CY1105097T1 - Χρηση παραγωγων ν-φαινυλο-2-πυριμιδιναμινης στην αγωγη εναντι φλεγμονωδων ασθενειων - Google Patents
Χρηση παραγωγων ν-φαινυλο-2-πυριμιδιναμινης στην αγωγη εναντι φλεγμονωδων ασθενειωνInfo
- Publication number
- CY1105097T1 CY1105097T1 CY20061100979T CY061100979T CY1105097T1 CY 1105097 T1 CY1105097 T1 CY 1105097T1 CY 20061100979 T CY20061100979 T CY 20061100979T CY 061100979 T CY061100979 T CY 061100979T CY 1105097 T1 CY1105097 T1 CY 1105097T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- inflammatory diseases
- phenyl
- inhibitor
- administration
- Prior art date
Links
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 150000004046 2-(N-anilino)pyrimidines Chemical class 0.000 title 1
- 108010002386 Interleukin-3 Proteins 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 2
- 230000030833 cell death Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
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- A—HUMAN NECESSITIES
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- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
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- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
Abstract
Η παρούσα εφεύρεση σχετίζεται με μέθοδο αγωγής έναντι φλεγμονωδών ασθενειών όπως η ρευματοειδής αρθρίτιδα (η RA), η οποία μέθοδος περιλαμβάνει τη χορήγηση αναστολέα τυροσινικής κινάσης σε ασθενή με χρεία της αγωγής αυτής, πιο συγκεκριμένα τη χορήγηση ενός μη τοξικού, επιλεκτικού και ικανού αναστολέα του c-kit. Κατά προτίμηση, ο αναφερθέν αναστολέας δεν είναι ικανός να προάγει τον κυτταρικό θάνατο των εξαρτώμενων από IL-3 κυττάρων τα οποία καλλιεργούνται παρουσία IL-3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30141001P | 2001-06-29 | 2001-06-29 | |
PCT/IB2002/003301 WO2003002108A2 (en) | 2001-06-29 | 2002-06-28 | Use of tyrosine kinase inhibitors for treating inflammatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105097T1 true CY1105097T1 (el) | 2010-03-03 |
Family
ID=23163226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100979T CY1105097T1 (el) | 2001-06-29 | 2006-07-14 | Χρηση παραγωγων ν-φαινυλο-2-πυριμιδιναμινης στην αγωγη εναντι φλεγμονωδων ασθενειων |
Country Status (11)
Country | Link |
---|---|
US (1) | US7741335B2 (el) |
EP (1) | EP1401415B1 (el) |
JP (1) | JP2004537537A (el) |
AT (1) | ATE330608T1 (el) |
CA (1) | CA2452169A1 (el) |
CY (1) | CY1105097T1 (el) |
DE (1) | DE60212627T2 (el) |
DK (1) | DK1401415T3 (el) |
ES (1) | ES2266553T3 (el) |
PT (1) | PT1401415E (el) |
WO (1) | WO2003002108A2 (el) |
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JP2004537542A (ja) * | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性腸疾患(ibd)を治療するための、チロシンキナーゼ阻害剤の使用 |
EP1401413B1 (en) | 2001-06-29 | 2006-11-22 | AB Science | Use of tyrosine kinase inhibitions for treating allergic diseases |
CA2452366A1 (en) * | 2001-06-29 | 2003-01-16 | Ab Science | Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis |
JP2005500041A (ja) * | 2001-06-29 | 2005-01-06 | アブ サイエンス | 強力で選択的かつ非毒性のc−kit阻害剤 |
DE60212627T2 (de) | 2001-06-29 | 2007-06-14 | Ab Science | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung von entzündlichen Krankheiten |
WO2003024386A2 (en) * | 2001-09-20 | 2003-03-27 | Ab Science | Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis |
CA2461182A1 (en) * | 2001-09-20 | 2003-05-01 | Ab Science | Use of tyrosine kinase inhibitors for promoting hair growth |
GB0201882D0 (en) * | 2002-01-28 | 2002-03-13 | Novartis Ag | Organic compounds |
PT1478380E (pt) * | 2002-02-27 | 2006-12-29 | Ab Science | Utilização de inibidores de tirosina-cinases para tratar doenças do snc |
CA2479257A1 (en) * | 2002-03-21 | 2003-10-02 | Dana-Farber Cancer Institute, Inc. | Inhibition of cell death responses induced by oxidative stress |
WO2004026930A2 (en) * | 2002-06-26 | 2004-04-01 | The Ohio State University Research Foundation | The method for reducing inflammation using sti-571 or its salt |
BRPI0313165B8 (pt) | 2002-08-02 | 2021-05-25 | Ab Science | 2-(3-aminoaril)amino-4-aril-tiazóis e sua utilização como inibidores de c-kit |
US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
JP4971797B2 (ja) | 2003-10-23 | 2012-07-11 | アブ サイエンス | チロシンキナーゼ阻害薬としての2−アミノアリールオキサゾール化合物 |
EP1746990A1 (en) * | 2004-05-18 | 2007-01-31 | AB Science | Use of mast cells inhibitors for treating patients exposed to chemical or biological weapons |
MX2007012392A (es) | 2005-04-04 | 2007-12-05 | Ab Science | Derivados de oxazol sustituidos y su uso como inhibidores de tirosina cinasa. |
WO2007119447A1 (ja) | 2006-03-20 | 2007-10-25 | Seikagaku Corporation | 関節リウマチの処置剤 |
ES2522169T3 (es) | 2007-02-13 | 2014-11-13 | Ab Science | Forma polimorfa de derivado de 2-amino (nitroaril) tiazol |
WO2013014170A1 (en) | 2011-07-27 | 2013-01-31 | Ab Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
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-
2002
- 2002-06-28 DE DE60212627T patent/DE60212627T2/de not_active Expired - Lifetime
- 2002-06-28 ES ES02758693T patent/ES2266553T3/es not_active Expired - Lifetime
- 2002-06-28 WO PCT/IB2002/003301 patent/WO2003002108A2/en active IP Right Grant
- 2002-06-28 EP EP02758693A patent/EP1401415B1/en not_active Expired - Lifetime
- 2002-06-28 DK DK02758693T patent/DK1401415T3/da active
- 2002-06-28 JP JP2003508347A patent/JP2004537537A/ja active Pending
- 2002-06-28 AT AT02758693T patent/ATE330608T1/de not_active IP Right Cessation
- 2002-06-28 CA CA002452169A patent/CA2452169A1/en not_active Abandoned
- 2002-06-28 US US10/482,039 patent/US7741335B2/en not_active Expired - Lifetime
- 2002-06-28 PT PT02758693T patent/PT1401415E/pt unknown
-
2006
- 2006-07-14 CY CY20061100979T patent/CY1105097T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2004537537A (ja) | 2004-12-16 |
ATE330608T1 (de) | 2006-07-15 |
ES2266553T3 (es) | 2007-03-01 |
US20050059688A1 (en) | 2005-03-17 |
DE60212627T2 (de) | 2007-06-14 |
US7741335B2 (en) | 2010-06-22 |
DE60212627D1 (de) | 2006-08-03 |
PT1401415E (pt) | 2006-09-29 |
WO2003002108A3 (en) | 2003-09-25 |
DK1401415T3 (da) | 2006-10-16 |
CA2452169A1 (en) | 2003-01-09 |
EP1401415B1 (en) | 2006-06-21 |
WO2003002108A2 (en) | 2003-01-09 |
EP1401415A2 (en) | 2004-03-31 |
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