DE60020677D1 - Mikroemulsionen mit adsorbierten makromolekülen und mikropartikeln - Google Patents
Mikroemulsionen mit adsorbierten makromolekülen und mikropartikelnInfo
- Publication number
- DE60020677D1 DE60020677D1 DE60020677T DE60020677T DE60020677D1 DE 60020677 D1 DE60020677 D1 DE 60020677D1 DE 60020677 T DE60020677 T DE 60020677T DE 60020677 T DE60020677 T DE 60020677T DE 60020677 D1 DE60020677 D1 DE 60020677D1
- Authority
- DE
- Germany
- Prior art keywords
- microparticles
- emulsifying agent
- oil
- microemulsions
- emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000011859 microparticle Substances 0.000 title abstract 5
- 229920002521 macromolecule Polymers 0.000 title abstract 2
- 239000004530 micro-emulsion Substances 0.000 title 1
- 239000003599 detergent Substances 0.000 abstract 3
- 239000003995 emulsifying agent Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002671 adjuvant Substances 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 230000003308 immunostimulating effect Effects 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12185899P | 1999-02-26 | 1999-02-26 | |
US121858P | 1999-02-26 | ||
US14639199P | 1999-07-29 | 1999-07-29 | |
US146391P | 1999-07-29 | ||
US16199799P | 1999-10-28 | 1999-10-28 | |
US161997P | 1999-10-28 | ||
PCT/US2000/003331 WO2000050006A2 (en) | 1999-02-26 | 2000-02-09 | Microemulsions with adsorbed macromoelecules and microparticles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60020677D1 true DE60020677D1 (de) | 2005-07-14 |
DE60020677T2 DE60020677T2 (de) | 2006-05-04 |
Family
ID=27382688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60020677T Expired - Lifetime DE60020677T2 (de) | 1999-02-26 | 2000-02-09 | Mikroemulsionen mit adsorbierten makromolekülen und mikropartikeln |
Country Status (9)
Country | Link |
---|---|
US (4) | US8206749B1 (de) |
EP (3) | EP2286792A1 (de) |
JP (4) | JP2002537102A (de) |
AT (1) | ATE297190T1 (de) |
AU (1) | AU2875700A (de) |
CA (2) | CA2689696C (de) |
DE (1) | DE60020677T2 (de) |
ES (2) | ES2579783T3 (de) |
WO (1) | WO2000050006A2 (de) |
Families Citing this family (141)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6589940B1 (en) | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
CA2689696C (en) | 1999-02-26 | 2013-08-06 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
RU2257198C2 (ru) | 2000-09-28 | 2005-07-27 | Чирон Корпорейшн | Композиции микрочастиц и способы их получения |
CA2421683C (en) * | 2000-09-28 | 2009-09-15 | Chiron Corporation | Microparticles for delivery of the heterologous nucleic acids |
FR2814958B1 (fr) * | 2000-10-06 | 2003-03-07 | Aventis Pasteur | Composition vaccinale |
US6552004B1 (en) * | 2000-10-30 | 2003-04-22 | Universite De Montreal | Delivery system for entrapping charged macromolecules and a method for preparing same |
AU2002231336B2 (en) * | 2000-12-27 | 2007-06-28 | Surefire Medical, Inc. D/B/A Trisalus Life Sciences | Immunomodulatory polynucleotides and methods of using the same |
EP1420829A4 (de) | 2001-08-07 | 2006-05-17 | Dynavax Tech Corp | Immunmodulierende zusammensetzungen, formulierungen sowie verfahren zu deren verwendung |
DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
WO2003028661A2 (en) * | 2001-10-03 | 2003-04-10 | Chiron Corporation | Adjuvanted meningococcus compositions |
AU2002347062B2 (en) * | 2001-10-06 | 2008-06-26 | Merial Ltd | CpG formulations and related methods |
US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
WO2003070909A2 (en) | 2002-02-20 | 2003-08-28 | Chiron Corporation | Microparticles with adsorbed polypeptide-containing molecules |
WO2004012751A1 (ja) * | 2002-08-02 | 2004-02-12 | Sumitomo Pharmaceuticals Company, Limited | 細菌細胞壁骨格成分製剤 |
EP1551376A4 (de) | 2002-08-12 | 2010-10-06 | Dynavax Tech Corp | Immunomodulatorische zusammensetzungen, herstellungsverfahren und verwendungsverfahren dafür |
US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
CA2511512C (en) | 2002-12-27 | 2013-10-29 | Chiron Corporation | Immunogenic compositions containing phospholipid |
EP1622566A4 (de) * | 2003-04-25 | 2008-06-25 | Novartis Vaccines & Diagnostic | Zusammensetzungen mit kationischen mikroteilchen und hcv e1e2 dna und anwendungsverfahren dafür |
PL1631264T5 (pl) | 2003-06-02 | 2018-09-28 | Glaxosmithkline Biologicals Sa | Kompozycje immunogenne oparte na biodegradowalnych mikrocząstkach zawierających toksoid błonicy i tężca |
US20050208083A1 (en) | 2003-06-04 | 2005-09-22 | Nanobio Corporation | Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof |
ES2899590T3 (es) | 2004-01-23 | 2022-03-14 | Eden Research Plc | Métodos de eliminación de nematodos que comprenden la aplicación de un componente terpénico |
EP2338332B1 (de) | 2004-05-20 | 2014-02-12 | Eden Research Plc | Hohles glukan- oder zellenwand-partikel, das eine terpenkomponente verkapselt |
PL1861120T3 (pl) | 2005-03-23 | 2016-11-30 | Zastosowanie wirusa grypy i adiuwantu emulsji olej-w-wodzie do indukcji komórek t cd4+ i/lub ulepszonej odpowiedzi komórek b pamięci | |
WO2006110699A1 (en) * | 2005-04-11 | 2006-10-19 | Nanobio Corporation | Quaternary ammonium halides for treatment of infectious conditions |
HUE045482T2 (hu) | 2005-06-27 | 2019-12-30 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
EP1951200A2 (de) * | 2005-08-09 | 2008-08-06 | Nanobio Corporation | Eine nanoemulsion enthaltende zusammensetzungen mit entzündungshemmender wirkung |
US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
WO2007052055A1 (en) * | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
NZ568212A (en) * | 2005-11-04 | 2012-03-30 | Novartis Vaccines & Diagnostic | Changing Th1/Th2 balance in split influenza vaccines with adjuvants |
AU2006310246B2 (en) * | 2005-11-04 | 2010-12-23 | Seqirus UK Limited | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines |
JP5539649B2 (ja) | 2005-12-13 | 2014-07-02 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 細胞移植のための足場 |
AU2006325225B2 (en) | 2005-12-14 | 2013-07-04 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
US9839685B2 (en) | 2006-04-13 | 2017-12-12 | The Regents Of The University Of Michigan | Methods of inducing human immunodeficiency virus-specific immune responses in a host comprising nasally administering compositions comprising a naonemulsion and recombinant GP120 immunogen |
US10138279B2 (en) | 2006-04-13 | 2018-11-27 | Regents Of The University Of Michigan | Compositions and methods for Bacillus anthracis vaccination |
SG172696A1 (en) | 2006-06-12 | 2011-07-28 | Cytos Biotechnology Ag | Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages |
MX2009000660A (es) | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
JP5389662B2 (ja) | 2006-12-12 | 2014-01-15 | サイトス バイオテクノロジー アーゲー | 高濃度のグアニン・モノマーを含有するオリゴヌクレオチド |
US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
AU2008241413A1 (en) * | 2007-04-18 | 2008-10-30 | The Regents Of The University Of California | Protein-modified nano-droplets, compositions and methods of production |
AR066405A1 (es) | 2007-04-20 | 2009-08-19 | Glaxosmithkline Biolog Sa | Vacuna |
EP3067048B1 (de) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Zusammensetzungen zur induzierung von immunreaktionen |
US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
EP2254602B1 (de) | 2008-02-13 | 2018-11-21 | President and Fellows of Harvard College | Kontinuierliche zellprogrammiervorrichtungen |
WO2009123480A1 (en) * | 2008-04-01 | 2009-10-08 | Virionyx Corporation Ltd | Anti-infective agents and uses thereof |
ES2712505T3 (es) | 2008-04-17 | 2019-05-13 | Pds Biotechnology Corp | Estimulación de una respuesta inmunitaria por enantiómeros de lípidos catiónicos |
CA2721510A1 (en) * | 2008-04-18 | 2009-10-22 | Nanobio Corporation | Methods for treating herpes virus infections |
EP3023107A1 (de) | 2008-04-21 | 2016-05-25 | Nanobio Corporation | Nanoemulsions-influenza-impfstoff |
EP2293787A1 (de) | 2008-04-25 | 2011-03-16 | Nanobio Corporation | Nanoemulsionen zur behandlung von pilz-, hefe- und schimmelpilzinfektionen |
US20090269394A1 (en) * | 2008-04-25 | 2009-10-29 | Nanobio Corporation | Methods and compositions for treating onchomycosis |
CA2826508C (en) | 2008-05-23 | 2016-07-19 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
NZ727616A (en) | 2008-06-27 | 2018-06-29 | Zoetis Services Llc | Novel adjuvant compositions |
WO2010036938A2 (en) | 2008-09-26 | 2010-04-01 | Nanobio Corporation | Nanoemulsion therapeutic compositions and methods of using the same |
CA2751379C (en) | 2009-02-10 | 2018-06-12 | Novartis Ag | Influenza vaccines with reduced amounts of squalene |
JP6110140B2 (ja) * | 2009-06-16 | 2017-04-05 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | ナノエマルションワクチン |
GB0913442D0 (en) * | 2009-07-31 | 2009-09-16 | Univ Ramot | Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof |
WO2011014871A1 (en) | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
CL2012001399A1 (es) | 2009-12-03 | 2013-03-08 | Novartis Ag | Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion. |
DE102009056884B4 (de) | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
AU2013202706B2 (en) * | 2009-12-03 | 2016-02-11 | Novartis Ag | Circulation of components during microfluidization and/or homogenization emulsions |
DE102009056871A1 (de) | 2009-12-03 | 2011-06-22 | Novartis AG, 4056 | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
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DK2356983T3 (da) * | 2009-12-03 | 2013-03-11 | Novartis Ag | Cirkulation af bestanddele under homogenisering af emulsioner |
DK2343052T3 (da) | 2009-12-03 | 2013-09-02 | Novartis Ag | Hydrofil filtrering under fremstilling af vaccineadjuvanter |
MX343410B (es) | 2010-07-06 | 2016-11-04 | Novartis Ag * | Emulsiones cationicas de agua en aceite. |
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- 2000-02-09 EP EP00907228A patent/EP1156781B1/de not_active Revoked
- 2000-02-09 AT AT00907228T patent/ATE297190T1/de active
- 2000-02-09 DE DE60020677T patent/DE60020677T2/de not_active Expired - Lifetime
- 2000-02-09 EP EP05075823.4A patent/EP1574210B1/de not_active Expired - Lifetime
-
2006
- 2006-04-18 US US11/406,144 patent/US8309139B2/en not_active Expired - Fee Related
-
2011
- 2011-10-21 JP JP2011232182A patent/JP6073053B2/ja not_active Expired - Lifetime
-
2012
- 2012-09-14 US US13/618,020 patent/US8771747B2/en not_active Expired - Fee Related
- 2012-09-15 US US13/621,174 patent/US8734832B2/en not_active Expired - Fee Related
-
2014
- 2014-05-28 JP JP2014110216A patent/JP2014169323A/ja not_active Withdrawn
-
2016
- 2016-06-24 JP JP2016125184A patent/JP2016172767A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1574210B1 (de) | 2016-04-06 |
US8206749B1 (en) | 2012-06-26 |
ES2242604T3 (es) | 2005-11-16 |
US8734832B2 (en) | 2014-05-27 |
EP1156781A2 (de) | 2001-11-28 |
JP2002537102A (ja) | 2002-11-05 |
WO2000050006A2 (en) | 2000-08-31 |
US8309139B2 (en) | 2012-11-13 |
ATE297190T1 (de) | 2005-06-15 |
EP1574210A2 (de) | 2005-09-14 |
EP1156781B1 (de) | 2005-06-08 |
US8771747B2 (en) | 2014-07-08 |
WO2000050006A3 (en) | 2001-01-18 |
CA2363141C (en) | 2010-04-06 |
CA2689696C (en) | 2013-08-06 |
EP2286792A1 (de) | 2011-02-23 |
JP2016172767A (ja) | 2016-09-29 |
AU2875700A (en) | 2000-09-14 |
US20130195898A1 (en) | 2013-08-01 |
EP1574210A3 (de) | 2007-02-21 |
JP6073053B2 (ja) | 2017-02-01 |
JP2012017344A (ja) | 2012-01-26 |
JP2014169323A (ja) | 2014-09-18 |
US20070116709A1 (en) | 2007-05-24 |
CA2363141A1 (en) | 2000-08-31 |
ES2579783T3 (es) | 2016-08-16 |
DE60020677T2 (de) | 2006-05-04 |
US20130195923A1 (en) | 2013-08-01 |
CA2689696A1 (en) | 2000-08-31 |
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8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US |