UY31775A - Compuestos heterocíclicos como inhibidores de mek - Google Patents

Compuestos heterocíclicos como inhibidores de mek

Info

Publication number
UY31775A
UY31775A UY0001031775A UY31775A UY31775A UY 31775 A UY31775 A UY 31775A UY 0001031775 A UY0001031775 A UY 0001031775A UY 31775 A UY31775 A UY 31775A UY 31775 A UY31775 A UY 31775A
Authority
UY
Uruguay
Prior art keywords
mek inhibitors
heterocyclic compounds
compounds
present
hyperpoliferative
Prior art date
Application number
UY0001031775A
Other languages
English (en)
Inventor
Chikkanna Dinesh
Mccarthy Clive
Moebitz Henrik
Pandit Chetan
Sistla Ramesh
Subramanya Hosahalli
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY31775A publication Critical patent/UY31775A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Abstract

La presente invención se refiere a los compuestos de la fórmla I: y las sales farmacéuticamente aceptables. Estos compuestos pueden actuar como inhibidores potenciales de MEK en el tratamiento de enfermedades hiperpoliferativas, como cáncer e inflamación. La presente invención también revela métodos de preparación de los mismos.
UY0001031775A 2008-04-21 2009-04-21 Compuestos heterocíclicos como inhibidores de mek UY31775A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN968CH2008 2008-04-21

Publications (1)

Publication Number Publication Date
UY31775A true UY31775A (es) 2010-11-30

Family

ID=40834537

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001031775A UY31775A (es) 2008-04-21 2009-04-21 Compuestos heterocíclicos como inhibidores de mek

Country Status (6)

Country Link
US (1) US20090275606A1 (es)
AR (1) AR071587A1 (es)
CL (1) CL2009000949A1 (es)
PE (1) PE20100747A1 (es)
TW (1) TW201038267A (es)
UY (1) UY31775A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5453290B2 (ja) * 2007-11-12 2014-03-26 武田薬品工業株式会社 Ｍａｐｋ／ｅｒｋキナーゼ阻害剤
AU2010317167B2 (en) * 2009-11-04 2012-11-29 Novartis Ag Heterocyclic sulfonamide derivatives useful as MEK inhibitors
WO2011067356A2 (en) 2009-12-03 2011-06-09 Novartis Ag Polymorphs of a mek inhibitor
WO2011067348A2 (en) * 2009-12-03 2011-06-09 Novartis Ag Mek inhibitor salts and solvates thereof
CN102020651B (zh) 2010-11-02 2012-07-18 北京赛林泰医药技术有限公司 6-芳基氨基吡啶酮甲酰胺mek抑制剂
WO2014071183A1 (en) 2012-11-02 2014-05-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of reducing adverse effects in a cancer patient undergoing treatment with a mek inhibitor
CN105061283B (zh) * 2015-08-09 2017-11-24 浙江大学 氨基酸苄酯盐酸盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1318995B1 (en) * 2000-09-19 2006-03-08 Centre National De La Recherche Scientifique (Cnrs) Pyridinone and pyridinethione derivatives having hiv inhibiting properties
WO2002053543A1 (fr) * 2000-12-28 2002-07-11 Shionogi & Co., Ltd. Derive de pyridone ayant une affinite pour le recepteur cannabinoide de type 2
WO2003070277A1 (fr) * 2002-02-19 2003-08-28 Shionogi & Co., Ltd. Antiprurigineux
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
MX2008013097A (es) * 2006-04-18 2008-10-27 Ardea Biosciences Inc Piridona sulfonamidas y piridona sulfamidas como inhibidores de metiletilcetona.
WO2008089459A1 (en) * 2007-01-19 2008-07-24 Ardea Biosciences, Inc. Inhibitors of mek
EP2155659A1 (en) * 2007-05-11 2010-02-24 Bayer Schering Pharma Aktiengesellschaft Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity
JP5453290B2 (ja) * 2007-11-12 2014-03-26 武田薬品工業株式会社 Ｍａｐｋ／ｅｒｋキナーゼ阻害剤

Also Published As

Publication number Publication date
TW201038267A (en) 2010-11-01
CL2009000949A1 (es) 2010-12-24
AR071587A1 (es) 2010-06-30
US20090275606A1 (en) 2009-11-05
PE20100747A1 (es) 2010-11-03

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20181025