CY1105441T1 - Ετepοκυκλικοι σουλφοναμιδικοι αναστολεις της παραγωγης βητα αμυλοειδους - Google Patents

Ετepοκυκλικοι σουλφοναμιδικοι αναστολεις της παραγωγης βητα αμυλοειδους

Info

Publication number
CY1105441T1
CY1105441T1 CY20061101305T CY061101305T CY1105441T1 CY 1105441 T1 CY1105441 T1 CY 1105441T1 CY 20061101305 T CY20061101305 T CY 20061101305T CY 061101305 T CY061101305 T CY 061101305T CY 1105441 T1 CY1105441 T1 CY 1105441T1
Authority
CY
Cyprus
Prior art keywords
beta
eteocyclic
amyloid production
sulfonamide inhibitors
compounds
Prior art date
Application number
CY20061101305T
Other languages
English (en)
Inventor
Anthony Frank Kreft
Derek Cecil Cole
Kevin Roger Woller
Joseph Raymond Stock
George Diamanitis
Dennis Michael Kurbrak
Kristina Martha Kutterer
William Jay Moore
David Scott Casebier
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22966854&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1105441(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth filed Critical Wyeth
Publication of CY1105441T1 publication Critical patent/CY1105441T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64—Sulfur atoms

Abstract

Ενώσεις του Χημικού τύπου (I), όπου τα R1, R2, R3, R4, R5, R6, Τ, W, Υ και Ζ είναι όπως ορίσθηκαν σε αυτό κείμενο, παρέχονται μαζί με φαρμακευτικώς αποδεκτά άλατα, υδατικά άλατα και/ή προφάρμακα αυτών. Μέθοδοι χρήσης αυτών των ενώσεων για την αναστολή της παραγωγής του βήτα αμυλοειδούς και για την θεραπεία της Νόσου του Alzheimer και του Συνδρόμου Down περιγράφονται.
CY20061101305T 2000-12-13 2006-09-14 Ετepοκυκλικοι σουλφοναμιδικοι αναστολεις της παραγωγης βητα αμυλοειδους CY1105441T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25510500P 2000-12-13 2000-12-13
PCT/US2001/048375 WO2002057252A2 (en) 2000-12-13 2001-12-11 Heterocyclic sulfonamide inhibitors of beta amyloid production

Publications (1)

Publication Number Publication Date
CY1105441T1 true CY1105441T1 (el) 2010-07-28

Family

ID=22966854

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101305T CY1105441T1 (el) 2000-12-13 2006-09-14 Ετepοκυκλικοι σουλφοναμιδικοι αναστολεις της παραγωγης βητα αμυλοειδους

Country Status (28)

Country Link
US (5) US6610734B2 (el)
EP (1) EP1341779B1 (el)
JP (2) JP2004517892A (el)
KR (1) KR100869061B1 (el)
CN (2) CN1800176A (el)
AR (1) AR035516A1 (el)
AT (1) ATE330950T1 (el)
AU (1) AU2002245123B2 (el)
BR (1) BR0116063A (el)
CA (1) CA2436526C (el)
CY (1) CY1105441T1 (el)
DE (1) DE60121032T2 (el)
DK (1) DK1341779T3 (el)
EA (1) EA009035B1 (el)
ES (1) ES2267853T3 (el)
HK (1) HK1059619A1 (el)
HU (1) HUP0303857A3 (el)
IL (3) IL156268A0 (el)
MX (1) MXPA03005255A (el)
NO (1) NO328885B1 (el)
NZ (2) NZ538100A (el)
PL (1) PL365950A1 (el)
PT (1) PT1341779E (el)
SG (1) SG128491A1 (el)
SI (1) SI1341779T1 (el)
TW (1) TWI235155B (el)
WO (1) WO2002057252A2 (el)
ZA (1) ZA200304135B (el)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1268412B8 (en) * 2000-03-20 2007-02-21 MERCK SHARP & DOHME LTD. Sulphonamido-substituted bridged bicycloalkyl derivatives
IL156268A0 (en) 2000-12-13 2004-01-04 Wyeth Corp Heterocyclic sulfonamide inhibitors of beta amyloid production
US6657070B2 (en) 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
JP4250529B2 (ja) * 2001-12-11 2009-04-08 ワイス キラル的に純粋なβ−アミノアルコールの合成方法
NZ536665A (en) * 2002-06-11 2006-11-30 Wyeth Corp Use of substituted phenylsulfonamide as inhibitors of beta amyloid production
EP1562897B1 (en) 2002-11-12 2009-09-16 Merck & Co., Inc. Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer s disease
RU2342374C2 (ru) * 2003-03-31 2008-12-27 Уайт Фтор- и трифторалкилсодержащие гетероциклические сульфонамидные ингибиторы образования бета-амилоида и их производные
CA2526487A1 (en) * 2003-06-30 2005-01-06 Daiichi Pharmaceutical Co., Ltd. Heterocyclic methyl sulfone derivative
DE602005016775D1 (de) * 2004-01-16 2009-11-05 Wyeth Corp Heterocyclische, ein azol enthaltende sulfonamidinhibitoren der beta-amyloid-produktion
CA2595173A1 (en) 2005-01-18 2006-07-27 Elan Pharmaceuticals, Inc. N-substituted heterocyclic sulfonamides
CN101142194B (zh) * 2005-03-14 2012-10-10 顶点制药有限责任公司 吲哚衍生物，组合物及用作β-分泌酶抑制剂的方法
TW200800959A (en) * 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
GB0602951D0 (en) * 2006-02-14 2006-03-29 Novartis Ag Organic Compounds
AU2007217965A1 (en) * 2006-02-17 2007-08-30 Wyeth Methods for preparing sulfonamide substituted alcohols and intermediates thereof
US7838550B2 (en) * 2006-02-17 2010-11-23 Wyeth Llc Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols
US7476762B2 (en) * 2006-04-21 2009-01-13 Wyeth Methods for preparing sulfonamide compounds
US7550629B2 (en) * 2006-04-21 2009-06-23 Wyeth Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors
MX2008013539A (es) * 2006-04-21 2008-10-29 Wyeth Corp Produccion de intermediarios de amino alcohol quiralmente puros, derivados de los mismos, y usos de los mismos.
TW200811144A (en) * 2006-06-09 2008-03-01 Wyeth Corp Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline
TW200808741A (en) * 2006-06-09 2008-02-16 Wyeth Corp 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
TW200808740A (en) * 2006-06-09 2008-02-16 Wyeth Corp Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof
WO2008059238A1 (en) * 2006-11-17 2008-05-22 Astrazeneca Ab Benzenesulfonamide compounds as edg-1 antagonists useful in the treatment of cancer
AU2007323540A1 (en) * 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity
TW200831096A (en) * 2006-11-28 2008-08-01 Wyeth Corp Metabolites of 5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl} quinoline and methods of preparation and uses thereof
CL2008000119A1 (es) * 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
EP2121633A2 (en) 2007-02-12 2009-11-25 Merck & Co., Inc. Piperazine derivatives for treatment of ad and related conditions
AR067534A1 (es) * 2007-07-16 2009-10-14 Wyeth Corp Proceso para la preparacion de trifluoroalquil - fenil sulfonamidas y de sulfonamidas heterociclicas
PE20090810A1 (es) * 2007-07-16 2009-07-20 Wyeth Corp Procesos e intermediarios para la preparacion de compuestos de sulfonamida heterociclica
PA8789701A1 (es) * 2007-07-16 2009-04-23 Wyeth Corp Inhibidores de producción de beta amiloide
CA2709677C (en) 2007-12-21 2017-03-14 Lin Zhi Selective androgen receptor modulators (sarms) and uses thereof
AR070120A1 (es) * 2008-01-11 2010-03-17 Wyeth Corp Derivados de aril sulfonamida que contienen o-sulfato y o-fosfato, utiles como inhibidores de beta-amiloide, proceso de preparacion de los mismos y composiciones farmaceuticas que los contienen.
US8461389B2 (en) 2008-04-18 2013-06-11 University College Dublin, National University Of Ireland, Dublin Psycho-pharmaceuticals
EP3403650A3 (en) 2008-07-28 2019-02-13 Blanchette Rockefeller Neurosciences, Institute Pkc-activating compounds for the treatment of neurodegenerative diseases
US8907098B2 (en) 2009-12-17 2014-12-09 Merck Patent Gmbh Inhibitors of sphingosine kinase
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
PL2945621T3 (pl) 2013-01-18 2019-05-31 Cardioxyl Pharmaceuticals Inc Kompozycje farmaceutyczne zawierające donory nitroksylu
CN104370769B (zh) * 2013-08-14 2017-05-31 重庆博腾制药科技股份有限公司 一种制备羟基金刚烷甘氨酸衍生物的方法
US10441567B2 (en) 2014-01-17 2019-10-15 Ligand Pharmaceuticals Incorporated Methods and compositions for modulating hormone levels
US11046668B2 (en) 2016-03-11 2021-06-29 Ohio State Innovation Foundation Small molecule antimicrobials
DE202022106287U1 (de) 2022-11-09 2022-11-21 Ahmad Salawi Eine Methode zur Synthese und biologischen Bewertung von neuen Sulfonamid-Analoga

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US656536A (en) * 1899-12-28 1900-08-21 David Fitzgibbons Boiler.
US3376523A (en) * 1966-12-27 1968-04-02 Univ California Transient-suppressing magnetic transmission line
US5591761A (en) 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5514691A (en) 1993-05-20 1996-05-07 Immunopharmaceutics, Inc. N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en) 1993-05-20 1996-11-05 Texas Biotechnology Corporation Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5464853A (en) 1993-05-20 1995-11-07 Immunopharmaceutics, Inc. N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) 1993-05-20 1997-01-14 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
KR920019763A (ko) 1991-04-26 1992-11-19 모리다 가즈라 아졸 화합물, 그의 제조방법 및 용도
GB9110722D0 (en) 1991-05-17 1991-07-10 Fujisawa Pharmaceutical Co Amine derivatives
US5766846A (en) 1992-07-10 1998-06-16 Athena Neurosciences Methods of screening for compounds which inhibit soluble β-amyloid peptide production
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
JP3599287B2 (ja) * 1993-04-28 2004-12-08 三菱化学株式会社 スルホンアミド誘導体
US6342610B2 (en) * 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
IL110525A0 (en) 1993-08-09 1994-11-11 Lilly Co Eli Identification and use of protease inhibitors
US5519040A (en) 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US5561146A (en) 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
US5624937A (en) 1995-03-02 1997-04-29 Eli Lilly And Company Chemical compounds as inhibitors of amyloid beta protein production
EP0761680A3 (en) 1995-09-12 1999-05-06 Ono Pharmaceutical Co., Ltd. Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity
JPH09136878A (ja) * 1995-09-12 1997-05-27 Ono Pharmaceut Co Ltd テトラゾール誘導体
ES2293651T3 (es) * 1995-11-28 2008-03-16 Cephalon, Inc. Inhibidores de cisteina y serina proteasas derivados de aminoacidos d.
WO1997024340A1 (en) 1995-12-27 1997-07-10 Takeda Chemical Industries, Ltd. Oxazole derivatives, their production and use
JPH09235276A (ja) * 1995-12-27 1997-09-09 Takeda Chem Ind Ltd オキサゾール誘導体、その製造法および用途
US5877193A (en) 1996-07-19 1999-03-02 Hoffmann-La Roche Inc. Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
EP0939629A4 (en) 1996-07-22 2002-07-17 Monsanto Co THIOL-SULFONAMIDES AS METALLOPROTEINAS INHIBITORS
US5703129A (en) 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production
CA2268103A1 (en) * 1996-10-11 1998-04-23 Warner-Lambert Company Sulfonamide substituted aspartic acid interleukin-1.beta. converting enzyme inhibitors
US5985930A (en) 1996-11-21 1999-11-16 Pasinetti; Giulio M. Treatment of neurodegenerative conditions with nimesulide
NZ335157A (en) 1996-11-22 2001-01-26 Elan Pharm Inc N-(aryl/heteroaryl) amino acid derivatives and methods for inhibiting beta-amyloid peptide release or its synthesis
DE19650196A1 (de) * 1996-12-04 1998-06-10 Bayer Ag Thienylsulfonylamino(thio)carbonylverbindungen
GB9725138D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Thiophenesulfonamide compounds
JPH11343279A (ja) 1998-03-16 1999-12-14 Shionogi & Co Ltd スルホンアミド誘導体およびそれらを含有するＴＮＦ―α産生抑制剤
US5981168A (en) 1998-05-15 1999-11-09 The University Of British Columbia Method and composition for modulating amyloidosis
CN1295561A (zh) * 1998-06-03 2001-05-16 Gpinil控股公司 N－杂环羧酸或羧酸等排物的n－结合氨磺酰
US7410995B1 (en) 1998-08-14 2008-08-12 Gpi Nil Holdings Inc. N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders
AU773273B2 (en) 1999-02-26 2004-05-20 Bristol-Myers Squibb Company Novel sulfonamide compounds and uses thereof
AU765203B2 (en) 1999-04-19 2003-09-11 Shionogi & Co., Ltd. Sulfonamide derivatives having oxadiazole rings
EP1088821A1 (en) * 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
EP1088815A1 (en) * 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonyl amino acid derivatives
CA2387493A1 (en) * 1999-10-08 2001-04-19 Lorin Andrew Thompson Amino lactam sulfonamides as inhibitors of a.beta. protein production
IL156268A0 (en) 2000-12-13 2004-01-04 Wyeth Corp Heterocyclic sulfonamide inhibitors of beta amyloid production
US6657070B2 (en) * 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
CA2470111A1 (en) 2001-12-11 2003-06-19 Wyeth Production of chirally pure .alpha.-amino acids and n-sulfonyl .alpha.-amino acids
JP4250529B2 (ja) 2001-12-11 2009-04-08 ワイス キラル的に純粋なβ−アミノアルコールの合成方法
NZ536665A (en) 2002-06-11 2006-11-30 Wyeth Corp Use of substituted phenylsulfonamide as inhibitors of beta amyloid production
RU2342374C2 (ru) * 2003-03-31 2008-12-27 Уайт Фтор- и трифторалкилсодержащие гетероциклические сульфонамидные ингибиторы образования бета-амилоида и их производные

Also Published As

Publication number Publication date
ATE330950T1 (de) 2006-07-15
US20110034513A1 (en) 2011-02-10
US6878742B2 (en) 2005-04-12
US7691884B2 (en) 2010-04-06
PT1341779E (pt) 2006-10-31
EA009035B1 (ru) 2007-10-26
NZ526213A (en) 2005-05-27
ES2267853T3 (es) 2007-03-16
IL156268A0 (en) 2004-01-04
HUP0303857A3 (en) 2007-07-30
US6610734B2 (en) 2003-08-26
AR035516A1 (es) 2004-06-02
US20050196813A1 (en) 2005-09-08
SG128491A1 (en) 2007-01-30
ZA200304135B (en) 2004-09-03
PL365950A1 (en) 2005-01-24
WO2002057252A3 (en) 2002-12-12
MXPA03005255A (es) 2004-10-14
US20020183361A1 (en) 2002-12-05
JP2010265280A (ja) 2010-11-25
NO328885B1 (no) 2010-06-07
CN1800176A (zh) 2006-07-12
CN1263750C (zh) 2006-07-12
NO20032645L (no) 2003-08-05
CN1503790A (zh) 2004-06-09
US20030229127A1 (en) 2003-12-11
HK1059619A1 (en) 2004-07-09
NZ538100A (en) 2006-07-28
CA2436526A1 (en) 2002-07-25
WO2002057252A2 (en) 2002-07-25
US7842718B2 (en) 2010-11-30
CA2436526C (en) 2010-10-19
SI1341779T1 (sl) 2006-12-31
TWI235155B (en) 2005-07-01
DK1341779T3 (da) 2006-10-30
IL188853A0 (en) 2011-08-01
KR100869061B1 (ko) 2008-11-17
KR20040018318A (ko) 2004-03-03
AU2002245123B2 (en) 2007-05-24
US20100022594A1 (en) 2010-01-28
IL156268A (en) 2008-04-13
DE60121032D1 (de) 2006-08-03
DE60121032T2 (de) 2007-01-11
JP2004517892A (ja) 2004-06-17
EP1341779A2 (en) 2003-09-10
BR0116063A (pt) 2004-08-03
HUP0303857A2 (hu) 2004-03-29
EP1341779B1 (en) 2006-06-21
NO20032645D0 (no) 2003-06-11
EA200300674A1 (ru) 2004-06-24

Similar Documents

Publication Publication Date Title
CY1105441T1 (el) Ετepοκυκλικοι σουλφοναμιδικοι αναστολεις της παραγωγης βητα αμυλοειδους
CY1107108T1 (el) Παραγωγα αρυλομεθυλο-καρβονυλαμινο-θειαζολης και χρησις των ως αντινεοπλασματικοι παραγοντες
CY1122863T1 (el) Φαρμακευτικη συνθεση που περιεχει γλυκοπυρρολικο και εναν αγωνιστη βητα2 αδρενοϋποδοχεα
CY1124837T1 (el) Ενωσεις βενζο[β]θειοφαινιου ως αγωνιστες sting
CY1107080T1 (el) Υποκατεστημενες ινδολο-βασεις του mannich
CY1116103T1 (el) Υποκατεστημενα παραγωγα 1,2,3,4-τετραϋδροϊσοκινολινης
ATE302775T1 (de) Carbolinderivate
BR0109703A (pt) Derivados de piperazina
CY1106801T1 (el) Νεες ετεροκυκλικες ενωσεις, η παρασκευη τους και η χρηση τους ως φαρμακα, ιδιαιτερα ως αντιβακτηριακα
CY1108451T1 (el) Παραγωγα τριαζολυλοτροπανιου ως ρυθμιστες ccr5
CY1105301T1 (el) Αρυλοσυμπυκνωμενες αζαπολυκυκλικες ενωσεις
CY1113487T1 (el) Νεα παραγωγα μανδελικου οξεος και η χρηση τους ως αναστολεις θροβινης
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
CY1110521T1 (el) Υποκατεστημενα ινδολια για τη διαμορφωση της nfkb-ενεργοτητας
CY1110247T1 (el) Παραγωγα βενζοκιναζολινης και η χρηση τους στην θεραπεια των διαταραχων των οστων
BG108268A (en) Pyrazolopyrimidines as therapeutic agents
PA8578601A1 (es) Derivados de 2,2- difenil-benzodioxol
CY1113171T1 (el) Αντιφλεγμονωδεις παραγοντες
CY1108894T1 (el) Νεα παραγωγα βενζιμιδαζολης
ATE408601T1 (de) Fredericamycin-derivate
CY1108347T1 (el) Ενωσεις ιμιδαζολιου για την θεραπεια νευροεκφυλιστικων διαταραχων
DK2314582T3 (da) Heterocykliske forbindelser som antivirusmidler
UY26872A1 (es) Derivados de la 4- fenil piridina
CY1110863T1 (el) Παραγωγα του 2-(8,9-διοξο-2,6-διαζαδικυκλο (5.2.0)-εννε-1(7)-εν-2-υλ)αλκυλ-φωσφονικου οξεος και η χρηση τους ως ανταγωνιστων του ν-μεθυλ- d-ασπαρτικου (nmda) υποδοχεα
CY1110332T1 (el) Παραγωγα βενζιμιδαζολης, συνθεσεις που τα περιεχουν, παρασκευη αυτων και χρηση τους