KR920019763A - 아졸 화합물, 그의 제조방법 및 용도 - Google Patents
아졸 화합물, 그의 제조방법 및 용도 Download PDFInfo
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- KR920019763A KR920019763A KR1019920007035A KR920007035A KR920019763A KR 920019763 A KR920019763 A KR 920019763A KR 1019920007035 A KR1019920007035 A KR 1019920007035A KR 920007035 A KR920007035 A KR 920007035A KR 920019763 A KR920019763 A KR 920019763A
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- South Korea
- Prior art keywords
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- salt
- optionally substituted
- compound
- formula
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- 150000003851 azoles Chemical class 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 5
- 239000001273 butane Substances 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 claims 3
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 3
- 125000002029 aromatic hydrocarbon group Chemical class 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 150000003456 sulfonamides Chemical class 0.000 claims 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Chemical group 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- PEUPUKDBCPLDIH-UHFFFAOYSA-N 1,2,4-triazole Chemical group C1=NC=N[N]1 PEUPUKDBCPLDIH-UHFFFAOYSA-N 0.000 claims 1
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- -1 azole compound Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 하기식(I)로 표시되는 아졸 화합물 또는 그의 염 :[상기식에서, X은 질소 원자 또는 CH이고 ; Ar은 치환된 페닐기이고 ; R1및 R2은 독립적으로 수소 원자 또는 저급 알킬기이거나, 이들이 함께 결합하여 저급 알킬렌기를 형성할 수도 있고 ; B은 하기식의 기 :(식중, R3및 R4은 독립적으로 수소 원자, 임의로 치환된 지방족 방향족 탄화수소 잔기, 또는 임의로 치환된 헤테로시클릭기이거나, 이들이 결합된 질소 원자와 함께 임의로 치환된 헤테로시클릭기를 형성할 수도 있고 ; n은 0∼2의 정수를 나타냄) 또는 하기식의 기 :(식중, R5및 R6은 독립적으로 수소 원자, 임의로 치환된 지방족 또는 방향족 탄화수소 잔기, 또는 임의로 치환된 헤테로시클릭기이거나, 이들이 결합된 질소 원자 및 황원자와 함께 임의로 치환된 헤테로시클릭기를 형성할 수도 있고 ; m은 0∼2의 정수를 나타냄)이며 ; R7은 수소 원자 또는 아실화된 히드록실기이거나, R1과 함께 결합을 형성할 수도 있다.]
- 제1항에 있어서, 하기식(Ia)으로 표시되는 화합물 또는 그의 염 :[상기식에서, X은 질소 원자이고 ; Ar은 치환된 페닐기이고 ; R1, R2, R7및 n은 식(I)에서 정의된 의미와 동일하며 ; R3a및 R4a는 독립적으로 임의로 치환된 지방족 또는 방향족 탄화수소 잔기 또는 임의로 치환된 헤테로시클릭이거나, 이들이 결합된 질소 원자와 함께 임의로 치환된 헤테로시클릭기를 형성할 수도 있다.]
- 제1항에 있어서, 하기식(Ib)으로 표시되는 화합물 또는 그의 염 :[상기식에서, X은 질소 원자이고 ; Ar은 치환된 페닐기이고 ; R1, R2, R7및 m은 식(I)에서 정의된 의미와 동일하며 ; R5및 R6a는 독립적으로 수소원자, 임의로 치환된 지방족 또는 방향족 탄화수소 잔기 또는 헤테로시클릭기이거나, 이들이 결합된 질소 원자 및 황원자와 함께 임의로 치환된 헤테로시클릭기를 형성할 수도 있다.]
- 제1항에 있어서, X가 질소원자이고, R1이 수소원자이고, R2가 메틸기이며 Ar이 할로겐-치환된 페닐기인 화합물 또는 그의 염.
- 제1항에 있어서, B가 하기식의 기인 화합물 또는 그의 염 :[상기식에서, R3및 R4은 독립적으로 수소 원자 또는 임의로 치환된 C1∼C12알킬기이며, n은 0∼2의 정수이다.]
- 제1항에 있어서, B가 하기식의 기인 화합물 또는 그의 염 :[상기식에서, R5및 R6은 독립적으로 수소 원자 또는 임의로 치환된 C1∼C12알킬기이며, m은 0∼2의 정수이다.]
- 제1항에 있어서, n 또는 m이 2의 정수인 화합물 또는 그의 염.
- 제4항에 있어서, Ar 및 R7이 결합된 탄소원자와 R1및 R2가 결합된 탄소원자가 각각 R-배열된 화합물 또는 그의 염.
- 제1항에 있어서, N,N-디메틸-[(2R,3R)-3-(2,4-디플루오로페닐)-3-히드록시-4-(1H-1,2,4-트리아졸-1-일)-2-부탄]술폰아미드, N-메틸-[(2R,3R)-3-(2,4-디플루오로페닐)-3-히드록시-4-(1H-1,2,4-트리아졸-1-일)-2-부탄]술폰아미드, N-[(2R,3R)-3-(2,4-디플루오로페닐)-3-히드록시-4-(1H-1,2,4-트리아졸-1-일)-2-부탄]메탄술폰아미드, N-[(2R,3R)-3-(2,4-디플루오로페닐)-3-히드록시-4-(1H-1,2,4-트리아졸-1-일)-2-부탄]-N-메틸 메탄술폰아미드, 또는 N-(3-피리딘메틸)-N-메틸-[(2R,3R)-3-(2,4-디플루오로페닐)-3-히드록시-4-(1H-1,2,4-트리아졸-1-일)-2-부탄]술폰아미드인 화합물 또는 그의 염.
- (i) 하기식(II)로 표시되는 화합물 또는 그의 염을 하기식(III)으로 표시되는 화합물 또는 그의 염과 반응시킨 다음, 필요하다면 얻어진 화합물을 산화시키거나,[상기식에서, Z은 활성기이고, 기타 부호들은 식(I)에서 정의된 의미와 동일하다] (ii) 하기식(IV)으로 표시되는 화합물 또는 그의 염을 하기식(V)으로 표시되는 화합물 또는 그의 염과 반응시킴을 특징으로 하는 제1항에 기재된 식(I)의 화합물 또는 그의 염의 제조방법 :[상기식에서, Z'은 활성기이고, 기타 부호들은 식(I)에서 정의한 의미와 동일하다.]
- 제1항에 기재된 식(I)의 아졸 화합물 또는 그의 염과 담체 또는 희석제를 함유하는 항진균제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP91-097638 | 1991-04-26 | ||
| JP9763891 | 1991-04-26 | ||
| JP91-188871 | 1991-07-29 | ||
| JP18887191 | 1991-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR920019763A true KR920019763A (ko) | 1992-11-19 |
Family
ID=26438812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920007035A KR920019763A (ko) | 1991-04-26 | 1992-04-25 | 아졸 화합물, 그의 제조방법 및 용도 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US5389663A (ko) |
| EP (1) | EP0510700A3 (ko) |
| KR (1) | KR920019763A (ko) |
| CA (1) | CA2067272A1 (ko) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2062941B1 (es) * | 1993-03-15 | 1995-10-01 | Uriach & Cia Sa J | Nuevos derivados de azol activos por via oral. |
| ES2164238T3 (es) | 1995-04-06 | 2002-02-16 | Sankyo Co | Agente antifungico de triazol. |
| WO1998033778A1 (en) * | 1997-02-04 | 1998-08-06 | Sankyo Company, Limited | Triazole derivatives |
| EP0884311A3 (en) * | 1997-06-06 | 1999-01-27 | Takeda Chemical Industries, Ltd. | Triazole Derivatives and their production |
| CA2436526C (en) | 2000-12-13 | 2010-10-19 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production |
| US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
| HUP0303249A3 (en) * | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| CN1713960A (zh) | 2002-11-04 | 2005-12-28 | 国际壳牌研究有限公司 | 细长型颗粒及其作为催化剂或催化剂载体的用途 |
| KR20060002908A (ko) | 2003-03-31 | 2006-01-09 | 와이어쓰 | 베타 아밀로이드 생산 억제제인 플루오로- 및트리플루오로알킬-함유 헤테로사이클릭 설폰아미드 및 이의유도체 |
| KR101404862B1 (ko) * | 2010-02-12 | 2014-06-09 | 주식회사 대웅제약 | 신규한 항진균성 트리아졸 유도체 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR930004193B1 (ko) * | 1984-10-02 | 1993-05-21 | 스미또모 세이야꾸 가부시끼가이샤 | N-치환된 트리아졸 유도체의 제조방법 |
| FI97382C (fi) * | 1988-03-04 | 1996-12-10 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten 1,2,4-triatsolijohdannaisten valmistamiseksi |
| IE903395A1 (en) * | 1989-09-26 | 1991-04-10 | Takeda Chemical Industries Ltd | Triazole compounds, their production and use |
| EP0446877A3 (en) * | 1990-03-15 | 1992-05-06 | Takeda Chemical Industries, Ltd. | Triazoles, their production and use |
| ES2024332A6 (es) * | 1990-10-08 | 1992-02-16 | Uriach & Cia Sa J | Procedimiento para la obtencion de nuevas sulfonamidas. |
-
1992
- 1992-04-25 KR KR1019920007035A patent/KR920019763A/ko not_active Application Discontinuation
- 1992-04-25 EP EP19920107092 patent/EP0510700A3/en not_active Withdrawn
- 1992-04-27 CA CA002067272A patent/CA2067272A1/en not_active Abandoned
-
1993
- 1993-11-24 US US08/156,925 patent/US5389663A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0510700A3 (en) | 1992-12-16 |
| CA2067272A1 (en) | 1992-10-27 |
| US5389663A (en) | 1995-02-14 |
| EP0510700A2 (en) | 1992-10-28 |
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