DE60029954D1 - Dermale anästhetika - Google Patents

Dermale anästhetika

Info

Publication number
DE60029954D1
DE60029954D1 DE60029954T DE60029954T DE60029954D1 DE 60029954 D1 DE60029954 D1 DE 60029954D1 DE 60029954 T DE60029954 T DE 60029954T DE 60029954 T DE60029954 T DE 60029954T DE 60029954 D1 DE60029954 D1 DE 60029954D1
Authority
DE
Germany
Prior art keywords
compounds
anesthetics
dermale
aminoindane
dermal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60029954T
Other languages
English (en)
Other versions
DE60029954T2 (de
Inventor
K Aberg
L Wright
L Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bridge Pharma Inc
Original Assignee
Bridge Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bridge Pharma Inc filed Critical Bridge Pharma Inc
Publication of DE60029954D1 publication Critical patent/DE60029954D1/de
Application granted granted Critical
Publication of DE60029954T2 publication Critical patent/DE60029954T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60029954T 1999-06-10 2000-06-06 Dermale anästhetika Expired - Fee Related DE60029954T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13835399P 1999-06-10 1999-06-10
US138353P 1999-06-10
US17926700P 2000-01-31 2000-01-31
US179267P 2000-01-31
PCT/US2000/015490 WO2000076510A1 (en) 1999-06-10 2000-06-06 Dermal anesthetic agents

Publications (2)

Publication Number Publication Date
DE60029954D1 true DE60029954D1 (de) 2006-09-21
DE60029954T2 DE60029954T2 (de) 2007-03-08

Family

ID=26836123

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60029954T Expired - Fee Related DE60029954T2 (de) 1999-06-10 2000-06-06 Dermale anästhetika

Country Status (18)

Country Link
US (1) US6413987B1 (de)
EP (1) EP1185267B1 (de)
JP (1) JP2003501469A (de)
CN (1) CN1355700A (de)
AT (1) ATE335482T1 (de)
AU (1) AU777517B2 (de)
BR (1) BR0011028A (de)
CA (1) CA2376819C (de)
CY (1) CY1105721T1 (de)
DE (1) DE60029954T2 (de)
DK (1) DK1185267T3 (de)
ES (1) ES2267546T3 (de)
IL (2) IL146190A0 (de)
MX (1) MXPA01012632A (de)
NO (1) NO323856B1 (de)
NZ (1) NZ515143A (de)
PT (1) PT1185267E (de)
WO (1) WO2000076510A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1321139B1 (de) * 2001-12-21 2006-08-23 CHIESI FARMACEUTICI S.p.A. 2-Indanylaminoderivate zur Therapie von chronischen, akuten oder entzündlichen Schmerzen
NZ539834A (en) 2002-11-26 2007-08-31 Maruishi Pharma Isoindoline derivatives
US20060079558A1 (en) * 2004-09-27 2006-04-13 Bridge Pharma. Inc. R-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine and other dermal anesthetics
WO2006036936A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
US20110218218A1 (en) * 2005-09-23 2011-09-08 Bridge Pharma, Inc. Formulations Of Indanylamines And The Use Thereof As Local Anesthetics And As Medication For Chronic Pain
US20090137628A1 (en) * 2005-09-23 2009-05-28 Bridge Pharma, Inc. Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain
WO2008011161A2 (en) * 2006-07-21 2008-01-24 Bridge Pharma, Inc. Dermal anesthetic compounds
US9675544B2 (en) * 2008-01-22 2017-06-13 The Board Of Regents Of The University Of Texas System Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief
ES2675510T3 (es) * 2011-02-18 2018-07-11 Endo Pharmaceuticals Inc. Compuestos aminoindano y uso de los mismos en el tratamiento del dolor
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
DK2771320T3 (en) 2011-10-24 2016-10-03 Endo Pharmaceuticals Inc Cyclohexylamines
TWI603957B (zh) 2012-08-15 2017-11-01 阿沙納生物科學有限責任公司 胺基氫茚化合物用於治療膀胱過動症及間質性膀胱炎之用途
JP7145363B2 (ja) 2015-11-23 2022-10-03 グレイス セラピューティクス インコーポレイテッド 局所皮膜形成スプレー
EA202191506A1 (ru) 2018-12-19 2021-10-08 Нортик Холдингз Инк. Терапевтическая композиция интраназального лидокаина

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE760018A (fr) * 1969-12-19 1971-06-08 Christiaens Sa A Nouveau derives du 2-amino-indane, leur preparation et leur utilisation
US3923813A (en) 1969-12-19 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindanes
AR206505A1 (es) * 1972-09-18 1976-07-30 Christiaens Sa A Procedimiento para obtener nuevos derivados de n-fenil-n-aminoalquil-2-aminoindano
ZA738419B (en) * 1972-11-06 1974-09-25 Christiaens Sa A New derivatives of 2-aminoindane,the preparation and use thereof
GB1462036A (en) 1973-02-05 1977-01-19 Manuf Prod Pharma Aminoindane derivatives
GB1468347A (en) * 1973-03-02 1977-03-23 Christiaens Sa A Aminoindanes

Also Published As

Publication number Publication date
NO20016037L (no) 2002-02-11
WO2000076510A1 (en) 2000-12-21
CY1105721T1 (el) 2010-12-22
BR0011028A (pt) 2002-02-19
DK1185267T3 (da) 2006-12-11
DE60029954T2 (de) 2007-03-08
JP2003501469A (ja) 2003-01-14
EP1185267B1 (de) 2006-08-09
ES2267546T3 (es) 2007-03-16
EP1185267A1 (de) 2002-03-13
US6413987B1 (en) 2002-07-02
PT1185267E (pt) 2006-12-29
WO2000076510A9 (en) 2002-07-04
NO323856B1 (no) 2007-07-16
ATE335482T1 (de) 2006-09-15
AU5596300A (en) 2001-01-02
NZ515143A (en) 2004-05-28
CN1355700A (zh) 2002-06-26
NO20016037D0 (no) 2001-12-10
MXPA01012632A (es) 2004-03-19
EP1185267A4 (de) 2003-09-03
AU777517B2 (en) 2004-10-21
IL146190A (en) 2008-11-03
CA2376819A1 (en) 2000-12-21
IL146190A0 (en) 2002-07-25
CA2376819C (en) 2008-09-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee