |
BRPI0512893B8 (pt) * | 2004-07-02 | 2021-07-27 | Univ Pittsburgh | métodos de determinação da eficácia da terapia no tratamento da amiloidose e de identificação de paciente como prodrômico para doença associada com a deposição amilóide e respectivos compostos |
JP2008505116A (ja) * | 2004-07-02 | 2008-02-21 | ユニバーシティー オブ ピッツバーグ | アミロイド沈着を伴う疾患の前駆形態の診断方法 |
WO2006026184A2 (en) * | 2004-08-20 | 2006-03-09 | Washington University | Blood brain barrier permeation peptides |
EP2913393B8 (de) | 2004-11-17 | 2020-02-26 | Seneca Biopharma, Inc. | Transplantation menschlicher Nervenzellen zur Behandlung neurodegenerativer Erkrankungen |
AU2006261917A1 (en) * | 2005-06-24 | 2007-01-04 | The Trustees Of The University Of Pennsylvania | Radiolabeled-pegylation of ligands for use as imaging agents |
US7666886B2 (en) * | 2005-07-15 | 2010-02-23 | The Regents Of The University Of California | Compounds and methods for the diagnosis and treatment of amyloid associated diseases |
EP1928237A4 (de) | 2005-09-02 | 2011-03-09 | Abbott Lab | Neue heterocyclen auf imidazo-basis |
US20080219922A1 (en) * | 2005-09-12 | 2008-09-11 | Goodman Mark M | Alzheimer's Disease Imaging Agents |
CA2627722A1 (en) † | 2005-10-31 | 2007-06-21 | Merck & Co., Inc. | Cetp inhibitors |
JP4738419B2 (ja) | 2005-11-30 | 2011-08-03 | 富士フイルムRiファーマ株式会社 | アミロイドの凝集及び/又は沈着に起因する疾患の診断薬及び治療薬 |
JPWO2007069565A1 (ja) * | 2005-12-12 | 2009-05-21 | 小野薬品工業株式会社 | 二環式複素環化合物 |
WO2007078335A2 (en) * | 2005-12-21 | 2007-07-12 | Decode Genetics, Ehf. | Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation |
TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
TW200803903A (en) * | 2006-04-28 | 2008-01-16 | Nihon Mediphysics Co Ltd | Novel compound having affinity to amyloid |
EP2023919A4 (de) * | 2006-05-08 | 2010-12-22 | Molecular Neuroimaging Llc | Verbindungen und amyloid-sonden für therapie- und bildgebungszwecke |
NZ573363A (en) | 2006-05-19 | 2012-01-12 | Nihon Mediphysics Co Ltd | Compound having affinity for amyloid based on an imidazopyridine-phenyl skeleton |
TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
US8277777B2 (en) | 2006-06-21 | 2012-10-02 | Nihon Medi-Physics Co., Ltd. | Compound having affinity for amyloid |
JPWO2008056481A1 (ja) * | 2006-11-09 | 2010-02-25 | 日本メジフィジックス株式会社 | 放射性画像診断剤 |
WO2008059714A1 (fr) * | 2006-11-17 | 2008-05-22 | Nihon Medi-Physics Co., Ltd. | Composés inédits présentant une affinité pour la substance amyloïde |
KR20090083414A (ko) | 2006-11-30 | 2009-08-03 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물 |
BRPI0806621A2 (pt) * | 2007-01-22 | 2011-09-13 | Astrazeneca Ab | composto, uso de um composto, composição farmacêutica, e, método in vivo para medir depósitos amilóides em um indivìduo |
EP2119458B9 (de) | 2007-02-13 | 2013-08-21 | Nihon Medi-Physics Co., Ltd. | Verfahren zur herstellung eines abbildungsmittels zur strahlendiagnose |
EP1964840A1 (de) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]pyridine und deren pharmazeutische Verwendung |
WO2008108729A1 (en) * | 2007-03-06 | 2008-09-12 | Astrazeneca Ab | Novel 2-heteroaryl substituted indoles 695 |
TW200901998A (en) | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
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WO2009054496A1 (ja) | 2007-10-24 | 2009-04-30 | Nihon Medi-Physics Co., Ltd. | 新規アミロイド親和性化合物 |
AU2008314871A1 (en) | 2007-10-26 | 2009-04-30 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
CA2704137A1 (en) * | 2007-10-30 | 2009-05-07 | Nihon Medi-Physics Co., Ltd. | Use of novel compound having affinity for amyloid, and process for production of the same |
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US20110046378A1 (en) | 2008-02-14 | 2011-02-24 | Siemens Medical Solutions Usa, Inc. | Novel Imaging Agents for Detecting Neurological Dysfunction |
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US8409419B2 (en) | 2008-05-21 | 2013-04-02 | Paul R. Kruesi | Conversion of carbon to hydrocarbons |
WO2009146388A1 (en) | 2008-05-28 | 2009-12-03 | The Trustees Of Columbia University In The City Of New York | Voxel-based methods for assessing subjects using positron emission tomography |
KR20110017407A (ko) * | 2008-05-30 | 2011-02-21 | 포스터 휠러 에너지아 오와이 | 순산소 연소에 의해 전력을 생성하는 방법과 시스템 |
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US8530483B2 (en) | 2008-05-30 | 2013-09-10 | Merck Sharp & Dohme Corp. | Substituted azabenzoxazoles |
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EP2910945B1 (de) * | 2008-09-30 | 2018-07-18 | Case Western Reserve University | Molekularsonden zur Bildgebung von Myelin |
JP2012508889A (ja) * | 2008-11-13 | 2012-04-12 | アビッド レディオファーマシューティカルズ、インク. | 神経変性疾患の検出と診断のためのヒストグラムに基づいた分析方法 |
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EP2218464A1 (de) * | 2009-02-11 | 2010-08-18 | Technische Universität München | Verbindungen zur nichtinvasiven Messung von Aggregaten von Amyloidpeptiden |
FR2942227B1 (fr) | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
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FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
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WO2013082508A1 (en) * | 2011-12-02 | 2013-06-06 | The Regents Of The University Of Michigan | Compositions and methods for the treatment and analysis of neurological disorders |
WO2014004664A2 (en) | 2012-06-27 | 2014-01-03 | Mayo Foundation For Medical Education And Research | Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives |
EP3563849A3 (de) | 2012-10-25 | 2020-02-12 | The General Hospital Corporation | Kombinationstherapien zur behandlung von morbus alzheimer und verwandten erkrankungen |
US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
CN103073520B (zh) * | 2012-12-24 | 2014-10-08 | 湖南大学 | 一种合成2-苯基苯并噻唑及其衍生物的方法 |
FR3001154B1 (fr) | 2013-01-23 | 2015-06-26 | Guerbet Sa | Magneto-emulsion vectorisee |
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WO2020007822A1 (en) | 2018-07-02 | 2020-01-09 | Conservatoire National Des Arts Et Metiers (Cnam) | Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof |
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GB9317949D0 (en) | 1993-08-28 | 1993-10-13 | Stevens Malcolm F G | Benzothiazole compounds |
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US6168776B1 (en) | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
US6417178B1 (en) | 1994-07-19 | 2002-07-09 | University Of Pittsburgh | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits |
US6054114A (en) * | 1996-05-08 | 2000-04-25 | Massachusetts Institute Of Technology | Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro |
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US6037473A (en) | 1997-11-13 | 2000-03-14 | Haarmann & Reimer Gmbh | Use of substituted benzazoles as UV absorbers, new benzazoles and processes for their preparation |
CN100422180C (zh) * | 2001-04-23 | 2008-10-01 | 宾夕法尼亚州大学理事会 | 淀粉样斑块聚集抑制剂和诊断成像剂 |
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2002
- 2002-04-23 CN CNB028086708A patent/CN100422180C/zh not_active Expired - Fee Related
- 2002-04-23 KR KR10-2003-7013709A patent/KR20040058111A/ko not_active Application Discontinuation
- 2002-04-23 AU AU2002258915A patent/AU2002258915B2/en not_active Ceased
- 2002-04-23 TW TW091108360A patent/TWI245764B/zh not_active IP Right Cessation
- 2002-04-23 JP JP2002583430A patent/JP4317955B2/ja not_active Expired - Fee Related
- 2002-04-23 WO PCT/US2002/012626 patent/WO2002085903A2/en active IP Right Grant
- 2002-04-23 AT AT02728893T patent/ATE349446T1/de not_active IP Right Cessation
- 2002-04-23 EP EP02728893A patent/EP1381604B1/de not_active Expired - Lifetime
- 2002-04-23 DE DE60217090T patent/DE60217090T2/de not_active Expired - Lifetime
- 2002-04-23 ES ES02728893T patent/ES2274973T3/es not_active Expired - Lifetime
- 2002-04-23 US US10/127,678 patent/US6696039B2/en not_active Expired - Lifetime
- 2002-04-23 CA CA002444214A patent/CA2444214A1/en not_active Abandoned
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2003
- 2003-12-19 US US10/739,217 patent/US6946116B2/en not_active Expired - Lifetime
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2005
- 2005-08-15 US US11/203,429 patent/US7425318B2/en not_active Expired - Lifetime
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2012
- 2012-07-17 US US13/550,885 patent/USRE44354E1/en not_active Expired - Lifetime
- 2012-07-17 US US13/550,853 patent/USRE44338E1/en not_active Expired - Lifetime
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CN100422180C (zh) | 2008-10-01 |
TWI245764B (en) | 2005-12-21 |
ES2274973T3 (es) | 2007-06-01 |
DE60217090T2 (de) | 2007-07-12 |
JP2005512945A (ja) | 2005-05-12 |
EP1381604B1 (de) | 2006-12-27 |
US6696039B2 (en) | 2004-02-24 |
AU2002258915B2 (en) | 2007-11-15 |
USRE44338E1 (en) | 2013-07-02 |
KR20040058111A (ko) | 2004-07-03 |
JP4317955B2 (ja) | 2009-08-19 |
US20060051293A1 (en) | 2006-03-09 |
US20030059369A1 (en) | 2003-03-27 |
ATE349446T1 (de) | 2007-01-15 |
US20040131545A1 (en) | 2004-07-08 |
EP1381604A2 (de) | 2004-01-21 |
WO2002085903A3 (en) | 2003-02-27 |
CN1620454A (zh) | 2005-05-25 |
US7425318B2 (en) | 2008-09-16 |
WO2002085903A2 (en) | 2002-10-31 |
US6946116B2 (en) | 2005-09-20 |
CA2444214A1 (en) | 2002-10-31 |
USRE44354E1 (en) | 2013-07-09 |
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