CY2382B1 - Substituted tetracyclic tetrahydrofuran derivatives. - Google Patents

Substituted tetracyclic tetrahydrofuran derivatives.

Info

Publication number
CY2382B1
CY2382B1 CY0300077A CY0300077A CY2382B1 CY 2382 B1 CY2382 B1 CY 2382B1 CY 0300077 A CY0300077 A CY 0300077A CY 0300077 A CY0300077 A CY 0300077A CY 2382 B1 CY2382 B1 CY 2382B1
Authority
CY
Cyprus
Prior art keywords
6alkyl
pct
zero
independently
optionally substituted
Prior art date
Application number
CY0300077A
Other languages
English (en)
Inventor
Pilar Gil-Lopetegui
Francisco Javi Fernandez-Gadea
Theo Franz Meert
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8223868&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2382(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CY2382B1 publication Critical patent/CY2382B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CY0300077A 1996-04-12 2003-11-04 Substituted tetracyclic tetrahydrofuran derivatives. CY2382B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96200990 1996-04-12

Publications (1)

Publication Number Publication Date
CY2382B1 true CY2382B1 (en) 2004-06-04

Family

ID=8223868

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300077A CY2382B1 (en) 1996-04-12 2003-11-04 Substituted tetracyclic tetrahydrofuran derivatives.

Country Status (30)

Country Link
US (3) US6057441A (fr)
EP (1) EP0892793B1 (fr)
JP (1) JP3199751B2 (fr)
KR (1) KR100389298B1 (fr)
CN (1) CN1116291C (fr)
AT (1) ATE236893T1 (fr)
BG (1) BG63083B1 (fr)
BR (1) BR9706639A (fr)
CA (1) CA2232141C (fr)
CY (1) CY2382B1 (fr)
CZ (1) CZ288865B6 (fr)
DE (1) DE69720709T2 (fr)
DK (1) DK0892793T3 (fr)
EA (1) EA001002B1 (fr)
EE (1) EE03612B1 (fr)
ES (1) ES2196328T3 (fr)
HK (1) HK1015771A1 (fr)
HU (1) HUP9901613A3 (fr)
IL (1) IL123655A (fr)
MY (1) MY119321A (fr)
NO (1) NO317156B1 (fr)
NZ (1) NZ329953A (fr)
PL (1) PL190960B1 (fr)
PT (1) PT892793E (fr)
SI (1) SI0892793T1 (fr)
SK (1) SK283400B6 (fr)
TR (1) TR199801164T2 (fr)
TW (1) TW504506B (fr)
WO (1) WO1997038991A1 (fr)
ZA (1) ZA973114B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0892793T3 (da) * 1996-04-12 2003-07-21 Janssen Pharmaceutica Nv Substituerede tetracykliske tetrahydrofuranderivater
UA52778C2 (uk) 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
US20050148018A1 (en) 1999-10-07 2005-07-07 David Weiner Methods of identifying inverse agonists of the serotonin 2A receptor
HRP20000310A2 (en) * 2000-05-17 2002-02-28 Pliva Farmaceutska Ind Dioniko New dibenzoazulene compounds as tumor necrosis factor inhibitors
WO2002056873A2 (fr) * 2000-12-22 2002-07-25 Bayer Pharmaceuticals Corporation Dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulene-8-ones a substitution en 2, comme secretagogues de l'hormone de corsante
UA79248C2 (en) 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
BR0214775A (pt) * 2001-12-07 2004-11-09 Janssen Pharmaceutica Nv Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidos
EP1456193B1 (fr) 2001-12-07 2005-04-27 Janssen Pharmaceutica N.V. Preparation de derives de 3,3a,8,12b-tetrahydro-2 i h /i -dibenzo 3,4:6,7]cyclohepta 1,2-b]furane a fusion trans
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
TW200612899A (en) * 2004-06-14 2006-05-01 Janssen Pharmaceutica Nv Novel tetracyclic tetrahydrofuran derivatives
US8022102B2 (en) 2004-06-23 2011-09-20 Janssen Pharmaceutica, Nv Unsaturated tetracyclic tetrahydrofuran derivatives
AU2011202995B2 (en) * 2004-12-07 2012-02-02 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
CA2588760C (fr) 2004-12-07 2014-05-13 Janssen Pharmaceutica N.V. Derives substitues de tetrahydropyrane tetracyclique, de pyrrolidine et de tetrahydrothiophene
MX2007009092A (es) 2005-01-27 2007-09-12 Janssen Pharmaceutica Nv Derivados de tetrahidrofurano tetraciclicos heterociclicos como inhibidores de 5ht2 en el tratamiento de trastornos del sistema nervioso central.
US20080214572A1 (en) * 2005-05-19 2008-09-04 Francisco Javier Fernandez-Gadea Selected Tetracyclic Tetrahydrofuran Derivatives Containing a Cyclic Amine Side Chain
AU2006251166A1 (en) * 2005-05-26 2006-11-30 Janssen Pharmaceutica N.V. Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament
DE602006012832D1 (de) 2005-06-17 2010-04-22 Janssen Pharmaceutica Nv Neue tetracyclische tetrahydrofuran-derivate mit cyclischer aminseitenkette

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
DE2742794A1 (de) * 1976-11-15 1978-05-18 Dec Int Vorrichtung zur befoerderung von gemahlenem kaese
DE68924751T2 (de) * 1988-09-26 1996-04-11 Smithkline Beecham Farma Azacyclische Verbindungen, verwendbar als Arzneimittel.
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
FR2681320B1 (fr) * 1991-09-12 1994-01-14 Synthelabo Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
FR2681325B1 (fr) * 1991-09-16 1993-12-17 Fabre Medicament Pierre Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
ATE256110T1 (de) * 1995-09-15 2003-12-15 Neurosearch As Piperindinverbindungen als calcium-kanal-blocker
DK0892793T3 (da) * 1996-04-12 2003-07-21 Janssen Pharmaceutica Nv Substituerede tetracykliske tetrahydrofuranderivater

Also Published As

Publication number Publication date
PL328575A1 (en) 1999-02-01
MY119321A (en) 2005-05-31
HUP9901613A2 (hu) 1999-09-28
AU2695997A (en) 1997-11-07
SI0892793T1 (en) 2003-10-31
US6288058B1 (en) 2001-09-11
CZ324398A3 (cs) 1999-01-13
WO1997038991A1 (fr) 1997-10-23
SK283400B6 (sk) 2003-07-01
US6057441A (en) 2000-05-02
HK1015771A1 (en) 1999-10-22
CA2232141C (fr) 2006-05-23
JP3199751B2 (ja) 2001-08-20
EP0892793A1 (fr) 1999-01-27
DE69720709D1 (de) 2003-05-15
DE69720709T2 (de) 2004-03-11
DK0892793T3 (da) 2003-07-21
TW504506B (en) 2002-10-01
BR9706639A (pt) 1999-01-12
EE9800326A (et) 1999-04-15
PT892793E (pt) 2003-08-29
NO981076D0 (no) 1998-03-11
IL123655A0 (en) 1998-10-30
US6194405B1 (en) 2001-02-27
CZ288865B6 (cs) 2001-09-12
EA199800348A1 (ru) 1998-10-29
KR100389298B1 (ko) 2003-10-30
KR19990067514A (ko) 1999-08-25
HUP9901613A3 (en) 2001-08-28
CA2232141A1 (fr) 1997-10-23
PL190960B1 (pl) 2006-02-28
EA001002B1 (ru) 2000-08-28
NO981076L (no) 1998-10-09
EE03612B1 (et) 2002-02-15
TR199801164T2 (xx) 1998-10-21
AU712154B2 (en) 1999-10-28
ES2196328T3 (es) 2003-12-16
EP0892793B1 (fr) 2003-04-09
JP2000508327A (ja) 2000-07-04
SK141898A3 (en) 1999-03-12
CN1116291C (zh) 2003-07-30
ATE236893T1 (de) 2003-04-15
NO317156B1 (no) 2004-08-30
IL123655A (en) 2001-03-19
NZ329953A (en) 1999-06-29
ZA973114B (en) 1998-10-12
BG102820A (en) 1999-08-31
CN1205006A (zh) 1999-01-13
BG63083B1 (bg) 2001-03-30

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