CY1113037T1 - Ανθρωπινο αντισωμα αντι-υποδοχεα επιδερμικου αυξητικου παραγοντα - Google Patents
Ανθρωπινο αντισωμα αντι-υποδοχεα επιδερμικου αυξητικου παραγονταInfo
- Publication number
- CY1113037T1 CY1113037T1 CY20121100704T CY121100704T CY1113037T1 CY 1113037 T1 CY1113037 T1 CY 1113037T1 CY 20121100704 T CY20121100704 T CY 20121100704T CY 121100704 T CY121100704 T CY 121100704T CY 1113037 T1 CY1113037 T1 CY 1113037T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- human antibody
- epidemiological
- receptors
- growth factor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει πλήρως ανθρώπινο αντίσωμα το οποίο δεσμεύεται με ανθρώπινο ΕGFR με συγγένεια συγκρίσιμη με, ή υψηλότερη από, αυτήν του ΙΜC-C225, και το οποίο εξουδετερώνει την ενεργοποίηση του ΕGFR. Τα αντισώματα περιλαμβάνουν ακέραιες ανοσοσφαιρίνες, μονοσθενή Fab και αντισώματα μονής αλυσίδας, πολυσθενή αντισώματα μονών αλυσίδων, διασώματα, τριασώματα, και αντισώματα μονής περιοχής. Η εφεύρεση παρέχει επιπλέον νουκλεϊκά οξέα και κύτταρα-ξενιστές και ζώα-ξενιστές που κωδικοποιούν και εκφράζουν αυτά τα αντισώματα. Η εφεύρεση παρέχει επιπλέον μέθοδο για εξουδετέρωση της ενεργοποίησης ΕGFR, για θεραπευτική αγωγή θηλαστικού με νεοπλασματική αύξηση και μη-καρκινικές υπερπλαστικές ασθένειες χρησιμοποιώντας τα αντισώματα, μόνα τους ή σε συνδυασμό με άλλους παράγοντες.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55455504P | 2004-03-19 | 2004-03-19 | |
US62426404P | 2004-11-02 | 2004-11-02 | |
EP05732383A EP1735348B1 (en) | 2004-03-19 | 2005-03-21 | Human anti-epidermal growth factor receptor antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113037T1 true CY1113037T1 (el) | 2016-04-13 |
Family
ID=34964896
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100704T CY1113037T1 (el) | 2004-03-19 | 2012-08-06 | Ανθρωπινο αντισωμα αντι-υποδοχεα επιδερμικου αυξητικου παραγοντα |
CY2016016C CY2016016I1 (el) | 2004-03-19 | 2016-05-20 | Ανθρωπινο αντισωμα αντι-υποδοχεα επιδερμικου αυξητικου παραγοντα |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY2016016C CY2016016I1 (el) | 2004-03-19 | 2016-05-20 | Ανθρωπινο αντισωμα αντι-υποδοχεα επιδερμικου αυξητικου παραγοντα |
Country Status (18)
Country | Link |
---|---|
US (1) | US7598350B2 (el) |
EP (2) | EP1735348B1 (el) |
JP (1) | JP4734319B2 (el) |
CN (1) | CN103007279B (el) |
AU (1) | AU2005224267B2 (el) |
CA (1) | CA2560305C (el) |
CY (2) | CY1113037T1 (el) |
DK (1) | DK1735348T3 (el) |
ES (1) | ES2387809T3 (el) |
HU (1) | HUS000495I2 (el) |
LT (1) | LTC1735348I2 (el) |
LU (1) | LU93093I2 (el) |
MX (1) | MXPA06010715A (el) |
NL (1) | NL300819I2 (el) |
PL (1) | PL1735348T3 (el) |
PT (1) | PT1735348E (el) |
RU (1) | RU2402569C2 (el) |
WO (1) | WO2005090407A1 (el) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
HUP0201480A3 (en) * | 1999-05-14 | 2009-03-30 | Imclone Systems Inc | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
JP2004527456A (ja) * | 2000-08-09 | 2004-09-09 | イムクローン システムズ インコーポレイティド | Egf受容体拮抗剤による過増殖性の疾患の治療 |
US20080008704A1 (en) * | 2001-03-16 | 2008-01-10 | Mark Rubin | Methods of treating colorectal cancer with anti-epidermal growth factor antibodies |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
EP3299393A1 (en) * | 2002-11-08 | 2018-03-28 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
ES2466716T3 (es) * | 2002-11-08 | 2014-06-11 | Ablynx N.V. | Anticuerpos de un solo dominio estabilizados |
US20060034845A1 (en) * | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
US20100003253A1 (en) * | 2002-11-08 | 2010-01-07 | Ablynx N.V. | Single domain antibodies directed against epidermal growth factor receptor and uses therefor |
AU2003286004A1 (en) * | 2002-11-08 | 2004-06-07 | Ablynx N.V. | Single domain antibodies directed against interferon- gamma and uses therefor |
EP1622941A2 (en) * | 2003-03-20 | 2006-02-08 | ImClone Systems Incorporated | Method of producing an antibody to epidermal growth factor receptor |
MX2008009977A (es) | 2006-02-03 | 2009-02-27 | Imclone Llc | Antagonistas de receptor de factor de crecimiento de tipo insulina (igf-ir) como auxiliares para el tratamiento de cancer de prostata. |
CN101058609B (zh) * | 2006-05-26 | 2011-04-13 | 神州细胞工程有限公司 | 人源抗体及其表达 |
EA200870538A1 (ru) * | 2006-06-14 | 2009-04-28 | Имклоун Системз Инкорпорейтед | Лиофилизированные композиции анти-egfr антител |
US20090280503A1 (en) * | 2006-09-15 | 2009-11-12 | James Fiore | Method for detecting and treating skin disorders |
US7820159B2 (en) * | 2006-10-31 | 2010-10-26 | Instiute of Virology of the Slovak Academy of Sciences | MN/CA IX and EGFR pathway inhibition |
WO2009067242A2 (en) * | 2007-11-20 | 2009-05-28 | Imclone Llc | Co-crystal of antibody 11f8 fab fragment and egfr extracellular domain and uses thereof |
KR101658247B1 (ko) * | 2008-01-03 | 2016-09-22 | 더 스크립스 리서치 인스티튜트 | 모듈 인식 도메인을 통한 항체 표적화 |
CN101977623A (zh) * | 2008-02-20 | 2011-02-16 | 亚利桑那生物医学研究委员会 | 治疗性肽治疗和预防癌症的用途 |
EP2322221B1 (en) | 2008-08-05 | 2014-07-09 | Toray Industries, Inc. | Pharmaceutical composition for treatment and prevention of cancer |
CN102171570B (zh) | 2008-08-05 | 2014-10-15 | 东丽株式会社 | 用于检测癌的方法 |
EP2385955B1 (en) | 2009-01-12 | 2020-08-12 | CytomX Therapeutics, Inc. | Modified antibody compositions, methods of making and using thereof |
KR101108642B1 (ko) | 2009-09-29 | 2012-02-09 | 주식회사 녹십자 | 표피 성장 인자 수용체에 특이적으로 결합하는 항체 |
CN101875696B (zh) | 2009-11-11 | 2012-02-08 | 中国人民解放军军事医学科学院生物工程研究所 | 一种抗体及其制备方法与应用 |
CN101875695B (zh) * | 2009-11-11 | 2012-07-04 | 中国人民解放军军事医学科学院生物工程研究所 | 一种抗体及其编码基因与应用 |
CN101704891B (zh) | 2009-11-11 | 2011-11-09 | 中国人民解放军军事医学科学院生物工程研究所 | 一种针对表皮生长因子受体的抗体及其编码基因与应用 |
WO2011073954A2 (en) * | 2009-12-18 | 2011-06-23 | Sanofi-Aventis | Novel antagonist antibodies and their fab fragments against gpvi and uses thereof |
WO2011096517A1 (ja) | 2010-02-04 | 2011-08-11 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
RU2624029C2 (ru) | 2010-02-04 | 2017-06-30 | Торэй Индастриз, Инк. | Лекарственный препарат для лечения и/или профилактики рака |
AU2011211699B2 (en) | 2010-02-04 | 2015-01-22 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
RU2607366C2 (ru) | 2010-02-04 | 2017-01-10 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или профилактики рака |
MX342291B (es) | 2010-02-04 | 2016-09-23 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
WO2012018260A1 (en) * | 2010-08-05 | 2012-02-09 | Universiteit Utrecht Holding B.V. | Epidermal growth factor receptor targeted immune therapy |
CA2810668A1 (en) | 2010-09-08 | 2012-03-15 | Halozyme, Inc. | Methods for assessing and identifying or evolving conditionally active therapeutic proteins |
KR101273918B1 (ko) | 2010-09-17 | 2013-06-13 | 강원대학교산학협력단 | 인간 항-상피세포성 성장인자수용체 Fab 항체 및 이를 포함하는 종양 치료용 약학 조성물 |
CA2814670A1 (en) | 2010-10-12 | 2012-04-19 | Arizona Biomedical Research Commission | Egfr-based peptides |
US10066004B2 (en) | 2010-10-12 | 2018-09-04 | Arizona Cancer Therapeutics, Llc | EGFR-based inhibitor peptides for combinatorial inactivation of ERBB1, ERBB2, and ERBB3 |
EP2632947A4 (en) | 2010-10-29 | 2015-03-18 | Immunogen Inc | NON-ANTAGONIST MOLECULES BINDING TO THE EGF RECEPTOR AND IMMUNOCONJUGATES THEREOF |
AU2011320314B2 (en) * | 2010-10-29 | 2015-08-06 | Immunogen, Inc. | Novel EGFR-binding molecules and immunoconjugates thereof |
WO2012106281A2 (en) | 2011-01-31 | 2012-08-09 | The General Hospital Corporation | Multimodal trail molecules and uses in cellular therapies |
KR20140122649A (ko) | 2011-04-21 | 2014-10-20 | 시애틀 지네틱스, 인크. | 신규 결합제-약물 콘주게이트 (ADCs) 및 그의 용도 |
CN106432506A (zh) | 2011-05-24 | 2017-02-22 | 泽恩格尼亚股份有限公司 | 多价和单价多特异性复合物及其用途 |
US9175074B2 (en) | 2011-08-04 | 2015-11-03 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
WO2013018885A1 (ja) | 2011-08-04 | 2013-02-07 | 東レ株式会社 | 膵臓癌の検出方法 |
CA2844042C (en) | 2011-08-04 | 2019-06-18 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
ES2609846T3 (es) | 2011-08-04 | 2017-04-24 | Toray Industries, Inc. | Composición farmacéutica para el tratamiento y/o prevención del cáncer pancreático |
ES2618026T3 (es) | 2011-08-04 | 2017-06-20 | Toray Industries, Inc. | Composición farmacológica para el tratamiento y/o la prevención del cáncer |
PT2740793T (pt) | 2011-08-04 | 2018-02-23 | Toray Industries | Composição de fármacos para o tratamento e/ou a prevenção de cancro |
JP6065591B2 (ja) | 2011-08-04 | 2017-01-25 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
CN104066481A (zh) | 2011-11-21 | 2014-09-24 | 伊缪诺金公司 | 利用egfr抗体细胞毒性剂缀合物治疗抗egfr疗法的肿瘤的方法 |
MX360211B (es) | 2012-02-21 | 2018-10-24 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
PT2818481T (pt) | 2012-02-21 | 2019-10-25 | Toray Industries | Composição farmacêutica para tratamento e/ou prevenção de cancro |
HUE034736T2 (en) | 2012-02-21 | 2018-02-28 | Toray Industries | A pharmaceutical composition for the treatment and / or prevention of cancer |
PT2818482T (pt) | 2012-02-21 | 2019-08-06 | Toray Industries | Composição farmacêutica para o tratamento de cancro |
SG11201405553YA (en) | 2012-03-08 | 2014-11-27 | Halozyme Inc | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof |
RU2640245C2 (ru) | 2012-03-30 | 2017-12-27 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или предотвращения рака печени |
RU2649802C2 (ru) | 2012-03-30 | 2018-04-04 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или предотвращения рака желчного пузыря |
WO2013173255A2 (en) | 2012-05-17 | 2013-11-21 | Sorrento Therapeutics Inc. | Antigen binding proteins that bind egfr |
JP6103832B2 (ja) | 2012-06-25 | 2017-03-29 | Hoya株式会社 | Egfr結合性ペプチド |
MX358772B (es) | 2012-07-19 | 2018-09-04 | Toray Industries | Metodo para detectar cancer. |
DK2876446T3 (en) | 2012-07-19 | 2019-03-11 | Toray Industries | Method for detecting cancer |
EP3473708B1 (en) | 2012-07-24 | 2021-01-27 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
EP2879712B1 (en) | 2012-07-31 | 2018-04-25 | Crown Bioscience, Inc. (Taicang) | Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug |
US9605074B2 (en) * | 2012-08-30 | 2017-03-28 | The General Hospital Corporation | Multifunctional nanobodies for treating cancer |
CN102993305B (zh) * | 2012-11-16 | 2015-05-13 | 上海赛伦生物技术有限公司 | 人源抗人表皮生长因子受体抗体及其编码基因与应用 |
WO2014166029A1 (zh) | 2013-04-07 | 2014-10-16 | 永卓博济(上海)生物医药技术有限公司 | 针对表皮生长因子受体的抗体 |
US9700485B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
BR112016001753B1 (pt) | 2013-08-09 | 2023-10-03 | Toray Industries, Inc | Anticorpo, composição de anticorpo, composição farmacêutica, dna e uso de um anticorpo |
AU2014318545A1 (en) | 2013-09-12 | 2016-03-24 | Halozyme, Inc. | Modified anti-epidermal growth factor receptor antibodies and methods of use thereof |
CN117603354A (zh) * | 2013-12-20 | 2024-02-27 | 英特维特国际股份有限公司 | 具有经修饰的ch2-ch3序列的犬抗体 |
CA2934617A1 (en) | 2013-12-23 | 2015-07-02 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) with kinesin spindle protein (ksp) |
KR101971770B1 (ko) | 2014-03-03 | 2019-04-24 | 아카데미아 시니카 | 이중특이성 항체 및 이의 용도 |
US20170226216A1 (en) * | 2014-07-24 | 2017-08-10 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
CN108251431B (zh) * | 2015-03-05 | 2020-12-08 | 北京百特美博生物科技有限公司 | 双载体***及其用途 |
TW201703769A (zh) | 2015-05-08 | 2017-02-01 | 美國禮來大藥廠 | 用於癌症的組合療法 |
BR112017027813A2 (pt) | 2015-06-22 | 2018-08-28 | Bayer Pharma Aktiengesellschaft | conjugados de agente de ligação-droga (adcs) e conjugados de agente de ligação-pró-droga (apdcs) tendo grupos enzimaticamente cliváveis |
MX2017017138A (es) | 2015-06-23 | 2018-04-30 | Bayer Pharma AG | Conjugados homogeneos especificos de sitio con inhibidores de ksp. |
TW201716439A (zh) | 2015-07-20 | 2017-05-16 | 美國禮來大藥廠 | Her3抗體 |
WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
WO2017160568A1 (en) | 2016-03-16 | 2017-09-21 | Eli Lilly And Company | Combination therapy comprising the cdk4/6 inhibitor necitumumab and the egfr inhibitor abemaciclib for use in treating cancer |
WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
WO2017162663A1 (de) | 2016-03-24 | 2017-09-28 | Bayer Pharma Aktiengesellschaft | Prodrugs von cytotoxischen wirkstoffen mit enzymatisch spaltbaren gruppen |
CN109310781A (zh) | 2016-06-15 | 2019-02-05 | 拜耳制药股份公司 | 具有ksp抑制剂和抗-cd123-抗体的特异性抗体-药物-缀合物(adc) |
US20190233523A1 (en) | 2016-09-26 | 2019-08-01 | Imclone Llc | Combination therapy for cancer |
JP7030811B2 (ja) | 2016-12-21 | 2022-03-07 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ksp阻害剤を有する特異的抗体-薬物コンジュゲート(adc) |
JP7066714B2 (ja) | 2016-12-21 | 2022-05-13 | バイエル・ファルマ・アクティエンゲゼルシャフト | 酵素的に切断可能な基を有する抗体薬物コンジュゲート(adc) |
CN110312533B (zh) | 2016-12-21 | 2023-11-03 | 拜耳公司 | 具有酶促可裂解的基团的细胞毒性活性剂的前药 |
JP7072792B2 (ja) * | 2017-12-11 | 2022-05-23 | 国立大学法人神戸大学 | 二重特異性抗体 |
MX2021005808A (es) | 2018-11-20 | 2021-07-02 | Univ Cornell | Complejos macrociclicos de radionucleidos alfa-emisores y su uso en radioterapia focalizada de cancer. |
US20230357410A1 (en) * | 2018-12-21 | 2023-11-09 | Zhejiang shimai Pharmaceutical Co.,Ltd. | Protease cleavable bispecific antibodies and uses thereof |
MX2022004311A (es) | 2019-10-15 | 2022-05-10 | Lilly Co Eli | Estirpes celulares de mamiferos con deficiencia de lipasa/esterasa modificadas geneticamente de manera recombinante. |
CN117003868B (zh) * | 2020-04-17 | 2024-04-16 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
CN116782932A (zh) * | 2020-08-05 | 2023-09-19 | 俄亥俄州国家创新基金会 | 衔接多肽及其使用方法 |
EP4223779A1 (en) * | 2020-09-30 | 2023-08-09 | Institute Of Zoology, Chinese Academy Of Sciences | Egfr-targeting chimeric antigen receptor |
WO2022140670A2 (en) * | 2020-12-23 | 2022-06-30 | Phenomic Ai | Anti-activin antibodies and methods of using the same |
Family Cites Families (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
BR7801185A (pt) * | 1977-04-18 | 1978-11-28 | Hitachi Metals Ltd | Ornato adaptado para ser fixado por pelo menos um ima permanente |
US4510924A (en) * | 1980-07-10 | 1985-04-16 | Yale-New Haven Hospital, Inc. | Brachytherapy devices and methods employing americium-241 |
GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4943533A (en) * | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
US5866363A (en) * | 1985-08-28 | 1999-02-02 | Pieczenik; George | Method and means for sorting and identifying biological information |
US4816401A (en) * | 1985-09-09 | 1989-03-28 | University Of Rochester | Serum free cell culture medium |
CA1275922C (en) * | 1985-11-28 | 1990-11-06 | Harunobu Amagase | Treatment of cancer |
US4846782A (en) * | 1986-03-14 | 1989-07-11 | Schering Corporation | Treatment of cancer with interferon and radiotherapy |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4763642A (en) * | 1986-04-07 | 1988-08-16 | Horowitz Bruce S | Intracavitational brachytherapy |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5260203A (en) * | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
AU612370B2 (en) | 1987-05-21 | 1991-07-11 | Micromet Ag | Targeted multifunctional proteins |
JP3040121B2 (ja) * | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
US5470571A (en) * | 1988-01-27 | 1995-11-28 | The Wistar Institute | Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425 |
IL89489A0 (en) | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
WO1989009622A1 (en) | 1988-04-15 | 1989-10-19 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
ATE119198T1 (de) | 1988-04-16 | 1995-03-15 | Celltech Ltd | Verfahren zur herstellung von proteinen mittels rekombinanter dna. |
AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
ATE179862T1 (de) * | 1989-07-06 | 1999-05-15 | Univ California | Rezeptoren für fibroblasten-wachstumsfaktoren |
US5705157A (en) * | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
EP0525109A4 (en) | 1990-04-16 | 1993-06-30 | Rhone-Poulenc Rorer International (Holdings) Inc. | Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit egf receptor tyrosine kinase |
US5196446A (en) | 1990-04-16 | 1993-03-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Certain indole compounds which inhibit EGF receptor tyrosine kinase |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
HU219537B (hu) * | 1991-03-06 | 2001-05-28 | Merck Patent Gmbh. | Humanizált és kiméra monoklonális antitestek, azokat tartalmazó gyógyászati készítmények, az antitesteket kódoló szekvenciát tartalmazó expressziós vektorok, valamint eljárás az antitestek előállítására |
US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
DE69233254T2 (de) * | 1991-06-14 | 2004-09-16 | Genentech, Inc., South San Francisco | Humanisierter Heregulin Antikörper |
MX9204374A (es) * | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
ES2136092T3 (es) * | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5559235A (en) * | 1991-10-29 | 1996-09-24 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
US5885793A (en) | 1991-12-02 | 1999-03-23 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
WO1993021319A1 (en) | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
US6177401B1 (en) * | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
JP3720353B2 (ja) * | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | 多価および多重特異性の結合タンパク質、それらの製造および使用 |
US5855885A (en) * | 1993-01-22 | 1999-01-05 | Smith; Rodger | Isolation and production of catalytic antibodies using phage technology |
US5550114A (en) * | 1993-04-02 | 1996-08-27 | Thomas Jefferson University | Epidermal growth factor inhibitor |
US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
US5840301A (en) * | 1994-02-10 | 1998-11-24 | Imclone Systems Incorporated | Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors |
US5861499A (en) | 1994-02-10 | 1999-01-19 | Imclone Systems Incorporated | Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain |
US6448077B1 (en) * | 1994-02-10 | 2002-09-10 | Imclone Systems, Inc. | Chimeric and humanized monoclonal antibodies specific to VEGF receptors |
AU686843B2 (en) * | 1994-02-23 | 1998-02-12 | Pfizer Inc. | 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents |
WO1995024190A2 (en) * | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
US5656655A (en) * | 1994-03-17 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Styryl-substituted heteroaryl compounds which inhibit EGF receptor tyrosine kinase |
JP3249007B2 (ja) * | 1994-03-17 | 2002-01-21 | 富士通株式会社 | 半導体装置、その特性評価方法及び設計方法 |
AU2071695A (en) * | 1994-03-17 | 1995-10-03 | Merck Patent Gmbh | Anti-EGFR single-chain FVS and anti-EGFR antibodies |
US5869465A (en) * | 1994-04-08 | 1999-02-09 | Receptagen Corporation | Methods of receptor modulation and uses therefor |
US5468754A (en) * | 1994-04-19 | 1995-11-21 | Bionumerik Pharmaceuticals, Inc. | 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof |
US5604233A (en) * | 1994-04-28 | 1997-02-18 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 7-ethyl camptothecin and methods for uses thereof |
US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
JP3088018B2 (ja) | 1995-03-30 | 2000-09-18 | ファイザー・インコーポレーテッド | キナゾリン誘導体 |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
US5663144A (en) * | 1995-05-03 | 1997-09-02 | The Trustees Of The University Of Pennsylvania | Compounds that bind to p185 and methods of using the same |
US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
US6685940B2 (en) * | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
ATE217873T1 (de) | 1996-01-23 | 2002-06-15 | Novartis Erfind Verwalt Gmbh | Pyrrolopyrimidinen und verfahren zu deren herstellung |
GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
US5925566A (en) * | 1996-06-06 | 1999-07-20 | University Of Massachusetts | Non-activated receptor complex proteins and uses thereof |
CA2258548C (en) | 1996-06-24 | 2005-07-26 | Pfizer Inc. | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases |
US6004967A (en) * | 1996-09-13 | 1999-12-21 | Sugen, Inc. | Psoriasis treatment with quinazoline compounds |
WO1998033798A2 (en) | 1997-02-05 | 1998-08-06 | Warner Lambert Company | Pyrido[2,3-d]pyrimidines and 4-amino-pyrimidines as inhibitors of cell proliferation |
US5942602A (en) * | 1997-02-13 | 1999-08-24 | Schering Aktiengessellschaft | Growth factor receptor antibodies |
US20030105057A1 (en) * | 1997-03-19 | 2003-06-05 | Yale University | Methods and compositions for stimulating apoptosis and cell death or for inhibiting cell growth and cell attachment |
US5914269A (en) * | 1997-04-04 | 1999-06-22 | Isis Pharmaceuticals, Inc. | Oligonucleotide inhibition of epidermal growth factor receptor expression |
US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US20020173629A1 (en) * | 1997-05-05 | 2002-11-21 | Aya Jakobovits | Human monoclonal antibodies to epidermal growth factor receptor |
US6417168B1 (en) * | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
JP2002515511A (ja) * | 1998-05-15 | 2002-05-28 | イムクローン システムズ インコーポレイティド | 放射線及び成長因子レセプター・チロシン・キナーゼのインヒビターを使用するヒト腫瘍の治療 |
PT1117659E (pt) | 1998-09-29 | 2004-04-30 | Wyeth Corp | Cianoquinolinas substituidas como inibidores de tirosina-quinases de proteinas |
ATE229008T1 (de) | 1998-11-19 | 2002-12-15 | Warner Lambert Co | N- 4-(3-chloro-4-fluoro-phenylamino)-7-(3- morfolin-4-yl-propoxy)-chinazolin-6-yl -akrylamid,ein irreversibler tyrosin-kinasen hemmer |
US7396810B1 (en) * | 2000-08-14 | 2008-07-08 | Oregon Health Sciences University | Compositions and methods for treating cancer by modulating HER-2 and EGF receptors |
HUP0201480A3 (en) * | 1999-05-14 | 2009-03-30 | Imclone Systems Inc | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
ES2549440T3 (es) | 1999-05-18 | 2015-10-28 | Dyax Corp. | Bibliotecas de fragmentos de Fab y métodos para su uso |
NZ517150A (en) * | 1999-08-27 | 2005-01-28 | Genentech Inc | Dosages for treatment with anti-ErbB2 antibodies |
JP2004527456A (ja) * | 2000-08-09 | 2004-09-09 | イムクローン システムズ インコーポレイティド | Egf受容体拮抗剤による過増殖性の疾患の治療 |
US6699473B2 (en) * | 2000-10-13 | 2004-03-02 | Uab Research Foundation | Human anti-epidermal growth factor receptor single-chain antibodies |
AU2002239486A1 (en) * | 2000-12-08 | 2002-06-18 | Uab Research Foundation | Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody |
WO2002087618A1 (fr) * | 2001-04-27 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Methode de prevention et de traitement du cancer |
US7595378B2 (en) * | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
BRPI0210405B8 (pt) * | 2001-06-13 | 2021-05-25 | Genmab As | anticorpo monoclonal humano, molécula biespecífica, método in vitro para inibir o crescimento de uma célula expressando egfr, para induzir a citólise de uma célula expressando egfr, e para detectar a presença de antígeno egfr ou uma célula expressando egfr em uma amostra, e, vetor de expressão |
DE10163459A1 (de) * | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
KR20040077889A (ko) * | 2002-01-28 | 2004-09-07 | 메다렉스, 인코포레이티드 | 전립선 특이적 막 항원 (psma)에 대한 인간모노클로날 항체 |
PT1916001E (pt) | 2002-03-04 | 2011-07-18 | Imclone Llc | Anticorpos humanos específicos para kdr e suas utilizações |
WO2003075947A1 (en) * | 2002-03-08 | 2003-09-18 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of egfr transactivation inhibitors in human cancer |
WO2003079997A2 (en) * | 2002-03-21 | 2003-10-02 | Cayman Chemical Company | Prostaglandin f2 alpha analogs in combinaiotn with antimicrobials for treating glaucoma |
US20050148607A1 (en) * | 2002-06-03 | 2005-07-07 | Tsuyoshi Suzuki | Preventives and/or remedies for subjects with the expression or activation of her2 and/or egfr |
WO2004005890A2 (en) * | 2002-07-03 | 2004-01-15 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits relating to anti-platelet autoantibodies and inhibitors thereof |
CN1703243B (zh) * | 2002-10-10 | 2011-05-04 | 默克专利有限公司 | 针对erb-b1受体的药物组合物 |
EP2365001A3 (en) | 2003-05-01 | 2012-03-28 | Imclone LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
EP1493445A1 (en) * | 2003-07-04 | 2005-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of stress-induced ligand-dependent EGFR activation |
ES2352697T3 (es) * | 2003-11-07 | 2011-02-22 | Ablynx N.V. | Anticuerpos de dominio único de camelidae vhh dirigidos contra el receptor del factor de crecimiento epidérmico y usos de los mismos. |
DE10355904A1 (de) * | 2003-11-29 | 2005-06-30 | Merck Patent Gmbh | Feste Formen von anti-EGFR-Antikörpern |
KR20120089307A (ko) * | 2004-02-12 | 2012-08-09 | 메르크 파텐트 게엠베하 | 항-egfr 항체들의 고농축 액체 제형물 |
TW200533339A (en) * | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
JP5835204B2 (ja) | 2012-12-20 | 2015-12-24 | 信越化学工業株式会社 | レジスト材料及びこれを用いたパターン形成方法 |
-
2005
- 2005-03-21 AU AU2005224267A patent/AU2005224267B2/en not_active Ceased
- 2005-03-21 JP JP2007504185A patent/JP4734319B2/ja active Active
- 2005-03-21 US US10/593,804 patent/US7598350B2/en active Active
- 2005-03-21 PL PL05732383T patent/PL1735348T3/pl unknown
- 2005-03-21 EP EP05732383A patent/EP1735348B1/en active Active
- 2005-03-21 CN CN201210509997.4A patent/CN103007279B/zh not_active Expired - Fee Related
- 2005-03-21 RU RU2006137060/13A patent/RU2402569C2/ru not_active IP Right Cessation
- 2005-03-21 ES ES05732383T patent/ES2387809T3/es active Active
- 2005-03-21 WO PCT/US2005/009583 patent/WO2005090407A1/en active Application Filing
- 2005-03-21 PT PT05732383T patent/PT1735348E/pt unknown
- 2005-03-21 DK DK05732383.4T patent/DK1735348T3/da active
- 2005-03-21 CA CA2560305A patent/CA2560305C/en not_active Expired - Fee Related
- 2005-03-21 MX MXPA06010715A patent/MXPA06010715A/es active IP Right Grant
- 2005-03-21 EP EP10176938A patent/EP2332990A1/en not_active Withdrawn
-
2012
- 2012-08-06 CY CY20121100704T patent/CY1113037T1/el unknown
-
2016
- 2016-05-20 CY CY2016016C patent/CY2016016I1/el unknown
- 2016-05-31 LU LU93093C patent/LU93093I2/fr unknown
- 2016-06-01 LT LTPA2016020C patent/LTC1735348I2/lt unknown
- 2016-06-14 NL NL300819C patent/NL300819I2/nl unknown
- 2016-06-14 HU HUS1600030C patent/HUS000495I2/hu unknown
Also Published As
Publication number | Publication date |
---|---|
AU2005224267A1 (en) | 2005-09-29 |
EP2332990A1 (en) | 2011-06-15 |
PL1735348T3 (pl) | 2012-11-30 |
US7598350B2 (en) | 2009-10-06 |
HUS000495I2 (hu) | 2021-03-29 |
RU2006137060A (ru) | 2008-04-27 |
CA2560305C (en) | 2016-07-05 |
CA2560305A1 (en) | 2005-09-29 |
HUS1600030I1 (hu) | 2016-07-28 |
DK1735348T3 (da) | 2012-07-16 |
CY2016016I2 (el) | 2016-12-14 |
ES2387809T3 (es) | 2012-10-02 |
RU2402569C2 (ru) | 2010-10-27 |
CY2016016I1 (el) | 2016-12-14 |
PT1735348E (pt) | 2012-07-24 |
CN103007279B (zh) | 2017-01-11 |
MXPA06010715A (es) | 2007-05-23 |
JP2008500815A (ja) | 2008-01-17 |
NL300819I2 (el) | 2016-07-21 |
EP1735348A1 (en) | 2006-12-27 |
JP4734319B2 (ja) | 2011-07-27 |
CN103007279A (zh) | 2013-04-03 |
WO2005090407A8 (en) | 2005-12-01 |
WO2005090407A1 (en) | 2005-09-29 |
LU93093I2 (fr) | 2016-08-01 |
AU2005224267B2 (en) | 2011-07-21 |
EP1735348B1 (en) | 2012-06-20 |
LTC1735348I2 (lt) | 2017-11-10 |
US20070264253A1 (en) | 2007-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1113037T1 (el) | Ανθρωπινο αντισωμα αντι-υποδοχεα επιδερμικου αυξητικου παραγοντα | |
CY1111141T1 (el) | Ανθρωπινα αντισωματα ειδικα για kdr και χρησεις αυτων | |
CY1125133T1 (el) | Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17 | |
NO2017032I1 (no) | bezlotoksumab | |
DK1565489T3 (da) | Internaliserende antistoffer specifikke for RAAG10-celleoverflademålet | |
CY1124435T1 (el) | Νουκλεικα οξεα που κωδικοποιουν ανθρωπινα αντισωματα σε sialyl-lewis α | |
MX2015012540A (es) | Ratón de cadena ligera común. | |
CY1117859T1 (el) | Αντισωματα και ανοσοσυζευγματα anti-cd79b και μεθοδοι χρησης | |
ES2572177T3 (es) | Anticuerpos neutralizantes anti-B7RP1 humanos | |
EA201390146A1 (ru) | Антитела к матриксной металлопротеиназе 9 | |
CY1112739T1 (el) | Αντισωματα και ανοσοσυζευγματα αντι-cd79β και μεθοδοι χρησης | |
CR20110577A (es) | Proteínas de unión a il-1 | |
ATE530195T1 (de) | Bispezifische einzelketten-fv-antikörper-moleküle und anwendungsverfahren dafür | |
AR084210A1 (es) | PROTEINAS DE UNION AL TNF-a | |
EA201491599A1 (ru) | Антитела к матриксной металлопротеиназе 9 | |
AR075790A2 (es) | Anticuerpos anti -ngf humanos neutralizantes como inhibidores selectivos de la via de ngf (factor de crecimiento neural) | |
ES2639026T3 (es) | Anticuerpos totalmente humanos específicos para CADM1 | |
EA201491575A1 (ru) | Антитела к матриксной металлопротеиназе 9 | |
ATE504602T1 (de) | Für humane matriptase spezifische bindungsproteine | |
AR099604A1 (es) | Anticuerpos de metaloproteinasa de matriz 9 y sus métodos de uso | |
EA201992186A1 (ru) | Антитела к par2 и пути их применения | |
TH169582A (th) | วิธีสำหรับการสร้างไบสเปซิฟิกแอนติบอดีแบบของมนุษย์อย่างสมบูรณ์โดยใช้สายเบาสามัญทั่วไป | |
CY1117395T1 (el) | Il-1βητα δεσμευτικα αντισωματα και θραυσματα αυτων | |
CY1114678T1 (el) | Μεθοδοι για τον καθορισμο της δραστικοτητας της αδαλιμουμαμπης σε υποκειμενα εχοντα αγκυλοποιητικη σπονδυλιτιδα με τη χρησιμοποιηση των ctx-ii kai mmp3 ως βιοδεικτες |