BR0317340A - Formulações de hfc em solução contendo tiotrópio - Google Patents
Formulações de hfc em solução contendo tiotrópioInfo
- Publication number
- BR0317340A BR0317340A BR0317340-2A BR0317340A BR0317340A BR 0317340 A BR0317340 A BR 0317340A BR 0317340 A BR0317340 A BR 0317340A BR 0317340 A BR0317340 A BR 0317340A
- Authority
- BR
- Brazil
- Prior art keywords
- solution
- tiotropium
- formulations
- hfc
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
"FORMULAçõES DE HFC EM SOLUçãO CONTENDO TIOTRóPIO". A presente invenção refere-se a formulações farmacêuticas em solução estáveis que contêm tiotrópio adequadas para administração por aerossol. Mais particularmente, esta invenção refere-se a formulações farmacêuticas em solução estáveis que contêm tiotrópio adequadas para administração por aerossol em que um ácido inorgânico ou um ácido orgânico é adicionado à formulação em solução por aerossol que contém um sal de tiotrópio, de preferência o brometo de tiotrópio em solução com um hidrofluorocarboneto (HFC) ambientalmente inofensivo como um propulsor, juntamente com um composto orgânico como um co-solvente. O ácido fornece estabilidade contra a degradação ou a decomposição do medicamento resultante amplamente da interação do medicamento com o co-solvente e/ou com a água presente na formulação em solução.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02028238 | 2002-12-16 | ||
PCT/EP2003/013692 WO2004054580A1 (en) | 2002-12-16 | 2003-12-04 | Tiotropium containing hfc solution formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0317340A true BR0317340A (pt) | 2005-11-08 |
Family
ID=32524008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0317340-2A Expired - Fee Related BR0317340A (pt) | 2002-12-16 | 2003-12-04 | Formulações de hfc em solução contendo tiotrópio |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1575588A1 (pt) |
JP (1) | JP2006510680A (pt) |
KR (1) | KR20050085650A (pt) |
CN (1) | CN1726038A (pt) |
AU (1) | AU2003303029A1 (pt) |
BR (1) | BR0317340A (pt) |
CA (1) | CA2510043A1 (pt) |
IL (1) | IL169178A0 (pt) |
MX (1) | MXPA05006383A (pt) |
PL (1) | PL375868A1 (pt) |
RU (1) | RU2005122444A (pt) |
WO (1) | WO2004054580A1 (pt) |
ZA (1) | ZA200503546B (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7273603B2 (en) * | 2003-07-11 | 2007-09-25 | Boehringer Ingelheim International Gmbh | HFC solution formulations containing an anticholinergic |
DK1881980T3 (da) * | 2005-05-02 | 2012-10-01 | Boehringer Ingelheim Int | Nye krystalline former af tiotropiumbromid |
EP1879888A2 (en) * | 2005-05-02 | 2008-01-23 | Boehringer Ingelheim International GmbH | Crystalline forms of tiotropium bromide |
CN102731494A (zh) * | 2005-12-19 | 2012-10-17 | 西科尔公司 | 噻托溴铵的新形式及其制备方法 |
US9108962B2 (en) | 2005-12-19 | 2015-08-18 | Sicor, Inc. | Forms of tiotropium bromide and processes for preparation thereof |
EP2201934A1 (en) | 2008-12-23 | 2010-06-30 | CHIESI FARMACEUTICI S.p.A. | Tiotropium aerosol formulation products with improved chemical stability |
WO2011076842A2 (en) | 2009-12-23 | 2011-06-30 | Chiesi Farmaceutici S.P.A. | Aerosol formulation for copd |
CN102665679B (zh) | 2009-12-23 | 2014-11-26 | 奇斯药制品公司 | 用于copd的联合治疗 |
GB201200525D0 (en) * | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
GB201200504D0 (en) | 2011-12-19 | 2012-02-22 | Teva Branded Pharmaceutical Prod R & D Inc | An inhaler |
WO2013127738A1 (de) | 2012-02-28 | 2013-09-06 | Boehringer Ingelheim International Gmbh | Neue treibgashaltige tiotropium-formulierung |
CN104918604A (zh) * | 2012-10-23 | 2015-09-16 | 西普拉有限公司 | 药物组合物 |
KR20160101929A (ko) * | 2013-11-22 | 2016-08-26 | 테바 브랜디드 파마슈티컬 프로덕츠 알앤디, 인코포레이티드 | 흡입 약제 |
US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
PE20191044A1 (es) * | 2016-09-19 | 2019-08-06 | Mexichem Fluor Sa De Cv | Composicion farmaceutica |
US10792256B2 (en) | 2016-09-19 | 2020-10-06 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
EP3515432B1 (en) | 2016-09-19 | 2021-08-25 | Mexichem Fluor S.A. de C.V. | Pharmaceutical composition comprising glycopyrrolate |
US20190374519A1 (en) * | 2016-09-19 | 2019-12-12 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
CA3037080C (en) | 2016-09-19 | 2021-05-18 | Mexichem Fluor S.A. De C.V. | Stable pharmaceutical compositions comprising indacaterol and 1,1-difluoroethane (hfa-152a) suitable for use in metered dose inhalers (mdis) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2126248C1 (ru) * | 1992-12-09 | 1999-02-20 | Берингер Ингельхейм Фармасьютикалз, Инк. | Жидкая фармацевтическая композиция в форме аэрозоля |
DE10056104A1 (de) * | 2000-11-13 | 2002-05-23 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols |
-
2003
- 2003-12-04 KR KR1020057010885A patent/KR20050085650A/ko not_active Application Discontinuation
- 2003-12-04 PL PL03375868A patent/PL375868A1/xx unknown
- 2003-12-04 CA CA002510043A patent/CA2510043A1/en not_active Abandoned
- 2003-12-04 RU RU2005122444/15A patent/RU2005122444A/ru not_active Application Discontinuation
- 2003-12-04 MX MXPA05006383A patent/MXPA05006383A/es not_active Application Discontinuation
- 2003-12-04 CN CNA2003801063667A patent/CN1726038A/zh active Pending
- 2003-12-04 AU AU2003303029A patent/AU2003303029A1/en not_active Abandoned
- 2003-12-04 JP JP2004559752A patent/JP2006510680A/ja active Pending
- 2003-12-04 WO PCT/EP2003/013692 patent/WO2004054580A1/en active Application Filing
- 2003-12-04 BR BR0317340-2A patent/BR0317340A/pt not_active Expired - Fee Related
- 2003-12-04 EP EP03813106A patent/EP1575588A1/en not_active Withdrawn
-
2005
- 2005-05-04 ZA ZA200503546A patent/ZA200503546B/xx unknown
- 2005-06-15 IL IL169178A patent/IL169178A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1575588A1 (en) | 2005-09-21 |
KR20050085650A (ko) | 2005-08-29 |
ZA200503546B (en) | 2006-10-25 |
IL169178A0 (en) | 2007-07-04 |
WO2004054580A1 (en) | 2004-07-01 |
CN1726038A (zh) | 2006-01-25 |
JP2006510680A (ja) | 2006-03-30 |
AU2003303029A1 (en) | 2004-07-09 |
MXPA05006383A (es) | 2005-08-29 |
CA2510043A1 (en) | 2004-07-01 |
RU2005122444A (ru) | 2007-01-27 |
PL375868A1 (en) | 2005-12-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010. |