CY1108746T1 - Παραγωγα 2-φαινοξυ- και 2-φαινυλοσουλφοναμιδιου με ανταγωνιστικη δραστικοτητα ccr3 για την θεραπεια του ασθματος και αλλων φλεγμονωδων ή ανοσολογικων διαταραχων - Google Patents

Παραγωγα 2-φαινοξυ- και 2-φαινυλοσουλφοναμιδιου με ανταγωνιστικη δραστικοτητα ccr3 για την θεραπεια του ασθματος και αλλων φλεγμονωδων ή ανοσολογικων διαταραχων

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Publication number
CY1108746T1
CY1108746T1 CY20091100112T CY091100112T CY1108746T1 CY 1108746 T1 CY1108746 T1 CY 1108746T1 CY 20091100112 T CY20091100112 T CY 20091100112T CY 091100112 T CY091100112 T CY 091100112T CY 1108746 T1 CY1108746 T1 CY 1108746T1
Authority
CY
Cyprus
Prior art keywords
treatment
ccr3
activity
asthma
fenylsulfonamide
Prior art date
Application number
CY20091100112T
Other languages
English (en)
Inventor
Yingfu Li
Kevin Bacon
Hiromi Sugimoto
Keiko Fukushima
Kentaro Hashimoto
Makiko Marumo
Toshiya Moriwaki
Noriko Nunami
Naoki Tsuno
Klaus Urbahns
Nagahiro Yoshida
Original Assignee
Axikin Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axikin Pharmaceuticals, Inc. filed Critical Axikin Pharmaceuticals, Inc.
Publication of CY1108746T1 publication Critical patent/CY1108746T1/el

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

Η παρούσα εφεύρεση αναφέρεται σε ένα παράγωγο βενζολοσουλφοναμιδίου του τύπου (I), το οποίο είναι χρήσιμο ως δραστικό συστατικό των φαρμακευτικών παρασκευασμάτων. Τα παράγωγα βενζολοσουλφοναμιδίου της παρούσας εφεύρεσης έχουν ανταγωνιστική δραστικότητα CCR3 (τύπου CC υποδοχέας χημειοκίνης 3), και μπορούν να χρησιμοποιηθούν για την προφύλαξη και την θεραπεία των ασθενειών που συνδέονται με την δραστικότητα του CCR3, ειδικότερα για την θεραπεία του άσθματος, της ατοπικής δερματίτιδας, της αλλεργικής ρινίτιδας και άλλων φλεγμονωδών/ανοσολογικών διαταραχών. Στον εν λόγω τύπο, το Χ αντιπροσωπεύει Ο ή S∙ το R4 αντιπροσωπεύει τους τύπους (a), (b), (c), (d), (e), (f), (g), (h), (i) ή (j), τα άλλα υποκατάστατα είναι όπως ορίζονται στην αξίωση 1.
CY20091100112T 2003-03-24 2009-01-30 Παραγωγα 2-φαινοξυ- και 2-φαινυλοσουλφοναμιδιου με ανταγωνιστικη δραστικοτητα ccr3 για την θεραπεια του ασθματος και αλλων φλεγμονωδων ή ανοσολογικων διαταραχων CY1108746T1 (el)

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