DE602008005928D1 - 1h-indol-3-carbonsäure-chinuclidin-4-ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit - Google Patents

1h-indol-3-carbonsäure-chinuclidin-4-ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit

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Publication number
DE602008005928D1
DE602008005928D1 DE602008005928T DE602008005928T DE602008005928D1 DE 602008005928 D1 DE602008005928 D1 DE 602008005928D1 DE 602008005928 T DE602008005928 T DE 602008005928T DE 602008005928 T DE602008005928 T DE 602008005928T DE 602008005928 D1 DE602008005928 D1 DE 602008005928D1
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Prior art keywords
chinuclidin
eter
indol
ylmethyl
ligands
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DE602008005928T
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English (en)
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Jurg R Pfister
Meenakshi S Venkatraman
Xiaoming Zhang
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CoMentis Inc
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CoMentis Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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DE602008005928T 2007-10-01 2008-09-30 1h-indol-3-carbonsäure-chinuclidin-4-ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit Active DE602008005928D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97672407P 2007-10-01 2007-10-01
PCT/US2008/078320 WO2009046025A1 (en) 2007-10-01 2008-09-30 Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
DE602008005928D1 true DE602008005928D1 (de) 2011-05-12

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DE602008005928T Active DE602008005928D1 (de) 2007-10-01 2008-09-30 1h-indol-3-carbonsäure-chinuclidin-4-ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit

Country Status (13)

Country Link
US (1) US8114891B2 (de)
EP (1) EP2217597B1 (de)
JP (1) JP5022494B2 (de)
KR (1) KR101565469B1 (de)
CN (2) CN101883771A (de)
AT (1) ATE503754T1 (de)
CA (1) CA2701126A1 (de)
DE (1) DE602008005928D1 (de)
DK (1) DK2217597T3 (de)
ES (1) ES2362326T3 (de)
HK (1) HK1204616A1 (de)
MX (1) MX2010003375A (de)
WO (1) WO2009046025A1 (de)

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JP6542794B2 (ja) 2013-12-12 2019-07-10 ゼノ ロイアルティー アンド マイルストーンズ リミテッド ライアビリティー カンパニー 二環式アルキル化合物、および合成
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JP2017524736A (ja) * 2014-07-11 2017-08-31 アルファーマゲン，エルエルシー アルファ７−ニコチン性アセチルコリン受容体活性を調節するためのキヌクリジン化合物
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CN104193741B (zh) 2016-08-24
ES2362326T3 (es) 2011-07-01
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JP2010540562A (ja) 2010-12-24
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CA2701126A1 (en) 2009-04-09
JP5022494B2 (ja) 2012-09-12
US8114891B2 (en) 2012-02-14
MX2010003375A (es) 2010-05-17
KR20100068290A (ko) 2010-06-22
ATE503754T1 (de) 2011-04-15
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