PE20121187A1 - Canfenos arilados con actividad sobre los receptores cb2 y procesos para su preparacion - Google Patents
Canfenos arilados con actividad sobre los receptores cb2 y procesos para su preparacionInfo
- Publication number
- PE20121187A1 PE20121187A1 PE2012000598A PE2012000598A PE20121187A1 PE 20121187 A1 PE20121187 A1 PE 20121187A1 PE 2012000598 A PE2012000598 A PE 2012000598A PE 2012000598 A PE2012000598 A PE 2012000598A PE 20121187 A1 PE20121187 A1 PE 20121187A1
- Authority
- PE
- Peru
- Prior art keywords
- receptors
- activity
- hept
- phenyl
- alkyl
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 208000029028 brain injury Diseases 0.000 abstract 1
- 229930003827 cannabinoid Natural products 0.000 abstract 1
- 239000003557 cannabinoid Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- IWPOSDLLFZKGOW-UHFFFAOYSA-N oct-3-enoic acid Chemical compound CCCCC=CCC(O)=O IWPOSDLLFZKGOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
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- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
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- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
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- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
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- Hematology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Gastroenterology & Hepatology (AREA)
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Abstract
REFERIDA A UN DERIVADO DE CANFENO DE FORMULA (I), DONDE LA LINEA PUNTEADA REPRESENTA UN ENLACE SIMPLE O DOBLE; Ra ES ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, ENTRE OTROS; Rb Y Rc SON H, OH, =O, =S, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: METIL-2-(2,6-DIMETOXI-4-(2-METILOCTAN-2-IL)FENIL)-7,7-DIMETILBICICLO[2.2.1]HEPT-2-EN-1-CARBOXILATO, 2-(2,6-DIMETOXI-4-(2-METILOCTAN-2-IL)FENIL)-1,7,7-TRIMETILBICICLO[2.2.1]HEPT-2-ENO, ACIDO 2-(2,6-DIMETOXI-4-PENTIL-FENIL)-7,7-DIMETILBICICLO[2.2.1]HEPT-2-EN-1-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE LOS RECEPTORES CANNABINOIDES CB2 Y SON UTILES EN EL TRATAMIENTO DE LA INFLAMACION, ENFERMEDADES HEPATICAS, LESIONES CEREBRALES, DIABETES, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26267709P | 2009-11-19 | 2009-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121187A1 true PE20121187A1 (es) | 2012-09-23 |
Family
ID=43875675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000598A PE20121187A1 (es) | 2009-11-19 | 2010-11-18 | Canfenos arilados con actividad sobre los receptores cb2 y procesos para su preparacion |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8722938B2 (es) |
| EP (1) | EP2501669B1 (es) |
| JP (1) | JP5960058B2 (es) |
| KR (1) | KR20120091196A (es) |
| CN (1) | CN102648174B (es) |
| AU (1) | AU2010320467B2 (es) |
| BR (1) | BR112012010518A2 (es) |
| CA (1) | CA2774868C (es) |
| CL (1) | CL2012001290A1 (es) |
| CO (1) | CO6481008A2 (es) |
| CR (1) | CR20120247A (es) |
| EC (1) | ECSP12011864A (es) |
| ES (1) | ES2665519T3 (es) |
| IL (1) | IL218216A (es) |
| MA (1) | MA33753B1 (es) |
| MX (2) | MX355972B (es) |
| MY (1) | MY184647A (es) |
| NZ (1) | NZ599106A (es) |
| PE (1) | PE20121187A1 (es) |
| RU (1) | RU2578715C2 (es) |
| SG (2) | SG179203A1 (es) |
| UA (1) | UA109414C2 (es) |
| WO (1) | WO2011061744A2 (es) |
| ZA (1) | ZA201200752B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2665519T3 (es) * | 2009-11-19 | 2018-04-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Canfenos arilados, procedimientos para su preparación y usos de los mismos |
| CA2956056A1 (en) | 2014-10-27 | 2016-05-06 | F. Hoffmann-La Roche Ag | Radiolabeled cannabinoid receptor 2 ligand |
| US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
| JP2018534362A (ja) * | 2015-10-16 | 2018-11-22 | スキティアン バイオサイエンシーズ インコーポレーテッドＳｃｙｔｈｉａｎ Ｂｉｏｓｃｉｅｎｃｅｓ Ｉｎｃ． | 外傷性脳損傷を処置するための方法および組成物 |
| US20190315669A1 (en) | 2016-11-13 | 2019-10-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Process for the preparation of hu-910 and crystalline structure thereof |
| RU2651754C1 (ru) * | 2016-11-25 | 2018-04-23 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | ПРИМЕНЕНИЕ АЛИФАТИЧЕСКИХ ИМИНОПРОИЗВОДНЫХ КАМФОРЫ В КАЧЕСТВЕ ЭФФЕКТИВНЫХ ИНГИБИТОРОВ РЕПРОДУКЦИИ ВИРУСА ГРИППА штамм A/California/07/09 (H1N1) pdm09 и A/Puerto Rico/8/34 (H1N1) |
| KR102063962B1 (ko) * | 2017-10-25 | 2020-01-08 | 대구대학교 산학협력단 | 캄펜을 유효성분으로 함유하는 골다공증의 예방 또는 치료용 약학적 조성물 |
| KR20210093231A (ko) * | 2018-08-20 | 2021-07-27 | 베서, 파마 엘엘씨 | 칸나비노이드의 생성 공정 |
| WO2023058033A1 (en) * | 2021-10-10 | 2023-04-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Arylated fenchone derivatives, compositions comprising them, processes for their preparation and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE876241C (de) * | 1943-04-07 | 1953-05-11 | Lech Chemie Gersthofen | Verfahren zur Herstellung von Riechstoffen aus Terpenphenolen |
| US2537647A (en) * | 1948-02-21 | 1951-01-09 | Firestone Tire & Rubber Co | Rearrangement of terpenyl aryl ethers |
| DE828394C (de) * | 1948-10-02 | 1952-01-17 | Chemische Werke Huels G M B H | Verfahren zur Herstellung von UEberzuegen |
| US2647152A (en) * | 1950-07-12 | 1953-07-28 | Firestone Tire & Rubber Co | Terpenylalkylphenols and their preparation |
| US3284359A (en) * | 1963-12-26 | 1966-11-08 | Gen Electric | Barium potassium ferrite magnetic material exhibiting non-vanishing rotational hysteresis in applied magnetic fields |
| GB1306217A (es) * | 1969-07-04 | 1973-02-07 | ||
| US3800051A (en) * | 1970-09-21 | 1974-03-26 | Dow Chemical Co | Reducing serum cholesterol with certain substituted phenols |
| GB1504862A (en) * | 1974-04-11 | 1978-03-22 | Mar Pha Etu Expl Marques | Terpeno-phenoxyalkylamines |
| US4112000A (en) * | 1974-04-11 | 1978-09-05 | Mar-Pha, Societe D'etude Et D'exploitation De Marques | Terpenophenols |
| GB1548875A (en) * | 1975-06-23 | 1979-07-18 | Mar Pha Etu Expl Marques | Terpnyl phen (oxy)elkyl amideines and their use in pharmaceutical compositions |
| US5648352A (en) | 1991-09-13 | 1997-07-15 | Merck & Co., Inc. | Piperazinylcamphorsulfonyl oxytocin antagonists |
| HU227114B1 (en) | 1999-05-11 | 2010-07-28 | Egis Gyogyszergyar Nyilvanosan | (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same |
| AR031130A1 (es) | 2000-09-20 | 2003-09-10 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| CA2426033A1 (en) | 2000-11-08 | 2002-05-16 | Syngenta Participations Ag | Pyrrolcarboxamides and pyrrolcarbothioamides and their agrochemical uses |
| US20070276034A1 (en) * | 2002-05-31 | 2007-11-29 | Luke Esposito | Compounds, compositions and methods for the treatment of synucleinopathies |
| US8455687B2 (en) | 2002-05-31 | 2013-06-04 | Proteotech, Inc. | Compounds and compositions for use as modulators of tau aggregation and alleviation of tauopathies |
| US7601876B2 (en) | 2002-05-31 | 2009-10-13 | Proteotech, Inc. | Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis |
| US8227643B2 (en) | 2002-05-31 | 2012-07-24 | Proteotech, Inc. | Sirtuin 1 and the treatment of neurodegenerative diseases |
| ES2473581T3 (es) | 2002-05-31 | 2014-07-07 | Proteotech Inc. | Compuestos, composiciones y métodos para el tratamiento de amiloidosis y sinucleinopat�as tales como la enfermedad de Alzheimer, la diabetes de tipo 2 y la enfermedad de Parkinson |
| RU2233262C1 (ru) * | 2003-03-11 | 2004-07-27 | Государственное учреждение Институт химии Коми научного центра Уральского отделения РАН | Способ получения орто-терпенофенолов |
| CN1847207A (zh) * | 2006-03-27 | 2006-10-18 | 上海应用技术学院 | 合成檀香的制备方法 |
| ES2665519T3 (es) * | 2009-11-19 | 2018-04-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Canfenos arilados, procedimientos para su preparación y usos de los mismos |
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