DE3876039D1 - Verfahren zur herstellung von optisch aktiven verbindungen mit pyridin-kernen. - Google Patents

Verfahren zur herstellung von optisch aktiven verbindungen mit pyridin-kernen.

Info

Publication number
DE3876039D1
DE3876039D1 DE8888112789T DE3876039T DE3876039D1 DE 3876039 D1 DE3876039 D1 DE 3876039D1 DE 8888112789 T DE8888112789 T DE 8888112789T DE 3876039 T DE3876039 T DE 3876039T DE 3876039 D1 DE3876039 D1 DE 3876039D1
Authority
DE
Germany
Prior art keywords
optically active
active connections
producing optically
cores
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888112789T
Other languages
English (en)
Other versions
DE3876039T2 (de
Inventor
Masakazu Kaneoya
Naoyuki Yoshida
Manabu Uchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JNC Corp
Original Assignee
Chisso Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chisso Corp filed Critical Chisso Corp
Application granted granted Critical
Publication of DE3876039D1 publication Critical patent/DE3876039D1/de
Publication of DE3876039T2 publication Critical patent/DE3876039T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
DE8888112789T 1987-08-28 1988-08-05 Verfahren zur herstellung von optisch aktiven verbindungen mit pyridin-kernen. Expired - Fee Related DE3876039T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62212674A JP2691986B2 (ja) 1987-08-28 1987-08-28 ピリジン骨格を有する光学活性化合物の製造法

Publications (2)

Publication Number Publication Date
DE3876039D1 true DE3876039D1 (de) 1992-12-24
DE3876039T2 DE3876039T2 (de) 1993-04-22

Family

ID=16626522

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888112789T Expired - Fee Related DE3876039T2 (de) 1987-08-28 1988-08-05 Verfahren zur herstellung von optisch aktiven verbindungen mit pyridin-kernen.

Country Status (4)

Country Link
US (1) US4971909A (de)
EP (1) EP0304706B1 (de)
JP (1) JP2691986B2 (de)
DE (1) DE3876039T2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2578658B2 (ja) * 1989-02-21 1997-02-05 チッソ株式会社 光学活性化合物及びその製造法
JP2542941B2 (ja) * 1990-02-02 1996-10-09 チッソ株式会社 光学活性ヒドロキシラクトン類の製造方法
US5126267A (en) * 1990-03-30 1992-06-30 Eastman Kodak Company Protected hydroxy method for alcohol-ester separation
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
WO1994005637A1 (en) * 1992-08-31 1994-03-17 Mercian Corporation Optically active 1,4-dihydropyridine compound and process for producing the same
AT401385B (de) * 1994-03-30 1996-08-26 Chemie Linz Gmbh Enzymatische racematspaltung asymmetrischer alkohole mittels vinylestern mehrbasiger carbonsäuren
DE4414273A1 (de) * 1994-04-23 1995-10-26 Chemie Linz Deutschland Enzymatische Racematspaltung asymmetrischer Alkohole mittels Vinylestern mehrbasiger Carbonsäuren
US5702928A (en) * 1994-07-18 1997-12-30 Daicel Chemical Industries, Ltd. Process for producing optically active triazole compounds and method of racemizing optically active triazole compounds
DE19809649A1 (de) * 1998-03-06 1999-09-09 Hoechst Marion Roussel De Gmbh Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester
RU2717829C2 (ru) 2015-04-20 2020-03-26 Толеро Фармасьютикалз, Инк. Прогнозирование ответа на альвоцидиб с помощью анализа профиля митохондрий
DK3298021T3 (da) 2015-05-18 2019-08-05 Tolero Pharmaceuticals Inc Alvocidib-prodrugs, der har øget biotilgængelighed
KR20180034538A (ko) 2015-08-03 2018-04-04 톨레로 파마수티컬스, 인크. 암의 치료를 위한 병행 요법
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
EP3762368B1 (de) 2018-03-08 2022-01-26 Incyte Corporation Aminopyrazindiolverbindungen als pi3k-y-hemmer
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
CA3119807A1 (en) 2018-12-04 2020-06-11 Sumitomo Dainippon Pharma Oncology, Inc. Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
JP2022525149A (ja) 2019-03-20 2022-05-11 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU587366B2 (en) * 1983-07-27 1989-08-17 Imperial Chemical Industries Plc Process for producing optically active aryloxypropionic acids and derivatives thereof
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds

Also Published As

Publication number Publication date
EP0304706B1 (de) 1992-11-19
EP0304706A3 (en) 1990-07-04
EP0304706A2 (de) 1989-03-01
US4971909A (en) 1990-11-20
JP2691986B2 (ja) 1997-12-17
JPS6460398A (en) 1989-03-07
DE3876039T2 (de) 1993-04-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee