EA201500207A1 - Гетероароматические соединения в качестве ингибиторов втк - Google Patents

Гетероароматические соединения в качестве ингибиторов втк

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Publication number
EA201500207A1
EA201500207A1 EA201500207A EA201500207A EA201500207A1 EA 201500207 A1 EA201500207 A1 EA 201500207A1 EA 201500207 A EA201500207 A EA 201500207A EA 201500207 A EA201500207 A EA 201500207A EA 201500207 A1 EA201500207 A1 EA 201500207A1
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EA
Eurasian Patent Office
Prior art keywords
vtk
inhibitors
heteroaromatic compounds
compounds
btk
Prior art date
Application number
EA201500207A
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English (en)
Other versions
EA029210B1 (ru
Inventor
Йёрг Мартин Бентцин
Анджела Кей Берри
Тодд Босанак
Майкл Джейсон Берк
Даррен Тодд Дисалво
Джошуа Кортни Хоран
Шуан Лян
Кан Мао
Ван Мао
Ю Шэнь
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201500207A1 publication Critical patent/EA201500207A1/ru
Publication of EA029210B1 publication Critical patent/EA029210B1/ru

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    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

В заявке описаны соединения формулы (I)в которой группы А, Су, Xи Y определены в настоящем изобретении, которые применимы для лечения заболеваний, связанных с ВТК, способ их получения, фармацевтические препараты, которые содержат эти соединения, и способы их применения.
EA201500207A 2012-08-10 2013-08-08 Гетероароматические соединения в качестве ингибиторов btk EA029210B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261681684P 2012-08-10 2012-08-10
PCT/US2013/054096 WO2014025976A1 (en) 2012-08-10 2013-08-08 Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors

Publications (2)

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EA201500207A1 true EA201500207A1 (ru) 2015-08-31
EA029210B1 EA029210B1 (ru) 2018-02-28

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EA201500207A EA029210B1 (ru) 2012-08-10 2013-08-08 Гетероароматические соединения в качестве ингибиторов btk

Country Status (25)

Country Link
US (5) US20140045813A1 (ru)
EP (1) EP2882741B1 (ru)
JP (1) JP6348492B2 (ru)
KR (1) KR20150040292A (ru)
CN (1) CN104603124B (ru)
AP (1) AP2015008203A0 (ru)
AU (1) AU2013299557B2 (ru)
BR (1) BR112015002590A2 (ru)
CA (1) CA2881519A1 (ru)
CL (1) CL2015000256A1 (ru)
EA (1) EA029210B1 (ru)
EC (1) ECSP15008851A (ru)
GE (1) GEP201706748B (ru)
HK (1) HK1210161A1 (ru)
IL (1) IL236495A0 (ru)
IN (1) IN2015DN00524A (ru)
MA (1) MA37830B1 (ru)
MX (1) MX2015001802A (ru)
NZ (1) NZ703607A (ru)
PE (1) PE20150756A1 (ru)
PH (1) PH12015500294B1 (ru)
SA (1) SA515360007B1 (ru)
SG (1) SG11201500499TA (ru)
TN (1) TN2015000029A1 (ru)
WO (1) WO2014025976A1 (ru)

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JP6916185B2 (ja) 2016-01-13 2021-08-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋ阻害剤としてのイソキノロン類
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EP3661939B1 (en) * 2017-08-01 2021-07-21 Boehringer Ingelheim International GmbH Intermediate compounds and methods
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