DE3778253D1 - Verfahren zum kalibrieren von durchflusszytometriegeraeten. - Google Patents
Verfahren zum kalibrieren von durchflusszytometriegeraeten.Info
- Publication number
- DE3778253D1 DE3778253D1 DE8787306145T DE3778253T DE3778253D1 DE 3778253 D1 DE3778253 D1 DE 3778253D1 DE 8787306145 T DE8787306145 T DE 8787306145T DE 3778253 T DE3778253 T DE 3778253T DE 3778253 D1 DE3778253 D1 DE 3778253D1
- Authority
- DE
- Germany
- Prior art keywords
- light
- signal
- instrument
- passing
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002245 particle Substances 0.000 abstract 7
- 238000000926 separation method Methods 0.000 abstract 4
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000000684 flow cytometry Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1012—Calibrating particle analysers; References therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1012—Calibrating particle analysers; References therefor
- G01N2015/1014—Constitution of reference particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1477—Multiparameters
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/901,860 US4704891A (en) | 1986-08-29 | 1986-08-29 | Method and materials for calibrating flow cytometers and other analysis instruments |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3778253D1 true DE3778253D1 (de) | 1992-05-21 |
Family
ID=25414938
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787306145T Expired - Lifetime DE3778253D1 (de) | 1986-08-29 | 1987-07-10 | Verfahren zum kalibrieren von durchflusszytometriegeraeten. |
DE8787306143T Expired - Lifetime DE3781855T2 (de) | 1986-08-29 | 1987-07-10 | Mittel zum kalibrieren von durchflusszytometriegeraeten und anderen analysevorrichtungen. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787306143T Expired - Lifetime DE3781855T2 (de) | 1986-08-29 | 1987-07-10 | Mittel zum kalibrieren von durchflusszytometriegeraeten und anderen analysevorrichtungen. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4704891A (de) |
EP (3) | EP0258983B1 (de) |
JP (3) | JPS6363942A (de) |
AT (2) | ATE75042T1 (de) |
DE (2) | DE3778253D1 (de) |
ES (2) | ES2035068T3 (de) |
GR (2) | GR3004885T3 (de) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK164144C (da) * | 1988-11-17 | 1992-10-12 | Slagteriernes Forskningsinst | Fremgangsmaade ved kontrol eller justering af maaleapparater med en optisk sonde og medium til anvendelse ved fremgangsmaaden |
CA2021658C (en) * | 1989-08-25 | 2001-10-09 | Myron J. Block | Multiplex immunoassay system |
US5853984A (en) * | 1990-06-11 | 1998-12-29 | Nexstar Pharmaceuticals, Inc. | Use of nucleic acid ligands in flow cytometry |
IE76732B1 (en) * | 1990-08-07 | 1997-11-05 | Becton Dickinson Co | One step test for absolute counts |
JP2913219B2 (ja) * | 1991-03-06 | 1999-06-28 | 株式会社シマ研究所 | 尿沈渣検査成績管理方法 |
WO1993005478A1 (en) * | 1991-08-28 | 1993-03-18 | Becton, Dickinson & Company | Gravitational attractor engine for adaptively autoclustering n-dimensional data streams |
US5451525A (en) * | 1992-02-14 | 1995-09-19 | Coulter Corporation | Method and materials for determining particle count in a flow cytometer |
DE69326731T2 (de) | 1992-09-04 | 2000-05-18 | Becton Dickinson And Co., Franklin Lakes | Kontroll-Teilchen für die Zellzählung und Instrumentenlinearität |
US5620842A (en) * | 1995-03-29 | 1997-04-15 | Becton Dickinson And Company | Determination of the number of fluorescent molecules on calibration beads for flow cytometry |
JP3875754B2 (ja) * | 1995-11-17 | 2007-01-31 | シスメックス株式会社 | フローサイトメータ用標準液 |
US6014904A (en) * | 1996-05-09 | 2000-01-18 | Becton, Dickinson And Company | Method for classifying multi-parameter data |
DE69830598T2 (de) | 1997-01-31 | 2006-05-18 | The Horticulture And Food Research Institute Of New Zealand Limited | Optische vorrichtung und methode |
US6074879A (en) | 1997-06-23 | 2000-06-13 | Bayer Corporation | Synthetic polymer particles for use as standards and calibrators in flow cytometry |
US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
US6197520B1 (en) * | 1999-08-13 | 2001-03-06 | University Of Utah Research Foundation | Solution-based color compensation adjusted for temperature and electronic gains |
US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
JP2004501358A (ja) | 2000-05-11 | 2004-01-15 | ベクトン・ディキンソン・アンド・カンパニー | 最適な境界を有する平滑化された多角形を使用して散布図中のクラスタを識別するシステム |
US6809804B1 (en) | 2000-05-11 | 2004-10-26 | Becton, Dickinson And Company | System and method for providing improved event reading and data processing capabilities in a flow cytometer |
BRPI0115791B1 (pt) | 2000-11-29 | 2020-05-05 | Colorado State Univ | sistema para fertilização in vitro com espematozóides separados em populações portadoras de cromossoma x e cromossoma y |
US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
EP1545203B1 (de) | 2002-08-01 | 2016-10-19 | Xy, Llc | Mit niederdruck arbeitendes spermazellentrennsystem |
US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
WO2004017041A2 (en) | 2002-08-15 | 2004-02-26 | Xy, Inc. | High resolution flow cytometer |
US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
EP2305172B1 (de) | 2003-03-28 | 2016-05-11 | Inguran, LLC | Vorrichtung und Verfahren zur Bereitstellung von geschlechtssortierten Tierspermien |
CA2566749C (en) | 2003-05-15 | 2017-02-21 | Xy, Inc. | Efficient haploid cell sorting for flow cytometer systems |
KR101166180B1 (ko) * | 2003-08-13 | 2012-07-18 | 루미넥스 코포레이션 | 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법 |
JP4850711B2 (ja) * | 2003-10-02 | 2012-01-11 | ベックマン コールター, インコーポレイテッド | 血液サンプルの有核赤血球の光学測定のリファレンスコントロール |
EP2151243B1 (de) | 2004-03-29 | 2012-10-24 | Inguran, LLC | Spermasuspensionen zur Sortierung in X- oder Y-Chromosomen-tragende angereicherte Populationen |
WO2006012597A2 (en) | 2004-07-22 | 2006-02-02 | Monsanto Technology Llc | Process for enriching a population of sperm cells |
DE102004044717B8 (de) * | 2004-09-10 | 2010-12-16 | BAM Bundesanstalt für Materialforschung und -prüfung | Verfahren und Kit zur Kalibrierung eines Photolumineszenzmesssystems |
EP1744145B1 (de) | 2005-07-12 | 2015-09-09 | Sysmex Corporation | Standardmaterial für ein Teilchenanalysegerät |
JP4953710B2 (ja) * | 2005-07-12 | 2012-06-13 | シスメックス株式会社 | 尿中有形成分分析装置用標準物質 |
JP4748719B2 (ja) * | 2006-03-02 | 2011-08-17 | 国立大学法人大阪大学 | 生細胞内の特定タンパク質の定量方法および標準蛍光マイクロビーズの作製方法 |
CN100386054C (zh) * | 2006-04-24 | 2008-05-07 | 西安交通大学 | 用于脉搏血氧仿真器的光散射介质及制备方法 |
EP2029999A2 (de) * | 2006-05-13 | 2009-03-04 | Dako Denmark A/S | Verfahren für durchflusszytometrie-analysen von zellen ohne lysieren von subpopulationen |
JP5010443B2 (ja) * | 2006-12-20 | 2012-08-29 | シスメックス株式会社 | 血球分析装置および血球分析方法 |
CN101226190B (zh) * | 2007-01-17 | 2013-07-03 | 深圳迈瑞生物医疗电子股份有限公司 | 流式细胞术的自动分类方法和装置 |
DE102007014413B4 (de) * | 2007-03-17 | 2016-02-04 | DüRR DENTAL AG | Verfahren zum Auswerten von Fluoreszenzbildsätzen und Vorrichtung zu seiner Durchführung |
US8102528B2 (en) * | 2007-09-13 | 2012-01-24 | Brightwell Technologies Inc. | Particle standard and method of calibrating or validating an optical particle analyzer |
WO2009042423A1 (en) * | 2007-09-27 | 2009-04-02 | Cellatope Corporation | Methods and compositions for improved diagnostic assays |
US8187885B2 (en) * | 2009-05-07 | 2012-05-29 | Nodality, Inc. | Microbead kit and method for quantitative calibration and performance monitoring of a fluorescence instrument |
US20120065092A1 (en) | 2010-09-14 | 2012-03-15 | Wai Hobert | Fusion analyte cytometric bead assay, and systems and kits for performing the same |
WO2012054783A2 (en) * | 2010-10-21 | 2012-04-26 | Nexcelom Bioscience Llc | Internal focus reference beads for imaging cytometry |
WO2012065004A2 (en) | 2010-11-12 | 2012-05-18 | Incelldx, Inc. | Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (cin) lesion from a suspension sample of cervical cells |
JP2013146263A (ja) * | 2011-12-21 | 2013-08-01 | Azbil Corp | 微生物検出装置の校正方法、及び微生物検出装置の校正キット |
EP2802871B1 (de) | 2012-01-11 | 2022-07-27 | Takeda Pharmaceutical Company Limited | Charakterisierung nicht-sichtbarer partikel mit hilfe eines partikelanalysators |
GB2499796B (en) | 2012-02-28 | 2016-06-15 | Ojk Consulting Ltd | Method and system for calibrating a flow cytometer |
US20150177115A1 (en) | 2012-04-06 | 2015-06-25 | Slingshot Biosciences | Hydrogel particles with tunable optical properties |
ITTV20130026A1 (it) * | 2013-02-27 | 2014-08-28 | Texa Spa | Metodo e sistema per calibrare uno strumento analizzatore di particolato di un gas |
WO2015000014A1 (en) | 2013-07-01 | 2015-01-08 | Newsouth Innovations Pty Limited | Diagnosis and treatment of autoimmune diseases |
ES2954937T3 (es) | 2014-12-04 | 2023-11-27 | Becton Dickinson Co | Sistemas de clasificación de células por citometría de flujo y métodos de uso de los mismos |
US9709769B2 (en) | 2014-12-10 | 2017-07-18 | Becton, Dickinson And Company | Methods for optically aligning light collection components and optically aligned light collection systems thereof |
KR102656644B1 (ko) | 2015-02-09 | 2024-04-09 | 슬링샷 바이오사이언시즈 인코포레이티드 | 튜닝가능한 광 특성을 갖는 하이드로겔 입자 및 이를 사용하기 위한 방법 |
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US9719998B2 (en) | 2015-03-12 | 2017-08-01 | Becton Dickinson And Company | Ultraviolet absorbing polymeric dyes and methods for using the same |
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CN108474728B (zh) | 2015-10-13 | 2022-04-26 | 贝克顿·迪金森公司 | 多模态荧光成像流式细胞术*** |
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EP3426296A4 (de) | 2016-03-10 | 2019-11-20 | Becton, Dickinson and Company | Verfahren zur bewertung einer zellulären probe für her-2/neu-expression und zusammensetzungen zur durchführung davon |
JP6237806B2 (ja) * | 2016-03-16 | 2017-11-29 | ソニー株式会社 | 微小粒子分取装置 |
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CN105928753B (zh) * | 2016-04-18 | 2019-01-15 | 中国科学院苏州生物医学工程技术研究所 | 流式细胞仪校准用鸡红细胞的制备方法 |
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US10935485B2 (en) | 2016-05-12 | 2021-03-02 | Bd Biosciences | Fluorescence imaging flow cytometry with enhanced image resolution |
US10604657B2 (en) | 2016-07-07 | 2020-03-31 | Becton, Dickinson And Company | Fluorescent water-solvated conjugated polymers |
EP4242631A3 (de) | 2016-09-13 | 2024-03-06 | Becton, Dickinson and Company | Durchflusszytometer mit optischer entzerrung |
KR102416357B1 (ko) | 2016-10-03 | 2022-07-04 | 벡톤 디킨슨 앤드 컴퍼니 | 유세포측정기 내 유동 흐름의 드롭 지연을 결정하기 위한 방법 및 시스템 |
US10684275B2 (en) | 2016-12-14 | 2020-06-16 | Becton, Dickinson And Company | Methods and compositions for obtaining a tuberculosis assessment in a subject |
CA3052595A1 (en) | 2017-02-08 | 2018-08-16 | Becton, Dickinson And Company | Dried dye reagent devices and methods for making and using the same |
SG11201907605YA (en) | 2017-02-27 | 2019-09-27 | Becton Dickinson Co | Light detection systems and methods for using thereof |
JP6955385B2 (ja) * | 2017-07-14 | 2021-10-27 | 株式会社堀場製作所 | 粒子分析装置における光照射を調整するためのモニター装置 |
BR112020013841A2 (pt) | 2018-01-23 | 2020-12-01 | Becton, Dickinson And Company | sistemas para obscuração dinâmica de detecção de luz e métodos para uso dos mesmos |
US10844228B2 (en) | 2018-03-30 | 2020-11-24 | Becton, Dickinson And Company | Water-soluble polymeric dyes having pendant chromophores |
CN112136034A (zh) | 2018-04-27 | 2020-12-25 | 贝克顿·迪金森公司 | 用于流式细胞术分选样品的收集***及其使用方法 |
WO2019245709A1 (en) | 2018-06-19 | 2019-12-26 | Becton, Dickinson And Company | Variable multiplexing switches for detector arrays, systems and methods of use thereof |
WO2020197787A1 (en) | 2019-03-22 | 2020-10-01 | Becton, Dickinson And Company | Spectral unmixing of fluorescence imaging using radiofrequency-multiplexed excitation data |
EP4094064A4 (de) | 2020-01-24 | 2024-02-28 | Slingshot Biosciences, Inc. | Zusammensetzungen und verfahren für zellähnliche kalibrierungspartikel |
US20210263019A1 (en) | 2020-02-25 | 2021-08-26 | Becton, Dickinson And Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
WO2021226036A1 (en) | 2020-05-04 | 2021-11-11 | Slingshot Biosciences, Inc. | Compositions and methods for passive optical barcoding for multiplexed assays |
EP4155349A1 (de) | 2021-09-24 | 2023-03-29 | Becton, Dickinson and Company | Wasserlösliche gelbe grünabsorbierende farbstoffe |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3406121A (en) * | 1965-10-01 | 1968-10-15 | Dade Reagents Inc | Blood cell counting standard and method of preparing the same |
US3412037A (en) * | 1966-01-26 | 1968-11-19 | Technicon Corp | Method and means for the calibration of particle counting apparatus |
US3791517A (en) * | 1973-03-05 | 1974-02-12 | Bio Physics Systems Inc | Digital fluidic amplifier particle sorter |
US4135821A (en) * | 1977-03-22 | 1979-01-23 | The United States Of America As Represented By The United States Department Of Energy | Calibration of optical particle-size analyzer |
US4331862A (en) * | 1979-02-23 | 1982-05-25 | Ryan Wayne L | Method for calibrating a particle counting machine and a calibration standard therefor |
US4380392A (en) * | 1981-03-18 | 1983-04-19 | Karabegov Mikhail A | Method and apparatus for calibration of instruments serving to count and to determine the size of particles suspended in dispersion medium |
US4438390A (en) * | 1981-03-23 | 1984-03-20 | Coulter Electronics, Inc. | Tandem sensing zones for improved signal-to-noise ratio in particle analyzer |
US4434647A (en) * | 1981-07-27 | 1984-03-06 | Lockheed Corporation | Dynamic spot calibration for automatic particle counters |
US4475236A (en) * | 1981-11-12 | 1984-10-02 | Ortho Diagnostic Systems Inc. | Method for counting overlapping cell populations in a distribution histogram |
US4499052A (en) * | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
JPS59184862A (ja) * | 1983-04-05 | 1984-10-20 | ベクトン・ディッキンソン・アンド・カンパニ− | 試料内細胞の複数副次集団を識別する方法と装置 |
US4596464A (en) * | 1983-10-14 | 1986-06-24 | Ortho Diagnostic Systems, Inc. | Screening method for red cell abnormality |
-
1986
- 1986-08-29 US US06/901,860 patent/US4704891A/en not_active Expired - Lifetime
-
1987
- 1987-07-10 AT AT87306145T patent/ATE75042T1/de not_active IP Right Cessation
- 1987-07-10 EP EP87306145A patent/EP0258983B1/de not_active Expired - Lifetime
- 1987-07-10 EP EP87306144A patent/EP0257759A3/de not_active Withdrawn
- 1987-07-10 EP EP87306143A patent/EP0258982B1/de not_active Expired - Lifetime
- 1987-07-10 AT AT87306143T patent/ATE80947T1/de not_active IP Right Cessation
- 1987-07-10 ES ES198787306143T patent/ES2035068T3/es not_active Expired - Lifetime
- 1987-07-10 ES ES198787306145T patent/ES2031507T3/es not_active Expired - Lifetime
- 1987-07-10 DE DE8787306145T patent/DE3778253D1/de not_active Expired - Lifetime
- 1987-07-10 DE DE8787306143T patent/DE3781855T2/de not_active Expired - Lifetime
- 1987-08-28 JP JP62214975A patent/JPS6363942A/ja active Granted
- 1987-11-06 JP JP62280840A patent/JPS63171343A/ja active Granted
- 1987-11-06 JP JP62280841A patent/JPS63177038A/ja active Granted
-
1992
- 1992-06-11 GR GR920401228T patent/GR3004885T3/el unknown
- 1992-12-02 GR GR920402771T patent/GR3006407T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE3781855T2 (de) | 1993-04-29 |
GR3004885T3 (de) | 1993-04-28 |
ES2035068T3 (es) | 1993-04-16 |
US4704891A (en) | 1987-11-10 |
EP0258982B1 (de) | 1992-09-23 |
JPH0350212B2 (de) | 1991-08-01 |
JPS6363942A (ja) | 1988-03-22 |
ES2031507T3 (es) | 1992-12-16 |
JPS63177038A (ja) | 1988-07-21 |
EP0258983B1 (de) | 1992-04-15 |
EP0258982A3 (en) | 1989-10-25 |
EP0258983A3 (en) | 1989-09-13 |
ATE80947T1 (de) | 1992-10-15 |
JPH0435709B2 (de) | 1992-06-11 |
EP0258983A2 (de) | 1988-03-09 |
GR3006407T3 (de) | 1993-06-21 |
ATE75042T1 (de) | 1992-05-15 |
EP0257759A2 (de) | 1988-03-02 |
DE3781855D1 (de) | 1992-10-29 |
EP0258982A2 (de) | 1988-03-09 |
JPH0350211B2 (de) | 1991-08-01 |
JPS63171343A (ja) | 1988-07-15 |
EP0257759A3 (de) | 1989-10-18 |
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