ECSP088645A - Nuevos benzotiazoles sustituidos con heteroaril - Google Patents

Nuevos benzotiazoles sustituidos con heteroaril

Info

Publication number
ECSP088645A
ECSP088645A EC2008008645A ECSP088645A ECSP088645A EC SP088645 A ECSP088645 A EC SP088645A EC 2008008645 A EC2008008645 A EC 2008008645A EC SP088645 A ECSP088645 A EC SP088645A EC SP088645 A ECSP088645 A EC SP088645A
Authority
EC
Ecuador
Prior art keywords
relates
benzotiazols
heteroaril
replaced
new
Prior art date
Application number
EC2008008645A
Other languages
English (en)
Inventor
Gunnar Nordvall
Daniel Sohn
David Wensbo
Ylva Gravenfors
Catrin Jonasson
Jonas Malmstroem
David Pyring
Can Slivo
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38309497&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088645(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP088645A publication Critical patent/ECSP088645A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se relaciona con nuevos derivados de benzotiazol sustituidos con heteroaril, precursores de los mismos, y usos terapéuticos para tales compuestos, que tienen la fórmula estructural (I) a continuación: y su sal farmacéuticamente aceptable, composiciones y métodos de uso. Además, la invención se relaciona con nuevos derivados de benzotiazol sustituidos con heteroaril que son adecuados para obtener imágenes de los depósitos amiloides en pacientes vivos, sus composiciones, métodos de uso y procesos para hacer tales compuestos. Más específicamente, la presente invención se relaciona con un método de obtener imágenes de los depósitos amiloides en el cerebro in vivo para permitir el diagnóstico antemortem de la enfermedad de Alzheimer así como medir la eficacia clínica de los agentes terapéuticos contra la enfermedad de Alzheimer.
EC2008008645A 2006-01-27 2008-07-22 Nuevos benzotiazoles sustituidos con heteroaril ECSP088645A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76265406P 2006-01-27 2006-01-27

Publications (1)

Publication Number Publication Date
ECSP088645A true ECSP088645A (es) 2008-08-29

Family

ID=38309497

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008645A ECSP088645A (es) 2006-01-27 2008-07-22 Nuevos benzotiazoles sustituidos con heteroaril

Country Status (20)

Country Link
US (2) US8163928B2 (es)
EP (1) EP1981883A4 (es)
JP (1) JP5289061B2 (es)
KR (1) KR101406248B1 (es)
CN (1) CN101410393B (es)
AR (1) AR059178A1 (es)
AU (1) AU2007207904C1 (es)
BR (1) BRPI0707283A2 (es)
CA (1) CA2640213A1 (es)
EC (1) ECSP088645A (es)
IL (1) IL192876A0 (es)
NO (1) NO20083394L (es)
NZ (1) NZ569667A (es)
RU (1) RU2448106C2 (es)
SA (1) SA07280009B1 (es)
TW (2) TW201018678A (es)
UA (1) UA95267C2 (es)
UY (1) UY30112A1 (es)
WO (1) WO2007086800A1 (es)
ZA (1) ZA200806075B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201018678A (en) 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
US8530483B2 (en) 2008-05-30 2013-09-10 Merck Sharp & Dohme Corp. Substituted azabenzoxazoles
US8193363B2 (en) * 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
AU2009309027A1 (en) * 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel substituted azabenzoxazoles
US20120263646A1 (en) * 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
JP6069661B2 (ja) * 2010-06-24 2017-02-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用
CN106729771A (zh) 2011-04-21 2017-05-31 加利福尼亚大学董事会 官能化磁性纳米颗粒及在淀粉样沉积物和神经原纤维缠结成像中用途
WO2013040183A1 (en) * 2011-09-16 2013-03-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof
CN102558091B (zh) * 2011-12-22 2014-10-08 合肥工业大学 一种苯并噻唑类衍生物及其用途
CN102659772B (zh) * 2012-05-03 2015-02-11 北京师范大学 一种与Aβ斑块有亲和力的2-芳基苯并杂环化合物及其制备方法和应用
JP5422782B1 (ja) * 2012-12-21 2014-02-19 独立行政法人放射線医学総合研究所 脳内に蓄積したタウタンパク質をイメージングするための新規化合物
EP2968296B1 (en) 2013-03-12 2020-09-02 The Regents of the University of California Gamma-secretase modulators
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
WO2015051188A1 (en) 2013-10-02 2015-04-09 Washington University Heterocyclic molecules for biomedical imaging and therapeutic applications
WO2016004513A1 (en) * 2014-07-11 2016-01-14 Simon Fraser University Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods
WO2016010092A1 (ja) * 2014-07-16 2016-01-21 国立研究開発法人科学技術振興機構 ベンゾチアゾール化合物及びこれを含有する医薬
BR112017009010A2 (pt) 2014-10-31 2017-12-26 Massachusetts Gen Hospital moduladores potentes de gama-secretase
CN107001361A (zh) 2014-12-02 2017-08-01 拜耳医药股份有限公司 杂芳基取代的咪唑并[1，2‑a]吡啶及其用途
JP2017537916A (ja) * 2014-12-02 2017-12-21 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 有害生物防除剤としての二環式化合物
US10647692B2 (en) * 2015-03-12 2020-05-12 Fmc Corporation Heterocycle-substituted bicyclic azole pesticides
SI3340796T1 (sl) * 2015-08-28 2022-02-28 Chdi Foundation, Inc. Sonde za slikanje proteina huntingtina
GB201617339D0 (en) * 2016-10-12 2016-11-23 Lytix Biopharma As Therapeutic compounds
JP7168650B2 (ja) * 2017-08-02 2022-11-09 スピノジェニックス， インコーポレイテッド ベンゾチアゾールおよび関連化合物
CA3100235A1 (en) 2018-05-16 2019-11-21 Emory University Styrylbenzothiazole derivatives and uses in imaging
JP2022523106A (ja) * 2019-01-31 2022-04-21 スピノジェニックス， インコーポレイテッド スパイン形成の促進因子の固体形態
GB201914989D0 (en) * 2019-10-16 2019-11-27 Karin & Sten Mortstedt Cbd Solutions Ab Selective ligands for TAU Aggregates
TWI759962B (zh) 2019-11-13 2022-04-01 香港商新旭生技股份有限公司 用於降解tau蛋白聚集體的化合物及其用途
KR20220153888A (ko) * 2021-05-12 2022-11-21 에이치케이이노엔 주식회사 신규한 벤조티아졸 유도체, 이의 제조방법 및 이의 간질환 예방 또는 치료 용도
CN114380731A (zh) * 2022-03-09 2022-04-22 台州学院 一种kcnq钾离子通道激动剂、药物组合物及其应用
CN114478431A (zh) * 2022-03-09 2022-05-13 台州学院 一种双取代苯并噻吩类钾离子通道激动剂的制备方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU369122A1 (ru) * 1971-01-05 1973-02-08 А. К. Арен, П. П. Заринь, С. К. Германе, Э. С. Лавринович Институт органического синтеза Латвийской ССР Способ получения 4-(бензазолил-2)- 1,2,5,6-тетрагидропиридинов
AU523040B2 (en) * 1978-05-15 1982-07-08 Kanebo Limited Calcium -antagonistic composition
GB8305245D0 (en) 1983-02-25 1983-03-30 Fujisawa Pharmaceutical Co Imidazo-heterocyclic compounds
US4556411A (en) * 1984-12-07 1985-12-03 Fmc Corporation Benzothiazole derivatives for plant growth and development modification
JPS6394248A (ja) 1986-10-08 1988-04-25 Canon Inc 電子写真感光体
CA2034309C (en) * 1990-01-22 1997-04-01 Takashi Iwaki Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus
JPH09507071A (ja) 1993-12-21 1997-07-15 イーライ・リリー・アンド・カンパニー アミロイド原性ペプチドに関連した状態を治療又は予防する方法
US5518713A (en) * 1995-02-13 1996-05-21 3V Inc. Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them
JPH11116476A (ja) 1997-10-16 1999-04-27 Sankyo Co Ltd 縮合複素環化合物
ES2536449T3 (es) * 2000-08-24 2015-05-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer
JP2004524289A (ja) * 2000-12-22 2004-08-12 アストラゼネカ・アクチエボラーグ 治療化合物
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
CN100422180C (zh) 2001-04-23 2008-10-01 宾夕法尼亚州大学理事会 淀粉样斑块聚集抑制剂和诊断成像剂
US7622479B2 (en) * 2001-11-26 2009-11-24 Takeda Pharmaceutical Company Limited Bicyclic derivative, its production and use
GB0130305D0 (en) 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
WO2003106439A1 (ja) 2002-06-12 2003-12-24 株式会社ビーエフ研究所 アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬
TW200401194A (en) 2002-07-11 2004-01-16 Advanced Micro Devices Inc Method and apparatus for determining a processor state without interrupting processor operation
US7498349B2 (en) 2002-08-02 2009-03-03 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
JP2004250411A (ja) 2003-02-21 2004-09-09 Bf Kenkyusho:Kk アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物
CA2438032C (en) 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
EP1612204A4 (en) 2003-03-31 2007-04-11 Daiichi Seiyaku Co HYDRAZONE DERIVATIVE
US7329682B2 (en) * 2003-04-03 2008-02-12 Ewha University-Industry Collaboration Foundation Method for inhibiting 5-lipoxygenase using a benzoxazole derivative
WO2004101558A1 (en) * 2003-05-13 2004-11-25 F. Hoffmann-La Roche Ag 2-imidazo-benzothiazoles as adenosine receptor ligands
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AU2006251832A1 (en) 2005-05-27 2006-11-30 Queen's University At Kingston Treatment of protein folding disorders
US20080219922A1 (en) 2005-09-12 2008-09-11 Goodman Mark M Alzheimer's Disease Imaging Agents
CN101355940B (zh) 2005-09-16 2013-03-27 匹兹堡大学高等教育联邦体系 用于检测具有至少一种促淀粉样变蛋白的淀粉样沉积物的体内或体外方法
ES2379987T3 (es) 2005-10-11 2012-05-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compuestos de benzofurano marcados isotópicamente como radiotrazadores para proteínas amiloidógenas
CA2627722A1 (en) * 2005-10-31 2007-06-21 Merck & Co., Inc. Cetp inhibitors
JP4738419B2 (ja) 2005-11-30 2011-08-03 富士フイルムＲｉファーマ株式会社 アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
TW201018678A (en) 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
EP2023919A4 (en) * 2006-05-08 2010-12-22 Molecular Neuroimaging Llc COMPOUNDS AND AMYLOID PROBES FOR THERAPY AND IMAGING USES
TW200813035A (en) * 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
BRPI0806621A2 (pt) 2007-01-22 2011-09-13 Astrazeneca Ab composto, uso de um composto, composição farmacêutica, e, método in vivo para medir depósitos amilóides em um indivìduo

Also Published As

Publication number Publication date
TW200736252A (en) 2007-10-01
US8163928B2 (en) 2012-04-24
AU2007207904B2 (en) 2011-03-10
US20090028787A1 (en) 2009-01-29
AU2007207904C1 (en) 2011-10-13
AU2007207904A1 (en) 2007-08-02
UY30112A1 (es) 2007-08-31
KR20080090542A (ko) 2008-10-08
JP5289061B2 (ja) 2013-09-11
TW201018678A (en) 2010-05-16
EP1981883A1 (en) 2008-10-22
CN101410393A (zh) 2009-04-15
US8957215B2 (en) 2015-02-17
JP2009528271A (ja) 2009-08-06
CA2640213A1 (en) 2007-08-02
AR059178A1 (es) 2008-03-12
RU2448106C2 (ru) 2012-04-20
NO20083394L (no) 2008-10-02
CN101410393B (zh) 2012-01-25
US20120207679A1 (en) 2012-08-16
EP1981883A4 (en) 2010-10-06
NZ569667A (en) 2011-09-30
BRPI0707283A2 (pt) 2011-04-26
IL192876A0 (en) 2009-02-11
KR101406248B1 (ko) 2014-06-19
RU2008130965A (ru) 2010-03-10
UA95267C2 (en) 2011-07-25
SA07280009B1 (ar) 2011-07-20
WO2007086800A1 (en) 2007-08-02
ZA200806075B (en) 2012-12-27

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