CY1112247T1 - Παραγωγα κινολινης για τη θεραπευτικη αντιμετωπιση της λανθανουσας φυματιωσης - Google Patents
Παραγωγα κινολινης για τη θεραπευτικη αντιμετωπιση της λανθανουσας φυματιωσηςInfo
- Publication number
- CY1112247T1 CY1112247T1 CY20111100563T CY111100563T CY1112247T1 CY 1112247 T1 CY1112247 T1 CY 1112247T1 CY 20111100563 T CY20111100563 T CY 20111100563T CY 111100563 T CY111100563 T CY 111100563T CY 1112247 T1 CY1112247 T1 CY 1112247T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- hydrogen
- treatment
- het
- alkyloxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Χρήση μιας ένωσης του τύπου (Ia) ή (Ib) για την παρασκευή φαρμάκου για την 5 θεραπεία της λανθάνουσας φυματίωσης, όπου η ένωση του τύπου (Ia) ή (Ib) είναι ένα φαρμακευτικά αποδεκτό άλας, μια τεταρτογενής αμίνη, ένα Ν-οξείδιο, μια ταυτομερής μορφή ή μια στερεοχημικά ισομερής μορφή αυτής, όπου R1 είναι υδρογόνο, αλογονο, αλογονοαλκυλο, κυανό, υδροξυ, Ar, Het, αλκυλο, αλκυλοξυ, αλκυλοθειο, αλκυλοξυαλκυλο, αλκυλοθειοαλκυλο, Ar-αλκυλο, ή δι(Αr)αλκυλο, το p είναι 1, 2, 3 ή 4, R2 είναι υδρογόνο, υδροξυ, μερκαπτο, αλκυλοξυ, αλκυλοξυαλκυλοξυ, αλκυλοθειο, μονο ή δι(αλκυλο)αμινο, ή μια ρίζα του τύπου (II), R3 είναι αλκυλο, Ar, Ar-αλκυλο, Het ή Het-αλκυλο, q είναι μηδέν, 1, 2, 3 ή 4, R4 και R5 καθένα ανεξάρτητα είναι υδρογόνο, αλκυλο ή βενζυλο, ή R4 και R5 μπορούν να ληφθούν μαζί συμπεριλαμβάνοντας το Ν στο οποίο είναι προσκολλημένα, R6 είναι υδρογόνο, αλογονο, αλογονοαλκυλο, υδροξυ, Ar, αλκυλο, αλκυλοξυ, αλκυλοθειο, αλκυλοξυαλκυλο, αλκυλοθειοαλκυλο, Ar-αλκυλο ή δι(Αr)αλκυλο, ή δύο γειτονικές ρίζες R6 μπορούν μαζί να σχηματίζουν μια δισθενή ρίζα -CH=CH-CH=CH-, r είναι 1, 2, 3, 4 ή 5, R7 είναι υδρογόνο, αλκυλο, Ar, ή Het, R8 είναι υδρογόνο ή αλκυλο, R9 είναι οξο, ή R8 και R9 μαζί σχηματίζουν την ρίζα =N-CH=CH-.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078529 | 2004-12-24 | ||
| EP05105008 | 2005-06-08 | ||
| EP05815816A EP1830850B1 (en) | 2004-12-24 | 2005-12-08 | Quinoline derivatives for the treatment of latent tuberculosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112247T1 true CY1112247T1 (el) | 2015-12-09 |
Family
ID=35717702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111100563T CY1112247T1 (el) | 2004-12-24 | 2011-06-15 | Παραγωγα κινολινης για τη θεραπευτικη αντιμετωπιση της λανθανουσας φυματιωσης |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20060142279A1 (el) |
| EP (1) | EP1830850B1 (el) |
| CN (1) | CN103142595B (el) |
| AP (1) | AP2327A (el) |
| AR (1) | AR051790A1 (el) |
| AT (1) | ATE501721T1 (el) |
| AU (1) | AU2005242138B2 (el) |
| BR (1) | BRPI0506400B8 (el) |
| CA (1) | CA2529265C (el) |
| CR (1) | CR9267A (el) |
| CY (1) | CY1112247T1 (el) |
| DE (1) | DE602005026984D1 (el) |
| DK (1) | DK1830850T3 (el) |
| EE (1) | EE05394B1 (el) |
| HK (1) | HK1186125A1 (el) |
| HR (1) | HRP20110392T1 (el) |
| IL (1) | IL184123A (el) |
| LV (1) | LV13469B (el) |
| ME (1) | ME01207B (el) |
| MY (1) | MY145845A (el) |
| NI (1) | NI200700146A (el) |
| NO (1) | NO340376B1 (el) |
| NZ (1) | NZ555460A (el) |
| PA (1) | PA8654801A1 (el) |
| PL (1) | PL1830850T3 (el) |
| PT (1) | PT1830850E (el) |
| RS (1) | RS51730B (el) |
| SI (1) | SI1830850T1 (el) |
| TR (1) | TR200504892A1 (el) |
| TW (1) | TWI404535B (el) |
| WO (1) | WO2006067048A1 (el) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL222801B1 (pl) * | 2002-07-25 | 2016-09-30 | Janssen Pharmaceutica Nv | Pochodne chinoliny, ich zastosowanie, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca je |
| JO3270B1 (ar) * | 2005-06-28 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
| JO2752B1 (en) * | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| BRPI0613999B8 (pt) * | 2005-06-28 | 2021-05-25 | Janssen Pharmaceutica Nv | uso de um composto derivado de quinolina, o referido composto, sua combinação, composição farmacêutica, uso da referida combinação, e produto |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2725B1 (en) * | 2006-12-06 | 2013-09-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO3271B1 (ar) | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| US20110059948A1 (en) * | 2008-01-14 | 2011-03-10 | Jyoti Chattopadhyaya | Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivatives as anti-mycobacterial agents |
| RU2404971C2 (ru) * | 2008-12-02 | 2010-11-27 | ЗАО "Фарм-Синтез" | Новые производные хинолина, способ их получения, их применение для лечения микобактериальных инфекций, фармацевтическая композиция на их основе |
| US8741917B2 (en) | 2009-01-15 | 2014-06-03 | Rutgers, The State University Of New Jersey | Benzo [C] phenanthridines as antimicrobial agents |
| US20120059026A1 (en) | 2009-04-30 | 2012-03-08 | University Of Medicine And Dentistry Of New Jersey | Antimicrobial agents |
| US8933096B2 (en) | 2010-06-09 | 2015-01-13 | Rugers, The State University of New Jersey | Antimicrobial agents |
| US9102617B2 (en) | 2010-06-25 | 2015-08-11 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| US9822108B2 (en) | 2012-01-13 | 2017-11-21 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| WO2013142712A1 (en) | 2012-03-21 | 2013-09-26 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| EA038350B1 (ru) | 2012-04-27 | 2021-08-12 | Янссен Фармацевтика Нв | Антибактериальные хинолиновые производные |
| ES2576491T3 (es) | 2012-04-27 | 2016-07-07 | Janssen Pharmaceutica, N.V. | Derivados de quinolina antibacterianos |
| US9458150B2 (en) | 2013-11-08 | 2016-10-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| AU2016212116B2 (en) | 2015-01-27 | 2021-07-15 | Janssen Pharmaceutica Nv | Dispersible compositions |
| WO2017147316A1 (en) | 2016-02-25 | 2017-08-31 | Taxis Pharmaceuticals, Inc. | Synthetic processes and intermediates |
| US10508097B2 (en) * | 2016-03-07 | 2019-12-17 | The Global Alliance For Tb Drug Development, Inc. | Antibacterial compounds and uses thereof |
| RU2629369C1 (ru) * | 2016-10-05 | 2017-08-29 | Федеральное Государственное Унитарное Предприятие "Государственный Ордена Трудового Красного Знамени Научно-Исследовательский Институт Химических Реактивов И Особо Чистых Химических Веществ" | Четвертичные аммонийные производные 2-аминотиофен-3-карбоксилатов, обладающие противотуберкулезной активностью |
| CA3058183A1 (en) | 2017-03-30 | 2018-10-04 | Taxis Pharmaceuticals, Inc. | Synthetic processes and synthetic intermediates |
| WO2019012100A1 (en) | 2017-07-14 | 2019-01-17 | Janssen Pharmaceutica Nv | EXTENDED ACTION FORMULATIONS |
| RU2661151C1 (ru) * | 2017-12-14 | 2018-07-12 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Селективные ингибиторы глицеральдегид-3-фосфатдегидрогеназы микобактерий |
| JP2022516671A (ja) | 2019-01-09 | 2022-03-01 | ヤンセン ファーマシューティカ エヌ．ベー． | 非結核性抗酸菌症の処置における組合せ |
| US20230241051A1 (en) | 2020-07-09 | 2023-08-03 | Janssen Pharmaceutica Nv | Long-acting formulations |
| JP2023532982A (ja) | 2020-07-09 | 2023-08-01 | ヤンセン ファーマシューティカ エヌ．ベー． | 長時間作用型配合物 |
| CN116406270A (zh) | 2020-11-12 | 2023-07-07 | 詹森药业有限公司 | 在治疗非结核分枝杆菌疾病时的贝达喹啉、乙胺丁醇和大环内酯的组合 |
| WO2023232838A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Pharmaceutica Nv | Bedaquiline for use in the treatment of leprosy |
| WO2024068693A1 (en) | 2022-09-28 | 2024-04-04 | Janssen Pharmaceutica Nv | Long-acting formulations |
| WO2024068699A1 (en) | 2022-09-28 | 2024-04-04 | Janssen Pharmaceutica Nv | Long-acting formulations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| PL222801B1 (pl) * | 2002-07-25 | 2016-09-30 | Janssen Pharmaceutica Nv | Pochodne chinoliny, ich zastosowanie, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca je |
-
2005
- 2005-12-05 EE EEP200500033A patent/EE05394B1/xx unknown
- 2005-12-06 CA CA2529265A patent/CA2529265C/en active Active
- 2005-12-07 PA PA20058654801A patent/PA8654801A1/es unknown
- 2005-12-07 MY MYPI20055732A patent/MY145845A/en unknown
- 2005-12-07 AU AU2005242138A patent/AU2005242138B2/en active Active
- 2005-12-08 ME MEP-2011-92A patent/ME01207B/me unknown
- 2005-12-08 TW TW094143290A patent/TWI404535B/zh active
- 2005-12-08 EP EP05815816A patent/EP1830850B1/en active Active
- 2005-12-08 SI SI200531294T patent/SI1830850T1/sl unknown
- 2005-12-08 AP AP2007004054A patent/AP2327A/xx active
- 2005-12-08 CN CN201210507318.XA patent/CN103142595B/zh active Active
- 2005-12-08 BR BRPI0506400A patent/BRPI0506400B8/pt active IP Right Grant
- 2005-12-08 WO PCT/EP2005/056594 patent/WO2006067048A1/en active Application Filing
- 2005-12-08 PT PT05815816T patent/PT1830850E/pt unknown
- 2005-12-08 RS RS20110221A patent/RS51730B/en unknown
- 2005-12-08 AT AT05815816T patent/ATE501721T1/de active
- 2005-12-08 US US11/296,992 patent/US20060142279A1/en not_active Abandoned
- 2005-12-08 NZ NZ555460A patent/NZ555460A/en unknown
- 2005-12-08 DK DK05815816.3T patent/DK1830850T3/da active
- 2005-12-08 PL PL05815816T patent/PL1830850T3/pl unknown
- 2005-12-08 TR TR2005/04892A patent/TR200504892A1/xx unknown
- 2005-12-08 DE DE602005026984T patent/DE602005026984D1/de active Active
- 2005-12-09 AR ARP050105140A patent/AR051790A1/es unknown
- 2005-12-09 LV LVP-05-161A patent/LV13469B/lv unknown
-
2007
- 2007-06-05 NI NI200700146A patent/NI200700146A/es unknown
- 2007-06-21 IL IL184123A patent/IL184123A/en active IP Right Grant
- 2007-07-20 CR CR9267A patent/CR9267A/es not_active Application Discontinuation
- 2007-07-23 NO NO20073823A patent/NO340376B1/no unknown
-
2011
- 2011-05-24 HR HR20110392T patent/HRP20110392T1/hr unknown
- 2011-06-15 CY CY20111100563T patent/CY1112247T1/el unknown
-
2013
- 2013-12-09 HK HK13113666.1A patent/HK1186125A1/xx unknown
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