BR112012008054A2 - domínios catalíticos de lisil oxidase e loxl2 - Google Patents

domínios catalíticos de lisil oxidase e loxl2

Info

Publication number
BR112012008054A2
BR112012008054A2 BR112012008054A BR112012008054A BR112012008054A2 BR 112012008054 A2 BR112012008054 A2 BR 112012008054A2 BR 112012008054 A BR112012008054 A BR 112012008054A BR 112012008054 A BR112012008054 A BR 112012008054A BR 112012008054 A2 BR112012008054 A2 BR 112012008054A2
Authority
BR
Brazil
Prior art keywords
catalytic domains
lysyl oxidase
loxl2
lox12
isolated
Prior art date
Application number
BR112012008054A
Other languages
English (en)
Inventor
Mccauley Scott
Smith Victoria
Original Assignee
Gilead Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Biologics Inc filed Critical Gilead Biologics Inc
Publication of BR112012008054A2 publication Critical patent/BR112012008054A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12Y104/03013—Protein-lysine 6-oxidase (1.4.3.13), i.e. lysyl-oxidase

Abstract

domínios catalíticos de lisil oxidase e loxl2. são reveladas aqui sequências de aminoácido, e sequências de nucleotídeo de codificação, de domínios catalíticos isolados das proteínas lox e loxl2 de humano e camundongo. métodos para a preparação e uso desses domínios catalíticos isolados são também providos.
BR112012008054A 2009-08-21 2010-08-20 domínios catalíticos de lisil oxidase e loxl2 BR112012008054A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23577609P 2009-08-21 2009-08-21
PCT/US2010/046192 WO2011022667A2 (en) 2009-08-21 2010-08-20 Catalytic domains from lysyl oxidase and loxl2

Publications (1)

Publication Number Publication Date
BR112012008054A2 true BR112012008054A2 (pt) 2017-05-23

Family

ID=43607608

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008054A BR112012008054A2 (pt) 2009-08-21 2010-08-20 domínios catalíticos de lisil oxidase e loxl2

Country Status (15)

Country Link
US (2) US8512990B2 (pt)
EP (1) EP2467396A4 (pt)
JP (1) JP2013502226A (pt)
KR (1) KR20120063488A (pt)
CN (1) CN102712683B (pt)
AU (1) AU2010284036B2 (pt)
BR (1) BR112012008054A2 (pt)
CA (1) CA2771702A1 (pt)
IL (1) IL218209A (pt)
MX (1) MX2012002272A (pt)
NZ (1) NZ598466A (pt)
RU (1) RU2012110585A (pt)
SG (2) SG2014004816A (pt)
WO (1) WO2011022667A2 (pt)
ZA (1) ZA201201289B (pt)

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CN102712683A (zh) 2012-10-03
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EP2467396A4 (en) 2012-12-26
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MX2012002272A (es) 2012-07-03
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SG178845A1 (en) 2012-04-27
CA2771702A1 (en) 2011-02-24
RU2012110585A (ru) 2013-09-27
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