CY1109096T1 - Σταθεροποιημενες υδατικες συνθεσεις οι οποιες περιλαμβανουν αναστολεα οδου ιστικου παραγοντα (tfpi) ή παραλλαγη αναστολεα οδου ιστικου παραγοντα - Google Patents
Σταθεροποιημενες υδατικες συνθεσεις οι οποιες περιλαμβανουν αναστολεα οδου ιστικου παραγοντα (tfpi) ή παραλλαγη αναστολεα οδου ιστικου παραγονταInfo
- Publication number
- CY1109096T1 CY1109096T1 CY20091100554T CY091100554T CY1109096T1 CY 1109096 T1 CY1109096 T1 CY 1109096T1 CY 20091100554 T CY20091100554 T CY 20091100554T CY 091100554 T CY091100554 T CY 091100554T CY 1109096 T1 CY1109096 T1 CY 1109096T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tfpi
- road
- staff
- compositions
- include historical
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Fodder In General (AREA)
Abstract
Σταθεροποιημένες υδατικές συνθέσεις του αναστολέα οδού ιστικού παράγοντα (TFPI) ή της TFPI παραλλαγής περιλαμβάνουν ένα διαλυτοποιητικό παράγοντα, ένα αντιοξειδωτικό και ένα ρυθμιστικό διάλυμα. Ο συνδυασμός ενός διαλυτοποιητικού παράγοντα και ενός αντιοξειδωτικού μπορεί να οδηγήσει σε σημαντική βελτίωση του χρόνου φύλαξης των συνθέσεων TFPI ή TFPI παραλλαγής. Ο διαλυτοποιητικός παράγοντας και το αντιοξειδωτικό ουσιαστικά εξουδετερώνουν τα αποτελέσματα της αποδόμησης του TFPI ή της TFPI παραλλαγής μέσω συσσωμάτωσης και οξείδωσης.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43851903P | 2003-01-08 | 2003-01-08 | |
US49457703P | 2003-08-13 | 2003-08-13 | |
US50926003P | 2003-10-08 | 2003-10-08 | |
US51209003P | 2003-10-20 | 2003-10-20 | |
EP04700828A EP1599222B1 (en) | 2003-01-08 | 2004-01-08 | Stabilized aqueous compositions comprising tissue factor pathway inhibitor (tfpi) or tissue factor pathway inhibitor variant |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109096T1 true CY1109096T1 (el) | 2014-07-02 |
Family
ID=32719506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100554T CY1109096T1 (el) | 2003-01-08 | 2009-05-22 | Σταθεροποιημενες υδατικες συνθεσεις οι οποιες περιλαμβανουν αναστολεα οδου ιστικου παραγοντα (tfpi) ή παραλλαγη αναστολεα οδου ιστικου παραγοντα |
Country Status (15)
Country | Link |
---|---|
US (2) | US20040224886A1 (el) |
EP (2) | EP1599222B1 (el) |
JP (1) | JP2006515882A (el) |
CN (1) | CN1756559B (el) |
AT (1) | ATE424215T1 (el) |
AU (1) | AU2004204720B2 (el) |
CA (1) | CA2512681A1 (el) |
CY (1) | CY1109096T1 (el) |
DE (1) | DE602004019761D1 (el) |
DK (1) | DK1599222T3 (el) |
EA (1) | EA008038B1 (el) |
ES (1) | ES2321297T3 (el) |
PT (1) | PT1599222E (el) |
SI (1) | SI1599222T1 (el) |
WO (1) | WO2004062689A1 (el) |
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2004
- 2004-01-08 SI SI200431119T patent/SI1599222T1/sl unknown
- 2004-01-08 EP EP04700828A patent/EP1599222B1/en not_active Expired - Lifetime
- 2004-01-08 US US10/753,068 patent/US20040224886A1/en not_active Abandoned
- 2004-01-08 WO PCT/US2004/000233 patent/WO2004062689A1/en active Application Filing
- 2004-01-08 EA EA200501097A patent/EA008038B1/ru not_active IP Right Cessation
- 2004-01-08 CN CN200480006044XA patent/CN1756559B/zh not_active Expired - Fee Related
- 2004-01-08 EP EP08075968A patent/EP2174663A1/en not_active Withdrawn
- 2004-01-08 CA CA002512681A patent/CA2512681A1/en not_active Abandoned
- 2004-01-08 DK DK04700828T patent/DK1599222T3/da active
- 2004-01-08 PT PT04700828T patent/PT1599222E/pt unknown
- 2004-01-08 AT AT04700828T patent/ATE424215T1/de not_active IP Right Cessation
- 2004-01-08 AU AU2004204720A patent/AU2004204720B2/en not_active Ceased
- 2004-01-08 JP JP2006500805A patent/JP2006515882A/ja active Pending
- 2004-01-08 DE DE602004019761T patent/DE602004019761D1/de not_active Expired - Lifetime
- 2004-01-08 ES ES04700828T patent/ES2321297T3/es not_active Expired - Lifetime
-
2005
- 2005-12-14 US US11/302,208 patent/US7659248B2/en not_active Expired - Fee Related
-
2009
- 2009-05-22 CY CY20091100554T patent/CY1109096T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE602004019761D1 (de) | 2009-04-16 |
ES2321297T3 (es) | 2009-06-04 |
SI1599222T1 (sl) | 2009-08-31 |
US20060079459A1 (en) | 2006-04-13 |
WO2004062689A1 (en) | 2004-07-29 |
AU2004204720B2 (en) | 2009-08-06 |
EP1599222B1 (en) | 2009-03-04 |
US20040224886A1 (en) | 2004-11-11 |
CN1756559B (zh) | 2010-04-28 |
EP2174663A1 (en) | 2010-04-14 |
ATE424215T1 (de) | 2009-03-15 |
EA008038B1 (ru) | 2007-02-27 |
CA2512681A1 (en) | 2004-07-29 |
EA200501097A1 (ru) | 2006-04-28 |
CN1756559A (zh) | 2006-04-05 |
PT1599222E (pt) | 2009-06-12 |
AU2004204720A1 (en) | 2004-07-29 |
DK1599222T3 (da) | 2009-04-27 |
JP2006515882A (ja) | 2006-06-08 |
US7659248B2 (en) | 2010-02-09 |
EP1599222A1 (en) | 2005-11-30 |
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