CY1111240T1 - Παραγωγα ετεροαρυλουριας χρησιμα για την αναστολη της chk1 - Google Patents

Παραγωγα ετεροαρυλουριας χρησιμα για την αναστολη της chk1

Info

Publication number
CY1111240T1
CY1111240T1 CY20111100117T CY111100117T CY1111240T1 CY 1111240 T1 CY1111240 T1 CY 1111240T1 CY 20111100117 T CY20111100117 T CY 20111100117T CY 111100117 T CY111100117 T CY 111100117T CY 1111240 T1 CY1111240 T1 CY 1111240T1
Authority
CY
Cyprus
Prior art keywords
chk1
hetero
inhibition
derivatives useful
aryl derivatives
Prior art date
Application number
CY20111100117T
Other languages
English (en)
Inventor
Frank Diaz
Francine S Farouz
Ryan Holcomb
Edward A Kesicki
Hua Chee Ooi
Alexander Rudolph
Frank Stappenbeck
Eugene Thorsett
John Joseph Gaudino
Kimba L Fisher
Adam Wade Cook
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of CY1111240T1 publication Critical patent/CY1111240T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Αποκαλύπτονται υποκατασταθείσες ενώσεις ουρίας χρήσιμες στην αγωγή νόσων και καταστάσεων σχετιζόμενων με την καταστροφή του DNA ή βλάβες στον αναδιπλασιασμό του DNA. Αποκαλύπτονται επίσης μέθοδοι παρασκευής των ενώσεων και η χρήση τους ως θεραπευτικών παραγόντων, για παράδειγμα στην αγωγή του καρκίνου και άλλων νόσων χαρακτηριζόμενων από ελαττώματα στον αναδιπλασιασμό του DNA, στο διαχωρισμό των χρωμοσωμάτων ή στην κυτταρική διαίρεση.
CY20111100117T 2005-03-29 2011-02-03 Παραγωγα ετεροαρυλουριας χρησιμα για την αναστολη της chk1 CY1111240T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66602605P 2005-03-29 2005-03-29
EP06748900A EP1869020B1 (en) 2005-03-29 2006-03-29 Heteroaryl urea derivatives useful for inhibiting chk1

Publications (1)

Publication Number Publication Date
CY1111240T1 true CY1111240T1 (el) 2015-06-11

Family

ID=36677174

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100117T CY1111240T1 (el) 2005-03-29 2011-02-03 Παραγωγα ετεροαρυλουριας χρησιμα για την αναστολη της chk1

Country Status (32)

Country Link
US (1) US8093244B2 (el)
EP (2) EP2330105A1 (el)
JP (2) JP5117374B2 (el)
KR (2) KR20090031459A (el)
CN (2) CN102219784A (el)
AR (1) AR056645A1 (el)
AT (1) ATE490248T1 (el)
AU (1) AU2006230337B2 (el)
BR (1) BRPI0609667A2 (el)
CA (1) CA2602199C (el)
CR (1) CR9395A (el)
CY (1) CY1111240T1 (el)
DE (1) DE602006018590D1 (el)
DK (1) DK1869020T3 (el)
EA (1) EA011287B1 (el)
ES (1) ES2356068T3 (el)
HK (1) HK1119670A1 (el)
HR (1) HRP20100678T1 (el)
IL (1) IL185481A0 (el)
MA (1) MA29439B1 (el)
MX (1) MX2007012116A (el)
NO (1) NO20074944L (el)
NZ (1) NZ561458A (el)
PL (1) PL1869020T3 (el)
PT (1) PT1869020E (el)
RS (1) RS51616B (el)
SI (1) SI1869020T1 (el)
TN (1) TNSN07369A1 (el)
TW (1) TWI375559B (el)
UA (1) UA92164C2 (el)
WO (1) WO2006105262A1 (el)
ZA (1) ZA200707715B (el)

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CN101200429B (zh) * 2006-12-13 2012-08-22 上海睿智化学研究有限公司 2-硝基-4,5-二卤代苯酚类和2-氨基-4,5-二卤代苯酚类及其盐及其合成方法
GB201008005D0 (en) 2010-05-13 2010-06-30 Sentinel Oncology Ltd Pharmaceutical compounds
CN112472699A (zh) 2013-07-26 2021-03-12 种族肿瘤学公司 改善比生群及衍生物的治疗益处的组合方法
SI3157566T1 (sl) 2014-06-17 2019-08-30 Vertex Pharmaceuticals Incorporated Postopek za zdravljenje raka z uporabo kombinacije inhibitorjev CHK1 in ATR
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
WO2017059357A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
PT3411036T (pt) 2016-02-04 2022-02-21 Pharmaengine Inc Pirazóis 3,5-dissubstituídos úteis como inibidores da checkpoint quinase 1 (chk1) e as suas preparações e aplicações
SG10201913331VA (en) 2016-03-15 2020-03-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
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EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
WO2021183973A1 (en) * 2020-03-13 2021-09-16 Research Development Foundation Methods for diagnosing and treating cancers

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Also Published As

Publication number Publication date
WO2006105262A1 (en) 2006-10-05
CN102219784A (zh) 2011-10-19
CN101151259A (zh) 2008-03-26
MX2007012116A (es) 2008-04-08
ZA200707715B (en) 2009-09-30
EP2330105A1 (en) 2011-06-08
ES2356068T3 (es) 2011-04-04
JP2008535830A (ja) 2008-09-04
KR20090031459A (ko) 2009-03-25
IL185481A0 (en) 2008-01-06
US20090143357A1 (en) 2009-06-04
TWI375559B (en) 2012-11-01
SI1869020T1 (sl) 2011-02-28
EP1869020A1 (en) 2007-12-26
AR056645A1 (es) 2007-10-17
EP1869020B1 (en) 2010-12-01
CN101151259B (zh) 2011-06-15
KR100912998B1 (ko) 2009-08-20
HRP20100678T1 (hr) 2011-02-28
MA29439B1 (fr) 2008-05-02
TW200722090A (en) 2007-06-16
CR9395A (es) 2008-03-31
RS51616B (en) 2011-08-31
ATE490248T1 (de) 2010-12-15
UA92164C2 (ru) 2010-10-11
PL1869020T3 (pl) 2011-05-31
HK1119670A1 (en) 2009-03-13
NO20074944L (no) 2007-10-24
KR20070107178A (ko) 2007-11-06
TNSN07369A1 (en) 2008-12-31
CA2602199C (en) 2013-09-10
DE602006018590D1 (de) 2011-01-13
DK1869020T3 (da) 2011-01-24
JP2009227682A (ja) 2009-10-08
BRPI0609667A2 (pt) 2010-04-20
EA011287B1 (ru) 2009-02-27
NZ561458A (en) 2011-03-31
EA200702094A1 (ru) 2008-02-28
US8093244B2 (en) 2012-01-10
JP5117374B2 (ja) 2013-01-16
AU2006230337B2 (en) 2011-10-27
AU2006230337A1 (en) 2006-10-05
PT1869020E (pt) 2010-12-23
CA2602199A1 (en) 2006-10-05

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