CY1106774T1 - Συνθεσεις φαρμακευτικων μεσων με βαση αλατα του τιοτροπιου και αλατα της σαλμετερολης - Google Patents
Συνθεσεις φαρμακευτικων μεσων με βαση αλατα του τιοτροπιου και αλατα της σαλμετεροληςInfo
- Publication number
- CY1106774T1 CY1106774T1 CY20071101011T CY071101011T CY1106774T1 CY 1106774 T1 CY1106774 T1 CY 1106774T1 CY 20071101011 T CY20071101011 T CY 20071101011T CY 071101011 T CY071101011 T CY 071101011T CY 1106774 T1 CY1106774 T1 CY 1106774T1
- Authority
- CY
- Cyprus
- Prior art keywords
- salts
- salmeterol
- pharmaceutical compositions
- tiotropium
- compositions based
- Prior art date
Links
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical class C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title abstract 2
- 229960004017 salmeterol Drugs 0.000 title 1
- 229940110309 tiotropium Drugs 0.000 title 1
- 238000000034 method Methods 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η προκειμένη εφεύρεση αφορά σε νέου είδους συνθέσεις φαρμακευτικών μέσων με βάση άλατα του τιοτροπίου και άλατα της σαλμετερόλης, σε μέθοδο για την παρασκευή τους, ως και στην χρήση τους κατά την θεραπεία παθήσεων των αναπνευστικών οδών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10056104A DE10056104A1 (de) | 2000-11-13 | 2000-11-13 | Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols |
EP01989446A EP1335728B1 (de) | 2000-11-13 | 2001-11-09 | Arzneimittelkompositionen auf der basis von tiotropiumsalzen und salzen des salmeterols |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106774T1 true CY1106774T1 (el) | 2012-05-23 |
Family
ID=7663071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071101011T CY1106774T1 (el) | 2000-11-13 | 2007-07-30 | Συνθεσεις φαρμακευτικων μεσων με βαση αλατα του τιοτροπιου και αλατα της σαλμετερολης |
Country Status (32)
Country | Link |
---|---|
EP (3) | EP1514546B1 (el) |
JP (2) | JP4282322B2 (el) |
KR (2) | KR100940752B1 (el) |
CN (1) | CN1678318A (el) |
AT (2) | ATE291428T1 (el) |
AU (3) | AU2791002A (el) |
BG (1) | BG107781A (el) |
BR (1) | BR0115226A (el) |
CA (1) | CA2429012A1 (el) |
CY (1) | CY1106774T1 (el) |
CZ (1) | CZ20031444A3 (el) |
DE (3) | DE10056104A1 (el) |
DK (2) | DK1514546T3 (el) |
EA (1) | EA007904B1 (el) |
EC (1) | ECSP034571A (el) |
EE (1) | EE200300228A (el) |
ES (2) | ES2240549T3 (el) |
HR (1) | HRP20030378A2 (el) |
HU (1) | HUP0301447A3 (el) |
IL (2) | IL155718A0 (el) |
MX (1) | MXPA03004164A (el) |
NO (1) | NO20032111L (el) |
NZ (1) | NZ526400A (el) |
PL (1) | PL205330B1 (el) |
PT (2) | PT1335728E (el) |
RS (2) | RS20090105A (el) |
SG (1) | SG167657A1 (el) |
SI (2) | SI1514546T1 (el) |
SK (2) | SK286939B6 (el) |
UA (1) | UA74853C2 (el) |
WO (1) | WO2002038154A1 (el) |
ZA (1) | ZA200302921B (el) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7214687B2 (en) | 1999-07-14 | 2007-05-08 | Almirall Ag | Quinuclidine derivatives and medicinal compositions containing the same |
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
ATE286716T1 (de) * | 1999-11-23 | 2005-01-15 | Glaxo Group Ltd | Pharmazeutische formulierungen enthaltend salmeterol |
EP1429768B1 (de) * | 2001-09-14 | 2016-11-16 | Boehringer Ingelheim Pharma GmbH & Co.KG | Neue arzneimittel zur inhalation |
US7311894B2 (en) | 2002-03-28 | 2007-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations containing an anticholinergic |
DE10214263A1 (de) * | 2002-03-28 | 2003-10-16 | Boehringer Ingelheim Pharma | HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum |
US7244415B2 (en) | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
US7250426B2 (en) | 2002-11-29 | 2007-07-31 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Tiotropium-containing pharmaceutical combination for inhalation |
DE10256080A1 (de) * | 2002-11-29 | 2004-06-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropiumhaltige Arzneimittelkombination für die Inhalation |
BR0317340A (pt) * | 2002-12-16 | 2005-11-08 | Boehringer Ingelheim Pharma | Formulações de hfc em solução contendo tiotrópio |
DE10351663A1 (de) * | 2002-12-20 | 2004-07-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverförmige Arzneimittel enthaltend ein Tiotropiumsalz und Salmeterolxinafoat |
DE10345065A1 (de) * | 2003-09-26 | 2005-04-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum |
PE20050485A1 (es) * | 2003-11-03 | 2005-10-05 | Boehringer Ingelheim Int | Nuevas sales de tiotropio, procedimiento para su preparacion, asi como formulaciones medicamentosas que las contienen |
CN100549010C (zh) | 2003-11-03 | 2009-10-14 | 贝林格尔.英格海姆国际有限公司 | 制备噻托铵盐类的方法,噻托铵盐类及含有该盐类的医药制剂 |
ES2257152B1 (es) | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
MXPA06013849A (es) * | 2004-05-31 | 2007-03-01 | Almirall Lab | Combinaciones que comprenden agentes antimuscarinicos e inhibidores de pde4. |
CA2606549A1 (en) | 2005-05-02 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Crystalline forms of tiotropium bromide |
EP1959942A1 (en) * | 2005-08-06 | 2008-08-27 | Boehringer Ingelheim International GmbH | Method for the treatment of dyspnea comprising combined administration of tiotropium salts and salts of salmeterol |
ES2298049B1 (es) | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
US20120220557A1 (en) * | 2011-02-17 | 2012-08-30 | Chiesi Farmaceutici S.P.A. | Liquid propellant-free formulation comprising an antimuscarinic drug |
EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
EP2819669B1 (de) * | 2012-02-28 | 2021-04-21 | Boehringer Ingelheim International GmbH | Neue treibgashaltige tiotropium-formulierung |
WO2015065222A1 (ru) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащий в качестве активного вещества микронизированный тиотропия бромид, и способ его получения |
TW201835041A (zh) | 2017-02-17 | 2018-10-01 | 印度商托仁特生技有限公司 | 具β-腎上腺素促效劑及抗蕈毒活性化合物 |
WO2019142214A1 (en) * | 2018-01-19 | 2019-07-25 | Cipla Limited | Pharmaceutical composition comprising tiotropium for inhalation |
CN111936124A (zh) * | 2018-07-26 | 2020-11-13 | 四川海思科制药有限公司 | 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用 |
CN116196298A (zh) * | 2018-07-26 | 2023-06-02 | 四川海思科制药有限公司 | 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用 |
US11642372B2 (en) | 2020-05-01 | 2023-05-09 | Tygrus, LLC | Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses |
WO2022119661A1 (en) * | 2020-12-04 | 2022-06-09 | Tygrus, LLC | THERAPEUTIC MATERIAL WITH LOW pH AND LOW TOXICITY ACTIVE AGAINST AT LEAST ONE PATHOGEN FOR ADDRESSING PATIENTS WITH RESPIRATORY ILLNESSES |
US11826382B2 (en) | 2020-05-01 | 2023-11-28 | Tygrus, LLC | Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2234266T3 (es) * | 1998-07-24 | 2005-06-16 | Jago Research Ag | Formulaciones medicas para aerosoles. |
DE19835346A1 (de) * | 1998-08-05 | 2000-02-10 | Boehringer Ingelheim Pharma | Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
DE19847971A1 (de) * | 1998-10-17 | 1999-09-02 | Schiering | Verfahren und Einrichtung zur Verhinderung von Filterbränden (Staubfilter) |
DE19847970A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Lagerfähige Wirkstoff-Formulierung |
DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
DE19961300A1 (de) * | 1999-12-18 | 2001-06-21 | Asta Medica Ag | Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator |
-
2000
- 2000-11-13 DE DE10056104A patent/DE10056104A1/de not_active Withdrawn
-
2001
- 2001-09-11 UA UA2003065486A patent/UA74853C2/uk unknown
- 2001-11-09 JP JP2002540737A patent/JP4282322B2/ja not_active Expired - Lifetime
- 2001-11-09 DE DE50112535T patent/DE50112535D1/de not_active Expired - Lifetime
- 2001-11-09 AU AU2791002A patent/AU2791002A/xx active Pending
- 2001-11-09 KR KR1020087020177A patent/KR100940752B1/ko not_active IP Right Cessation
- 2001-11-09 BR BR0115226-2A patent/BR0115226A/pt active Pending
- 2001-11-09 EP EP04028508A patent/EP1514546B1/de not_active Expired - Lifetime
- 2001-11-09 RS RSP-2009/0105A patent/RS20090105A/sr unknown
- 2001-11-09 AU AU2002227910A patent/AU2002227910B2/en not_active Ceased
- 2001-11-09 KR KR1020037006434A patent/KR100886094B1/ko not_active IP Right Cessation
- 2001-11-09 AT AT01989446T patent/ATE291428T1/de active
- 2001-11-09 CA CA002429012A patent/CA2429012A1/en not_active Abandoned
- 2001-11-09 AT AT04028508T patent/ATE362761T1/de active
- 2001-11-09 ES ES01989446T patent/ES2240549T3/es not_active Expired - Lifetime
- 2001-11-09 ES ES04028508T patent/ES2287629T3/es not_active Expired - Lifetime
- 2001-11-09 EA EA200300503A patent/EA007904B1/ru not_active IP Right Cessation
- 2001-11-09 PT PT01989446T patent/PT1335728E/pt unknown
- 2001-11-09 SI SI200130751T patent/SI1514546T1/sl unknown
- 2001-11-09 HU HU0301447A patent/HUP0301447A3/hu unknown
- 2001-11-09 PT PT04028508T patent/PT1514546E/pt unknown
- 2001-11-09 SG SG200505149-5A patent/SG167657A1/en unknown
- 2001-11-09 DK DK04028508T patent/DK1514546T3/da active
- 2001-11-09 SI SI200130347T patent/SI1335728T1/xx unknown
- 2001-11-09 CZ CZ20031444A patent/CZ20031444A3/cs unknown
- 2001-11-09 RS YUP-355/03A patent/RS50286B/sr unknown
- 2001-11-09 IL IL15571801A patent/IL155718A0/xx unknown
- 2001-11-09 EP EP01989446A patent/EP1335728B1/de not_active Expired - Lifetime
- 2001-11-09 SK SK741-2003A patent/SK286939B6/sk not_active IP Right Cessation
- 2001-11-09 EP EP07104722A patent/EP1808174A1/de not_active Withdrawn
- 2001-11-09 CN CNA018187773A patent/CN1678318A/zh active Pending
- 2001-11-09 WO PCT/EP2001/012962 patent/WO2002038154A1/de active Application Filing
- 2001-11-09 SK SK50015-2009A patent/SK286950B6/sk not_active IP Right Cessation
- 2001-11-09 MX MXPA03004164A patent/MXPA03004164A/es active IP Right Grant
- 2001-11-09 DE DE50105729T patent/DE50105729D1/de not_active Expired - Lifetime
- 2001-11-09 NZ NZ526400A patent/NZ526400A/en unknown
- 2001-11-09 DK DK01989446T patent/DK1335728T3/da active
- 2001-11-09 PL PL365989A patent/PL205330B1/pl not_active IP Right Cessation
- 2001-11-09 EE EEP200300228A patent/EE200300228A/xx unknown
-
2003
- 2003-04-14 ZA ZA200302921A patent/ZA200302921B/en unknown
- 2003-04-28 EC EC2003004571A patent/ECSP034571A/es unknown
- 2003-05-01 IL IL155718A patent/IL155718A/en not_active IP Right Cessation
- 2003-05-08 BG BG107781A patent/BG107781A/bg active Pending
- 2003-05-12 NO NO20032111A patent/NO20032111L/no not_active Application Discontinuation
- 2003-05-12 HR HR20030378A patent/HRP20030378A2/hr not_active Application Discontinuation
-
2004
- 2004-12-08 JP JP2004355226A patent/JP4282594B2/ja not_active Expired - Lifetime
-
2007
- 2007-05-22 AU AU2007202303A patent/AU2007202303B2/en not_active Ceased
- 2007-07-30 CY CY20071101011T patent/CY1106774T1/el unknown
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