EA199800348A1 - Замещенные тетрациклические производные тетрагидрофурана - Google Patents

Замещенные тетрациклические производные тетрагидрофурана

Info

Publication number
EA199800348A1
EA199800348A1 EA199800348A EA199800348A EA199800348A1 EA 199800348 A1 EA199800348 A1 EA 199800348A1 EA 199800348 A EA199800348 A EA 199800348A EA 199800348 A EA199800348 A EA 199800348A EA 199800348 A1 EA199800348 A1 EA 199800348A1
Authority
EA
Eurasian Patent Office
Prior art keywords
independently
optionally substituted
6alkyl
halomethyl
cyan
Prior art date
Application number
EA199800348A
Other languages
English (en)
Other versions
EA001002B1 (ru
Inventor
Пилар Хиль-Лопетеги
Франсиско Хавьер Фернандес-Гадеа
Тео Франц Меерт
Original Assignee
Жансен Фармасетика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8223868&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199800348(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Жансен Фармасетика Н.В. filed Critical Жансен Фармасетика Н.В.
Publication of EA199800348A1 publication Critical patent/EA199800348A1/ru
Publication of EA001002B1 publication Critical patent/EA001002B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered

Abstract

Данное изобретение относится к соединениям формулы (I)их N-оксидным формам, фармацевтически приемлемым аддитивным солям и стереоизомерным формам, где n принимает значения от 0 до 6, р и g принимают значения от 0 до 4, r принимает значения от 0 до 5; Rи R, каждый независимо является водородом, необязательно замещенным Cалкилом, Cалкилкарбонилом, галогенметилкарбонилом или арилом; Rи R, взятые вместе с атомом азота, к которому они присоединены, могут образовать морфолиниловое кольцо или необязательно замещенный гетероцикл; каждый Rи Rнезависимо являются галогеном, цианом, гидроксилом, галогенметилом, галогенметокси, карбоксилом, нитро, амино, моно- или ди(Cалкил)аминогруппой, Cалкилкарбониламиногруппой, аминосульфонилом, моно- или ди(Cалкил)аминосульфонилом, Cалкилом, Cалкилокси, Cалкилкарбонилом, Cалкилоксикарбонилом; каждый Rнезависимо является Cалкилом, цианом или галогенметилом; X является CRR, NR, O, S, S(=O) или S(=O); арил является необязательно замещенным фенилом, при условии, что это соединение не является (±)3,3а,8,12b-тетрагидро-N-метил-2H-дибензо[3,4:6,7]-циклогепта[1,2-b]фуран-2-метанамином щавелевой кислоты. Соединения формулы (I) могут использоваться в качестве лекарственных средств для лечения или профилактики расстройств ЦНС, сердечно-сосудистых расстройств или желудочно-кишечных расстройств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800348A 1996-04-12 1997-04-09 Замещенные тетрациклические производные тетрагидрофурана EA001002B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200990 1996-04-12
PCT/EP1997/001829 WO1997038991A1 (en) 1996-04-12 1997-04-09 Substituted tetracyclic tetrahydrofuran derivatives

Publications (2)

Publication Number Publication Date
EA199800348A1 true EA199800348A1 (ru) 1998-10-29
EA001002B1 EA001002B1 (ru) 2000-08-28

Family

ID=8223868

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800348A EA001002B1 (ru) 1996-04-12 1997-04-09 Замещенные тетрациклические производные тетрагидрофурана

Country Status (30)

Country Link
US (3) US6057441A (ru)
EP (1) EP0892793B1 (ru)
JP (1) JP3199751B2 (ru)
KR (1) KR100389298B1 (ru)
CN (1) CN1116291C (ru)
AT (1) ATE236893T1 (ru)
BG (1) BG63083B1 (ru)
BR (1) BR9706639A (ru)
CA (1) CA2232141C (ru)
CY (1) CY2382B1 (ru)
CZ (1) CZ288865B6 (ru)
DE (1) DE69720709T2 (ru)
DK (1) DK0892793T3 (ru)
EA (1) EA001002B1 (ru)
EE (1) EE03612B1 (ru)
ES (1) ES2196328T3 (ru)
HK (1) HK1015771A1 (ru)
HU (1) HUP9901613A3 (ru)
IL (1) IL123655A (ru)
MY (1) MY119321A (ru)
NO (1) NO317156B1 (ru)
NZ (1) NZ329953A (ru)
PL (1) PL190960B1 (ru)
PT (1) PT892793E (ru)
SI (1) SI0892793T1 (ru)
SK (1) SK283400B6 (ru)
TR (1) TR199801164T2 (ru)
TW (1) TW504506B (ru)
WO (1) WO1997038991A1 (ru)
ZA (1) ZA973114B (ru)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
HUP9901613A3 (en) * 1996-04-12 2001-08-28 Janssen Pharmaceutica Nv Substituted tetracyclic fused furanamine derivatives, process for their preparation, use thereof and pharmaceutical compositions containing them
UA52778C2 (ru) * 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозамещенные тетрациклические производные тетрагидрофурана, способ их получения и композиции на их основе
US20050148018A1 (en) 1999-10-07 2005-07-07 David Weiner Methods of identifying inverse agonists of the serotonin 2A receptor
HRP20000310A2 (en) * 2000-05-17 2002-02-28 Pliva Farmaceutska Ind Dioniko New dibenzoazulene compounds as tumor necrosis factor inhibitors
WO2002056873A2 (en) * 2000-12-22 2002-07-25 Bayer Pharmaceuticals Corporation 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones as growth hormone secretagogues
UA79248C2 (en) * 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
CA2468038C (en) * 2001-12-07 2011-04-26 Janssen Pharmaceutica Nv Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
PL370440A1 (en) 2001-12-07 2005-05-30 Janssen Pharmaceutica N.V. Preparation of cis-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
AU2005251948A1 (en) * 2004-06-14 2005-12-22 Janssen Pharmaceutica N.V. Novel tetracyclic tetrahydrofuran derivatives
CN1972949A (zh) 2004-06-23 2007-05-30 詹森药业有限公司 新型的不饱和四环四氢呋喃衍生物
AU2011202995B2 (en) * 2004-12-07 2012-02-02 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
RU2401257C2 (ru) * 2004-12-07 2010-10-10 Янссен Фармацевтика Н.В. Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена
JP4937141B2 (ja) 2005-01-27 2012-05-23 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃｎｓ障害の処置における５ｈｔ２インヒビターとしての複素環式四環式テトラヒドロフラン誘導体
US20080214572A1 (en) * 2005-05-19 2008-09-04 Francisco Javier Fernandez-Gadea Selected Tetracyclic Tetrahydrofuran Derivatives Containing a Cyclic Amine Side Chain
EP1891073A1 (en) * 2005-05-26 2008-02-27 Janssen Pharmaceutica N.V. Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament
ES2342110T3 (es) * 2005-06-17 2010-07-01 Janssen Pharmaceutica Nv Nuevos derivados tetraciclicos de tetrahidrofurano que contienen una cadena lateral de amina ciclica.

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FR2681320B1 (fr) * 1991-09-12 1994-01-14 Synthelabo Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
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HUP9901613A3 (en) * 1996-04-12 2001-08-28 Janssen Pharmaceutica Nv Substituted tetracyclic fused furanamine derivatives, process for their preparation, use thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU712154B2 (en) 1999-10-28
US6057441A (en) 2000-05-02
ATE236893T1 (de) 2003-04-15
WO1997038991A1 (en) 1997-10-23
SI0892793T1 (en) 2003-10-31
ZA973114B (en) 1998-10-12
KR19990067514A (ko) 1999-08-25
EA001002B1 (ru) 2000-08-28
EE03612B1 (et) 2002-02-15
ES2196328T3 (es) 2003-12-16
SK141898A3 (en) 1999-03-12
IL123655A (en) 2001-03-19
IL123655A0 (en) 1998-10-30
NZ329953A (en) 1999-06-29
PL190960B1 (pl) 2006-02-28
DE69720709D1 (de) 2003-05-15
EE9800326A (et) 1999-04-15
TR199801164T2 (xx) 1998-10-21
US6194405B1 (en) 2001-02-27
TW504506B (en) 2002-10-01
PL328575A1 (en) 1999-02-01
CN1116291C (zh) 2003-07-30
NO317156B1 (no) 2004-08-30
EP0892793B1 (en) 2003-04-09
JP3199751B2 (ja) 2001-08-20
MY119321A (en) 2005-05-31
BG102820A (en) 1999-08-31
NO981076L (no) 1998-10-09
BG63083B1 (bg) 2001-03-30
NO981076D0 (no) 1998-03-11
EP0892793A1 (en) 1999-01-27
HK1015771A1 (en) 1999-10-22
DK0892793T3 (da) 2003-07-21
DE69720709T2 (de) 2004-03-11
SK283400B6 (sk) 2003-07-01
BR9706639A (pt) 1999-01-12
US6288058B1 (en) 2001-09-11
CY2382B1 (en) 2004-06-04
HUP9901613A3 (en) 2001-08-28
AU2695997A (en) 1997-11-07
CN1205006A (zh) 1999-01-13
CZ324398A3 (cs) 1999-01-13
PT892793E (pt) 2003-08-29
CZ288865B6 (cs) 2001-09-12
JP2000508327A (ja) 2000-07-04
CA2232141A1 (en) 1997-10-23
KR100389298B1 (ko) 2003-10-30
CA2232141C (en) 2006-05-23
HUP9901613A2 (hu) 1999-09-28

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU