NO20080481L - Kinolinderivater som antibakterielle midler - Google Patents
Kinolinderivater som antibakterielle midlerInfo
- Publication number
- NO20080481L NO20080481L NO20080481A NO20080481A NO20080481L NO 20080481 L NO20080481 L NO 20080481L NO 20080481 A NO20080481 A NO 20080481A NO 20080481 A NO20080481 A NO 20080481A NO 20080481 L NO20080481 L NO 20080481L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- het
- alkyloxy
- alkylthio
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- -1 cyano, hydroxy Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Anvendelse av en forbindelse for fremstilling av et medikament for behandling av en bakteriell infeksjon, forutsatt at den bakterielle infeksjon er noe annet enn en mykobakteriell infeksjon, hvor nevnte forbindelse er en forbindelse med formel (Ia) eller (Ib). et farmasøytisk akseptabelt syre- eller baseaddisjonssalt derav, en stereokjemisk isomer form derav, en tautomer form derav eller en N-oksidform derav, hvori Rer hydrogen, halogen, haloalkyl, cyano, hydroksy, Ar, Het, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl; p er 1 til 4; Rer hydrogen, hydroksy, merkapto, alkyloksy, alkyloksyalkyloksy, alkyltio, mono- eller di(alkyl)amino eller. hvori Y er CH, O, S, NH eller JV-alkyl; Rer Ar eller Het; Rog Rhver uavhengig er hydrogen, alkyl eller benzyl; eller Rog Rer tatt sammen iberegnet N-atomet som de er bundet til; Rer hydrogen, halogen, haloalkyl, hydroksy, Ar, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl; eller to nærliggende R6-radikaler kan være tatt sammen og danner -CH=CH-CH=CH-; r er 1 til 5; Rer hydrogen, alkyl, Ar eller Het; Rer hydrogen eller alkyl; Rer okso; eller Rog Rsammen danner -CH=CH-N=; Alk er et rettkjedet eller forgrenet mettet hydrokarbonradikal med fra 1 til 6 karbonatomer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105769 | 2005-06-28 | ||
| PCT/EP2006/063556 WO2007000436A1 (en) | 2005-06-28 | 2006-06-26 | Quinoline derivatives as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20080481L true NO20080481L (no) | 2008-02-29 |
| NO341283B1 NO341283B1 (no) | 2017-10-02 |
Family
ID=35445742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080481A NO341283B1 (no) | 2005-06-28 | 2008-01-25 | Kinolinderivater som antibakterielle midler |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US20100204270A1 (no) |
| EP (1) | EP1898910B1 (no) |
| JP (1) | JP5193859B2 (no) |
| KR (1) | KR101423229B1 (no) |
| CN (1) | CN101252928B (no) |
| AP (1) | AP2733A (no) |
| AR (1) | AR057654A1 (no) |
| AU (1) | AU2006263884B2 (no) |
| BR (1) | BRPI0612534B8 (no) |
| CA (1) | CA2612623C (no) |
| CY (1) | CY1118515T1 (no) |
| DK (1) | DK1898910T3 (no) |
| EA (1) | EA014163B1 (no) |
| ES (1) | ES2606772T3 (no) |
| HK (1) | HK1120734A1 (no) |
| HR (1) | HRP20161704T1 (no) |
| HU (1) | HUE031268T2 (no) |
| IL (1) | IL188394A (no) |
| JO (1) | JO3270B1 (no) |
| LT (1) | LT1898910T (no) |
| ME (1) | ME02690B (no) |
| MX (1) | MX2008000082A (no) |
| MY (1) | MY151030A (no) |
| NO (1) | NO341283B1 (no) |
| NZ (1) | NZ564339A (no) |
| PL (1) | PL1898910T3 (no) |
| PT (1) | PT1898910T (no) |
| RS (1) | RS55408B1 (no) |
| SG (1) | SG166799A1 (no) |
| SI (1) | SI1898910T1 (no) |
| TW (1) | TWI392494B (no) |
| UA (1) | UA91549C2 (no) |
| WO (1) | WO2007000436A1 (no) |
| ZA (1) | ZA200711149B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9790186B2 (en) | 2009-07-21 | 2017-10-17 | Trustees Of Dartmouth College | Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection |
| US9617244B2 (en) | 2012-04-27 | 2017-04-11 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| AU2013254674B2 (en) | 2012-04-27 | 2017-02-02 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| CN105037497B (zh) * | 2015-03-27 | 2018-06-26 | 中牧实业股份有限公司 | 一种恩拉霉素的提纯方法 |
| WO2017035288A1 (en) * | 2015-08-27 | 2017-03-02 | Trustees Of Dartmouth College | Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| DE19937116A1 (de) * | 1999-08-06 | 2001-02-08 | Bayer Ag | Moxifloxacin Kochsalzformulierung |
| EP1527050B1 (en) * | 2002-07-25 | 2010-04-07 | Janssen Pharmaceutica N.V. | Quinoline derivatives and their use as mycobacterial inhibitors |
| KR20130024969A (ko) * | 2004-05-28 | 2013-03-08 | 얀센 파마슈티카 엔.브이. | 약물 내성 마이코박테리아 질환 치료를 위한 치환된 퀴놀린 유도체의 용도 |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
-
2006
- 2006-06-25 JO JOP/2006/0189A patent/JO3270B1/ar active
- 2006-06-26 JP JP2008518812A patent/JP5193859B2/ja active Active
- 2006-06-26 LT LTEP06763891.6T patent/LT1898910T/lt unknown
- 2006-06-26 WO PCT/EP2006/063556 patent/WO2007000436A1/en active Application Filing
- 2006-06-26 AP AP2008004300A patent/AP2733A/xx active
- 2006-06-26 KR KR1020087002248A patent/KR101423229B1/ko active IP Right Grant
- 2006-06-26 MX MX2008000082A patent/MX2008000082A/es active IP Right Grant
- 2006-06-26 ES ES06763891.6T patent/ES2606772T3/es active Active
- 2006-06-26 CA CA2612623A patent/CA2612623C/en active Active
- 2006-06-26 US US11/917,923 patent/US20100204270A1/en not_active Abandoned
- 2006-06-26 EA EA200800152A patent/EA014163B1/ru unknown
- 2006-06-26 ME MEP-2016-291A patent/ME02690B/me unknown
- 2006-06-26 EP EP06763891.6A patent/EP1898910B1/en active Active
- 2006-06-26 UA UAA200714716A patent/UA91549C2/ru unknown
- 2006-06-26 HU HUE06763891A patent/HUE031268T2/en unknown
- 2006-06-26 AU AU2006263884A patent/AU2006263884B2/en active Active
- 2006-06-26 DK DK06763891.6T patent/DK1898910T3/en active
- 2006-06-26 BR BRPI0612534A patent/BRPI0612534B8/pt not_active IP Right Cessation
- 2006-06-26 SI SI200632126A patent/SI1898910T1/sl unknown
- 2006-06-26 NZ NZ564339A patent/NZ564339A/en unknown
- 2006-06-26 SG SG201007977-0A patent/SG166799A1/en unknown
- 2006-06-26 RS RS20161121A patent/RS55408B1/sr unknown
- 2006-06-26 PT PT67638916T patent/PT1898910T/pt unknown
- 2006-06-26 CN CN2006800313527A patent/CN101252928B/zh active Active
- 2006-06-26 PL PL06763891T patent/PL1898910T3/pl unknown
- 2006-06-27 MY MYPI20063045 patent/MY151030A/en unknown
- 2006-06-27 AR ARP060102760A patent/AR057654A1/es unknown
- 2006-06-27 TW TW095123051A patent/TWI392494B/zh active
-
2007
- 2007-12-20 ZA ZA200711149A patent/ZA200711149B/xx unknown
- 2007-12-25 IL IL188394A patent/IL188394A/en active IP Right Grant
-
2008
- 2008-01-25 NO NO20080481A patent/NO341283B1/no not_active IP Right Cessation
- 2008-11-18 HK HK08112595.6A patent/HK1120734A1/xx unknown
-
2012
- 2012-08-07 US US13/568,597 patent/US20130030017A1/en not_active Abandoned
-
2016
- 2016-12-13 HR HRP20161704TT patent/HRP20161704T1/hr unknown
- 2016-12-20 CY CY20161101322T patent/CY1118515T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |