CY1120715T1 - Παραγωγα ετεροαρυλιου βουτανικου οξεος ως αναστολεις lta4h - Google Patents

Παραγωγα ετεροαρυλιου βουτανικου οξεος ως αναστολεις lta4h

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Publication number
CY1120715T1
CY1120715T1 CY181100992T CY181100992T CY1120715T1 CY 1120715 T1 CY1120715 T1 CY 1120715T1 CY 181100992 T CY181100992 T CY 181100992T CY 181100992 T CY181100992 T CY 181100992T CY 1120715 T1 CY1120715 T1 CY 1120715T1
Authority
CY
Cyprus
Prior art keywords
heteroyarly
products
butanic acid
lta4h
lta4h inhibitors
Prior art date
Application number
CY181100992T
Other languages
English (en)
Inventor
Birgit Bollbuck
Christian Markert
Wofgang Miltz
Till Roehn
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1120715T1 publication Critical patent/CY1120715T1/el

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/42—Oxazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

Η παρούσα εφεύρεση περιγράφει καινοτόμα παράγωγα ετεροαρυλίου βουτανικού οξέος τα οποία είναι καλά υποψήφια φάρμακα ειδικά ως προς την υδρολάση του λευκοτριαινίου Α4 (LTA4H). Η παρούσα εφεύρεση αναφέρεται επίσης σε φαρμακευτικές συνθέσεις που περιέχουν τα αναφερόμενα παράγωγα ετεροαρυλίου βουτανικού οξέος, μεθόδους χρήσης των αναφερόμενων ενώσεων στην αντιμετώπιση διαφόρων νοσημάτων και διαταραχών και διαδικασίες για τη παρασκευή των αναφερόμενων καινοτόμων ενώσεων.
CY181100992T 2013-12-20 2018-09-26 Παραγωγα ετεροαρυλιου βουτανικου οξεος ως αναστολεις lta4h CY1120715T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13199138 2013-12-20
EP14181155 2014-08-15
EP14833234.9A EP3083564B1 (en) 2013-12-20 2014-12-18 Heteroaryl butanoic acid derivatives as lta4h inhibitors
PCT/IB2014/067086 WO2015092740A1 (en) 2013-12-20 2014-12-18 Heteroaryl butanoic acid derivatives as lta4h inhibitors

Publications (1)

Publication Number Publication Date
CY1120715T1 true CY1120715T1 (el) 2019-12-11

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CY181100992T CY1120715T1 (el) 2013-12-20 2018-09-26 Παραγωγα ετεροαρυλιου βουτανικου οξεος ως αναστολεις lta4h

Country Status (38)

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US (4) US9981926B2 (el)
EP (1) EP3083564B1 (el)
JP (1) JP6500024B2 (el)
KR (2) KR102368958B1 (el)
CN (1) CN105829286B (el)
AP (1) AP2016009301A0 (el)
AU (1) AU2014369180B2 (el)
BR (1) BR112016011170B1 (el)
CA (1) CA2927564C (el)
CL (1) CL2016001255A1 (el)
CR (1) CR20160279A (el)
CU (1) CU24360B1 (el)
CY (1) CY1120715T1 (el)
DK (1) DK3083564T3 (el)
EA (1) EA034436B1 (el)
EC (1) ECSP16062173A (el)
ES (1) ES2690790T3 (el)
GT (1) GT201600132A (el)
HR (1) HRP20181506T1 (el)
HU (1) HUE039615T2 (el)
IL (1) IL245011B (el)
LT (1) LT3083564T (el)
MX (1) MX2016008247A (el)
MY (1) MY180165A (el)
NZ (1) NZ719169A (el)
PE (1) PE20160899A1 (el)
PH (1) PH12016500814A1 (el)
PL (1) PL3083564T3 (el)
PT (1) PT3083564T (el)
RS (1) RS57642B1 (el)
SG (1) SG11201602787YA (el)
SI (1) SI3083564T1 (el)
SV (1) SV2016005230A (el)
TN (1) TN2016000127A1 (el)
UA (1) UA117498C2 (el)
UY (1) UY36178A (el)
WO (1) WO2015092740A1 (el)
ZA (1) ZA201602445B (el)

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JP7356496B2 (ja) * 2018-07-31 2023-10-04 ノバルティス アーゲー Ｌｔａ４ｈ阻害剤の結晶形態
WO2020095983A1 (ja) * 2018-11-07 2020-05-14 中外製薬株式会社 Ｏ－置換セリン誘導体の製造方法
WO2020144604A1 (en) * 2019-01-11 2020-07-16 Novartis Ag Lta4h inhibitors for the treatment of hidradenitis suppurativa
US10610280B1 (en) 2019-02-02 2020-04-07 Ayad K. M. Agha Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
WO2021044351A1 (en) 2019-09-06 2021-03-11 Novartis Ag Methods of treating liver disease using lta4h inhibitors
UY39377A (es) 2020-08-14 2022-03-31 Novartis Ag Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos
US11932630B2 (en) * 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
WO2023076679A1 (en) 2021-11-01 2023-05-04 Alkahest, Inc. Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases
TW202406550A (zh) 2022-08-03 2024-02-16 瑞士商諾華公司 Ｎｌｒｐ３炎性小體抑制劑

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