DE3615180C2 - Disubstituierte 1,4-Piperazinylderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel - Google Patents

Disubstituierte 1,4-Piperazinylderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel

Info

Publication number
DE3615180C2
DE3615180C2 DE3615180A DE3615180A DE3615180C2 DE 3615180 C2 DE3615180 C2 DE 3615180C2 DE 3615180 A DE3615180 A DE 3615180A DE 3615180 A DE3615180 A DE 3615180A DE 3615180 C2 DE3615180 C2 DE 3615180C2
Authority
DE
Germany
Prior art keywords
compound
formula
general formula
compounds
meanings given
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3615180A
Other languages
German (de)
English (en)
Other versions
DE3615180A1 (de
Inventor
James Stewart New
Joseph P Yevich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DE3615180A1 publication Critical patent/DE3615180A1/de
Application granted granted Critical
Publication of DE3615180C2 publication Critical patent/DE3615180C2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3615180A 1985-05-06 1986-05-05 Disubstituierte 1,4-Piperazinylderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel Expired - Lifetime DE3615180C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73120185A 1985-05-06 1985-05-06

Publications (2)

Publication Number Publication Date
DE3615180A1 DE3615180A1 (de) 1986-11-06
DE3615180C2 true DE3615180C2 (de) 1996-03-07

Family

ID=24938510

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3615180A Expired - Lifetime DE3615180C2 (de) 1985-05-06 1986-05-05 Disubstituierte 1,4-Piperazinylderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel

Country Status (25)

Country Link
JP (1) JPH0753728B2 (xx)
KR (1) KR940000829B1 (xx)
CN (1) CN1017901B (xx)
AT (1) AT398572B (xx)
AU (1) AU593244B2 (xx)
BE (1) BE904724A (xx)
CA (1) CA1278792C (xx)
CH (1) CH672787A5 (xx)
DE (1) DE3615180C2 (xx)
DK (1) DK165745C (xx)
EG (1) EG18206A (xx)
ES (6) ES8801250A1 (xx)
FI (1) FI85484C (xx)
FR (1) FR2581385B1 (xx)
GB (1) GB2174703B (xx)
GR (1) GR861149B (xx)
HU (1) HU195509B (xx)
IE (1) IE59201B1 (xx)
IT (1) IT1208607B (xx)
LU (1) LU86421A1 (xx)
MY (1) MY100777A (xx)
NL (1) NL8601146A (xx)
PT (1) PT82523B (xx)
SE (1) SE465270B (xx)
ZA (1) ZA862046B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801186A (en) * 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
IE903410A1 (en) * 1989-10-09 1991-04-10 Novo Nordisk As Indole derivatives, their preparation and use
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
FR2738824B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1 -yl)alkyl)-3,4-dihydroquinazolin-2(1h)-one,leur preparation et leur application en therapeutique
FR2738822B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
WO1997010238A1 (fr) * 1995-09-15 1997-03-20 Synthelabo Derives de quinolein-2(1h)-one comme antagonistes de la serotonine
FR2738823B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique
FR2761071B1 (fr) * 1997-03-20 1999-12-03 Synthelabo Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines

Also Published As

Publication number Publication date
PT82523B (pt) 1988-10-14
FI85484C (fi) 1992-04-27
ES8900253A1 (es) 1989-05-16
FI861820A0 (fi) 1986-04-30
CN86103071A (zh) 1987-03-18
NL8601146A (nl) 1986-12-01
AT398572B (de) 1994-12-27
SE8602061L (sv) 1986-11-07
ES557839A0 (es) 1989-01-16
ES8802149A1 (es) 1988-04-01
ATA121486A (de) 1994-05-15
ES8802614A1 (es) 1988-09-01
AU5679586A (en) 1986-11-13
DK207186D0 (da) 1986-05-05
FR2581385B1 (fr) 1991-10-04
FR2581385A1 (fr) 1986-11-07
SE465270B (sv) 1991-08-19
DK165745B (da) 1993-01-11
AU593244B2 (en) 1990-02-08
GR861149B (en) 1986-09-09
SE8602061D0 (sv) 1986-05-05
ES8900138A1 (es) 1989-01-16
EG18206A (en) 1992-09-30
IE59201B1 (en) 1994-01-26
IT1208607B (it) 1989-07-10
KR940000829B1 (ko) 1994-02-02
IE861193L (en) 1986-11-06
ES557855A0 (es) 1989-05-16
CH672787A5 (xx) 1989-12-29
ES554659A0 (es) 1987-12-16
ES557757A0 (es) 1988-04-01
PT82523A (en) 1986-06-01
ES557809A0 (es) 1988-09-01
KR860009008A (ko) 1986-12-19
ZA862046B (en) 1986-11-26
ES9000005A1 (es) 1989-11-01
GB2174703B (en) 1988-10-26
FI861820A (fi) 1986-11-07
GB8610810D0 (en) 1986-06-11
DK207186A (da) 1986-11-07
ES8801250A1 (es) 1987-12-16
DE3615180A1 (de) 1986-11-06
IT8620313A0 (it) 1986-05-06
FI85484B (fi) 1992-01-15
GB2174703A (en) 1986-11-12
HUT43848A (en) 1987-12-28
LU86421A1 (fr) 1986-12-05
CN1017901B (zh) 1992-08-19
BE904724A (fr) 1986-11-05
JPH0753728B2 (ja) 1995-06-07
HU195509B (en) 1988-05-30
MY100777A (en) 1991-02-14
DK165745C (da) 1993-06-14
JPS61268681A (ja) 1986-11-28
CA1278792C (en) 1991-01-08

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: BRISTOL-MYERS SQUIBB CO. (N.D.GES.D.STAATES DELAWA

8128 New person/name/address of the agent

Representative=s name: KINZEBACH, W., DIPL.-CHEM. DR.PHIL. RIEDL, P., DIP

8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition