DE60041243D1 - Gebrauchsverfaheren eines neuen lysyloxidase-verwandten proteins - Google Patents
Gebrauchsverfaheren eines neuen lysyloxidase-verwandten proteinsInfo
- Publication number
- DE60041243D1 DE60041243D1 DE60041243T DE60041243T DE60041243D1 DE 60041243 D1 DE60041243 D1 DE 60041243D1 DE 60041243 T DE60041243 T DE 60041243T DE 60041243 T DE60041243 T DE 60041243T DE 60041243 D1 DE60041243 D1 DE 60041243D1
- Authority
- DE
- Germany
- Prior art keywords
- lor
- nucleic acid
- proteins
- new
- related protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical compound NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 239000013604 expression vector Substances 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11758099P | 1999-01-27 | 1999-01-27 | |
| US09/276,400 US6140056A (en) | 1999-01-27 | 1999-03-25 | MSP-18 protein and nucleic acid molecules and uses therefor |
| US09/448,076 US6300092B1 (en) | 1999-01-27 | 1999-11-23 | Methods of use of a novel lysyl oxidase-related protein |
| PCT/US2000/002125 WO2000044910A1 (en) | 1999-01-27 | 2000-01-27 | Methods of use of a novel lysyl oxidase-related protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60041243D1 true DE60041243D1 (de) | 2009-02-12 |
Family
ID=27382012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60041243T Expired - Lifetime DE60041243D1 (de) | 1999-01-27 | 2000-01-27 | Gebrauchsverfaheren eines neuen lysyloxidase-verwandten proteins |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6300092B1 (de) |
| EP (1) | EP1149169B1 (de) |
| AT (1) | ATE419358T1 (de) |
| AU (1) | AU3217100A (de) |
| DE (1) | DE60041243D1 (de) |
| ES (1) | ES2320622T3 (de) |
| WO (1) | WO2000044910A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001092495A2 (en) * | 2000-05-26 | 2001-12-06 | Millennium Pharmaceuticals, Inc. | A human lysyl ixodase (47765) and uses thereof |
| US20030114410A1 (en) * | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| ES2387329T3 (es) * | 2000-08-08 | 2012-09-20 | Technion Research And Development Foundation Ltd. | Composiciones farmacéuticas y procedimientos útiles para modular la angiogénesis |
| US6489456B1 (en) * | 2000-10-27 | 2002-12-03 | Pe Corporation (Ny) | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
| US20030040604A1 (en) * | 2001-05-29 | 2003-02-27 | Anderson Dirk M. | Siglec-12 polypeptides, polynucleotides, and methods of use thereof |
| US7172858B2 (en) | 2001-11-28 | 2007-02-06 | The General Hospital Corporation | Blood-based assay for dysferlinopathies |
| FR2855968B1 (fr) * | 2003-06-13 | 2012-11-30 | Coletica | Stimulation de la synthese et de l'activite d'une isoforme de la lysyl oxydase-like loxl pour stimuler la formation de fibres elastiques |
| EP1706139A4 (de) | 2004-01-23 | 2009-06-17 | Massachusetts Eye & Ear Infirm | Lysyloxidase-like 1 (loxl 1) und elastogenese |
| US20070021365A1 (en) * | 2005-06-21 | 2007-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto |
| US20070225242A1 (en) * | 2005-06-21 | 2007-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method and composition for treating and preventing tumor metastasis in vivo |
| IL184627A0 (en) * | 2007-07-15 | 2008-12-29 | Technion Res & Dev Foundation | Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue |
| CA2693208A1 (en) | 2007-08-02 | 2009-02-05 | Victoria Smith | Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis |
| US9107935B2 (en) | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
| KR20110140121A (ko) * | 2009-02-06 | 2011-12-30 | 길리아드 바이오로직스, 인크. | 혈관신생의 치료를 위한 방법 및 조성물 |
| BR112012008054A2 (pt) * | 2009-08-21 | 2017-05-23 | Gilead Biologics Inc | domínios catalíticos de lisil oxidase e loxl2 |
| CA2771786A1 (en) * | 2009-08-21 | 2011-02-24 | Gilead Biologics, Inc. | In vivo screening assays |
| JP2013502228A (ja) * | 2009-08-21 | 2013-01-24 | ギリアド バイオロジクス，インク． | ｉｎｖｉｔｒｏスクリーニングアッセイ |
| JP2013506005A (ja) * | 2009-09-29 | 2013-02-21 | ギリアド バイオロジクス，インク． | 眼の繊維症の処置のための方法及び組成物 |
| JP6134142B2 (ja) * | 2010-02-04 | 2017-05-24 | ギリアド バイオロジクス, インク.Gilead Biologics, Inc. | リシルオキシダーゼ様２（ｌｏｘｌ２）に結合する抗体及びその使用方法 |
| EP2694554A1 (de) | 2011-04-08 | 2014-02-12 | Gilead Biologics, Inc. | Verfahren und zusammensetzungen zur normalisierung einer tumorvaskulatur mittels loxl2-hemmung |
| WO2012155071A1 (en) * | 2011-05-12 | 2012-11-15 | Gilead Biologics, Inc. | Methods of identifying lysyl oxidase - like - 2 (loxl2) binding partners |
-
1999
- 1999-11-23 US US09/448,076 patent/US6300092B1/en not_active Expired - Fee Related
-
2000
- 2000-01-27 WO PCT/US2000/002125 patent/WO2000044910A1/en active Application Filing
- 2000-01-27 AT AT00910005T patent/ATE419358T1/de not_active IP Right Cessation
- 2000-01-27 EP EP00910005A patent/EP1149169B1/de not_active Expired - Lifetime
- 2000-01-27 DE DE60041243T patent/DE60041243D1/de not_active Expired - Lifetime
- 2000-01-27 ES ES00910005T patent/ES2320622T3/es not_active Expired - Lifetime
- 2000-01-27 AU AU32171/00A patent/AU3217100A/en not_active Abandoned
-
2001
- 2001-07-20 US US09/909,743 patent/US20020151007A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE419358T1 (de) | 2009-01-15 |
| WO2000044910A1 (en) | 2000-08-03 |
| US6300092B1 (en) | 2001-10-09 |
| ES2320622T3 (es) | 2009-05-27 |
| AU3217100A (en) | 2000-08-18 |
| EP1149169B1 (de) | 2008-12-31 |
| EP1149169A1 (de) | 2001-10-31 |
| US20020151007A1 (en) | 2002-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |