CY1111884T1 - Μονοκλωνικο αντισωμα αντι-met, θραυσματα και κομιστες αυτου, για την αγωγη νεοπλασιων και αντιστοιχα προϊοντα - Google Patents

Μονοκλωνικο αντισωμα αντι-met, θραυσματα και κομιστες αυτου, για την αγωγη νεοπλασιων και αντιστοιχα προϊοντα

Info

Publication number
CY1111884T1
CY1111884T1 CY20111100926T CY111100926T CY1111884T1 CY 1111884 T1 CY1111884 T1 CY 1111884T1 CY 20111100926 T CY20111100926 T CY 20111100926T CY 111100926 T CY111100926 T CY 111100926T CY 1111884 T1 CY1111884 T1 CY 1111884T1
Authority
CY
Cyprus
Prior art keywords
treatment
monoclonal antibody
monoclonic
cottages
fragrances
Prior art date
Application number
CY20111100926T
Other languages
English (en)
Inventor
Paolo Maria Comoglio
Elisa Vigna
Silvia Giordano
Original Assignee
Metheresis Translational Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metheresis Translational Research Sa filed Critical Metheresis Translational Research Sa
Publication of CY1111884T1 publication Critical patent/CY1111884T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/867—Retroviral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Abstract

Αποκαλύπτεται η χρήση μονοκλωνικού αντισώματος κατευθυνόμενου έναντι της εξωκυτταρικής επικράτειας του αυξητικού παράγοντα ηπατοκυττάρων για την παρασκευή φαρμάκου για την αγωγή νεοπλασιών και/ή μεταστάσεων και διαγνωστικού εργαλείου για την ανίχνευση νεοπλαστικών κυττάρων καθώς και κομιστών περιλαμβανόντων τουλάχιστον κάποιο τμήμα της νουκλεοτιδοαλληλουχίας που κωδικεύει το μονοκλωνικό αντίσωμα αντι-Met, προϊόντα περιέχοντα το μονοκλωνικό αντίσωμα αντι-Met και/ή τουλάχιστον ένα θραύσμα αυτού και τουλάχιστον έναν αναστολέα κινάσης.
CY20111100926T 2006-02-06 2011-09-26 Μονοκλωνικο αντισωμα αντι-met, θραυσματα και κομιστες αυτου, για την αγωγη νεοπλασιων και αντιστοιχα προϊοντα CY1111884T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06101345 2006-02-06
EP07704350A EP1981981B1 (en) 2006-02-06 2007-02-05 Anti-met monoclonal antibody, fragments and vectors thereof, for the treatment of tumors and corresponding products

Publications (1)

Publication Number Publication Date
CY1111884T1 true CY1111884T1 (el) 2015-11-04

Family

ID=36616994

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100926T CY1111884T1 (el) 2006-02-06 2011-09-26 Μονοκλωνικο αντισωμα αντι-met, θραυσματα και κομιστες αυτου, για την αγωγη νεοπλασιων και αντιστοιχα προϊοντα

Country Status (21)

Country Link
US (2) US8388958B2 (el)
EP (2) EP1981981B1 (el)
JP (1) JP5306828B2 (el)
KR (1) KR101429297B1 (el)
CN (1) CN101379192B (el)
AT (1) ATE514715T1 (el)
AU (1) AU2007213804B2 (el)
BR (1) BRPI0707480A8 (el)
CA (1) CA2638889C (el)
CY (1) CY1111884T1 (el)
DK (1) DK1981981T3 (el)
EA (1) EA015580B1 (el)
ES (1) ES2368864T3 (el)
IL (1) IL192879A (el)
MX (1) MX2008009833A (el)
PL (1) PL1981981T3 (el)
PT (1) PT1981981E (el)
SG (2) SG169382A1 (el)
SI (1) SI1981981T1 (el)
WO (1) WO2007090807A1 (el)
ZA (1) ZA200806559B (el)

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EP2014681A1 (en) 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
IL198545A0 (en) 2008-05-14 2011-07-31 Metheresis Translational Res Sa High affinity binding site of hgfr and methods for identification of antagonists thereof
EP2127683A1 (en) * 2008-05-29 2009-12-02 Metheresis Translational Research SA Anti-Met monoclonal antibody, fragments and derivatives thereof for use in tumor imaging, corresponding compositions and kits
PA8849001A1 (es) 2008-11-21 2010-06-28 Lilly Co Eli Anticuerpos de c-met
EP2287197A1 (en) * 2009-08-21 2011-02-23 Pierre Fabre Medicament Anti-cMET antibody and its use for the detection and the diagnosis of cancer
KR101671378B1 (ko) 2009-10-30 2016-11-01 삼성전자 주식회사 ｃ-Ｍｅｔ에 특이적으로 결합하는 항체 및 그의 용도
KR101748707B1 (ko) 2009-11-27 2017-06-20 삼성전자주식회사 ｃ-Ｍｅｔ에 특이적으로 결합하는 항체 및 그를 이용한 암 진단용 키트
AU2011226103C1 (en) 2010-03-10 2016-04-28 Genmab A/S Monoclonal antibodies against c-Met
WO2011125458A1 (ja) 2010-04-02 2011-10-13 富士レビオ株式会社 抗癌剤の効果の診断用マーカー
WO2011150454A1 (en) * 2010-06-01 2011-12-08 Monash University ANTIBODIES DIRECTED TO THE UNPROCESSED RECEPTOR TYROSINE KINASE c-MET
WO2012030842A2 (en) * 2010-09-03 2012-03-08 Academia Sinica Anti-c-met antibody and methods of use thereof
US8637027B2 (en) 2010-11-03 2014-01-28 Argen-X B.V. Anti c-Met antibodies
EP2500036B1 (en) * 2011-03-18 2014-05-07 Metheresis Translational Research SA MET inhibitors for enhancing radiotherapy efficacy
JP2014530201A (ja) 2011-09-20 2014-11-17 イーライ リリー アンド カンパニー 抗ｃ−Ｍｅｔ抗体
EP2773660A2 (en) 2011-11-03 2014-09-10 Argen-X B.V. Chimeric human-camel antigens and their use
RU2014124842A (ru) 2011-11-21 2015-12-27 Дженентек, Инк. Очистка анти-с-мет антител
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WO2016149116A1 (en) * 2015-03-13 2016-09-22 University Of Maryland, Baltimore Antibodies targeting s100b and methods of use
CN113150147A (zh) 2015-03-16 2021-07-23 塞尔德克斯医疗公司 抗-met抗体及其使用方法
GB201611123D0 (en) 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
IT201800000534A1 (it) * 2018-01-03 2019-07-03 Procedimenti per la promozione della crescita cellulare degli isolotti pancreatici.
US11299547B2 (en) * 2016-09-29 2022-04-12 Mitsubishi Tanabe Pharma Corporation CMET monoclonal binding agents, drug conjugates thereof and uses thereof
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
CN106872695B (zh) * 2017-01-20 2019-06-11 中山大学 一种h7亚型禽流感病毒血凝素抗体间接elisa检测试剂盒
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Also Published As

Publication number Publication date
ATE514715T1 (de) 2011-07-15
DK1981981T3 (da) 2011-09-26
ES2368864T3 (es) 2011-11-23
AU2007213804B2 (en) 2012-12-13
SI1981981T1 (sl) 2012-01-31
AU2007213804A8 (en) 2008-08-28
IL192879A (en) 2014-02-27
EP1981981B1 (en) 2011-06-29
IL192879A0 (en) 2009-02-11
US20090285807A1 (en) 2009-11-19
PL1981981T3 (pl) 2011-11-30
KR20090013745A (ko) 2009-02-05
BRPI0707480A8 (pt) 2022-11-08
ZA200806559B (en) 2012-12-27
WO2007090807A1 (en) 2007-08-16
SG169382A1 (en) 2011-03-30
EA015580B1 (ru) 2011-10-31
KR101429297B1 (ko) 2014-08-12
CA2638889A1 (en) 2007-08-16
US8388958B2 (en) 2013-03-05
MX2008009833A (es) 2008-10-23
CN101379192A (zh) 2009-03-04
EP2192188A1 (en) 2010-06-02
JP5306828B2 (ja) 2013-10-02
US20120134996A1 (en) 2012-05-31
EP1981981A1 (en) 2008-10-22
JP2009526010A (ja) 2009-07-16
SG169383A1 (en) 2011-03-30
EA200870234A1 (ru) 2009-02-27
CA2638889C (en) 2015-06-02
AU2007213804A1 (en) 2007-08-16
CN101379192B (zh) 2013-07-31
PT1981981E (pt) 2011-10-04
US8729043B2 (en) 2014-05-20
BRPI0707480A2 (pt) 2011-05-03

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