GB1468347A - Aminoindanes - Google Patents

Aminoindanes

Info

Publication number
GB1468347A
GB1468347A GB1030473A GB1030473A GB1468347A GB 1468347 A GB1468347 A GB 1468347A GB 1030473 A GB1030473 A GB 1030473A GB 1030473 A GB1030473 A GB 1030473A GB 1468347 A GB1468347 A GB 1468347A
Authority
GB
United Kingdom
Prior art keywords
aminoindane
phenyl
aminopropyl
substituted
aminoindanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1030473A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Christiaens SA
Original Assignee
A Christiaens SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Christiaens SA filed Critical A Christiaens SA
Priority to GB1030473A priority Critical patent/GB1468347A/en
Priority to AR252609A priority patent/AR204526A1/en
Priority to CA193,354A priority patent/CA1036164A/en
Priority to ZA00741232A priority patent/ZA741232B/en
Priority to AU66070/74A priority patent/AU485528B2/en
Priority to IL44320A priority patent/IL44320A/en
Priority to CH297474A priority patent/CH593909A5/xx
Priority to JP2470474A priority patent/JPS547789B2/ja
Priority to BE141546A priority patent/BE811762A/en
Priority to HUCI1459A priority patent/HU169840B/hu
Priority to FR7407092A priority patent/FR2219787B1/fr
Priority to LU69535A priority patent/LU69535A1/xx
Priority to ES423789A priority patent/ES423789A1/en
Priority to AT170774A priority patent/AT333742B/en
Priority to DE2409791A priority patent/DE2409791C3/en
Priority to CH257877A priority patent/CH593910A5/xx
Priority to NL7402830A priority patent/NL7402830A/xx
Priority to CH257777A priority patent/CH605619A5/xx
Priority to DD176932A priority patent/DD112262A5/xx
Priority to DD181958A priority patent/DD113999A5/xx
Priority to MX579774U priority patent/MX5318E/en
Priority to AR260957A priority patent/AR206653A1/en
Priority to AR260956A priority patent/AR206652A1/en
Priority to AT359175A priority patent/AT336017B/en
Publication of GB1468347A publication Critical patent/GB1468347A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1468347 Aminoindanes A CHRISTIAENS SA 28 Feb 1974 [2 March 1973] 10304/73 Heading C2C Compounds of the general formula (n=2-4; R 1 , 2 =C 1-3 alkyl or hydroxyalkyl, C 2-3 alkenyl or alkynyl or NR 1 R 2 = ring; A= Ph, substituted Ph, 2-Py; provided that when n = 2 or 3 and A = Ph or substituted Ph, R 1 and R 2 do not represent the same alkyl group) and their acid addition salts are prepared by introduction of the aminoalkyl or aryl group by standard methods in one or more stages, or from methanesulphonylindane. The preparation of N-phenyl-N-(γ-chlorobutyryl and diethylaminobutyryl) - 2 - aminoindane, N - phenyl - N - [(γ - N<SP>1</SP> - ethyl - N<SP>1</SP> - propionyl)aminopropyl] - 2 - aminoindane, pyrid - 2- yl - 2 - aminoindane, N - phenyl - N - isopropylaminopropyl - 2 - aminoindane and its hydrochloride and N - phenyl - N - [(γ - N<SP>1</SP> - isopropyl- N<SP>1</SP> - acetyl]aminopropyl]- 2 - aminoindane is described. The above compounds are active against heart arrhythmia, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB1030473A 1973-03-02 1973-03-02 Aminoindanes Expired GB1468347A (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
GB1030473A GB1468347A (en) 1973-03-02 1973-03-02 Aminoindanes
AR252609A AR204526A1 (en) 1973-03-02 1974-01-01 PROCEDURE TO PREPARE NEW 2-AMINOINDANE DERIVATIVES
CA193,354A CA1036164A (en) 1973-03-02 1974-02-25 Derivatives of 2-amino-indane, the preparation and use thereof
ZA00741232A ZA741232B (en) 1973-03-02 1974-02-25 New derivatives of 2-aminoindane, the preparation and use thereof
AU66070/74A AU485528B2 (en) 1973-03-02 1974-02-27 New derivatives of 2-aminoindane the preparation and use thereof
IL44320A IL44320A (en) 1973-03-02 1974-02-28 Derivatives of 2-aminoindane their preparation and pharmaceutical compositions containing them
CH297474A CH593909A5 (en) 1973-03-02 1974-03-01
JP2470474A JPS547789B2 (en) 1973-03-02 1974-03-01
BE141546A BE811762A (en) 1973-03-02 1974-03-01 NEW DERIVATIVES OF 2-AMINOINDANE
HUCI1459A HU169840B (en) 1973-03-02 1974-03-01
FR7407092A FR2219787B1 (en) 1973-03-02 1974-03-01
LU69535A LU69535A1 (en) 1973-03-02 1974-03-01
ES423789A ES423789A1 (en) 1973-03-02 1974-03-01 Aminoindanes
AT170774A AT333742B (en) 1973-03-02 1974-03-01 PROCESS FOR THE PREPARATION OF NEW 2-AMINOINDANE DERIVATIVES
DE2409791A DE2409791C3 (en) 1973-03-02 1974-03-01 Derivatives of 2-aminoindane and drugs containing them
CH257877A CH593910A5 (en) 1973-03-02 1974-03-01
NL7402830A NL7402830A (en) 1973-03-02 1974-03-01
CH257777A CH605619A5 (en) 1973-03-02 1974-03-01
DD176932A DD112262A5 (en) 1973-03-02 1974-03-04
DD181958A DD113999A5 (en) 1973-03-02 1974-03-04
MX579774U MX5318E (en) 1973-03-02 1974-03-04 PROCEDURE FOR PREPARING 2-AMINOINDANE DERIVATIVES
AR260957A AR206653A1 (en) 1973-03-02 1975-01-01 PROCEDURE FOR PREPARING NEW DERIVATIVES OF N-AMINOALKYL-2-AMINO-INDANO
AR260956A AR206652A1 (en) 1973-03-02 1975-01-01 PROCEDURE FOR PREPARING NEW N-AMINO-ALKYL-2-AMINOINDANE DERIVATIVES
AT359175A AT336017B (en) 1973-03-02 1975-05-12 PROCESS FOR THE PRODUCTION OF NEW 2-AMINOINDANE DERIVATIVES AND THEIR ACID ADDITIONAL SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1030473A GB1468347A (en) 1973-03-02 1973-03-02 Aminoindanes

Publications (1)

Publication Number Publication Date
GB1468347A true GB1468347A (en) 1977-03-23

Family

ID=9965409

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1030473A Expired GB1468347A (en) 1973-03-02 1973-03-02 Aminoindanes

Country Status (16)

Country Link
JP (1) JPS547789B2 (en)
AR (3) AR204526A1 (en)
AT (1) AT333742B (en)
BE (1) BE811762A (en)
CA (1) CA1036164A (en)
CH (3) CH605619A5 (en)
DD (2) DD112262A5 (en)
DE (1) DE2409791C3 (en)
ES (1) ES423789A1 (en)
FR (1) FR2219787B1 (en)
GB (1) GB1468347A (en)
HU (1) HU169840B (en)
IL (1) IL44320A (en)
LU (1) LU69535A1 (en)
NL (1) NL7402830A (en)
ZA (1) ZA741232B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1185267A1 (en) * 1999-06-10 2002-03-13 Bridge Pharma, Inc. Dermal anesthetic agents
EP1658847A2 (en) * 1999-06-10 2006-05-24 Bridge Pharma, Inc. Indane derivatives as dermal anesthetic agents
US7592458B2 (en) 2006-07-21 2009-09-22 Wright George E Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain
US7718674B2 (en) 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE760018A (en) * 1969-12-19 1971-06-08 Christiaens Sa A NEW DERIVATIVES OF 2-AMINO-INDANE, THEIR PREPARATION AND THEIR USE
JPS4922702A (en) * 1972-06-22 1974-02-28
JPS5216322B2 (en) * 1972-06-22 1977-05-09

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1185267A1 (en) * 1999-06-10 2002-03-13 Bridge Pharma, Inc. Dermal anesthetic agents
EP1185267A4 (en) * 1999-06-10 2003-09-03 Bridge Pharma Inc Dermal anesthetic agents
EP1658847A2 (en) * 1999-06-10 2006-05-24 Bridge Pharma, Inc. Indane derivatives as dermal anesthetic agents
EP1658847A3 (en) * 1999-06-10 2006-07-26 Bridge Pharma, Inc. Indane derivatives as dermal anesthetic agents
US7718674B2 (en) 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
US7592458B2 (en) 2006-07-21 2009-09-22 Wright George E Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain

Also Published As

Publication number Publication date
AR206653A1 (en) 1976-08-06
NL7402830A (en) 1974-09-04
DE2409791A1 (en) 1974-09-12
ES423789A1 (en) 1976-05-16
CH605619A5 (en) 1978-09-29
BE811762A (en) 1974-09-02
DE2409791C3 (en) 1979-07-12
ATA170774A (en) 1976-04-15
IL44320A0 (en) 1974-05-16
DD112262A5 (en) 1975-04-05
JPS5029543A (en) 1975-03-25
LU69535A1 (en) 1974-06-21
IL44320A (en) 1977-06-30
DD113999A5 (en) 1975-07-12
ZA741232B (en) 1975-01-29
AR204526A1 (en) 1976-02-12
HU169840B (en) 1977-02-28
AR206652A1 (en) 1976-08-06
CA1036164A (en) 1978-08-08
JPS547789B2 (en) 1979-04-10
AU6607074A (en) 1975-08-28
CH593909A5 (en) 1977-12-30
FR2219787B1 (en) 1978-01-06
CH593910A5 (en) 1977-12-30
DE2409791B2 (en) 1978-11-16
AT333742B (en) 1976-12-10
FR2219787A1 (en) 1974-09-27

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee