CY1122221T1 - Μεθοδοι αφαιρεσης ρυπου χρησιμοποιωντας ιοντοανταλλακτικη μεμβρανικη χρωματογραφια μετατοπισης γηγενων πρωτεϊνων - Google Patents
Μεθοδοι αφαιρεσης ρυπου χρησιμοποιωντας ιοντοανταλλακτικη μεμβρανικη χρωματογραφια μετατοπισης γηγενων πρωτεϊνωνInfo
- Publication number
- CY1122221T1 CY1122221T1 CY20191101072T CY191101072T CY1122221T1 CY 1122221 T1 CY1122221 T1 CY 1122221T1 CY 20191101072 T CY20191101072 T CY 20191101072T CY 191101072 T CY191101072 T CY 191101072T CY 1122221 T1 CY1122221 T1 CY 1122221T1
- Authority
- CY
- Cyprus
- Prior art keywords
- polypeptide
- exchange membrane
- ion
- rough
- proteins
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000003014 ion exchange membrane Substances 0.000 title abstract 2
- 238000011140 membrane chromatography Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 239000000356 contaminant Substances 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
Abstract
Περιγράφονται μέθοδοι καθαρισμού πολυπεπτιδίου από σύνθεση που περιλαμβάνει το πολυπεπτίδιο και τουλάχιστον ένα ρύπο, οι οποίες μέθοδοι περιλαμβάνουν τα εξής διαδοχικά στάδια: (a) διέλευση της σύνθεσης μέσω ιοντοανταλλακτικής μεμβράνης, όπου το πολυπεπτίδιο και η μεμβράνη έχουν αντίθετα φορτία, υπό συνθήκες λειτουργίας που αποτελούνται από ρυθμιστικό διάλυμα που έχει pΗ επαρκώς διαφορετικό από το ρI του πολυπεπτιδίου για να ενισχύεται το φορτίο του πολυπεπτιδίου και χαμηλή ιοντική ισχύ αποτελεσματική στο να αποτρέπει την θωράκιση φορτίων από ιόντα ρυθμιστικού διαλύματος, που προκαλούν την δέσμευση στην μεμβράνη του πολυπεπτιδίου και τουλάχιστον ενός ρύπου, και (b) ανάκτηση του καθαρισμένου πολυπεπτιδίου από την εκροή.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14189582.1A EP2848625B1 (en) | 2008-08-14 | 2008-08-14 | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
PCT/US2008/073179 WO2010019148A1 (en) | 2008-08-14 | 2008-08-14 | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
EP08797895.3A EP2321337B2 (en) | 2008-08-14 | 2008-08-14 | Methods for removing a contaminant using protein displacement ion exchange membrane chromatography |
Publications (1)
Publication Number | Publication Date |
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CY1122221T1 true CY1122221T1 (el) | 2020-11-25 |
Family
ID=39899038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101072T CY1122221T1 (el) | 2008-08-14 | 2019-10-11 | Μεθοδοι αφαιρεσης ρυπου χρησιμοποιωντας ιοντοανταλλακτικη μεμβρανικη χρωματογραφια μετατοπισης γηγενων πρωτεϊνων |
Country Status (21)
Country | Link |
---|---|
US (2) | US10927144B2 (el) |
EP (3) | EP3604324B1 (el) |
JP (1) | JP5666447B2 (el) |
KR (3) | KR102196883B1 (el) |
CN (1) | CN102149724B (el) |
AU (1) | AU2008360625C1 (el) |
CA (1) | CA2731943C (el) |
CY (1) | CY1122221T1 (el) |
DK (2) | DK3604324T3 (el) |
ES (2) | ES2527943T5 (el) |
HK (1) | HK1210181A1 (el) |
HR (1) | HRP20191848T1 (el) |
HU (1) | HUE047316T2 (el) |
IL (2) | IL210912B (el) |
LT (1) | LT2848625T (el) |
MX (1) | MX2011001506A (el) |
PL (1) | PL2848625T3 (el) |
PT (1) | PT2848625T (el) |
RS (1) | RS59232B1 (el) |
SI (1) | SI2848625T1 (el) |
WO (1) | WO2010019148A1 (el) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
AU2007294731B2 (en) | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
HUE047316T2 (hu) | 2008-08-14 | 2020-04-28 | Genentech Inc | Eljárások szennyezés eltávolítására indigén fehérjekiszorításos ioncserés membrán kromatográfia alkalmazásával |
CA2932207A1 (en) | 2008-10-20 | 2010-12-09 | Abbvie Inc. | Isolation and purification of antibodies using protein a affinity chromatography |
JP5856845B2 (ja) | 2008-10-20 | 2016-02-10 | アッヴィ・インコーポレイテッド | 抗体精製中におけるウイルスの不活性化 |
ES2637613T5 (es) † | 2010-05-25 | 2022-07-20 | Hoffmann La Roche | Procedimientos de purificación de polipéptidos |
WO2012030512A1 (en) * | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
KR20140092227A (ko) * | 2010-12-10 | 2014-07-23 | 트레이시 톰슨 | 분리 방법용 조성물 |
EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
TR201815709T4 (tr) * | 2011-12-22 | 2018-11-21 | Hoffmann La Roche | İyon değişim membranı kromatografisi. |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
SG10201610955SA (en) * | 2013-02-26 | 2017-02-27 | Agency Science Tech & Res | Protein purification in the presence of nonionic organic polymers and electropositive surfaces |
EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
WO2014171437A1 (ja) * | 2013-04-16 | 2014-10-23 | 旭化成メディカル株式会社 | 抗体タンパク質の精製方法 |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
WO2015103545A1 (en) | 2014-01-03 | 2015-07-09 | Bio-Rad Laboratories, Inc. | Removal of impurities from protein a eluates |
BR112019004459A2 (pt) * | 2016-09-07 | 2019-05-28 | Glaxosmithkline Ip Dev Ltd | métodos para purificar anticorpos |
JP7085533B2 (ja) | 2016-09-09 | 2022-06-16 | スリーエム イノベイティブ プロパティズ カンパニー | 官能化コポリマー及びその使用 |
US10053368B1 (en) * | 2017-09-07 | 2018-08-21 | Chevron U.S.A. Inc. | Synthesis of AFX framework type molecular sieves |
EP3546475A1 (en) * | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
TW202348297A (zh) * | 2018-05-02 | 2023-12-16 | 美商里珍納龍藥品有限公司 | 用於評估生化過濾器的適合性的方法 |
WO2019246153A1 (en) * | 2018-06-19 | 2019-12-26 | Bristol-Myers Squibb Company | Methods of purifying proteins using chromatography |
CN109324143B (zh) * | 2018-10-19 | 2021-10-29 | 张骐 | 利用二维液相分离制备抗体类产品相关杂质的方法 |
CN109806916B (zh) * | 2019-03-15 | 2021-12-21 | 中科森辉微球技术(苏州)有限公司 | 高性能阴离子交换介质及其制备方法 |
KR20220112014A (ko) | 2021-02-03 | 2022-08-10 | 고인석 | 십전대보탕을 이용하여 만든 오리목뼈 간식 |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
US4515893A (en) | 1979-04-26 | 1985-05-07 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells |
US4347322A (en) † | 1981-01-12 | 1982-08-31 | Nabisco Brands, Inc. | Chromatographic process for enzyme purification |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
US5091178A (en) | 1986-02-21 | 1992-02-25 | Oncogen | Tumor therapy with biologically active anti-tumor antibodies |
US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
US5091313A (en) | 1988-08-05 | 1992-02-25 | Tanox Biosystems, Inc. | Antigenic epitopes of IgE present on B cell but not basophil surface |
US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
DE68919361T2 (de) | 1988-06-21 | 1995-05-24 | Genentech Inc | Therapeutische zusammensetzungen für die behandlung von myocard-infarkten. |
DE68925971T2 (de) | 1988-09-23 | 1996-09-05 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
CA2113813C (en) | 1991-08-14 | 2005-04-12 | Paula M. Jardieu | Immunoglobulin variants for specific fc epsilon receptors |
JPH07501451A (ja) | 1991-11-25 | 1995-02-16 | エンゾン・インコーポレイテッド | 多価抗原結合タンパク質 |
AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
MX9305070A (es) | 1992-08-21 | 1994-04-29 | Genentech Inc | Compocicion farmaceutica que contiene un antagonista de lfa-1 para el tratamiento de transtornos o desordenes mediados por el lfa-1 |
US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
CA2106612C (en) † | 1993-09-21 | 2001-02-06 | Diana Pliura | Displacement chromatography process |
WO1995016203A2 (en) | 1993-12-10 | 1995-06-15 | Genentech, Inc. | Methods for diagnosis of allergy and screening of anti-allergy therapeutics |
DK0739214T3 (da) | 1994-01-18 | 1998-10-07 | Genentech Inc | Fremgangsmåde til behandling af parasitinfektionerunder anvendelse af IgE antagonister |
WO1995023865A1 (en) | 1994-03-03 | 1995-09-08 | Genentech, Inc. | Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders |
US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
CA2222231A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
EP1297847A3 (en) | 1996-01-23 | 2003-05-07 | Genentech, Inc. | Anti-CD18 antibodies in stroke |
WO1997027757A1 (en) | 1996-01-31 | 1997-08-07 | John Stephen Ayers | Production of an immunoglobulin enriched fraction from whey protein solutions |
US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
IL130143A0 (en) | 1996-11-27 | 2000-06-01 | Genentech Inc | Humanized anti-CD11a antibodies |
EP0973804B1 (en) | 1997-04-07 | 2006-12-27 | Genentech, Inc. | Anti-vegf antibodies |
PT1860187E (pt) | 1997-05-15 | 2011-10-04 | Genentech Inc | Receptor apo-2 |
ATE321066T1 (de) | 1998-05-06 | 2006-04-15 | Genentech Inc | Anti-her2 antikörperzusammensetzung |
US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
IL149116A0 (en) | 1999-10-29 | 2002-11-10 | Genentech Inc | Anti-prostate stem cell antigen (psca) antibody compositions and methods of use |
US6479636B1 (en) * | 2000-04-11 | 2002-11-12 | Honiron Corporation (A Louisiana Corporation) | Sugarcane fractioning system |
US6633462B2 (en) | 2000-07-13 | 2003-10-14 | Koninklijke Philips Electronics N.V. | Magnetoresistive angle sensor having several sensing elements |
UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
GB2372464B (en) * | 2001-02-22 | 2003-05-14 | Vivascience Ltd | Method of isolating a charged compound |
US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
AU2002351495A1 (en) | 2001-10-17 | 2003-04-28 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
CA2476166C (en) | 2002-02-14 | 2011-11-15 | Immunomedics, Inc. | Anti-cd20 antibodies and fusion proteins thereof and methods of use |
CA2478925C (en) * | 2002-04-26 | 2016-06-07 | Robert Lee Fahrner | Non-affinity purification of proteins |
ES2558303T3 (es) * | 2002-09-11 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Método de purificación de proteínas |
SI1558648T1 (sl) | 2002-10-17 | 2012-05-31 | Genmab As | Človeška monoklonalna protitelesa proti CD |
DE60332957D1 (de) | 2002-12-16 | 2010-07-22 | Genentech Inc | Immunoglobulinvarianten und deren verwendungen |
WO2005000901A2 (en) | 2003-05-09 | 2005-01-06 | Duke University | Cd20-specific antibodies and methods of employing same |
AR044388A1 (es) | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
AU2004263538B2 (en) | 2003-08-08 | 2009-09-17 | Immunomedics, Inc. | Bispecific antibodies for inducing apoptosis of tumor and diseased cells |
US8147832B2 (en) | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
EP1678208B1 (en) | 2003-10-27 | 2013-05-15 | Wyeth LLC | Removal of high molecular weight aggregates using hydroxyapatite chromatography |
MX2007009466A (es) | 2005-02-10 | 2007-12-07 | Baylor Res Inst | Anticuerpos monoclonales de anti-interferon alfa y metodos para su uso. |
MX2007011129A (es) | 2005-03-11 | 2007-11-06 | Wyeth Corp | Un metodo de cromatografia de particion debil. |
WO2007108955A1 (en) † | 2006-03-20 | 2007-09-27 | Medarex, Inc. | Protein purification |
EP2054521A4 (en) * | 2006-10-03 | 2012-12-19 | Novo Nordisk As | METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES |
WO2009135656A1 (en) | 2008-05-06 | 2009-11-12 | Lonza Biologics Plc. | A method for the purification of antibodies using displacement chromatography |
HUE047316T2 (hu) | 2008-08-14 | 2020-04-28 | Genentech Inc | Eljárások szennyezés eltávolítására indigén fehérjekiszorításos ioncserés membrán kromatográfia alkalmazásával |
JP5731726B1 (ja) | 2014-06-26 | 2015-06-10 | 楽天株式会社 | 情報処理装置、情報処理方法及び情報処理プログラム |
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2008
- 2008-08-14 HU HUE14189582A patent/HUE047316T2/hu unknown
- 2008-08-14 MX MX2011001506A patent/MX2011001506A/es active IP Right Grant
- 2008-08-14 JP JP2011522953A patent/JP5666447B2/ja active Active
- 2008-08-14 ES ES08797895T patent/ES2527943T5/es active Active
- 2008-08-14 AU AU2008360625A patent/AU2008360625C1/en active Active
- 2008-08-14 WO PCT/US2008/073179 patent/WO2010019148A1/en active Application Filing
- 2008-08-14 EP EP19181531.5A patent/EP3604324B1/en active Active
- 2008-08-14 KR KR1020187036563A patent/KR102196883B1/ko active IP Right Grant
- 2008-08-14 CN CN200880131059.7A patent/CN102149724B/zh active Active
- 2008-08-14 EP EP14189582.1A patent/EP2848625B1/en active Active
- 2008-08-14 US US13/058,796 patent/US10927144B2/en active Active
- 2008-08-14 SI SI200832092T patent/SI2848625T1/sl unknown
- 2008-08-14 CA CA2731943A patent/CA2731943C/en active Active
- 2008-08-14 PL PL14189582T patent/PL2848625T3/pl unknown
- 2008-08-14 EP EP08797895.3A patent/EP2321337B2/en active Active
- 2008-08-14 DK DK19181531.5T patent/DK3604324T3/da active
- 2008-08-14 KR KR1020117005824A patent/KR101843915B1/ko active IP Right Grant
- 2008-08-14 DK DK14189582.1T patent/DK2848625T3/da active
- 2008-08-14 PT PT141895821T patent/PT2848625T/pt unknown
- 2008-08-14 LT LTEP14189582.1T patent/LT2848625T/lt unknown
- 2008-08-14 ES ES14189582T patent/ES2749190T3/es active Active
- 2008-08-14 KR KR1020187008461A patent/KR20180033311A/ko not_active Application Discontinuation
- 2008-08-14 RS RSP20191119 patent/RS59232B1/sr unknown
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- 2011-01-27 IL IL210912A patent/IL210912B/en active IP Right Grant
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2015
- 2015-09-18 HK HK15109226.0A patent/HK1210181A1/xx unknown
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2018
- 2018-10-28 IL IL262657A patent/IL262657B/en active IP Right Grant
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2019
- 2019-10-11 CY CY20191101072T patent/CY1122221T1/el unknown
- 2019-10-14 HR HRP20191848TT patent/HRP20191848T1/hr unknown
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2021
- 2021-01-20 US US17/153,826 patent/US20210284685A1/en active Pending
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