CY1114141T1 - Ενωσεις που εχουν ανταγωνιστικη του crth2 δραστηριοτητα - Google Patents

Ενωσεις που εχουν ανταγωνιστικη του crth2 δραστηριοτητα

Info

Publication number
CY1114141T1
CY1114141T1 CY20121100744T CY121100744T CY1114141T1 CY 1114141 T1 CY1114141 T1 CY 1114141T1 CY 20121100744 T CY20121100744 T CY 20121100744T CY 121100744 T CY121100744 T CY 121100744T CY 1114141 T1 CY1114141 T1 CY 1114141T1
Authority
CY
Cyprus
Prior art keywords
competiting
units
crth2 activity
crth2
activity
Prior art date
Application number
CY20121100744T
Other languages
English (en)
Inventor
Richard Edward Armer
Graham Michael Wynne
Colin Richard Dorgan
Peter David Johnson
Original Assignee
Oxagen Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0614608A external-priority patent/GB0614608D0/en
Priority claimed from GB0624176A external-priority patent/GB0624176D0/en
Application filed by Oxagen Limited filed Critical Oxagen Limited
Publication of CY1114141T1 publication Critical patent/CY1114141T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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Abstract

Ενώσεις του γενικού χημικού τύπου (Ι) όπου το R είναι φαινύλιο προαιρετικώς υποκατεστημένο με ένα ή περισσότερα αλο- υποκατάστατα· και τα φαρμακευτικώς αποδεκτά άλατα, ένυδρα άλατα, επιδιαλυτωμένα άλατα, σύμπλοκα ή προφάρμακα αυτών είναι χρήσιμα στις εκ του στόματος δυνάμενες χορήγησης συνθέσεις για την αγωγή αλλεργικών παθήσεων όπως είναι το άσθμα, η αλλεργική ρινίτιδα και η ατοπική δερματίτιδα.
CY20121100744T 2006-07-22 2012-08-20 Ενωσεις που εχουν ανταγωνιστικη του crth2 δραστηριοτητα CY1114141T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0614608A GB0614608D0 (en) 2006-07-22 2006-07-22 Compounds having CRTH2 antagonist activity
GB0624176A GB0624176D0 (en) 2006-12-04 2006-12-04 Compounds having CRTH2 antagonist activity
EP07766323A EP2046740B1 (en) 2006-07-22 2007-07-20 Compounds having crth2 antagonist activity

Publications (1)

Publication Number Publication Date
CY1114141T1 true CY1114141T1 (el) 2016-07-27

Family

ID=38566827

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100744T CY1114141T1 (el) 2006-07-22 2012-08-20 Ενωσεις που εχουν ανταγωνιστικη του crth2 δραστηριοτητα

Country Status (20)

Country Link
US (2) US7999119B2 (el)
EP (2) EP2046740B1 (el)
JP (1) JP5270542B2 (el)
KR (1) KR20090042808A (el)
AU (1) AU2007279079A1 (el)
BR (1) BRPI0714840A2 (el)
CA (1) CA2658496A1 (el)
CY (1) CY1114141T1 (el)
DK (1) DK2046740T3 (el)
ES (1) ES2391671T3 (el)
HK (1) HK1130256A1 (el)
IL (1) IL196640A (el)
MX (1) MX2009000801A (el)
NO (1) NO20090216L (el)
NZ (1) NZ574375A (el)
PL (1) PL2046740T3 (el)
PT (1) PT2046740E (el)
RU (1) RU2458918C2 (el)
SI (1) SI2046740T1 (el)
WO (1) WO2008012511A1 (el)

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