CY1105680T1 - Μολυσματικος κλωνος cdna βορειοαμερικανικου ιου χοιρειου αναπαραγωγικου και αναπνευστικου συνδρομου (prrs) και χρησεις αυτου - Google Patents

Μολυσματικος κλωνος cdna βορειοαμερικανικου ιου χοιρειου αναπαραγωγικου και αναπνευστικου συνδρομου (prrs) και χρησεις αυτου

Info

Publication number
CY1105680T1
CY1105680T1 CY061100160T CY061100160T CY1105680T1 CY 1105680 T1 CY1105680 T1 CY 1105680T1 CY 061100160 T CY061100160 T CY 061100160T CY 061100160 T CY061100160 T CY 061100160T CY 1105680 T1 CY1105680 T1 CY 1105680T1
Authority
CY
Cyprus
Prior art keywords
north american
viruses
encoding
viral vectors
host cells
Prior art date
Application number
CY061100160T
Other languages
English (en)
Inventor
Jay Gregory Calvert
Siao-Kun Wan Welch
Michael George Sheppard
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of CY1105680T1 publication Critical patent/CY1105680T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2770/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C12N2770/10062—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

Η εφεύρεση παρέχει απομονωμένα μόρια πολυνουκλεοτιδίων, που περιλαμβάνουν πλασμίδια, ιικούς φορείς, και διαμολυσμένα κύτταρα-ξενιστές που περιλαμβάνουν αλληλουχία DNA που κωδικοποιεί μολυσματική αλληλουχία RNA που κωδικοποιεί Βορειοαμερικανικό ιό PRRS, και επίσης Βορειοαμερικανικούς ιούς PRRS που κωδικοποιούνται από αυτά τα απομονωμένα μόρια πολυνουκλεοτιδίων. Η εφεύρεση παρέχει επιπλέον απομονωμένα μολυσματικά μόρια RNA που κωδικοποιούν Βορειοαμερικανικό ιό PRRS. Η εφεύρεση παρέχει επίσης απομονωμένα μόρια πολυνουκλεοτιδίων, μολυσματικά μόρια RNA, ιικούς φορείς, και διαμολυσμένα κύτταρα-ξενιστές που κωδικοποιούν γενετικά τροποποιημένους Βορειοαμερικανικούς ιούς PRRS, και γενετικά τροποποιημένους Βορειοαμερικανικούς ιούς PRRS που κωδικοποιούνται από αυτά τα απομονωμένα μόρια πολυνουκλεοτιδίων. Η εφεύρεση παρέχει επίσης εμβόλια που περιλαμβάνουν αυτά τα πλασμίδια, μόρια RNA, ιικούς φορείς και Βορειοαμερικανικούς ιούς PRRS, και μεθόδους χρήσης αυτών των εμβολίων σε χοιροειδή και σε άλλα ζώα. Παρέχονται επίσης απομονωμένα μόρια πολυνουκλεοτιδίων, ιικοί φορείς, και διαμολυσμένα κύτταρα-ξενιστές που περιλαμβάνουν αλληλουχία νουκλεοτιδίων που κωδικοποιεί πεπτίδιο Βορειοαμερικανικού ιού PRRS. Αυτοί οι ιικοί φορείς και κυτταρικές σειρές διαμολυσμένων κυττάρων-ξενιστών χρησιμεύουν στο να παρέχουν πεπτίδια που να αναπληρώνουν αλληλουχίες που κωδικοποιούν μεταλλαγμένα πεπτίδια των αλληλουχιών DNA που κωδικοποιούν γενετικά τροποποιημένους Βορειοαμερικανικούς ιούς PRRS έτσι ώστε να παράγονται λειτουργικά ιοσώματα.
CY061100160T 1998-12-22 2006-02-07 Μολυσματικος κλωνος cdna βορειοαμερικανικου ιου χοιρειου αναπαραγωγικου και αναπνευστικου συνδρομου (prrs) και χρησεις αυτου CY1105680T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11334598P 1998-12-22 1998-12-22
EP19990309409 EP1018557B9 (en) 1998-12-22 1999-11-25 Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof

Publications (1)

Publication Number Publication Date
CY1105680T1 true CY1105680T1 (el) 2014-07-02

Family

ID=22348908

Family Applications (2)

Application Number Title Priority Date Filing Date
CY061100160T CY1105680T1 (el) 1998-12-22 2006-02-07 Μολυσματικος κλωνος cdna βορειοαμερικανικου ιου χοιρειου αναπαραγωγικου και αναπνευστικου συνδρομου (prrs) και χρησεις αυτου
CY20141100252T CY1115010T1 (el) 1998-12-22 2014-04-03 ΕΝΑΣ ΜΟΛΥΣΜΑΤΙΚΟΣ cDNA ΚΛΩΝΟΣ ΤΟΥ ΙΟΥ ΤΟΥ ΧΟΙΡΕΙΟΥ ΑΝΑΠΑΡΑΓΩΓΙΚΟΥ ΚΑΙ ΑΝΑΠΝΕΥΣΤΙΚΟΥ ΣΥΝΔΡΟΜΟΥ ΒΟΡΕΙΟΥ ΑΜΕΡΙΚΗΣ (PRRS) ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΟΥ

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20141100252T CY1115010T1 (el) 1998-12-22 2014-04-03 ΕΝΑΣ ΜΟΛΥΣΜΑΤΙΚΟΣ cDNA ΚΛΩΝΟΣ ΤΟΥ ΙΟΥ ΤΟΥ ΧΟΙΡΕΙΟΥ ΑΝΑΠΑΡΑΓΩΓΙΚΟΥ ΚΑΙ ΑΝΑΠΝΕΥΣΤΙΚΟΥ ΣΥΝΔΡΟΜΟΥ ΒΟΡΕΙΟΥ ΑΜΕΡΙΚΗΣ (PRRS) ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΟΥ

Country Status (18)

Country Link
US (2) US6500662B1 (el)
EP (2) EP1627919B1 (el)
JP (7) JP4113642B2 (el)
CN (1) CN1171996C (el)
AR (2) AR025146A1 (el)
AT (1) ATE309364T1 (el)
AU (1) AU769841B2 (el)
BR (1) BRPI9905902B8 (el)
CA (2) CA2440933A1 (el)
CY (2) CY1105680T1 (el)
DE (1) DE69928209T9 (el)
DK (2) DK1627919T3 (el)
ES (2) ES2459568T3 (el)
HK (1) HK1029140A1 (el)
MX (1) MXPA03009354A (el)
NZ (2) NZ513289A (el)
PT (1) PT1627919E (el)
ZA (1) ZA997289B (el)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US7618797B2 (en) 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7691389B2 (en) * 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
JP3961222B2 (ja) 1999-03-08 2007-08-22 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー Ｐｒｒｓｖワクチン
CA2370372C (en) 1999-04-22 2009-02-24 United States Department Of Agriculture Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142
WO2002038753A1 (fr) * 2000-11-09 2002-05-16 Junichi Watanabe Procede de criblage d'un gene agissant sur les conditions pathologiques ou la survie d'un animal infecte par un pathogene
US6841364B2 (en) * 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
US7906311B2 (en) * 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
KR101146545B1 (ko) * 2003-07-24 2012-07-05 메리얼 리미티드 수중유 에멀젼을 포함하는 백신 제형물
AR049924A1 (es) 2004-06-18 2006-09-13 Univ Minnesota Identificacion de organismos viralmente infectados y vacunados
KR100872840B1 (ko) 2004-07-09 2008-12-22 (주)씨아이디 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도
US7632636B2 (en) * 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
JP2008519594A (ja) * 2004-11-11 2008-06-12 ファイザー・プロダクツ・インク 変異体ブタ生殖器呼吸器症候群ウイルス
RU2007130801A (ru) 2005-01-13 2009-02-20 Берингер Ингельхайм Ветмедика Гмбх (De) Улучшенные вакцины против репродуктивно-респираторного синдрома свиней (prrs)
WO2006129139A1 (en) * 2005-02-25 2006-12-07 Pfizer Products Inc. N protein mutants of porcine reproductive and respiratory syndrome virus
ES2386973T3 (es) 2005-06-24 2012-09-10 Regents Of The University Of Minnesota Virus PRRS, clones infecciosos, mutantes de los mismos, y métodos de utilización
EP1929047B1 (en) * 2005-08-30 2010-03-17 Board of Regents of the University of Nebraska Methods and compositions for vaccination of animals with prrsv antigens with improved immunogenicity
AR064888A1 (es) 2007-01-12 2009-04-29 Univ Illinois Celulas no simias para el crecimiento del virus del sindrome reproductor y respiratorio porcino (prrs)
US7666585B2 (en) 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
MX2010000235A (es) * 2007-06-25 2010-08-02 Univ South Dakota Virus del sindrome respiratorio y reproductivo porcino tipo 1 norteamericano recombinante y metodos de uso.
MX2011002046A (es) * 2008-08-25 2011-04-21 Boehringer Ingelheim Vetmed Vacuna contra sindrome disgenesico y respiratorio porcino altamente patogeno (hp prrs).
US8012735B2 (en) * 2009-03-02 2011-09-06 University Of Kentucky Research Foundation Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
SG179037A1 (en) * 2009-09-10 2012-04-27 Merial Ltd New vaccine formulations comprising saponin-containing adjuvants
UA108902C2 (uk) * 2010-11-10 2015-06-25 Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування
DK2675476T3 (en) 2011-02-17 2015-12-14 Boehringer Ingelheim Vetmed Process for producing PRRSV on a commercial scale
ME02271B (me) 2011-02-17 2016-02-20 Boehringer Ingelheim Vetmedica Gmbh Novi evropski prrsv soj
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
WO2013017568A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
KR102012109B1 (ko) * 2012-05-17 2019-08-19 조에티스 엘엘씨 이유 전 돼지 생식기 호흡기 증후군(prrs) 바이러스에 대한 효과적인 백신접종
EP2968513A2 (en) 2013-03-15 2016-01-20 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
JP6821429B2 (ja) 2013-09-25 2021-01-27 ゾエティス・サービシーズ・エルエルシー Ｐｃｖ２ｂ分岐ワクチン組成物及び使用方法
HUE061768T2 (hu) * 2013-12-20 2023-08-28 Boehringer Ingelheim Vetmedica Gmbh PRRS virus variáns, európai PRRS virus cDNS klón, és alkalmazásuk
CN104198773A (zh) * 2014-08-29 2014-12-10 苏州市吴中区胥口广博模具加工厂 三轴联动式大型电路板测试夹具的第二转轴组
TWI554609B (zh) 2014-11-19 2016-10-21 國立屏東科技大學 抗豬生殖與呼吸綜合症病毒感染之重組融合抗原基因、重組融合抗原蛋白及含彼之次單位疫苗組成物
UA124140C2 (uk) 2015-08-31 2021-07-28 Бьорінгер Інгельхайм Ветмедіка Гмбх Пестивірусна вакцина проти вродженого тремору поросят
EP3389706A1 (en) 2015-12-14 2018-10-24 Boehringer Ingelheim Vetmedica, Inc. Hybrid core feline vaccines
MX2019001395A (es) 2016-08-05 2019-06-17 Hipra Scient S L U Clon de adnc del virus del sindrome reproductivo y respiratorio porcino y usos del mismo.
CA3047294A1 (en) 2016-12-14 2018-06-21 Zoetis Services Llc Effective vaccination against european strains of porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
CN107586780B (zh) * 2017-10-25 2019-10-11 中国农业科学院兰州兽医研究所 一种抑制猪繁殖与呼吸综合征病毒的长链非编码rna
CN109943590B (zh) * 2019-04-18 2022-11-18 西南大学 一种复制缺陷型猪圆环病毒、其制备方法及应用
CN111996174A (zh) * 2020-02-06 2020-11-27 广西大学 猪繁殖与呼吸综合征病毒及其克隆载体和***基因方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3959457A (en) 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4015100A (en) 1974-01-07 1977-03-29 Avco Everett Research Laboratory, Inc. Surface modification
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4205060A (en) 1978-12-20 1980-05-27 Pennwalt Corporation Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
US4452747A (en) 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
US4744933A (en) 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
US5008050A (en) 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
US5009956A (en) 1987-02-24 1991-04-23 Univ Minnesota Phospholipase A2-resistant liposomes
IT8819772A0 (it) * 1988-03-15 1988-03-15 Honeywell Bull Spa Dispositivo selettivo a terra per apparecchiature elettroniche.
US4927637A (en) 1989-01-17 1990-05-22 Liposome Technology, Inc. Liposome extrusion method
US4944948A (en) 1989-02-24 1990-07-31 Liposome Technology, Inc. EGF/Liposome gel composition and method
US5132117A (en) 1990-01-11 1992-07-21 Temple University Aqueous core microcapsules and method for their preparation
CA2103460C (en) 1991-06-06 2000-09-26 Gert Wensvoort Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
CA2076744C (en) 1991-08-26 2000-06-27 Danny W. Chladek Viral agent associated with mystery swine disease
CA2116348C (en) 1991-08-26 2001-07-03 James E. Collins Sirs vaccine and diagnosis method
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
WO1993006211A1 (en) 1991-09-16 1993-04-01 Collins James E Vaccine for mystery swine disease and method for diagnosis thereof
FR2686097B1 (fr) 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5203054A (en) 1992-09-28 1993-04-20 Emhart Inc. Retainer for trunk lid torsion bars
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US6773908B1 (en) * 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6251397B1 (en) * 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
ATE197314T1 (de) 1993-02-08 2000-11-15 Bayer Ag Verfahren zum vermehren des das reproduktions- und atemwegs-syndrom verursachenden schweinevirus und dessen verwendung als impfstoff.
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
JPH10500889A (ja) 1994-04-15 1998-01-27 テンプル・ユニバーシティ 水性溶媒封入法、装置およびマイクロカプセル
WO1996004010A1 (en) * 1994-08-05 1996-02-15 Regents Of The University Of Minnesota Vr-2332 viral nucleotide sequence and methods of use
ES2223058T3 (es) 1995-03-14 2005-02-16 Akzo Nobel N.V. Expresion en la misma celula de polipeptidos del virus del sindrome reproductivo y respiratorio porcino.
CN1165342C (zh) 1996-03-01 2004-09-08 先灵公司 猪生殖和呼吸综合症疫苗
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
WO1998055626A2 (en) 1997-06-05 1998-12-10 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
US6288199B1 (en) * 1999-11-02 2001-09-11 Ppg Industries Ohio, Inc. Blocked isocyanate-based compounds and compositions containing the same

Also Published As

Publication number Publication date
EP1627919B1 (en) 2014-02-12
AU769841B2 (en) 2004-02-05
US20020172690A1 (en) 2002-11-21
DK1018557T5 (da) 2006-05-15
JP2001224384A (ja) 2001-08-21
JP4159242B2 (ja) 2008-10-01
AR058249A2 (es) 2008-01-30
CN1263945A (zh) 2000-08-23
DK1018557T3 (da) 2005-12-05
AU6173399A (en) 2000-06-29
PT1627919E (pt) 2014-05-02
BR9905902A (pt) 2000-12-12
MXPA03009354A (es) 2004-03-02
AR025146A1 (es) 2002-11-13
BRPI9905902B1 (pt) 2015-09-01
ATE309364T1 (de) 2005-11-15
DK1627919T3 (en) 2014-03-10
JP4130729B2 (ja) 2008-08-06
JP4335287B2 (ja) 2009-09-30
DE69928209T9 (de) 2006-10-19
JP4113642B2 (ja) 2008-07-09
HK1029140A1 (en) 2001-03-23
EP1627919A1 (en) 2006-02-22
EP1018557A3 (en) 2002-05-02
DE69928209D1 (de) 2005-12-15
BRPI9905902B8 (pt) 2021-05-25
CA2290220A1 (en) 2000-06-22
NZ513289A (en) 2003-04-29
DE69928209T2 (de) 2006-06-08
NZ501264A (en) 2001-09-28
CA2440933A1 (en) 2000-06-22
JP2008113670A (ja) 2008-05-22
ES2251162T3 (es) 2006-04-16
CN1171996C (zh) 2004-10-20
US6500662B1 (en) 2002-12-31
CY1115010T1 (el) 2016-12-14
CA2290220C (en) 2013-11-19
JP2008131957A (ja) 2008-06-12
ZA997289B (en) 2001-05-24
EP1018557B1 (en) 2005-11-09
JP2004081218A (ja) 2004-03-18
US7232680B2 (en) 2007-06-19
JP2008289485A (ja) 2008-12-04
EP1018557A2 (en) 2000-07-12
JP2000189178A (ja) 2000-07-11
EP1018557B9 (en) 2006-06-28
JP2001218591A (ja) 2001-08-14
ES2459568T3 (es) 2014-05-09

Similar Documents

Publication Publication Date Title
CY1105680T1 (el) Μολυσματικος κλωνος cdna βορειοαμερικανικου ιου χοιρειου αναπαραγωγικου και αναπνευστικου συνδρομου (prrs) και χρησεις αυτου
CA2196555A1 (en) Vr-2332 viral nucleotide sequence and methods of use
ES8500322A1 (es) Un metodo de modificar un virus para conferirle una nueva funcion biologica.
RU2351651C2 (ru) Выделенный рекомбинантный вирус гриппа и способы его получения
DK0776361T3 (da) Rekombinant herpesvirus fra kalkuner og anvendelser deraf
ATE309367T1 (de) Nukleotid- und aminosäuresequenzen der gene des hüllproteins 1 und des kernproteins von hepatitis c virus
NZ500540A (en) Purified proteins, fusion proteins, recombinant vector, vaccine, kit, comprising proteins from Actinobacillus pleuropneumoniae
CY1106570T1 (el) Σταθερες, εξασθενημενες μεταλλαγμενες μορφες ιου λυσσας και ζωντανια εμβολια αυτων
DK0484382T3 (da) Felint calicivirus-capsid-protein og nucleotidsekvens
CY1106433T1 (el) Εμβολια κοκκιδιωσης
BG105065A (en) A vaccine-induced hepatitis b viral strain and uses thereof
PE20001287A1 (es) Composicion farmaceutica que contiene fragmentos de adn codificador de una proteina antigenica con efecto antitumoral
DE69935599D1 (de) Modifizierte hcv peptid-impfstoffe
ZA200602107B (en) Piroplasmid vaccine
ES2192433A1 (es) Produccion del antigeno vp60, o de un fragmento del mismo, del virus de la enfermedad hemorragica de los conejos en plantas y vacuna contra la enfermedad hemorragica virica de los conejos que comprende dicho antigeno.
ES2079493T3 (es) Proteina de membrana externa p1 y peptidos haemophilus influenzae tipo b.
DE60330795D1 (de) Impfstoff gegen west nile virus
NO20005482D0 (no) Rekombinant virus som uttrykker fremmed DNA som koder for Felin CD80, Felin CTLA-4 eller Felin CD86 og anvendelse derav
HUP0103871A2 (hu) Rekombináns CELO-vírus és CELO vírus DNS
EP0789563A4 (en) Vaccines against the hepatitis virus
EP0924295A3 (en) DNA encoding neospora dihydrofolate reductase-thymidylate synthase
BG105066A (en) A mutant human hepatitis b viral strain and uses thereof
DE69942611D1 (de) Schützende hochmolekulargewichtsproteine aus haemophilus influenzae
TH1348EX (th) การประดิษฐ์ไวรัสที่มีโปรตีนพื้นผิวเป็นรีคอมบิแนนท์โปรตีน
TH51753B (th) cDNA โคลน ที่ติดเชื้อของไวรัสกลุ่มอาการโรคเกี่ยวกับการสืบพันธ์และการหายใจของสุกร (PRRS) สายพันธ์อเมริกาเหนือและการใช้ cDNA โคลนนี้