WO2000018890A3 - Protein phosphatase molecules and uses therefor - Google Patents

Protein phosphatase molecules and uses therefor Download PDF

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Publication number
WO2000018890A3
WO2000018890A3 PCT/US1999/022924 US9922924W WO0018890A3 WO 2000018890 A3 WO2000018890 A3 WO 2000018890A3 US 9922924 W US9922924 W US 9922924W WO 0018890 A3 WO0018890 A3 WO 0018890A3
Authority
WO
WIPO (PCT)
Prior art keywords
csaptp
nucleic acid
proteins
expression vectors
acid molecules
Prior art date
Application number
PCT/US1999/022924
Other languages
French (fr)
Other versions
WO2000018890A2 (en
WO2000018890A9 (en
Inventor
Susan Acton
Original Assignee
Millennium Pharm Inc
Susan Acton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/164,193 external-priority patent/US6258582B1/en
Priority claimed from US09/163,833 external-priority patent/US6268135B1/en
Application filed by Millennium Pharm Inc, Susan Acton filed Critical Millennium Pharm Inc
Priority to AU64105/99A priority Critical patent/AU6410599A/en
Publication of WO2000018890A2 publication Critical patent/WO2000018890A2/en
Publication of WO2000018890A3 publication Critical patent/WO2000018890A3/en
Publication of WO2000018890A9 publication Critical patent/WO2000018890A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

CSAPTP (Cardiovascular System Associated Protein Tyrosine Phosphatase) polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length CSAPTP proteins, the invention further provides isolated CSAPTP fusion proteins, antigenic peptides and anti-CSAPTP antibodies. The invention also provides CSAPTP nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CSAPTP gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
PCT/US1999/022924 1998-09-30 1999-09-30 Protein phosphatase molecules and uses therefor WO2000018890A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64105/99A AU6410599A (en) 1998-09-30 1999-09-30 Novel protein phosphatase molecules and uses therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/163,833 1998-09-30
US09/164,193 US6258582B1 (en) 1998-09-30 1998-09-30 CSAPTP nucleic acid molecules and uses therefor
US09/163,833 US6268135B1 (en) 1998-09-30 1998-09-30 Phospholipase molecule and uses therefor
US09/164,193 1998-09-30

Publications (3)

Publication Number Publication Date
WO2000018890A2 WO2000018890A2 (en) 2000-04-06
WO2000018890A3 true WO2000018890A3 (en) 2000-09-28
WO2000018890A9 WO2000018890A9 (en) 2001-02-01

Family

ID=26859984

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/022924 WO2000018890A2 (en) 1998-09-30 1999-09-30 Protein phosphatase molecules and uses therefor

Country Status (2)

Country Link
AU (1) AU6410599A (en)
WO (1) WO2000018890A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110283803B (en) * 2016-06-02 2021-08-03 天津科技大学 Phospholipase D and method for preparing phosphatidic acid and phosphatidylserine by using phospholipase D

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492157B1 (en) 1999-04-07 2002-12-10 Ceptyr, Inc. DSP-9 dual-specificity phosphatase
WO2000060098A1 (en) * 1999-04-07 2000-10-12 Ceptyr, Inc. Dsp-7 dual-specificity map kinase phosphatase
EP1212433A2 (en) * 1999-08-13 2002-06-12 Sugen, Inc. Protein phosphatases and diagnosis and treatment of phosphatase-related disorders
EP1402010A2 (en) * 2000-10-11 2004-03-31 Millennium Pharmaceuticals, Inc. 8843, a human dual specificity phosphatase family member and uses therefor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003611A2 (en) * 1992-08-05 1994-02-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Ptp-d subfamily of protein tyrosine phosphatases
WO1998014596A2 (en) * 1996-10-03 1998-04-09 Incyte Pharmaceuticals, Inc. Disease associated protein tyrosine phosphatases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003611A2 (en) * 1992-08-05 1994-02-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Ptp-d subfamily of protein tyrosine phosphatases
WO1998014596A2 (en) * 1996-10-03 1998-04-09 Incyte Pharmaceuticals, Inc. Disease associated protein tyrosine phosphatases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ZENG ET AL.: "Homo sapiens potentially prenylated protein tyrosine phosphatase", EMBL SEQUENCE DATABASE, 10 August 1998 (1998-08-10), HEIDELBERG DE, XP002132488 *
ZENG ET AL.: "HPRL-3", EMBL SEQUENCE DATABASE, 1 November 1998 (1998-11-01), HEIDELBERG DE, XP002132489 *
ZENG ET AL.: "Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1", BIOCHEM BIOPHYS RES COMMUN, vol. 244, 1998, pages 421 - 427 *
ZENG ET AL.: "Mus musculus potentially prenylated protein tyrosine phosphatase mPRL-3 (Prl3) mRNA, complet compound", EMBL SEQUENCE DATABASE, 30 March 1998 (1998-03-30), HEIDELBERG DE, XP002132491 *
ZENG ET AL.: "Protein tyrosine phosphatase 4A3 (MPRL-3)", EMBL SEQUENCE DATABASE, 1 August 1998 (1998-08-01), HEIDELBERG DE, XP002132490 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110283803B (en) * 2016-06-02 2021-08-03 天津科技大学 Phospholipase D and method for preparing phosphatidic acid and phosphatidylserine by using phospholipase D

Also Published As

Publication number Publication date
AU6410599A (en) 2000-04-17
WO2000018890A2 (en) 2000-04-06
WO2000018890A9 (en) 2001-02-01

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