MX343410B - Emulsiones cationicas de agua en aceite. - Google Patents
Emulsiones cationicas de agua en aceite.Info
- Publication number
- MX343410B MX343410B MX2013000171A MX2013000171A MX343410B MX 343410 B MX343410 B MX 343410B MX 2013000171 A MX2013000171 A MX 2013000171A MX 2013000171 A MX2013000171 A MX 2013000171A MX 343410 B MX343410 B MX 343410B
- Authority
- MX
- Mexico
- Prior art keywords
- cationic
- water emulsions
- molecule
- nucleic acid
- oil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invención se refiere a una composición que comprende una molécula de ARN acomplejada con una partícula de emulsión catiónica de aceite en agua, caracterizada porque la partícula comprende: (a) un núcleo de aceite que se encuentra en fase líquida a 25°C, y (b) un lípido catiónico, de manera que la carga neta total de la partícula de emulsión antes de la complejación de ARN es positiva, y en donde la molécula de ARN es un ARN autorreplicante que codifica par aun antígeno proteínico y el ARN se ancla a la superficie de la partícula por interacciones no covalentes; en donde, cuando se administra en una cantidad eficaz a un mamífero, la composición induce títulos de anticuerpo al antígeno iguales a o mayores que el ARN autorreplicante administrado al mamífero no acomplejado con la partícula. Esta invención se refiere generalmente a emulsiones catiónicas de aceite en agua que pueden ser usadas para suministrar moléculas cargadas negativamente, tales como una molécula de ARN. Las partículas de la emulsión comprenden un núcleo de aceite y un lípido catiónico. El lípido catiónico puede interactuar con la molécula cargada negativamente anclando de esta manera la molécula a las partículas de la emulsión. Las emulsiones catiónicas descritas en la presente son particularmente adecuadas para suministrar moléculas de ácido nucleico (tal como una molécula de ARN que codifica para un antígeno) a células, y para formular vacunas a base de ácido nucleico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36189210P | 2010-07-06 | 2010-07-06 | |
PCT/US2011/043108 WO2012006380A2 (en) | 2010-07-06 | 2011-07-06 | Cationic oil-in-water emulsions |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013000171A MX2013000171A (es) | 2013-03-05 |
MX343410B true MX343410B (es) | 2016-11-04 |
Family
ID=44629230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000171A MX343410B (es) | 2010-07-06 | 2011-07-06 | Emulsiones cationicas de agua en aceite. |
Country Status (12)
Country | Link |
---|---|
US (3) | US9295646B2 (es) |
EP (2) | EP2590625B1 (es) |
JP (2) | JP6025721B2 (es) |
CN (2) | CN108042799A (es) |
AU (1) | AU2011276236B2 (es) |
BR (1) | BR112013000391B8 (es) |
CA (1) | CA2804591C (es) |
ES (1) | ES2649896T3 (es) |
MX (1) | MX343410B (es) |
NZ (1) | NZ606591A (es) |
RU (1) | RU2625546C2 (es) |
WO (1) | WO2012006380A2 (es) |
Families Citing this family (174)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
PT2591114T (pt) | 2010-07-06 | 2016-08-02 | Glaxosmithkline Biologicals Sa | Imunização de mamíferos de grande porte com doses baixas de arn |
LT4005592T (lt) | 2010-07-06 | 2023-01-10 | Glaxosmithkline Biologicals S.A. | Viriono tipo tiekimo dalelės, skirtos savaime besireplikuojančioms rnr molekulėms |
ES2646669T3 (es) | 2010-07-06 | 2017-12-14 | Glaxosmithkline Biologicals Sa | Procedimientos de aumento de una respuesta inmunitaria mediante el suministro de ARN |
AU2011276236B2 (en) * | 2010-07-06 | 2016-03-10 | Glaxosmithkline Biologicals S.A. | Cationic oil-in-water emulsions |
PT2590626E (pt) | 2010-07-06 | 2016-01-26 | Glaxosmithkline Biolog Sa | Lipossomas com lípidos que têm um valor de pka vantajoso para administração de arn |
EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
EP4066857B1 (en) | 2010-08-31 | 2022-12-21 | GlaxoSmithKline Biologicals SA | Pegylated liposomes for delivery of immunogen-encoding rna |
NZ608972A (en) | 2010-10-01 | 2015-09-25 | Moderna Therapeutics Inc | Engineered nucleic acids and methods of use thereof |
KR102162111B1 (ko) | 2010-10-11 | 2020-10-07 | 노파르티스 아게 | 항원 전달 플랫폼 |
US8710200B2 (en) | 2011-03-31 | 2014-04-29 | Moderna Therapeutics, Inc. | Engineered nucleic acids encoding a modified erythropoietin and their expression |
KR20220025112A (ko) | 2011-06-08 | 2022-03-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | Mrna 전달을 위한 지질 나노입자 조성물 및 방법 |
US9655845B2 (en) | 2011-07-06 | 2017-05-23 | Glaxosmithkline Biologicals, S.A. | Oil-in-water emulsions that contain nucleic acids |
WO2013006837A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Cationic oil-in-water emulsions |
EP2729165B1 (en) | 2011-07-06 | 2017-11-08 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CA2850624A1 (en) | 2011-10-03 | 2013-04-11 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
CN110201187A (zh) | 2011-12-16 | 2019-09-06 | 现代泰克斯公司 | 经修饰的核苷、核苷酸和核酸组合物 |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
AU2013243952A1 (en) | 2012-04-02 | 2014-10-30 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
CA2868391A1 (en) | 2012-04-02 | 2013-10-10 | Stephane Bancel | Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same |
CN104853770A (zh) * | 2012-07-06 | 2015-08-19 | 诺华股份有限公司 | 免疫原性组合物及其应用 |
KR20150031322A (ko) | 2012-07-06 | 2015-03-23 | 노파르티스 아게 | 사이토메갈로바이러스 단백질의 복합체 |
EP2885419A4 (en) | 2012-08-14 | 2016-05-25 | Moderna Therapeutics Inc | ENZYMES AND POLYMERASES FOR RNA SYNTHESIS |
FR2998899B1 (fr) * | 2012-11-30 | 2015-07-17 | Commissariat Energie Atomique | Methode de criblage a haut-debit pour l'identification de biomarqueurs, cibles therapeutiques ou d'agents therapeutiques |
FR2994849B1 (fr) * | 2012-08-30 | 2015-01-02 | Commissariat Energie Atomique | Formulation pour la delivrance de sequences nucleotidiques susceptibles de moduler des mecanismes endogenes d'arn interferents |
US10253315B2 (en) | 2012-08-30 | 2019-04-09 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Method for transfection of nucleic acids into eukaryotic cells in 3D scaffold |
PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
WO2014108515A1 (en) | 2013-01-10 | 2014-07-17 | Novartis Ag | Influenza virus immunogenic compositions and uses thereof |
EP3434774A1 (en) | 2013-01-17 | 2019-01-30 | ModernaTX, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
PT2970948T (pt) | 2013-03-15 | 2019-03-20 | Glaxosmithkline Biologicals Sa | Métodos de purificação de arn |
AU2014315287A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
EP3122774B1 (en) | 2014-03-25 | 2020-11-04 | Yale University | Uses of parasite macrophage migration inhibitory factors |
SG11201608798YA (en) | 2014-04-23 | 2016-11-29 | Modernatx Inc | Nucleic acid vaccines |
EP2974739A1 (en) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF trimerization domains |
EP3766916B1 (en) | 2014-06-25 | 2022-09-28 | Acuitas Therapeutics Inc. | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
US20170204152A1 (en) | 2014-07-16 | 2017-07-20 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
WO2016014846A1 (en) | 2014-07-23 | 2016-01-28 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of intrabodies |
EP3048114A1 (en) | 2015-01-22 | 2016-07-27 | Novartis AG | Cytomegalovirus antigens and uses thereof |
EP3061826A1 (en) | 2015-02-27 | 2016-08-31 | Novartis AG | Flavivirus replicons |
CA2979998A1 (en) * | 2015-03-20 | 2016-09-29 | Protiva Biotherapeutics, Inc. | Compositions and methods for treating hypertriglyceridemia |
CN114085198A (zh) | 2015-06-29 | 2022-02-25 | 爱康泰生治疗公司 | 用于递送核酸的脂质和脂质纳米颗粒制剂 |
US11007260B2 (en) | 2015-07-21 | 2021-05-18 | Modernatx, Inc. | Infectious disease vaccines |
US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
EP3359670B2 (en) | 2015-10-05 | 2024-02-14 | ModernaTX, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
CA3002819A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Sexually transmitted disease vaccines |
EP3364950A4 (en) | 2015-10-22 | 2019-10-23 | ModernaTX, Inc. | VACCINES AGAINST TROPICAL DISEASES |
BR112018008051A2 (pt) | 2015-10-22 | 2018-11-13 | Modernatx Inc | vacinas de ácido nucleico para vírus de varicella zoster (vzv) |
LT3368507T (lt) | 2015-10-28 | 2023-03-10 | Acuitas Therapeutics Inc. | Nauji lipidai ir lipidų nanodalelių kompozicijos, skirtos nukleorūgščių tiekimui |
US10801041B2 (en) * | 2015-11-18 | 2020-10-13 | Orbis Health Solutions, Llc | T7 alpha viral vector system |
RS63135B1 (sr) | 2015-12-23 | 2022-05-31 | Modernatx Inc | Postupci upotrebe polinukleotida koji kodiraju ox40 ligand |
US20190241658A1 (en) | 2016-01-10 | 2019-08-08 | Modernatx, Inc. | Therapeutic mRNAs encoding anti CTLA-4 antibodies |
WO2017147470A1 (en) * | 2016-02-26 | 2017-08-31 | The Regents Of The University Of California | Bicontinuous microemulsions and methods of use thereof |
WO2017162266A1 (en) | 2016-03-21 | 2017-09-28 | Biontech Rna Pharmaceuticals Gmbh | Rna replicon for versatile and efficient gene expression |
WO2017162265A1 (en) | 2016-03-21 | 2017-09-28 | Biontech Rna Pharmaceuticals Gmbh | Trans-replicating rna |
WO2017196979A1 (en) * | 2016-05-10 | 2017-11-16 | The Regents Of The University Of Michigan | Emulsion adjuvant for intramuscular, intradermal and subcutaneous administration |
CN115837014A (zh) | 2016-05-18 | 2023-03-24 | 摩登纳特斯有限公司 | 编码松弛素的多核苷酸 |
WO2017208191A1 (en) | 2016-06-02 | 2017-12-07 | Glaxosmithkline Biologicals Sa | Zika viral antigen constructs |
US11191849B2 (en) | 2016-06-30 | 2021-12-07 | Arbutus Biopharma Corporation | Compositions and methods for delivering messenger RNA |
EP3518966A1 (en) | 2016-09-29 | 2019-08-07 | GlaxoSmithKline Biologicals S.A. | Compositions and methods of treatment of persistent hpv infection |
GB201616904D0 (en) | 2016-10-05 | 2016-11-16 | Glaxosmithkline Biologicals Sa | Vaccine |
CN107951862B (zh) * | 2016-10-17 | 2021-03-12 | 南京绿叶制药有限公司 | 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法 |
US10925958B2 (en) | 2016-11-11 | 2021-02-23 | Modernatx, Inc. | Influenza vaccine |
WO2018091540A1 (en) | 2016-11-17 | 2018-05-24 | Glaxosmithkline Biologicals Sa | Zika viral antigen constructs |
EP3551230A1 (en) | 2016-12-08 | 2019-10-16 | CureVac AG | Rna for treatment or prophylaxis of a liver disease |
WO2018107088A2 (en) | 2016-12-08 | 2018-06-14 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
US11542490B2 (en) | 2016-12-08 | 2023-01-03 | CureVac SE | RNAs for wound healing |
WO2018115525A1 (en) | 2016-12-23 | 2018-06-28 | Curevac Ag | Lassa virus vaccine |
WO2018115527A2 (en) | 2016-12-23 | 2018-06-28 | Curevac Ag | Mers coronavirus vaccine |
US20190365665A1 (en) * | 2017-01-24 | 2019-12-05 | Nuvox Pharma Llc | Iso-osmotic and near iso-osmotic oxygen therapeutic formulations and methods thereof |
US11576961B2 (en) | 2017-03-15 | 2023-02-14 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
US11464848B2 (en) | 2017-03-15 | 2022-10-11 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
JP2020514370A (ja) | 2017-03-17 | 2020-05-21 | キュアバック アーゲー | 組合せ抗癌療法のためのrnaワクチン及び免疫チェックポイント阻害剤 |
MX2019011215A (es) | 2017-03-24 | 2020-02-12 | Curevac Ag | Ácidos nucleicos que codifican proteínas asociadas a crispr y usos de los mismos. |
US11504421B2 (en) | 2017-05-08 | 2022-11-22 | Gritstone Bio, Inc. | Alphavirus neoantigen vectors |
KR101950579B1 (ko) * | 2017-05-12 | 2019-02-20 | 고려대학교 산학협력단 | 이산화탄소 흡수제 및 그 제조 방법 |
WO2018213731A1 (en) | 2017-05-18 | 2018-11-22 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof |
EP4253544A3 (en) | 2017-05-18 | 2023-12-20 | ModernaTX, Inc. | Modified messenger rna comprising functional rna elements |
MA49395A (fr) | 2017-06-14 | 2020-04-22 | Modernatx Inc | Polynucléotides codant pour le facteur viii de coagulation |
WO2018232257A1 (en) * | 2017-06-15 | 2018-12-20 | Infectious Disease Research Institute | Nanostructured lipid carriers and stable emulsions and uses thereof |
JP2020530980A (ja) | 2017-07-04 | 2020-11-05 | キュアバック アーゲー | 新規核酸分子 |
CA3075549A1 (en) | 2017-09-13 | 2019-03-21 | Biontech Rna Pharmaceuticals Gmbh | Rna replicon for reprogramming somatic cells |
AU2018333530A1 (en) | 2017-09-13 | 2020-02-27 | Biontech Cell & Gene Therapies Gmbh | RNA replicon for expressing a T cell receptor or an artificial T cell receptor |
EP3681514A4 (en) | 2017-09-14 | 2021-07-14 | ModernaTX, Inc. | RNA VACZINE AGAINST ZIKA VIRUS |
EP3461497A1 (en) | 2017-09-27 | 2019-04-03 | GlaxoSmithKline Biologicals S.A. | Viral antigens |
MX2020003995A (es) | 2017-10-19 | 2020-07-22 | Curevac Ag | Nuevas moleculas de acido nucleico artificiales. |
WO2019094702A1 (en) | 2017-11-10 | 2019-05-16 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
EP3714048A1 (en) | 2017-11-22 | 2020-09-30 | Modernatx, Inc. | Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders |
MA50801A (fr) | 2017-11-22 | 2020-09-30 | Modernatx Inc | Polynucléotides codant pour la phénylalanine hydroxylase pour le traitement de la phénylcétonurie |
WO2019104195A1 (en) | 2017-11-22 | 2019-05-31 | Modernatx, Inc. | Polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits for the treatment of propionic acidemia |
US20200323975A1 (en) * | 2017-12-04 | 2020-10-15 | Intervet Inc. | Vaccination with replicon particles and oil adjuvant |
WO2019110067A1 (en) * | 2017-12-07 | 2019-06-13 | Aarhus Universitet | Hybrid nanoparticle |
KR20200118029A (ko) | 2018-01-04 | 2020-10-14 | 아이코닉 테라퓨틱스, 인코포레이티드 | 항-조직 인자 항체, 항체-약물 결합체, 및 관련 방법 |
MA51523A (fr) | 2018-01-05 | 2020-11-11 | Modernatx Inc | Polynucléotides codant pour des anticorps anti-virus du chikungunya |
EP3746090A4 (en) | 2018-01-29 | 2021-11-17 | ModernaTX, Inc. | RSV RNA Vaccines |
CN112088014A (zh) | 2018-02-28 | 2020-12-15 | 华盛顿大学 | 自组装纳米结构疫苗 |
US20210163928A1 (en) | 2018-04-11 | 2021-06-03 | Modernatx, Inc. | Messenger rna comprising functional rna elements |
WO2019226650A1 (en) | 2018-05-23 | 2019-11-28 | Modernatx, Inc. | Delivery of dna |
EP3581201A1 (en) | 2018-06-15 | 2019-12-18 | GlaxoSmithKline Biologicals S.A. | Escherichia coli o157:h7 proteins and uses thereof |
WO2020023390A1 (en) | 2018-07-25 | 2020-01-30 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
JP2021534182A (ja) | 2018-08-17 | 2021-12-09 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物及びその使用 |
WO2020047201A1 (en) | 2018-09-02 | 2020-03-05 | Modernatx, Inc. | Polynucleotides encoding very long-chain acyl-coa dehydrogenase for the treatment of very long-chain acyl-coa dehydrogenase deficiency |
US20220243182A1 (en) | 2018-09-13 | 2022-08-04 | Modernatx, Inc. | Polynucleotides encoding branched-chain alpha-ketoacid dehydrogenase complex e1-alpha, e1-beta, and e2 subunits for the treatment of maple syrup urine disease |
JP2022500436A (ja) | 2018-09-13 | 2022-01-04 | モダーナティエックス・インコーポレイテッドModernaTX, Inc. | 糖原病を処置するためのグルコース−6−ホスファターゼをコードするポリヌクレオチド |
WO2020056239A1 (en) | 2018-09-14 | 2020-03-19 | Modernatx, Inc. | Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome |
EP3856233A1 (en) | 2018-09-27 | 2021-08-04 | Modernatx, Inc. | Polynucleotides encoding arginase 1 for the treatment of arginase deficiency |
WO2020097409A2 (en) | 2018-11-08 | 2020-05-14 | Modernatx, Inc. | Use of mrna encoding ox40l to treat cancer in human patients |
US20220062439A1 (en) | 2019-01-10 | 2022-03-03 | Biontech Rna Pharmaceuticals Gmbh | Localized administration of rna molecules for therapy |
KR20210138569A (ko) | 2019-01-11 | 2021-11-19 | 아퀴타스 테라퓨틱스 인크. | 활성제의 지질 나노입자 전달을 위한 지질 |
CN109771373B (zh) * | 2019-01-23 | 2021-03-02 | 浙江工商大学 | 脂质体稳定的水包油Pickering乳液及其制备方法 |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
WO2020227642A1 (en) | 2019-05-08 | 2020-11-12 | Modernatx, Inc. | Compositions for skin and wounds and methods of use thereof |
MX2021014525A (es) | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
CA3142608A1 (en) | 2019-06-04 | 2020-12-10 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
US20220387628A1 (en) | 2019-06-24 | 2022-12-08 | Modernatx, Inc. | Messenger rna comprising functional rna elements and uses thereof |
WO2020263883A1 (en) | 2019-06-24 | 2020-12-30 | Modernatx, Inc. | Endonuclease-resistant messenger rna and uses thereof |
JP2022542032A (ja) | 2019-07-21 | 2022-09-29 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 治療用ウイルスワクチン |
US11679163B2 (en) | 2019-09-20 | 2023-06-20 | Hdt Bio Corp. | Compositions and methods for delivery of RNA |
CN110624472B (zh) * | 2019-09-28 | 2023-06-20 | 重庆威能钻井助剂有限公司 | 一种乳化剂及其制备方法和应用 |
EP3819377A1 (en) | 2019-11-08 | 2021-05-12 | Justus-Liebig-Universität Gießen | Circular rna and uses thereof for inhibiting rna-binding proteins |
CA3171231A1 (en) | 2020-03-09 | 2021-09-16 | Sean Michael Sullivan | Compositions and methods for inducing immune responses |
EP4126021A1 (en) | 2020-03-23 | 2023-02-08 | HDT Bio Corp. | Compositions and methods for delivery of rna |
EP4135761A1 (en) | 2020-04-16 | 2023-02-22 | GlaxoSmithKline Biologicals S.A. | Sars cov-2 spike protein construct |
JP2023527875A (ja) | 2020-06-01 | 2023-06-30 | モダーナティエックス・インコーポレイテッド | フェニルアラニンヒドロキシラーゼバリアント及びその使用 |
WO2021245090A1 (en) | 2020-06-04 | 2021-12-09 | BioNTech SE | Rna replicon for versatile and efficient gene expression |
WO2021245611A1 (en) | 2020-06-05 | 2021-12-09 | Glaxosmithkline Biologicals Sa | Modified betacoronavirus spike proteins |
WO2022002783A1 (en) | 2020-06-29 | 2022-01-06 | Glaxosmithkline Biologicals Sa | Adjuvants |
BR112023000327A2 (pt) | 2020-07-16 | 2023-01-31 | Acuitas Therapeutics Inc | Lipídeos catiônicos para o uso em nanopartículas lipídicas |
IL300026A (en) | 2020-08-06 | 2023-03-01 | Gritstone Bio Inc | Multiepitope vaccine cassettes |
US20230225970A1 (en) * | 2020-08-26 | 2023-07-20 | Canadian Nano Pharmaceutical Technology Inc. | Nano-Emulsion Based Compositions, Methods for Their Preparation and Their Use in Delivery of Active Ingredients |
AU2021377895A1 (en) | 2020-11-13 | 2023-06-15 | Modernatx, Inc. | Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis |
WO2022103967A1 (en) | 2020-11-13 | 2022-05-19 | Icosavax, Inc. | Protein-based nanoparticle vaccine for metapneumovirus |
EP4008785A1 (en) | 2020-12-03 | 2022-06-08 | Justus-Liebig-Universität Gießen | Circular nucleic acids and uses thereof for interfering with genome expression and proliferation of coronaviruses |
WO2022137128A2 (en) | 2020-12-23 | 2022-06-30 | Glaxosmithkline Biologicals Sa | Self-amplifying messenger rna |
US20220226465A1 (en) | 2021-01-18 | 2022-07-21 | ConserV Bioscience | Coronavirus Immunogenic Compositions, Methods and Uses Thereof |
EP4032546A1 (en) | 2021-01-20 | 2022-07-27 | GlaxoSmithKline Biologicals S.A. | Therapeutic viral vaccine |
WO2022204370A1 (en) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Lipid nanoparticles and polynucleotides encoding ornithine transcarbamylase for the treatment of ornithine transcarbamylase deficiency |
WO2022204369A1 (en) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia |
WO2022204390A1 (en) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof |
WO2022204371A1 (en) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof |
WO2022204380A1 (en) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof |
JP2024511206A (ja) | 2021-03-26 | 2024-03-12 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
WO2022248353A1 (en) | 2021-05-24 | 2022-12-01 | Glaxosmithkline Biologicals Sa | Adjuvants |
EP4352247A1 (en) | 2021-06-09 | 2024-04-17 | GlaxoSmithKline Biologicals s.a. | Release assay for determining potency of self-amplifying rna drug product and methods for using |
EP4355882A2 (en) | 2021-06-15 | 2024-04-24 | Modernatx, Inc. | Engineered polynucleotides for cell-type or microenvironment-specific expression |
WO2022271776A1 (en) | 2021-06-22 | 2022-12-29 | Modernatx, Inc. | Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome |
GB202110644D0 (en) * | 2021-07-23 | 2021-09-08 | Sisaf Ltd | Improved nucleic acid vector particles |
WO2023006999A2 (en) | 2021-07-30 | 2023-02-02 | CureVac SE | Mrnas for treatment or prophylaxis of liver diseases |
WO2023018345A1 (ru) * | 2021-08-09 | 2023-02-16 | Общество с ограниченной ответственностью "Научно-производственное объединение "Квантовые технологии" | Реагент для очистки сточных вод и способ его получения |
WO2023020994A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
WO2023020992A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
WO2023056044A1 (en) | 2021-10-01 | 2023-04-06 | Modernatx, Inc. | Polynucleotides encoding relaxin for the treatment of fibrosis and/or cardiovascular disease |
AU2022369342A1 (en) | 2021-10-18 | 2024-03-14 | BioNTech SE | Modified replicable rna and related compositions and their use |
CA3234214A1 (en) | 2021-10-18 | 2023-04-27 | BioNTech SE | Methods for determining mutations for increasing modified replicable rna function and related compositions and their use |
WO2023144193A1 (en) | 2022-01-25 | 2023-08-03 | CureVac SE | Mrnas for treatment of hereditary tyrosinemia type i |
WO2023161350A1 (en) | 2022-02-24 | 2023-08-31 | Io Biotech Aps | Nucleotide delivery of cancer therapy |
WO2023183909A2 (en) | 2022-03-25 | 2023-09-28 | Modernatx, Inc. | Polynucleotides encoding fanconi anemia, complementation group proteins for the treatment of fanconi anemia |
WO2023213378A1 (en) | 2022-05-02 | 2023-11-09 | BioNTech SE | Replicon compositions and methods of using same for the treatment of diseases |
WO2023225562A1 (en) | 2022-05-17 | 2023-11-23 | Icosavax, Inc. | Multivalent vaccine for paramyxoviruses and uses thereof |
US20230381303A1 (en) * | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid Nanoparticles for Delivery of Nucleic Acids and Methods of Use Thereof |
WO2024017479A1 (en) | 2022-07-21 | 2024-01-25 | BioNTech SE | Multifunctional cells transiently expressing an immune receptor and one or more cytokines, their use and methods for their production |
WO2024026254A1 (en) | 2022-07-26 | 2024-02-01 | Modernatx, Inc. | Engineered polynucleotides for temporal control of expression |
WO2024056856A1 (en) | 2022-09-15 | 2024-03-21 | BioNTech SE | Systems and compositions comprising trans-amplifying rna vectors with mirna |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA583561A (en) | 1959-09-22 | H. Edgerton William | Therapeutically valuable esters and methods for obtaining the same | |
US367363A (en) | 1887-08-02 | Joseph f | ||
US3130011A (en) | 1958-09-17 | 1964-04-21 | British Titan Products | Production of silicon halides |
FR1317586A (es) | 1961-03-17 | 1963-05-08 | ||
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
US4668777A (en) | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
US4373071A (en) | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
CA1341482C (en) | 1984-10-31 | 2005-05-10 | Paul A. Luciw | Process for preparing fragments of aids-associated retroviruses |
US4689225A (en) | 1984-11-02 | 1987-08-25 | Institut Merieux | Vaccine for cytomegalovirus |
US5153319A (en) | 1986-03-31 | 1992-10-06 | University Patents, Inc. | Process for preparing polynucleotides |
DK341386D0 (da) | 1986-07-18 | 1986-07-18 | Voetman Karin Glassau | Fremgangsmaade og apparat til oprulning af flade dejstykker, f.eks. til roulader |
DE3886363T3 (de) | 1987-11-18 | 2004-09-09 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | NANBV-Diagnostika |
WO1989007143A1 (en) | 1988-01-29 | 1989-08-10 | Chiron Corporation | Recombinant cmv neutralizing proteins |
US5262530A (en) | 1988-12-21 | 1993-11-16 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
US5047524A (en) | 1988-12-21 | 1991-09-10 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
KR0185373B1 (ko) | 1989-03-17 | 1999-05-01 | 로버트 피. 블랙버언 | Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용 |
CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
EP0702516A4 (en) | 1993-06-01 | 1998-04-22 | Life Technologies Inc | GENETIC IMMUNIZATION WITH CATIONIC LIPIDS |
US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
EP0833613A1 (en) * | 1995-05-26 | 1998-04-08 | Somatix Therapy Corporation | Delivery vehicles comprising stable lipid/nucleic acid complexes |
US5654452A (en) * | 1995-06-07 | 1997-08-05 | Molecular Biosystems, Inc. | Lipophilic contrast agents for use in hepatocyte-selective oil-in-water emulsions |
US6120794A (en) | 1995-09-26 | 2000-09-19 | University Of Pittsburgh | Emulsion and micellar formulations for the delivery of biologically active substances to cells |
US6451592B1 (en) | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
DE69738521T2 (de) | 1996-04-05 | 2009-05-07 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Alphaviren-vektors mit einer reduzierten inhibierung der synthese von zellmakromolekülen |
EP0910343A1 (en) | 1996-07-03 | 1999-04-28 | University Of Pittsburgh | Emulsion formulations for hydrophilic active agents |
ATE395904T1 (de) | 1996-09-13 | 2008-06-15 | Lipoxen Technologies Ltd | Liposome |
US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
JP2002509545A (ja) | 1997-07-08 | 2002-03-26 | カイロン コーポレイション | Dnaワクチンを伴うサブミクロン水中油型エマルジョンの使用 |
ATE215385T1 (de) | 1997-12-16 | 2002-04-15 | Chiron Corp | Verwendung von mikropartikeln mit submikron öl/wasser emulsionen |
WO2000006120A1 (en) * | 1998-07-31 | 2000-02-10 | Korea Institute Of Science And Technology | Lipid emulsion and solid lipid nanoparticle as a gene or drug carrier |
US6770282B1 (en) | 1998-10-23 | 2004-08-03 | Heska Corporation | Cationic lipid-mediated enhancement of nucleic acid immunization of cats |
WO2000050006A2 (en) * | 1999-02-26 | 2000-08-31 | Chiron Corporation | Microemulsions with adsorbed macromoelecules and microparticles |
GB0012597D0 (en) * | 2000-05-25 | 2000-07-12 | Astrazeneca Ab | Formulation |
ATE350015T1 (de) | 2000-09-28 | 2007-01-15 | Novartis Vaccines & Diagnostic | Mikropartikelzusammensetzungen und verfahren zu ihrer herstellung |
SG137691A1 (en) | 2000-09-28 | 2007-12-28 | Chiron Corp | Microparticles for delivery of the heterologous nucleic acids |
US20030077829A1 (en) | 2001-04-30 | 2003-04-24 | Protiva Biotherapeutics Inc.. | Lipid-based formulations |
AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
JP2005510244A (ja) * | 2001-11-26 | 2005-04-21 | ザ・ユニヴァーシティ・オヴ・クイーンズランド | フラビウイルスワクチン送達系 |
US6861410B1 (en) | 2002-03-21 | 2005-03-01 | Chiron Corporation | Immunological adjuvant compositions |
US20060189554A1 (en) | 2002-09-24 | 2006-08-24 | Russell Mumper | Nanoparticle-Based vaccine delivery system containing adjuvant |
DK2311848T3 (da) | 2002-12-23 | 2013-10-14 | Vical Inc | Kodon-optimerede polynukleotidbaserede vacciner mod human cytomegalovirus-infektion |
RU2364419C2 (ru) * | 2003-04-25 | 2009-08-20 | Новартис Вэксинес Энд Дайэгностикс, Инк. | Композиции, содержащие катионные микрочастицы и днк hcv е1е2, и способы их применения |
NZ592917A (en) | 2003-09-15 | 2012-12-21 | Protiva Biotherapeutics Inc | Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates |
US7303881B2 (en) | 2004-04-30 | 2007-12-04 | Pds Biotechnology Corporation | Antigen delivery compositions and methods of use |
AU2005248361B2 (en) | 2004-05-18 | 2010-03-11 | Vical Incorporated | Influenza virus vaccine composition and methods of use |
CA2572439A1 (en) | 2004-07-02 | 2006-01-12 | Protiva Biotherapeutics, Inc. | Immunostimulatory sirna molecules and uses therefor |
US7749520B2 (en) * | 2004-07-07 | 2010-07-06 | Statens Serum Institut | Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids |
FR2885813B1 (fr) * | 2005-05-19 | 2008-01-11 | Oreal | Vectorisation de dsrna par des particules cationiques et leur utilisation sur modele de peau. |
ES2367194T3 (es) * | 2005-11-04 | 2011-10-31 | Novartis Vaccines And Diagnostics S.R.L. | Cambio del equilibrio th1/th2 en vacunas contra la gripe fraccionadas con adyuvantes. |
US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
HUE034483T2 (en) * | 2008-04-15 | 2018-02-28 | Protiva Biotherapeutics Inc | New lipid preparations for introducing a nucleic acid |
CA2721366C (en) | 2008-04-17 | 2017-06-06 | Elizabeth Ann Vasievich | Stimulation of an immune response by enantiomers of cationic lipids |
WO2009149418A2 (en) * | 2008-06-06 | 2009-12-10 | Asuragen, Inc. | Novel compositions for the in vivo delivery of rnai agents |
JP5781929B2 (ja) | 2008-07-15 | 2015-09-24 | ノバルティス アーゲー | 免疫原性の両親媒性ペプチド組成物 |
EP2451475A2 (en) | 2009-07-06 | 2012-05-16 | Novartis AG | Self replicating rna molecules and uses thereof |
US20110200582A1 (en) | 2009-12-23 | 2011-08-18 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
CN102792149B (zh) | 2010-03-12 | 2015-05-20 | 柯尼卡美能达先进多层薄膜株式会社 | 分子间相互作用的检测方法及其检测装置 |
LT4005592T (lt) | 2010-07-06 | 2023-01-10 | Glaxosmithkline Biologicals S.A. | Viriono tipo tiekimo dalelės, skirtos savaime besireplikuojančioms rnr molekulėms |
AU2011276236B2 (en) | 2010-07-06 | 2016-03-10 | Glaxosmithkline Biologicals S.A. | Cationic oil-in-water emulsions |
JP6136343B2 (ja) | 2012-06-12 | 2017-05-31 | 株式会社リコー | 情報処理システム、情報処理方法、プログラム、及び記録媒体 |
-
2011
- 2011-07-06 AU AU2011276236A patent/AU2011276236B2/en active Active
- 2011-07-06 RU RU2013104870A patent/RU2625546C2/ru active
- 2011-07-06 CN CN201810021419.3A patent/CN108042799A/zh active Pending
- 2011-07-06 MX MX2013000171A patent/MX343410B/es active IP Right Grant
- 2011-07-06 NZ NZ606591A patent/NZ606591A/en not_active IP Right Cessation
- 2011-07-06 BR BR112013000391A patent/BR112013000391B8/pt active IP Right Grant
- 2011-07-06 CA CA2804591A patent/CA2804591C/en active Active
- 2011-07-06 JP JP2013518815A patent/JP6025721B2/ja active Active
- 2011-07-06 ES ES11738344.8T patent/ES2649896T3/es active Active
- 2011-07-06 EP EP11738344.8A patent/EP2590625B1/en active Active
- 2011-07-06 CN CN2011800427868A patent/CN103327963A/zh active Pending
- 2011-07-06 EP EP17191981.4A patent/EP3449910A1/en not_active Withdrawn
- 2011-07-06 WO PCT/US2011/043108 patent/WO2012006380A2/en active Application Filing
- 2011-09-18 US US13/235,454 patent/US9295646B2/en active Active
-
2016
- 2016-03-11 US US15/067,216 patent/US10238733B2/en active Active
- 2016-09-05 JP JP2016172965A patent/JP2016204389A/ja not_active Withdrawn
-
2019
- 2019-03-07 US US16/295,563 patent/US11135287B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2011276236A1 (en) | 2013-02-21 |
US20120156251A1 (en) | 2012-06-21 |
MX2013000171A (es) | 2013-03-05 |
US20160256541A1 (en) | 2016-09-08 |
JP2016204389A (ja) | 2016-12-08 |
NZ606591A (en) | 2015-02-27 |
BR112013000391B8 (pt) | 2022-10-04 |
US11135287B2 (en) | 2021-10-05 |
US10238733B2 (en) | 2019-03-26 |
EP3449910A1 (en) | 2019-03-06 |
EP2590625B1 (en) | 2017-09-20 |
CA2804591A1 (en) | 2012-01-12 |
RU2013104870A (ru) | 2014-08-20 |
WO2012006380A3 (en) | 2012-07-05 |
WO2012006380A2 (en) | 2012-01-12 |
CN103327963A (zh) | 2013-09-25 |
JP2013531680A (ja) | 2013-08-08 |
US20190262448A1 (en) | 2019-08-29 |
CN108042799A (zh) | 2018-05-18 |
BR112013000391B1 (pt) | 2020-12-15 |
EP2590625A2 (en) | 2013-05-15 |
RU2625546C2 (ru) | 2017-07-14 |
AU2011276236B2 (en) | 2016-03-10 |
BR112013000391A2 (pt) | 2016-06-07 |
JP6025721B2 (ja) | 2016-11-16 |
US9295646B2 (en) | 2016-03-29 |
ES2649896T3 (es) | 2018-01-16 |
CA2804591C (en) | 2019-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX343410B (es) | Emulsiones cationicas de agua en aceite. | |
MX350258B (es) | Emulsiones cationicas de aceite en agua. | |
MX350198B (es) | Emulsiones aceite en agua que contienen acidos nucleicos. | |
AU2017279565B2 (en) | RNA formulation for immunotherapy | |
EP4303229A3 (en) | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules | |
MX2018016389A (es) | Composiciones y metodos para suministro de arn mensajero. | |
CL2013003123A1 (es) | Molécula de nucleasa híbrida; composición que comprende dicha molécula; método para preparar dicha molécula; método para tratar lupus eritematoso sistémico. | |
MX2014000053A (es) | Liposomas con relacion nitrogeno:fosfato (n:p) util para el suministro de moleculas de arn. | |
HK1198538A1 (en) | Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof | |
BR112014026990A2 (pt) | anticorpo , ácido nucleico , vetores , célula hospedeira , composição farmacêutica , uso de um anticorpo e método para o tratamento de um paciente com necessidade de terapia. | |
MX2015014423A (es) | Administración efectiva de genes grandes por vectores aav duales. | |
EP2994167A4 (en) | ASSAYS AND METHODS FOR ADMINISTERING LIPID-FORMULATED NUCLEIC ACID MOLECULES | |
MX2022006512A (es) | Lipidos cationicos de trialquilo y metodos de uso de los mismos. | |
BR112013008700B8 (pt) | Molécula de rna auto-replicante, partícula de replicon de alfavírus, composição, molécula de dna recombinante, uso da molécula de rna auto-replicante | |
AR090903A1 (es) | Anticuerpos e inmunoconjugados anti-pmel17 | |
EP3563865A3 (en) | Prostate-associated antigens and vaccine-based immunotherapy regimens | |
EP2638055A4 (en) | PROSTATE CONSENSUS ANTIGENS, NUCLEIC ACID MOLECULE ENCODING THEREOF, AND VACCINE AND USES THEREOF | |
AR089752A1 (es) | Anticuerpos anti-lrp5 y metodos de uso | |
EP3698631A3 (en) | Methods of delivering oligonucleotides to immune cells | |
AR088322A1 (es) | Anticuerpos anti-htra1 y metodos de uso | |
WO2013170170A3 (en) | Compositions and methods for gene therapy | |
WO2014070687A3 (en) | Polycationic methyl phospholipids for improved delivery of nucleic acids to eukaryotic cells | |
AR079704A1 (es) | Anticuerpos anti-bv8 y sus usos | |
WO2013084071A3 (en) | Clostridium difficile toxin-based vaccine | |
WO2013177593A3 (en) | Identification of mhc class i phospho-peptide antigens from breast cancer utilizing shla technology and complementary enrichment strategies |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |