CU23844B1 - Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer - Google Patents

Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer

Info

Publication number
CU23844B1
CU23844B1 CU2009000057A CU20090057A CU23844B1 CU 23844 B1 CU23844 B1 CU 23844B1 CU 2009000057 A CU2009000057 A CU 2009000057A CU 20090057 A CU20090057 A CU 20090057A CU 23844 B1 CU23844 B1 CU 23844B1
Authority
CU
Cuba
Prior art keywords
alkylene
alkyl
halide
compounds
arylsulfonate
Prior art date
Application number
CU2009000057A
Other languages
English (en)
Other versions
CU20090057A6 (es
Inventor
Carrazana Marquiza Sablón
Chryslaine Rodríguez-Tanty
Pintado Alejandro Perera
Marrero Suchitil Rivera
Perera Rafaela Pérez
Barroso Rosa María López
Capote Anais I Prats
Castro Hermán Vélez
Martínez Carlos Serafín Pérez
Sosa Pedro Antonio Valdés
Original Assignee
Ct De Neurociencias De Cuba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Neurociencias De Cuba filed Critical Ct De Neurociencias De Cuba
Priority to CU2009000057A priority Critical patent/CU23844B1/es
Priority to CA2789869A priority patent/CA2789869C/en
Priority to ES14075021.7T priority patent/ES2692072T3/es
Priority to BRPI1014595-8A priority patent/BRPI1014595B1/pt
Priority to MX2013011331A priority patent/MX338943B/es
Priority to EP10764119.3A priority patent/EP2436666B1/en
Priority to US13/574,050 priority patent/US9764047B2/en
Priority to MX2011013405A priority patent/MX2011013405A/es
Priority to BR122020016643A priority patent/BR122020016643B8/pt
Priority to PL10764119T priority patent/PL2436666T3/pl
Priority to ES10764119.3T priority patent/ES2478442T3/es
Priority to EP14075021.7A priority patent/EP2860169B1/en
Priority to MYPI2012003534A priority patent/MY162719A/en
Priority to DK10764119.3T priority patent/DK2436666T3/da
Priority to PCT/CU2010/000001 priority patent/WO2010118706A2/es
Priority to SI201030668T priority patent/SI2436666T1/sl
Priority to HUE14075021A priority patent/HUE042030T2/hu
Priority to PT107641193T priority patent/PT2436666E/pt
Publication of CU20090057A6 publication Critical patent/CU20090057A6/es
Publication of CU23844B1 publication Critical patent/CU23844B1/es
Priority to HRP20140628AT priority patent/HRP20140628T1/hr
Priority to SM201400118T priority patent/SMT201400118B/xx
Priority to US14/636,316 priority patent/US10155053B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Esta invención se relaciona con la rama de la química, en particular con el campo de la síntesis orgánica de compuestos que pertenecen a la categoría de aromáticos bicíclicos o naftalénicos, utilizados en la detección de placas amiloideas. Estos nuevos derivados de naftaleno tienen fórmula general: ESPACIO PARA FÓRMULA Donde R representa a grupos independientes entre sí. En I: R1: -alquilenil-C(O)NH-alquilenil-R3, -alquilenil-C(O)O-R4; R3: -COOH, -OH, -SH, -NH2, -alquil-NH, -alquil-N-ditiocarbamato de sales de metales alcalino térreo; R4: H, grupo succinimido; R2: -H,-alquil. En II: R1: -alquilo, -alquilenil-haluro, -alquilenil-hidroxilo, -alquilenil-O-arilsulfonato, alquilenil-O-alquilsulfonato; R2: haluro, -alquilenil-O-arilsulfonato, -alquilenil-O-alquilsulfonato, -alquilenil-haluro, -CH(O), -HC=CHNO2, -alquilenil-NH2, -alquilenil-NH-alquil, -alquilenil-alquil-N-ditiocarbamato de sales alcalinas. Los terminos "alquil" y "alquileni"l se refieren a cadenas alifáticas lineales o ramificadas, prepferentemente de 1 a 4 átomos de carbono y el término haluro a Flúor, Bromo o Yodo. Estos compuestos son neutros, lipofílicos y de bajo peso molecular por lo que atraviesan la barrera hematoencefálica y se adhieren a las placas amiloideas. La presente invención proporciona los procedimientos para la obtención de derivados de naftaleno con buenos rendimientos, que pueden ser prácticos, económicos y ser adaptados a una manufactura a mayor escala. No tenemos conocimiento de que los compuestos presentados en esta invención hayan sido reportados anteriormente.
CU2009000057A 2009-04-17 2009-04-17 Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer CU23844B1 (es)

Priority Applications (21)

Application Number Priority Date Filing Date Title
CU2009000057A CU23844B1 (es) 2009-04-17 2009-04-17 Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
EP14075021.7A EP2860169B1 (en) 2009-04-17 2010-04-17 Method for obtaining novel derivatives of naphtalene for the in vivo diagnosis of Alzheimer's disease
MYPI2012003534A MY162719A (en) 2009-04-17 2010-04-17 Method for obtaining novel derivatives of naphthalene for the in vivo diagnosis of alzheimer's disease
ES14075021.7T ES2692072T3 (es) 2009-04-17 2010-04-17 Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de Alzheimer
MX2013011331A MX338943B (es) 2009-04-17 2010-04-17 Procedimiento de obtencion de nuevos derivados de naftaleno para el diagnostico in vivo de la enfermedad de alzheimer.
EP10764119.3A EP2436666B1 (en) 2009-04-17 2010-04-17 Method for obtaining novel derivatives of naphtalene for the in vivo diagnosis of alzheimer 's disease
US13/574,050 US9764047B2 (en) 2009-04-17 2010-04-17 Method for obtaining novel derivatives of naphthalene for the in vivo diagnosis of alzheimer's disease
MX2011013405A MX2011013405A (es) 2009-04-17 2010-04-17 Procedimiento de obtencion de nuevos derivados de naftaleno para el diagnostico in vivo de la enfermedad de alzheimer.
BR122020016643A BR122020016643B8 (pt) 2009-04-17 2010-04-17 compostos derivados de naftaleno, procedimento para a preparação de derivados de alquilfluoronaftaleno e procedimento para marcação dos compostos com 99mtc
DK10764119.3T DK2436666T3 (da) 2009-04-17 2010-04-17 Metode til at finde nye derivater af naftalin til in vivo diagnose af alzheimers sygdom
ES10764119.3T ES2478442T3 (es) 2009-04-17 2010-04-17 Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de Alzheimer
CA2789869A CA2789869C (en) 2009-04-17 2010-04-17 Method for obtaining novel derivatives of naphthalene for the in vivo diagnosis of alzheimer's disease
BRPI1014595-8A BRPI1014595B1 (pt) 2009-04-17 2010-04-17 Compostos derivados de naftaleno e procedimento para preparação dos mesmos
PL10764119T PL2436666T3 (pl) 2009-04-17 2010-04-17 Sposób otrzymywania nowych pochodnych naftalenu do diagnostyki choroby Alzheimera in vivo
PCT/CU2010/000001 WO2010118706A2 (es) 2009-04-17 2010-04-17 Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
SI201030668T SI2436666T1 (sl) 2009-04-17 2010-04-17 Postopek za pridobivanje novih derivatov naftalena za diagnozo alzheimerjeve bolezni in vivo
HUE14075021A HUE042030T2 (hu) 2009-04-17 2010-04-17 Eljárás újfajta naftalénszármazékok kinyerésére Alzheimer-kór in vivo megállapításához
PT107641193T PT2436666E (pt) 2009-04-17 2010-04-17 Processo para obter novos derivados de naftalina para o diagnóstico in vivo da doença de alzheimer
HRP20140628AT HRP20140628T1 (hr) 2009-04-17 2014-07-01 Metoda za dobivanje novih derivata naftalena za dijagnosticiranje alzheimerove bolesti in vivo
SM201400118T SMT201400118B (it) 2009-04-17 2014-08-29 Metodo per ottenere nuovi derivati naftalenici perla diagnosi in vivo della malattia di alzheimer
US14/636,316 US10155053B2 (en) 2009-04-17 2015-03-03 Method for obtaining novel derivatives of naphthalene for the in vivo diagnosis of Alzheimer's disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU2009000057A CU23844B1 (es) 2009-04-17 2009-04-17 Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer

Publications (2)

Publication Number Publication Date
CU20090057A6 CU20090057A6 (es) 2011-10-14
CU23844B1 true CU23844B1 (es) 2012-10-15

Family

ID=45000046

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2009000057A CU23844B1 (es) 2009-04-17 2009-04-17 Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer

Country Status (16)

Country Link
US (2) US9764047B2 (es)
EP (2) EP2436666B1 (es)
BR (2) BRPI1014595B1 (es)
CA (1) CA2789869C (es)
CU (1) CU23844B1 (es)
DK (1) DK2436666T3 (es)
ES (2) ES2692072T3 (es)
HR (1) HRP20140628T1 (es)
HU (1) HUE042030T2 (es)
MX (2) MX2011013405A (es)
MY (1) MY162719A (es)
PL (1) PL2436666T3 (es)
PT (1) PT2436666E (es)
SI (1) SI2436666T1 (es)
SM (1) SMT201400118B (es)
WO (1) WO2010118706A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU20130027A7 (es) * 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
US9850183B2 (en) 2014-06-27 2017-12-26 Reiley Pharmaceuticals, Inc. Conjugates derived from non-steroidal anti-inflammatory drugs and methods of use thereof in imaging
EP3242688B1 (en) 2015-01-09 2020-01-29 Reiley Pharmaceuticals, Inc. Cox-2-targeting, platinum-containing conjugates and their use in the treatment of tumors and cancers
CU24583B1 (es) 2018-11-06 2022-02-04 Centro De Neurociencias De Cuba Nanopartículas de óxido metálicos conjugados con derivados de naftaleno como agentes de contrastes para la detección de placas amiloides por resonancia magnética (mri)
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
CU20200087A7 (es) 2020-11-24 2022-07-08 Centro De Neurociencias De Cuba Composición farmacéutica de derivados de naftaleno como agentes terapéuticos multiblancos para el tratamiento de la enfermedad de alzheimer

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976305A (en) * 1958-07-30 1961-03-21 Albert Ag Chem Werke Salts of dithiocarbamic acids derived from amino amides of dicarboxylic acids
US4327022A (en) * 1973-08-16 1982-04-27 Sterling Drug Inc. Heterocyclic alkyl naphthols
US4615876A (en) 1983-04-25 1986-10-07 Curators Of The University Of Missouri Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
EP0194843B1 (en) 1985-03-11 1993-01-13 AMERSHAM INTERNATIONAL plc Complexes of technetium-99m with propylene amine oximes
GB8601003D0 (en) 1986-01-16 1986-02-19 Amersham Int Plc Labelling blood cells
GB8603778D0 (en) * 1986-02-15 1986-03-19 Beecham Group Plc Chemical process
DE3631013A1 (de) * 1986-09-12 1988-03-24 Thomae Gmbh Dr K Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4933156A (en) 1987-04-08 1990-06-12 Salutar, Inc. Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor
US5008099A (en) 1987-04-08 1991-04-16 Salutar, Inc. Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor
CN1072020A (zh) 1991-10-28 1993-05-12 国营八二一厂 多用途血液稀释剂
US5690904A (en) 1993-07-12 1997-11-25 Amersham International Plc Diagnostic radiopharmaceutical compounds (That)
US6417178B1 (en) 1994-07-19 2002-07-09 University Of Pittsburgh Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits
US6168776B1 (en) 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US5955472A (en) * 1995-11-02 1999-09-21 Warner-Lambert Company Naphthylazo inhibition of amyloidosis
AU759945B2 (en) * 1998-08-20 2003-05-01 Regents Of The University Of California, The Methods for labeling beta-amyloid plaques and neurofibrillary tangles
TW438596B (en) 1999-02-26 2001-06-07 Inst Of Nuclear Energy Res Roc Preparation of a new technetium-99m radiopharmaceutical kit for dopamine transporter imaging
DE10018199A1 (de) * 2000-04-12 2001-10-31 Few Chemicals Gmbh Fluoreszenzmarker
IT1317048B1 (it) 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Uso dell'acido pamoico o di un suo derivato, o di un suo analogo, perla preparazione di un medicamento per il trattamento di patologie
GB0023467D0 (en) * 2000-09-25 2000-11-08 Btg Int Ltd Amine compounds
US6379650B1 (en) 2001-03-19 2002-04-30 Wesley Scott Ashton Technetium 99m-N2S2-congo red complexes utilizing diamide dithiolate ligand systems for radioimaging
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
ES2274973T3 (es) 2001-04-23 2007-06-01 The Trustees Of The University Of Pennsylvania Inhibidores de la agregacion de placas amiloides y agentes de obtencion de imagenes diagnosticas.
CA2446716A1 (en) * 2001-06-05 2002-12-12 Eli Lilly And Company Sulfonamide derivatives
AU2002323417B2 (en) 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US7317111B2 (en) * 2002-09-23 2008-01-08 Aries Associates, Inc. Green and orange fluorescent labels and their uses
WO2005040337A2 (en) 2003-05-20 2005-05-06 The Regents Of The University Of California METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES
WO2005077962A2 (en) * 2004-02-10 2005-08-25 Purdue Research Foundation Crowned dithiocarbamate metal complexes and methods for their use
WO2006026184A2 (en) 2004-08-20 2006-03-09 Washington University Blood brain barrier permeation peptides
WO2006083378A2 (en) 2004-11-29 2006-08-10 The Regents Of The University Of California IN VIVO MONITORING OF β-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES
SI2213652T1 (sl) 2004-12-17 2015-03-31 The Trustees Of The University Of Pennsylvania Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov
JPWO2006115137A1 (ja) * 2005-04-22 2008-12-18 キッセイ薬品工業株式会社 ２−アミノベンズイミダゾール誘導体及びその医薬用途
BRPI0617423A2 (pt) * 2005-10-18 2011-07-26 Sigma Tau Ind Farmaceuti inibidores de derivados de naftila da agregaÇço de beta-amilàides
WO2007089781A2 (en) * 2006-01-30 2007-08-09 University Of North Dakota Divalent metal ion sensors and binders
WO2008013997A2 (en) * 2006-07-27 2008-01-31 The Trustees Of Columbia University In The City Of New York Fluorescent substrates for monoamine transporters as optical false neurotransmitters
WO2009086303A2 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
GB0819280D0 (en) * 2008-10-21 2008-11-26 Gen Electric Imgaing and radiotherapy methods

Also Published As

Publication number Publication date
EP2436666B1 (en) 2014-04-09
EP2860169A2 (en) 2015-04-15
US20120321560A1 (en) 2012-12-20
CA2789869A1 (en) 2010-10-21
EP2436666A2 (en) 2012-04-04
BRPI1014595B1 (pt) 2021-07-06
SI2436666T1 (sl) 2014-09-30
HUE042030T2 (hu) 2019-06-28
BR122020016643B8 (pt) 2021-07-27
BRPI1014595A2 (pt) 2016-04-05
PL2436666T3 (pl) 2014-09-30
EP2436666A4 (en) 2013-02-13
SMT201400118B (it) 2014-11-10
ES2478442T3 (es) 2014-07-22
WO2010118706A3 (es) 2010-12-02
DK2436666T3 (da) 2014-07-14
PT2436666E (pt) 2014-07-18
BR122020016643B1 (pt) 2021-03-30
ES2692072T3 (es) 2018-11-30
WO2010118706A2 (es) 2010-10-21
MX338943B (es) 2016-05-06
HRP20140628T1 (hr) 2014-11-21
EP2860169A3 (en) 2015-10-21
US10155053B2 (en) 2018-12-18
US9764047B2 (en) 2017-09-19
EP2860169B1 (en) 2018-08-29
CA2789869C (en) 2016-06-21
MY162719A (en) 2017-07-14
US20150217005A1 (en) 2015-08-06
CU20090057A6 (es) 2011-10-14
WO2010118706A4 (es) 2011-01-20
MX2011013405A (es) 2012-10-23

Similar Documents

Publication Publication Date Title
CU23844B1 (es) Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
ECSP088645A (es) Nuevos benzotiazoles sustituidos con heteroaril
UY29469A1 (es) Compuestos sulfoximino-macrocíclicos y sus sales, composiciones farmacéuticas que comprenden dichos compuestos, métodos de preparación y usos de los mismos.
DOP2010000045A (es) Derivados de n-(arilamino) sulfonamidas que incluyen polimorfos como inhibidores de mek, asi como composiciones, metodos de uso y de preparacion de los mismos
ECSP088587A (es) Compuestos de piperidina 3,5-sustituida como inhibidores de renina
GT200500102A (es) Compuestos de aril-o-heteroarilamida ortosustituidos
RU2014145281A (ru) Фотодинамические тиофены на основе металла и их применение
AR084058A1 (es) Composicion y metodo para fabricar una composicion para el cuidado de telas
UY29343A1 (es) Pirazolopiridinas y sales de las mismas, una composición farmacéutica que comprende dichos compuestos, un método para prepararlos y su uso.
CY1118390T1 (el) Θεραπευτικος παραγων για τη φλεγμονωδη νοσο του εντερου
DOP2005000071A (es) "compuestos de metil-aril o heteroaril-amida sustituida"
EA200970461A1 (ru) ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ
BRPI0808503B8 (pt) composto, uso de um composto, e, composição farmacêutica
AR114029A2 (es) Compuestos adecuados como precursores de compuestos que son útiles para obtener imágenes de depósitos amiloides, usos y procesos
AR057291A1 (es) Proceso para la preparacion de acidos bisfosfonicos geminales y las sales y/o hidratos farmaceuticamente aceptables de los mismos, una composicion farmaceutica que los contiene y el uso de esta en el tratamiento de la osteoporosis
PE20121187A1 (es) Canfenos arilados con actividad sobre los receptores cb2 y procesos para su preparacion
CO6561809A2 (es) Composiciones antimicrobianas líquidas
AR082507A1 (es) Compuestos de tetrahidrofuranilo, medicamento en base al compuesto y un procedimiento para la fabricacion del medicamento
RU2008152751A (ru) Соли тримебутина и n-десметилтримебутина
AR086803A1 (es) Derivados de oxazetidinas, composiciones farmaceuticas y cosmeticas que los contienen y uso de los mismos para tratar enfermedades dermatologicas fundamentalmente, y del aparato respiratorio, digestivo y cardiovascular, entre otras
CU20130027A7 (es) Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
CU20100204A7 (es) Procedimientos de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
JP2017101118A5 (es)
PE20060350A1 (es) Derivados de benceno halogenados sustituidos con trimeros macrociclicos
AR059597A1 (es) Derivados de aza-tia-benzo-azuleno

Legal Events

Date Code Title Description
FG Grant of patent