WO2001077151A3 - Fdrg proteins and nucleic acid molecules and uses therefor - Google Patents

Fdrg proteins and nucleic acid molecules and uses therefor Download PDF

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Publication number
WO2001077151A3
WO2001077151A3 PCT/US2001/011400 US0111400W WO0177151A3 WO 2001077151 A3 WO2001077151 A3 WO 2001077151A3 US 0111400 W US0111400 W US 0111400W WO 0177151 A3 WO0177151 A3 WO 0177151A3
Authority
WO
WIPO (PCT)
Prior art keywords
fdrg
nucleic acid
proteins
acid molecules
uses therefor
Prior art date
Application number
PCT/US2001/011400
Other languages
French (fr)
Other versions
WO2001077151A2 (en
Inventor
Douglas A Holtzman
Bruce M Spiegelman
Clifford Hyunsuk Yoon
Original Assignee
Millennium Pharm Inc
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Dana Farber Cancer Inst Inc filed Critical Millennium Pharm Inc
Priority to AU2001249929A priority Critical patent/AU2001249929A1/en
Publication of WO2001077151A2 publication Critical patent/WO2001077151A2/en
Publication of WO2001077151A3 publication Critical patent/WO2001077151A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Novel FDRG polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FDRG proteins, the invention further provides isolated FDRG fusion proteins, antigenic peptides and anti-FDRG antibodies. The invention also provides FDRG nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FDRG gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
PCT/US2001/011400 2000-04-07 2001-04-06 Fdrg proteins and nucleic acid molecules and uses therefor WO2001077151A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001249929A AU2001249929A1 (en) 2000-04-07 2001-04-06 Fdrg proteins and nucleic acid molecules and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54654700A 2000-04-07 2000-04-07
US09/546,547 2000-04-07

Publications (2)

Publication Number Publication Date
WO2001077151A2 WO2001077151A2 (en) 2001-10-18
WO2001077151A3 true WO2001077151A3 (en) 2002-09-12

Family

ID=24180907

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011400 WO2001077151A2 (en) 2000-04-07 2001-04-06 Fdrg proteins and nucleic acid molecules and uses therefor

Country Status (2)

Country Link
AU (1) AU2001249929A1 (en)
WO (1) WO2001077151A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2006014729A2 (en) 2004-07-20 2006-02-09 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
EP1781698B1 (en) 2004-07-20 2016-07-06 Genentech, Inc. Compositions and methods of using angiopoietin-like 4 protein
KR101387781B1 (en) 2005-01-07 2014-04-21 렉시컨 파마슈티컬스 인코퍼레이티드 Monoclonal antibodies against angiopoietin-like protein 4 (angptl4)
CN107827974B (en) * 2017-11-10 2021-01-01 中国科学院过程工程研究所 Preparation method of human fibrinogen
CA3117750A1 (en) 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Angptl4 oligonucleotides influencing the regulation of the fatty acid metabolism

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032515A2 (en) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Angiopoietin homolog, dna encoding it, and method of making it
WO1999045135A1 (en) * 1998-03-02 1999-09-10 Millennium Pharmaceuticals, Inc. Novel fdrg protein and nucleic acid molecules and uses therefor
WO1999066041A1 (en) * 1998-06-16 1999-12-23 Human Genome Sciences, Inc. 94 human secreted proteins
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032515A2 (en) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Angiopoietin homolog, dna encoding it, and method of making it
WO1999045135A1 (en) * 1998-03-02 1999-09-10 Millennium Pharmaceuticals, Inc. Novel fdrg protein and nucleic acid molecules and uses therefor
WO1999066041A1 (en) * 1998-06-16 1999-12-23 Human Genome Sciences, Inc. 94 human secreted proteins
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences

Also Published As

Publication number Publication date
AU2001249929A1 (en) 2001-10-23
WO2001077151A2 (en) 2001-10-18

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